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  • rRNA
  • A particularity of eukaryotic nuclear genomes is the occurrence of multiple 5S rRNA gene copies (5S rDNA) clustered in tandem repeats, with copy number varying from species to species. (wikipedia.org)
  • Binding between 5S rRNA and TFIIIA serves to both repress further transcription of the 5S RNA gene and stabilize the 5S RNA transcript until it is required for ribosome assembly. (wikipedia.org)
  • Candidate rRNA-snoRNA interactions can be found for one domain in each of the C/D element-containing RNAs. (asm.org)
  • The most prominent examples of non-coding RNAs are transfer RNA (tRNA) and ribosomal RNA (rRNA), both of which are involved in the process of translation.There are also non-coding RNAs involved in gene regulation, RNA processing and other roles. (wikibooks.org)
  • This process requires two other types of RNA: transfer RNA (tRNA) mediates recognition of the codon and provides the corresponding amino acid, while ribosomal RNA (rRNA) is the central component of the ribosome's protein manufacturing machinery. (wikibooks.org)
  • tRNA
  • Remarkably, the mutation rate at broadly expressed cytosolic tRNA loci is likely between 7 and 10 times greater than the nuclear genome average. (pnas.org)
  • snRNPs
  • Little is known about how snRNPs are built inside cells, but defects in snRNP assembly can lead to devestating diseases such as spinal muscular atrophy or retinitis pigmentosa, a genetic form of blindness. (beckman-foundation.org)
  • The RNA components of snRNPs interact with the intron and are involved in catalysis. (wikipedia.org)
  • nucleotide
  • A mistake in even a single nucleotide can be devastating to the cell, and a reliable, repeatable method of RNA processing is necessary to ensure cell survival. (wikipedia.org)
  • The present invention relates to kits and methods for efficiently generating 5′ capped RNA having a modified cap nucleotide and for use of such modified-nucleotide-capped RNA molecules. (freepatentsonline.com)
  • In particular, the present invention provides kits and methods for capping RNA using a modified cap nucleotide and a capping enzyme system, such as poxvirus capping enzyme. (freepatentsonline.com)
  • The present invention finds use for in vitro production of 5′-capped RNA having a modified cap nucleotide and for in vitro or in vivo production of polypeptides by in vitro or in vivo translation of such modified-nucleotide-capped RNA. (freepatentsonline.com)
  • In 1976, Walter Fiers and his team determined the first complete nucleotide sequence of an RNA virus genome, that of bacteriophage MS2. (wikibooks.org)
  • transcript
  • The RNA product, which is synthesised in the 5' to 3'direction, is known as the primary transcript. (ebi.ac.uk)
  • ribosome
  • Certain RNAs are able to catalyse chemical reactions such as cutting and ligating other RNA molecules, and the catalysis of peptide bond formation in the ribosome;these are known as ribozymes. (wikibooks.org)
  • metabolism
  • RNA FISH analyses suggest that these noncoding RNAs function in mRNA metabolism as they demonstrate an intimate association of these RNA species with SC35 nuclear speckles in both human and mouse cells. (biomedcentral.com)
  • The function of these noncoding RNAs in mRNA metabolism is suggested by their high levels of conservation and their intimate association with SC35 splicing domains in multiple mammalian species. (biomedcentral.com)
  • Initiation Factor
  • L. Li and C. C. Wang, "Identification in the ancient protist Giardia lamblia of two eukaryotic translation initiation factor 4E homologues with distinctive functions," Eukaryotic Cell , vol. 4, no. 5, pp. 948-959, 2005. (hindawi.com)
  • Subunits
  • Most RNA polymerases are multimeric enzymes and are composed of a variable number of subunits. (ebi.ac.uk)
  • It has been shown [ PMID: 12694606 , PMID: 2187864 , PMID: 8367291 , PMID: 12860379 ] that small subunits of about 30 to 40 kDa found in archebacterial and all three types of eukaryotic polymerases are highly conserved. (ebi.ac.uk)
  • analyses
  • Broadly sampled multigene analyses yield a well-resolved eukaryotic tree of life," Systematic Biology , vol. 59, no. 5, pp. 518-533, 2010. (hindawi.com)
  • microRNAs
  • At about the same time, 22 nt long RNAs, now called microRNAs, were found to have a role in the development of C. elegans . (wikibooks.org)
  • locus
  • First characterized in Trypanosoma brucei , the spliced leader-associated (SLA) RNA gene locus has now been isolated from the kinetoplastids Leishmania tarentolae and Trypanosoma cruzi . (asm.org)
  • NEAT1 , a noncoding RNA from the locus encoding for TncRNA , and NEAT2 (also known as MALAT-1 ). (biomedcentral.com)
  • Cajal
  • this excludes the Cajal Bodies and smaller entities defined by the snRNP "speckle" staining pattern, but otherwise, SC35 domains overlap nuclear speckles, splicing factor compartments (SFCs), and interchromatin granule clusters (IGCs). (biomedcentral.com)
  • ribonucleoprotein
  • However, for all classes of RNA molecules, nuclear export is dependent on the assembly of the RNA into the appropriate ribonucleoprotein complex, and nuclear export therefore also appears to function as an important proofreading mechanism. (biologists.org)
  • yeast
  • Three lines of evidence show that UK-118005 inhibits cell growth by targeting RNA Pol III in yeast. (asm.org)
  • whereas
  • These results showed that whereas some analogs inhibit RNA Pol III as expected, others caused growth inhibition by an entirely different mechanism. (asm.org)