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  • Cells
  • TOP mRNAs can be translationally activated when PC12 or embryonic stem (ES) cells are induced to grow (increase their size) by nerve growth factor and retinoic acid, respectively, while remaining mitotically arrested. (asm.org)
  • Mutation
  • For example, patients with X-linked α-thalassemia/mental retardation syndrome exhibit α-thalassemia resulting from the mutation of a general transcription factor needed for α-globin expression ( 7 ). (asm.org)
  • proteins
  • In response to exogenous stimuli or to biological factors such as age or nutrition, the muscle increases its size, the amount of contractile proteins and consequently force production. (frontiersin.org)
  • responses
  • Together, these studies demonstrate that CHOP should be viewed more broadly as a cell- and context-specific mediator of adaptive or maladaptive responses to stress rather than a proapoptotic transcription factor. (pubmedcentralcanada.ca)
  • Control
  • Control assays and synthetic DNA templates were designed to facilitate the assessment of the key experimental factors impacting your real-time PCR results. (bio-rad.com)