• Background Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. (qedbio.com)
  • HSPs (Heat shock proteins) are highly conserved ubiquitous proteins among species which are involved in maintaining appropriate folding and conformation of other proteins and are thus referred to as molecular chaperones. (biomedcentral.com)
  • The 90 KDa heat shock protein (Hsp90) is a highly conserved molecular chaperone crucially involved in maintaining cellular homoeostasis in organisms from most kingdoms of life with the exception of archea 1 . (nature.com)
  • Heat shock proteins (HSPs) are highly conserved and immunogenic proteins that are shared among diverse groups of mammals and microbial agents. (eg.net)
  • Throughout evolution, eukaryotes adopted a network of highly conserved proteins that buffer the positive charges of histones, maintaining their solubility and, therefore, avoiding aberrant interactions with other cellular components. (aging-us.com)
  • from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin. (lookformedical.com)
  • The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
  • On the other hand translocation of the remaining 50% of Mgm1 continues with the aid of the mitochondrial Hsp70-associated motor and chaperone (MMC) proteins of the TIM23 complex until lateral release of the second TM segment into the IM takes place. (biongenex.com)
  • Development and further characterization of a small subclass of rat olfactory receptor neurons that shows immunoreactivity for the HSP70 heat shock protein. (morimotolab.org)
  • Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature. (medchemexpress.cn)
  • To observe these conformational changes and to understand their interplay with the ATPase function, we developed a single-molecule assay that allows examination of yeast Hsp90 dimers in real time under various nucleotide conditions. (cipsm.de)
  • Previous studies have shown that ClpB-cyt/HSP100 gene belongs to the group class I Clp ATPase proteins and ClpB-cyt/HSP100 transcript is regulated by heat stress and developmental cues. (biomedcentral.com)
  • Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. (nih.gov)
  • However, the fact that OsClpC3 protein appears mitochondrial/chloroplastic with equal probability and OsClpC4 a plasma membrane protein reflects functional diversity of this class. (biomedcentral.com)
  • those of protein transport recent studies using yeast as a model system began to provide intriguing insights into phospholipid exchange between the ER and mitochondria as well as between the mitochondrial outer and inner membranes. (biongenex.com)
  • We have originally recognized Ups1 as a factor important for biogenesis of Mgm1 a mitochondrial fusion protein (56). (biongenex.com)
  • Recently, the signaling proteins involved in LPLI-induced proliferation merit special attention, some of which are regulated by mitochondrial signaling. (biomedcentral.com)
  • Additionally, the crosstalk between protein synthesis and proteasome-mediated protein degradation was analyzed in eukaryotic organisms under various cellular conditions. (diva-portal.org)
  • Protein synthesis inhibition was observed to increase proteasome function and assembly in human primary embryonic fibroblasts, with heat shock protein chaperone machinery to contribute to the elevated proteasome assembly. (diva-portal.org)
  • Alternatively, protein synthesis inhibition increased the protein levels of specific proteasome subunits without influencing the proteasome activity in C. elegans. (diva-portal.org)
  • Furthermore, proteasome activation by means which have also pro-longevity effects decreased the protein synthesis rate both in human fibroblast cellsand nematodes. (diva-portal.org)
  • Endoplasmic reticulum stress (ERS) is a state induced by increased synthesis of intracellular proteins, accumulation of mal-folded proteins, changes in cytosolic calcium levels, or imbalances in endoplasmic reticulum (ER) redox homeostasis [ 8 ]. (biomedcentral.com)
  • In all living cells, protein synthesis occurs on ribonucleoprotein particles called ribosomes. (cipsm.de)
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
  • Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)
  • During protein synthesis, ribosomes become stalled on polyproline-containing sequences, unless they are rescued in archaea and eukaryotes by the initiation factor 5A (a/eIF-5A) and in bacteria by the homologous protein EF-P. While a structure of EF-P bound to the 70S ribosome exists, structural insight into eIF-5A on the 80S ribosome has been lacking. (cipsm.de)
  • Ribonucleic acid in protozoa having regulatory and catalytic roles as well as involvement in protein synthesis. (lookformedical.com)
  • Description Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp90 Polyclonal Antibody (11107). (qedbio.com)
  • Primary Antibody: Rabbit Anti-Hsp90 Polyclonal Antibody (11107) at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. (qedbio.com)
  • Description Western blot analysis of Human Cell line lysates showing detection of HSP90 protein using Rabbit Anti-HSP90 Polyclonal Antibody (11107). (qedbio.com)
  • Primary Antibody: Rabbit Anti-HSP90 Polyclonal Antibody (11107) at 1:10000 for 2 hours at RT. (qedbio.com)
  • Primary Antibody: Rabbit Anti-HSP90 Polyclonal Antibody (11107) at 1:100 for 1 hour at RT. (qedbio.com)
  • Arresting the chaperone cycle at these stages by targeting different co-chaperone/Hsp90 interactions seems to be quite a viable alternative and is likely to achieve similar consequences as that of Hsp90 direct inhibition with added favors of high specificity and reduced side effect profile. (biomedcentral.com)
  • Thus the molecular docking analysis of WA into Hsp90 and active Hsp90/Cdc37 complex conducted in this study provides significant evidence in support of the proposed mechanism of chaperone assembly suppression by inhibition or disruption of active Hsp90/Cdc37 complex formation being accounted by non-assembly of the catalytically active Hsp90/Cdc37 complex. (biomedcentral.com)
  • Thus specific inhibition of individual proteins or signalling pathways holds a great potential for subversion of this genetic plasticity of cancers. (biomedcentral.com)
  • One option involves modulation of the protein through allosteric activation/inhibition. (nature.com)
  • Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
  • This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. (nih.gov)
  • This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. (nih.gov)
  • Altered expression of mismatch repair proteins associated with acquisition of microsatellite instability in a clonal model of human T lymphocyte aging. (nih.gov)
  • The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. (nih.gov)
  • Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma. (nih.gov)
  • The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
  • G-protein coupled receptors (GPCRs) are membrane proteins that transmit the effects of extracellular ligands to effect changes in the intracellular G-protein signaling system. (gauss-centre.eu)
  • I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
  • I further investigated membrane proteins and the targeting of tail-anchored proteins at Sheffield Hallam University. (brookes.ac.uk)
  • Furthermore, the results proved that the Hsf1, an upstream transcription factor of Hsps, had a positive effect on alleviating the unfolded protein response and that overexpression of Hsf1 reprogramed the pattern of ATF1 gene transcript levels. (biomedcentral.com)
  • From the complementation assays, OsClpD1 appears to be more effective than OsClpB-cyt protein in rescuing the thermosensitive defect of the yeast ScΔhsp104 mutant cells. (biomedcentral.com)
  • Although CS domains are frequently found in co-chaperones of the Hsp90 molecular chaperone, no interaction was detected between the Shq1p CS domain and yeast Hsp90 in vitro. (cornell.edu)
  • After the pathogenic bacterium Legionella pneumophila is phagocytosed, it injects more than 250 different proteins into the cytoplasm of host cells to evade lysosomal digestion and to replicate inside the host cell. (cipsm.de)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • Proteasome degradation machinery is responsible for the turnover of a huge variety of normal and abnormal proteins, thus regulating a plethora of cellular processes. (diva-portal.org)
  • The degradation tag (dTAG) system for target protein degradation can remove proteins from biological systems without the drawbacks of some genetic methods, such as slow kinetics, lack of reversibility, low specificity, and the inability to titrate dosage. (bvsalud.org)
  • In bone marrow cells and duodenum organoids derived from these mice, treatment with the dTAG degrader dTAG-13 resulted in rapid and robust protein degradation but caused no appreciable change in viability or the transcriptome. (bvsalud.org)
  • Our results suggest that the dTAG system can provide robust protein degradation in vivo and that loss of CDK2 or CDK5 in adult mice causes no previously unknown phenotypes. (bvsalud.org)
  • And, a large number of protein biosynthesis, degradation and assembly-related were up-regulated by JA to promote tuber protein biosynthesis and maintain strict protein quality control during tuber development. (biomedcentral.com)
  • Along with PTMs, the partial or complete disassembly of nucleosomes allows the exchange and degradation of pre-existing histone proteins, with the incorporation of newly synthesised histones onto chromatin that can eventually result in the resetting of previous epigenetic marks. (aging-us.com)
  • Members of the Alb3/Oxa1/YidC protein family function as insertases in chloroplasts, mitochondria, and bacteria. (cipsm.de)
  • Using the respective signal sequences cloned upstream to GFP/CFP reporter proteins and transient expression studies with onion epidermal cells, evidence is provided that rice ClpB-m and Clp-c proteins are indeed localized to their respective cell locations mitochondria and chloroplasts, respectively. (biomedcentral.com)
  • Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. (hindawi.com)
  • Mitochondria are the energy producing organelles in eukaryotic cell providing ATP through oxidative phosphorylation (OXPHOS). (hindawi.com)
  • The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
  • The co-localization of BmHSP60 candidate interaction proteins with mitochondria was analyzed by Mito-Tracker-Green. (chinaagrisci.com)
  • Conclusion】 Heat shock protein BmHSP60 of B. mori was identified to interact with BmANT and BmHSP90, and co-localized in mitochondria. (chinaagrisci.com)
  • A novel PA transfer protein Ups1 Once PS and PA are supplied from your ER to the OM in mitochondria they need to be further transported to the IM where phospholipid synthetic enzymes for PE and CL are located. (biongenex.com)
  • However little was known about how phospholipids are transported within mitochondria until Ups1 a conserved IMS protein was found to mediate lipid transport from your OM to IM (55). (biongenex.com)
  • We probe the open conformation of human Hsp90α for druggable sites that overlap with these allosteric control elements, and identify three putative natural compound allosteric modulators: Cephalostatin 17, 20(29)-Lupene-3β-isoferulate and 3′-Bromorubrolide F. We assess the allosteric potential of these ligands by examining their effect on the conformational dynamics of the protein. (nature.com)
  • Illustration of Hsp90α in the open conformation. (nature.com)
  • Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)
  • Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)
  • The change of cells tradition cells with plasmid DNA can be consequently beneficial for antigen creation, since these cells secrete viral prM and E proteins in VLPs having proper conformation and presentation of epitopes similar to those of virion particles. (techuniq.com)
  • Satyal, SH and Morimoto, R. I Biochemical events in the activation and attenuation of the heat shock transcriptional response. (morimotolab.org)
  • Combined, Hsp90A and Hsp90B are predicted to interact with 10% of the eukaryotic proteome. (wikipedia.org)
  • Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
  • Due to independent gene duplications, all organisms possess two isoforms, Oxa1 and Oxa2 except gram-negative bacteria, which encode only for one YidC-like protein. (cipsm.de)
  • HSP100 is a major heat-regulated protein family in diverse organisms. (biomedcentral.com)
  • It is also highly expressed in unstressed cells where it participates in controlling the activity, turnover, and trafficking of a variety of proteins. (qedbio.com)
  • Formation of active Hsp90/Cdc37 complex is one of the essential steps for facilitation of chaperone client interaction, non-assembly of which can lead to prevention of the chaperone-client association resulting in apoptosis of tumor cells. (biomedcentral.com)
  • It is one of the most abundant proteins in the eukaryotic cells comprising 1-2% of total proteins under non-stress conditions [ 3 ]. (biomedcentral.com)
  • The molecular chaperone heat-shock protein 90 (Hsp90) is one of the most abundant proteins in unstressed eukaryotic cells. (cipsm.de)
  • Evaluation of the antiaging and protein anti-aggregation effects of this bioactive compound indicated that 18α-GA promoted longevity in nematodes through proteasome-and SKN-1-mediated activation and decelerated Alzheimer'sdisease progression and neuropathology both in nematodes and neuronal cells. (diva-portal.org)
  • Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)
  • Finally, the cloning vector of candidate interaction proteins was constructed and fused with HA tag, and transferred into B. mori cells with BmHSP60, respectively. (chinaagrisci.com)
  • The BmHSP60 candidate interaction protein clone expression vector was constructed and fused with HA tag, and co-transfected with BmHSP60 into B. mori cells. (chinaagrisci.com)
  • As scaffolding molecules, they significantly regulate the DNA packaging into the nucleus of all eukaryotic cells. (aging-us.com)
  • Eukaryotic cells compact their large genome into highly ordered chromatin structures within the nucleus. (aging-us.com)
  • Given the considerable stability of the nucleosome, eukaryotic cells employ a staggering array of interconnected molecular mechanisms that locally modify the electrostatic interaction between the highly basic histones and the negatively charged DNA molecules. (aging-us.com)
  • These approaches include analysis of spatial and temporal responses by plants to infection, and techniques that allow the expression of viral genes transiently or transgenically in planta, the expression of plant and foreign genes from virus vectors, the silencing of plants genes, imaging of live, infected cells, and the detection of interactions between viral proteins and plant gene products, both in planta and in various in vitro or in vivo systems. (springer.com)
  • In eukaryotic cells complex membrane structures called organelles are highly designed to exert specialized functions. (biongenex.com)
  • Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. (biomedcentral.com)
  • In cell biology, the nucleus is a membrane-enclosed organelle found in eukaryotic cells. (absoluteastronomy.com)
  • Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
  • We've referred to WNV previously, JEV, SLEV, and DENV-1 to -4 plasmid constructs that immediate the manifestation of prM/M and E protein and secretion of VLPs in to the cells culture press of plasmid-transformed cells. (techuniq.com)
  • A total of 257 differentially expressed proteins (DEPs) were identified by iTRAQ, which provided a comprehensive overview on the functional protein profile changes of tuber development regulated by JA. (biomedcentral.com)
  • A total of 32 differentially expressed proteins were identified by comparing the results of silver-linked mass spectrometry with those of silkworm genome database and NCBI database. (chinaagrisci.com)
  • Principal Component Analysis (PCA) demonstrated that the protein patterns between PR and MF were more similar than ST. Differentially accumulated proteins (DAPs) analysis showed that there were 510, 173 and 514 DAPs in the comparisons of ST vs. PR, PR vs. MF and ST vs. MF, respectively. (peerj.com)
  • Current research on Hsp90A focuses in its role as a drug target due to its interaction with a large number of tumor promoting proteins and its role in cellular stress adaptation. (wikipedia.org)
  • This connectivity allows Hsp90 to function as a network hub linking diverse protein interaction networks. (wikipedia.org)
  • Hsp90's diverse array of clientele implicate the chaperone in several associated biological functions and place it at the intersection of various fundamental cellular pathways, where it acts as a central hub in maintaining numerous protein interaction networks 1 . (nature.com)
  • The objective of this study is to identify the interaction proteins of BmHSP60, and to provide a basis for further exploring the mechanism in the innate immunity of B. mori . (chinaagrisci.com)
  • The antibody was incubated with the magnetic beads to capture the interaction proteins. (chinaagrisci.com)
  • The size of the bands was aligned with the NCBI database to screen for candidate interaction proteins according to the mass spectrometry results. (chinaagrisci.com)
  • Co-immunoprecipitation and fluorescence co-localization confirmed the interaction between BmHSP60 and candidate proteins. (chinaagrisci.com)
  • The 5 bands were mixed into a protein pool for mass spectrometry, and 5 interaction proteins were screened consistent with the differential bands in silver staining according to the number of peptides and molecular weight of proteins. (chinaagrisci.com)
  • Objective】 HSP60 is an important member of heat shock proteins, which plays an important role in the innate immunity of insects, and is also an essential factor for insect growth and development. (chinaagrisci.com)
  • The study conducted here is an attempt to explore the potential of Withania somnifera's major constituent WA (Withaferin A) in attenuating the Hsp90/Cdc37 chaperone/co-chaperone interactions for enhanced tumor arresting activity and to elucidate the underlying mode of action using computational approaches. (biomedcentral.com)
  • This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. (nih.gov)
  • Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
  • Biological Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. (qedbio.com)
  • Hsp90 is involved in the folding, assembly, maturation, and stabilization of specific proteins as a member of a chaperone complex. (qedbio.com)
  • Hsp90 requires a series of co-chaperones to assemble into a super-chaperone complex for its function. (biomedcentral.com)
  • The molecular chaperone Hsp90 has been a promising target for cancer therapy. (biomedcentral.com)
  • Our docking results obtained substantiate the hypothesis that WA has the potential to inhibit the association of chaperone (Hsp90) to its co-chaperone (Cdc37) by disrupting the stability of attachment of Hsp90 to Cdc37. (biomedcentral.com)
  • ClpB-cyt/HSP100 protein acts as chaperone, mediating disaggregation of denatured proteins. (biomedcentral.com)
  • Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein P23. (morimotolab.org)
  • Most of the Hsp90-regulated proteins are involved in cell signaling and include the kinases, v-Src, Wee1, c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of hepatitis B virus and telomerase. (qedbio.com)
  • Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI Negative regulation of the heat shock transcriptional response by HSBP1. (morimotolab.org)
  • Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI and Nagata K. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. (morimotolab.org)
  • Plasmid DNA including a eukaryotic transcriptional device comprising the human being cytomegalovirus instant early gene promoter, Kozak consensus ribosomal binding series, the signal series produced from the carboxy terminus from the C proteins of JEV, as well as the E and prM/M gene regions is enough for production of VLPs. (techuniq.com)
  • This cycle probably induces conformational changes in the client proteins, thereby causing their activation. (qedbio.com)
  • The compiled distributions of dwell times allow us to assign all rate constants to a minimal kinetic model for the conformational changes of Hsp90 and to delineate the influence of ATP hydrolysis. (cipsm.de)
  • The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)
  • It contains most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. (absoluteastronomy.com)
  • This overview considers these technologies and how they have been used to identify novel viral and plant proteins or genes involved in disease and resistance responses, as well as defense signaling. (springer.com)
  • It provides a very informative, albeit preliminary, glimpse into the expression of genes encoding functionally relevant proteins as potential targets for chemotherapy, and evidence for the presence of a relict plastid. (biomedcentral.com)
  • Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
  • Shq1p contains two predicted domains as follows: an N-terminal CS (named after CHORD-containing proteins and SGT1) or HSP20-like domain, and a C-terminal region of high sequence homology called the Shq1 domain. (cornell.edu)
  • This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. (nih.gov)
  • Chloroplast-located proteins which are encoded by the nuclear genome have to be imported from the cytosol into the organelle in a post-translational manner. (cipsm.de)
  • The vesicle-inducing protein in plastids 1 (Vipp1) is an essential component for thylakoid biogenesis in cyanobacteria and chloroplasts. (cipsm.de)
  • Shq1p has been identified as an essential eukaryotic H/ACA small nucleolar (sno) ribonucleoparticle (snoRNP) biogenesis and assembly factor. (cornell.edu)
  • These results show that the CS domain is essential for Shq1p function in H/ACA snoRNP biogenesis in vivo, possibly in an Hsp90-independent manner. (cornell.edu)
  • The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. (nih.gov)
  • Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O⁶-methylguanine-induced apoptosis. (nih.gov)
  • This gene has a closely related paralog that encodes a protein with similar binding activities. (nih.gov)
  • For breeding heat tolerant rice, it is important that molecular components that underlie the heat shock response in this species are understood [ 3 ]. (biomedcentral.com)
  • However it is also involved in the maturation and stabilization of a wide range of oncogenic client proteins which are crucial for oncogenesis and malignant progression. (biomedcentral.com)
  • 16. Knorr, D.A. and Dawson, W.O. (1988) A point mutation in the tobacco mosaic capsid protein gene induces hypersensitivity in Nicotiana sylvestris . (springer.com)
  • An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • I took up a position at Oxford Brookes University in 2012 investigating the role of reticulon proteins in ER tubulation and viral trafficking in order to develop my international reputation in ER research and advanced imaging. (brookes.ac.uk)
  • A variety of techniques have been used to examine plant viral genomes, the functions of virus-encoded proteins, plant responses induced by virus infection and plant-virus interactions. (springer.com)
  • Proteins in this class include those that perform functions such as telomere capping, telomere maintenance and telomere stabilization. (lookformedical.com)
  • These dedicated proteins are generally known as histone chaperones and effectively control histone supply and chromatin dynamics [ 8 ]. (aging-us.com)
  • Specificity This antibody recognizes eukaryotic Hsp90alphab. (qedbio.com)
  • Members from the genus come with an 11-kb, single-stranded, positive-sense RNA genome which translates and encodes capsid (C), premembrane/membrane SCKL1 (prM/M), and envelope (E) structural protein and seven non-structural protein. (techuniq.com)
  • Structure and functional studies of the CS domain of the essential H/ACA ribonucleoparticle assembly protein SHQ1. (cornell.edu)
  • Conclusively our results strongly suggest that withaferin A is a potent anticancer agent as ascertained by its potent Hsp90-client modulating capability. (biomedcentral.com)
  • Arachidonate is a potent modulator of human heat shock gene transcription. (morimotolab.org)
  • Mgm1 is usually synthesized as a precursor protein with an N-terminal cleavable presequence followed by two option TM segments both of which could function as a stop-transfer transmission for its integration into the IM via the TIM23 translocator complex (57). (biongenex.com)
  • Candidate proteins were ADP/ATP translocase (ANT), Actin, Alpha-tubulin, Elongation factor 1-alpha (EF-1 α ) and HSP90, respectively. (chinaagrisci.com)
  • The gene, HSP90AA1, encodes the human stress-inducible 90-kDa heat shock protein alpha (Hsp90A). (wikipedia.org)
  • However, if the stress on the ER is chronic or severe and quality control of protein folding cannot be met, ER activates its stress receptor, the unfolded protein response, which triggers programmed cell death [ 9 ]. (biomedcentral.com)
  • Of these 9, only 3 belonging to ClpB group are heat stress regulated. (biomedcentral.com)
  • Heat stress threatens future prospects of increased grain production in crops. (biomedcentral.com)
  • Understandably, the major molecular changes in rice plants as affected by heat stress need to be worked out. (biomedcentral.com)
  • We determined subnanometer-resolution cryo-electron microscopy structures of eukaryotic ribosome-Sec61 complexes. (cipsm.de)
  • Crystal structures often deviate from the natural system: Proteins, especially membrane-bound ones, do not necessarily crystallize in their biologically active structures and the measures needed to obtain suitable GPCR crystals tend to increase the diversity between the natural environment and the crystal. (gauss-centre.eu)
  • Associated with their diverse cell locations, domain structures of OsClpB-c, OsClpB-m and OsClpB-cyt proteins are noted to possess a high-level conservation. (biomedcentral.com)