Eukaryotic cell adhesion molecules neuronal. Medical search. Frequent questions

Like cell division and differentiation, cell death is also critical for normal development and maintenance of healthy tissues. (hopkinsmedicine.org)
DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
It is involved in cell differentiation, maintenance of cell differentiation state, tumorigenesis, and cell senescence, mainly through DNA methylation, histone acetylation, and RNA-related silencing [ 6 ]. (hindawi.com)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. (biomedcentral.com)
MSCs can be defined by their ability to adhere to tissue culture plastic, their expression of several cell surface molecular epitopes-cluster of differentiation CD73, CD90, and CD105, and others-as well as their lack of several surface markers, including CD45 [ 6 ]. (biomedcentral.com)
While acknowledging progress in the other areas mentioned, this work will focus on the current debates concerning sourcing, MSC alterations of angiogenesis, cell differentiation/stimulation, and strategies to improve MSC differentiation. (biomedcentral.com)
The perception of those external signals, provided, e.g., by the extracellular matrix (ECM) or cell surface molecules of neighboring cells, is critically involved in regulating cell intrinsic processes that orchestrate cellular proliferation, differentiation, and migration. (biomedcentral.com)
Upon differentiation, polarized cells establish specialized membrane domains with distinct protein composition. (rupress.org)
This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. (nih.gov)
This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)

Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells. (kyoto-u.ac.jp)
Of particular interest to our group are the mechanisms by which Bcl-2 family proteins and other factors regulate programmed cell death, particularly in the nervous system, in cancer and in virus infections. (hopkinsmedicine.org)
We have reported that many insults can trigger cells to activate a cellular death pathway (Nature, 361:739-742, 1993), that several viruses encode proteins to block attempted cell suicide (Proc. (hopkinsmedicine.org)
We have shown that anti-apoptotic Bcl-2 family proteins can be converted into killer molecules (Science 278:1966-8, 1997), that Bcl-2 family proteins interact with regulators of caspases and regulators of cell cycle check point activation (Molecular Cell 6:31-40, 2000). (hopkinsmedicine.org)
In addition, Bcl-2 family proteins have normal physiological roles in regulating mitochondrial fission/fusion and mitochondrial energetics to facilitate neuronal activity in healthy brains. (hopkinsmedicine.org)
Cell migration is controlled by a force-driven cellular brake system called focal adhesion (FA), a multiprotein assembly of almost 200 proteins. (shubhasis-haldar-cmt.com)
These FA proteins interact mechanically and control the cell migration through traction force. (shubhasis-haldar-cmt.com)
Mechanosensitive proteins play a crucial role in focal adhesion-mediated neurodegeneration, a process that involves the breakdown of nerve cells in the central nervous system due to abnormal mechanical forces acting on the cells. (shubhasis-haldar-cmt.com)
In the context of neurodegeneration, these mechanosensitive proteins become instrumental in transmitting and translating mechanical signals, ultimately contributing to neuronal damage. (shubhasis-haldar-cmt.com)
Understanding the role of mechanosensitive proteins in focal adhesion-mediated neurodegeneration is critical for developing targeted therapeutic interventions. (shubhasis-haldar-cmt.com)
185 genes in signature reported in the publication with PubMedID mRNA_KAT5_22196727 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. (maayanlab.cloud)
At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)
This Review addresses single-molecule force spectroscopy experiments conducted on proteins with a known role in mechanosensing and mechanotransduction in eukaryotic cells. (ibecbarcelona.eu)
With the advent, development and refining of single-molecule nanomechanical techniques that enable the conformational dynamics of individual proteins under the effect of a calibrated force to be probed, we have begun to acquire a comprehensive knowledge of the diverse physicochemical principles that regulate the elasticity of single proteins. (ibecbarcelona.eu)
In this scholarly study, we present proof that MAGI proteins, structural the different parts of AJC whose function continued to be unclear, regulate apical constriction of epithelial cells through the Par polarity proteins. (aboutsciencenow.info)
By coupling the adhesion equipment towards the polarity proteins to modify mobile contractility, we suggest that MAGIs play important and central tasks in maintaining stable state intercellular pressure through the entire epithelial cell sheet. (aboutsciencenow.info)
Right here, we propose a molecular system where AJC scaffolding proteins control apical cell contractility by differentially recruiting MAGI-1 and MAGI-3 to apical AZD-3965 junctions. (aboutsciencenow.info)
Therefore, we exposed the MAGIs are crucial regulators of Par polarity proteins that are central towards the rules of pressure distribution in epithelial cells homeostasis. (aboutsciencenow.info)
Results Lack of ZO proteins highly perturbs Par-3 localization and alters apical morphology We previously demonstrated that depletion of ZO proteins in the mouse mammary epithelial cell range, EpH4, delays the forming of the contractile belt-like AJ18, recommending that ZO proteins are necessary for epithelial polarization. (aboutsciencenow.info)
Open up in another windowpane Fig. 1 Lack of ZO proteins dysregulates ROCK-dependent contractility to improve apical morphology.a Consultant immunofluorescence pictures of ZO-1 and WT, dKO cells stained for activated -catenin -2. (aboutsciencenow.info)

Cell migration is negatively modulated by ABCA1. (kyoto-u.ac.jp)
studies indicated that RANTES is Purpureaside C an adipokine that can be produced by adipocytes and takes on an important part in T cell migration, suggesting a potential part of the RANTES/CCR5 axis in adipose T cell build up in obesity (24). (exposed-skin-care.net)
Since each single protein molecule has its own contribution to the overall FA dynamics and thereby the cell migration, the force response of a single protein is of prime importance to understanding the underlying mechanism. (shubhasis-haldar-cmt.com)
We propose a new computation-based approach for elucidating how signaling molecules are decoded in cell migration. (nature.com)
Using the response function, we could predict the morphological change from molecular activity and its predictive performance provides a new quantitative measure of how much the Rho GTPases participate in the cell migration. (nature.com)
Thus, our proposed predictive approach enabled us to uncover the hidden information processing rules of Rho GTPases in the cell migration. (nature.com)
To examine this issue, we focused on cell migration as a model biological system, because both molecular activity (as input signal) and morphological changes (as output signal) during cell migration can be monitored by FRET imaging. (nature.com)
Many studies have extensively investigated the molecular mechanisms involved in cell migration and have recognized the Rho small GTPases as key regulators of actin dynamics 7 , 8 . (nature.com)
In spite of such accumulating knowledge of Rac1 and Cdc42 downstream pathways, little is known about the functional differences between Rac1 and Cdc42, in particular, how these Rho GTPases participate in cell migration. (nature.com)
Moreover, a quantified discussion has been missing: although these molecules are involved in cell migration, how much are they quantitatively responsible for? (nature.com)
LINC00659 knock-down promoted the proliferation, migration, and angiogenesis ability of EPCs, while an pcDNA-eukaryotic translation initiation factor 4A3 (EIF4A3), a EIF4A3 overexpression vector, or fibroblast growth factor 1 (FGF1) small interfering RNA (siRNA) combined with LINC00659 siRNA could not enhance this effect. (biomedcentral.com)
Cell-cell communication is mediated by membrane receptors and their ligands, such as the Eph/ephrin system, orchestrating cell migration during development and in diverse cancer types. (biomedcentral.com)
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)

A method based on atomic force microscopy is used to delineate the properties that determine single-molecule adhesion onto solid substrates in aqueous environment. (cipsm.de)
Single-molecule techniques are very handy in knowing their mechanical response and that becomes our strength. (shubhasis-haldar-cmt.com)

The construction of the blood-brain barrier (BBB), which is a natural barrier for maintaining brain homeostasis, is the result of a meticulous organisation in space and time of cell-cell communication processes between the endothelial cells that carry the BBB phenotype, the brain pericytes, the glial cells (mainly the astrocytes), and the neurons. (mdpi.com)
An In Vitro Blood-Brain Barrier Model to Study Firm Shear Stress-Resistant Leukocyte Adhesion to Human Brain Endothelial Cells. (open.ac.uk)
They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
An increasing number of studies have demonstrated that EPCs are of great value in regenerative medicine and clinical applications, which can not only directly participate in angiogenesis but also participate in vascularization and endothelial repair by differentiating into endothelial cells [ 7 ]. (biomedcentral.com)

It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. (wikipedia.org)
Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Molecular and Cellular Biology. (wikipedia.org)
[3] Ubiquitin is a small (76-amino acid) protein highly conserved among eukaryotic cells. (wikidoc.org)
Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
Focal adhesions are multi-protein complexes that connect the cell's cytoskeleton to the extracellular matrix, allowing the cell to sense and respond to mechanical cues from its environment. (shubhasis-haldar-cmt.com)
miRNAs are also an important cargo of the EVs that have been implicated in tissue morphogenesis and have gained special attention due to their ability to regulate protein expression through post-transcriptional modulation, thereby influencing cell phenotype. (bvsalud.org)
Secondly, we employed qRT-PCR and Western blotting to detect the mRNA and protein levels of GRHL2 in leukemia cell lines. (hindawi.com)
Then we investigated the demethylating effect of arsenic trioxide and 5-azacitidine on the mRNA and protein expression levels of GRHL2 in cell lines of acute leukemia. (hindawi.com)
The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. (hindawi.com)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Previously, we reported ephrinA5 to trigger transcriptional changes of lncRNAs and protein-coding genes in cerebellar granule cells, a cell model for medulloblastoma. (biomedcentral.com)
However, protein levels of components of cell membranes, vesicles and synapses, RNA modulation, and cellular structures (including tau and tubulin filaments) are markedly altered from the age of 75. (ibecbarcelona.eu)
The Unit also characterizes protein kinase-mediated cell signaling especially in the control of the brain function such as emotions, learning and memory. (oist.jp)
The NAMPT protein manifestation in siRNA-treated cells was estimated by enzyme-linked immunosorbent assay. (forgetmenotinitiative.org)

give basic review over the regulatory mechanisms of the cycle, and mechanisms for controlled cell death. (setur.fo)
B cells are therefore particularly dependent on 'quality control' mechanisms to oversee antibody production. (cipsm.de)
For instance, the existence of tissue-specific gene clusters may be related to the efficient activation of gene expression in a particular cell lineage, by genetic and epigenetic mechanisms, or related to the repression of entire chromosomal regions containing genes expressed in a specific cell type, e.g. during the developmental switches leading to different cell lineages [ 25 ]. (biomedcentral.com)
Therefore, the understanding of the diverse signalling molecules, signal recognition mechanisms and signal transduction pathways is fundamental for the insight into physiological and pathophysiological processes. (mdpi.com)
Epigenetic mechanisms are key for integrating external "signals", e.g., from neighboring cells, into the transcriptome in health and disease. (biomedcentral.com)
However, the molecular mechanisms that regulate force-induced functionalities across a wide range of scales, encompassing the cell, tissue or organ levels, are not well understood in comparison. (ibecbarcelona.eu)
Innate or acquired resistance to small molecule BRAF or MEK1/2 inhibitors (BRAFi or MEKi) typically arises through mechanisms that sustain or reinstate ERK1/2 activation. (babraham.ac.uk)
Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)
Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)

indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)
showed that adipose tissue from obese mice induced proliferation of splenic CD8+ T cells, indicating a CD8+ T cell-activating environment in obese adipose tissue (31). (exposed-skin-care.net)
Finally, we studied the effects of arsenide trioxide and 5-azacitidine on the proliferation of leukemia cells and the TGF- β signaling pathway. (hindawi.com)
In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
Combined treatment with selumetinib and a dose of palbociclib sufficient to reinforce G1 arrest in selumetinib-sensitive cells, but not to impair proliferation of resistant cells, delays the emergence of resistant colonies, meaning that escape from G1 arrest is critical in the formation of resistant clones. (babraham.ac.uk)
Cell proliferation was decided using MTT assay, while apoptosis was analyzed with circulation cytometry using Annexin V-fluorescein isothiocyanate/propidium iodide assay. (forgetmenotinitiative.org)
or gene silencing significantly inhibited cell proliferation and induced apoptosis in RPMI 8226 cells ( (forgetmenotinitiative.org)

The Journal of Cell Biology. (wikipedia.org)
Cell Biology International Reports. (wikipedia.org)
Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press (CSHLP) announced the release of The Digital Cell: Cell Biology as a Data Science, available on its website in hardcover format. (cshlpress.com)
Laboratory demonstrations of cell culture, and laboratory exercises elucidating some cellular processes and some methods in cell biology, including use of light microscopy and epifluorescence microscopy. (setur.fo)
Model organisms such as yeast, fruit flies, and worms have advanced the study of genomics, eukaryotic biology, and evolution. (cshlpress.org)

Yeasts are unicellular eukaryotic fungi and they belong to the phyla Ascomycota (e.g., etc.,) and Basidiomycota (e.g., strains is the capability of transfer of resistant gene to the pathogenic bacteria. (enmd-2076.com)
Gene expression data from 24 experiments for 8 different cell types of the human myelopoietic lineage were used to generate an integrated myelopoiesis dataset of 9,425 genes, each reliably associated to a unique genomic position and chromosomal coordinate. (biomedcentral.com)
Here, we investigate a lncRNA-mediated targeting of DNMT1 to specific gene loci by the combined power of in silico modeling of RNA/DNA interactions and wet lab approaches, in the context of the clinically relevant use case of ephrinA5-dependent regulation of cellular motility of cerebellar granule cells. (biomedcentral.com)
Even though the physiological relevance of Eph/ephrin signaling has been well-proven for developmental and cancer-related processes, whether and how the ligand-mediated activation of Eph receptors triggers changes in gene expression that underlie discrete cell physiological responses is greatly unknown. (biomedcentral.com)
Our findings demonstrate that acquisition of MEK inhibitor resistance often occurs through gene amplification and can be suppressed by impeding cell cycle entry in drug. (babraham.ac.uk)
Our study exhibited that and play pivotal functions in the molecular pathogenesis of MM. This is usually the first statement describing the possible functions of in myelomagenesis and its potential role as a SU 11654 therapeutic target in MM. gene promotes tumorigenesis through constant NAD resynthesis to provide adequate energy for rapidly proliferating malignancy cells [9]. (forgetmenotinitiative.org)
Besides CHS, mutation in gene is usually one of the important factors that trigger hemophagocytic lymphohistiocytosis, a insufficiency in resistant program function, and life-threatening disease characterized by uncontrolled macrophage and T-cell account activation [14]. (forgetmenotinitiative.org)
No.: SR300809, USA) were used to silence the respective gene in RPMI 8226 cells. (forgetmenotinitiative.org)

In this approach, we performed FRET time-lapse imaging of Rac1 and Cdc42, members of Rho GTPases which are responsible for cell motility and quantitatively identified the response functions that describe the conversion from the molecular activities to the morphological changes. (nature.com)
Hence, we here propose a triple helix recognition mechanism, underlying cell motility regulation via lncRNA-targeted DNA methylation in a clinically relevant context. (biomedcentral.com)

In this area, our recent research has included studying cutaneous shave biopsies for diagnosing primary colonic adenocarcinoma as well as growth inhibition and apoptosis in human brain tumor cell lines using selenium. (hopkinsmedicine.org)
In the later generations, when telomeres are short, cells die via apoptosis or senescence. (hopkinsmedicine.org)
Apoptosis and other forms of cell death are required for trimming excess, expired and damaged cells. (hopkinsmedicine.org)

12. Describe two major types of tissues (connective and epithelial tissues), the concept of cellular communities and their organization (like communication between cells and the adhesion between cells), and show how stem cells maintain and renew tissues. (setur.fo)
Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs, liver and bone marrow. (wikidoc.org)
An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system. (mcw.edu)
In obese humans, adipocyte-secreted CCL20 may contribute to the deposition of Compact disc4+ helper and Compact disc8+ cytotoxic T lymphocytes within adipose tissues, possibly via connections with CCR6 which was upregulated on T cells in obese adipose tissues (100). (exposed-skin-care.net)
However, the main element substances that mediate T cell infiltration into adipose tissues in maturing remain to become discovered. (exposed-skin-care.net)
Activation of Typical T Cells in Adipose Tissues Compact disc4+ Purpureaside C T Cell Activation TCRs recognize the current presence of a particular antigen by binding to brief peptide sequences in the antigen that's shown on APCs. (exposed-skin-care.net)
further defined that mostly huge adipocytes from obese adipose tissues exhibited an increased expression degree of MHCII substances and acted as APCs to activate Compact disc4+ T cells to secrete IFN- (103). (exposed-skin-care.net)
The results displayed that LINC00659 is upregulated in IVC tissues and isolated endothelial group cells (EPCs) of patients with LEDVT. (biomedcentral.com)
The scope of the special issue is to summarize and enlarge the knowledge in signalling processes and networks in diverse cells and tissues. (mdpi.com)
Development of new or improved laboratory/experimental techniques, instruments, or supporting software that measure the location and dynamics of molecules in situ, and organelles, cells, or tissues on the nanometer and micrometer length scales. (nih.gov)
Gram-negative bacteria not only have different factors of virulence and generate products and sub-products that are toxic to apical and periapical tissues, but also contain endotoxin in the outer membrane of their cell wall. (bvsalud.org)

Through them, the cells modify their microenvironment and the behavior of neighboring cells. (frontiersin.org)
The response of target cells is further regulated by their microenvironment, involving the extracellular matrix, which may be modified by MSC-produced matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs. (biomedcentral.com)
Cells communicate with the local microenvironment. (biomedcentral.com)

Rattus norvegicus leucine rich repeat transmembrane neuronal 4 (Lrrtm4), mRNA. (genscript.com)

Describe the structures of eukaryotic cells and their major organelles. (setur.fo)
We determined subnanometer-resolution cryo-electron microscopy structures of eukaryotic ribosome-Sec61 complexes. (cipsm.de)
The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)
Similarly, marked modifications occur in the larger phosphoprotein clusters involving cytoskeleton and neuronal structures, membrane stabilization, and kinase regulation in the late elderly.Present findings may increase understanding of human brain proteostasis modifications in the elderly in the subpopulation of individuals not having AD neuropathological change and any other neurodegenerative change in any telencephalon region. (ibecbarcelona.eu)

A key component of the ICM niche are the extracellular vesicles (EVs), produced by distinct cell types, that carry and transfer key molecules that regulate target cells and modulate cell renewal or cell fate. (bvsalud.org)
The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. (mdpi.com)

To provide the students with knowledge of cell structure and function, organelles, growth and cell cycle, and cellular and molecular interactions. (setur.fo)
Evidence in numerous animal models suggests ubiquitin is anti-inflammatory immune modulator and endogenous opponent of proinflammatory damage associated molecular pattern molecules. (wikidoc.org)
ICM cells receive, from diverse sources, complex molecular and spatiotemporal signals that orchestrate the finely-tuned processes associated with embryogenesis. (bvsalud.org)
The Cell Signal Unit studies molecular and cellular events that are relevant to and important for maintaining healthy life in a variety of environmental conditions. (oist.jp)
Through the studies, Unit explores the cause of various diseases that include cancer, neuronal disorder, immunological diseases, diabetes/obesity, and defects in development at the molecular level. (oist.jp)
Our results offer a even more unique understanding of the jobs of and genes in the molecular pathogenesis of MM. MATERIALS AND METHODS Cell collection The myeloma cell collection RPMI 8226 was purchased from the American Type Culture Collection (ATCC, USA). (forgetmenotinitiative.org)

Interestingly, cell death regulators also regulate many other cellular processes prior to a death stimulus, including neuronal activity, mitochondrial dynamics and energetics. (hopkinsmedicine.org)

This junction is comprised of axonal and glial adhesion molecules linked to the axonal actin-spectrin membrane cytoskeleton through specific adaptors. (rupress.org)

[9] WHIM like mutations in CXCR4 were recently identified in patients with Waldenstrom's macroglobulinemia , a B-cell malignancy. (wikidoc.org)
Melanoma in particular exhibits a high incidence of activating BRAF and NRAS mutations and such cells are addicted to the activity of these mutant oncoproteins. (babraham.ac.uk)

There was an age-related upregulation in expression of genes involved in synaptogenesis, axonogenesis and neuroprotection suggesting preservation of neuronal processes with age. (nature.com)
It was subsequently demonstrated to be a cell surface molecule involved in many physiological processes, such as vesicle trafficking. (bvsalud.org)

The EV composition depends on the producer cell type and its physiological conditions. (frontiersin.org)

The blastocyst inner cell mass (ICM) that gives rise to a whole embryo in vivo can be derived and cultured in vitro as embryonic stem cells (ESCs), which retain full developmental potential. (bvsalud.org)
MAGI ortholog localizes apically to cadherin-based adhesions and its own loss qualified prospects to actin disorganization and decreases the entire robustness of cell adhesions in the embryonic epidermis14,15. (aboutsciencenow.info)

Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. (babraham.ac.uk)

We employ a range of techniques, such as covalent magnetic tweezers to study mechanochemical signaling, microfabricated substrates to apply controlled mechanical forces, and live-cell imaging to observe cellular responses in real time. (shubhasis-haldar-cmt.com)

10. Describe and categorize cellular signaling pathways, including the transfer of a stimulus across a cell membrane, and how the stimulus is propagated to its effector, it be an enzyme or one or several genes. (setur.fo)
We combined in-depth analysis of chaperone genes in human datasets, analysis of a neuronal cell line lacking STI1 and of a mouse line with a hypomorphic Stip1 allele to investigate the requirement for STI1 in aging. (bvsalud.org)

CXCR4 is present in newly generated neurons during embryogenesis and adult life where it plays a role in neuronal guidance. (wikidoc.org)

Therefore, many genetically programmed cell suicide pathways have evolved to promote long-term survival of species from yeast to humans. (hopkinsmedicine.org)
NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
Recent mechanistic insights into the trophic activities of these cells point to ultimate regulation by nitric oxide, nuclear factor-kB, and indoleamine, among other signaling pathways. (biomedcentral.com)

Thus, it may refer to the "exosome complex ," being a proteic (enzymatic) macromolecular machinery, present in archaea and eukaryotic cells, being involved in RNA degradation. (frontiersin.org)
On the other hand, the "exosome vesicle " is an extracellular particle released from the endosomal compartment of most eukaryotic cells. (frontiersin.org)

These MSC influences can range from relatively rare activities that require cell contact, such as mitochondrial transfer and cell fusion, to relatively common paracrine MSC actions through extracellular microvesicles or secreted factors. (biomedcentral.com)

[14] Another explanation of this observation is provided by a study that shows the ability of CXCL12 (and CCL2 ) producing tumors to entrain neutrophils that inhibit seeding of tumor cells in the lung. (wikidoc.org)
Telomerase is required for cells that undergo many rounds of divisions, especially tumor cells and some stem cells. (hopkinsmedicine.org)

CXCR4's ligand SDF-1 is known to be important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence . (wikidoc.org)

Taken together, one important mechanism for obese adipose CD4+ T cell activation may be mediated through MHCII expressed on ATMs and adipocytes. (exposed-skin-care.net)
The mechanism for CD8+ T cell activation in adipose tissue is not fully understood. (exposed-skin-care.net)

Cold Spring Harbor Laboratory Press (CSHLP) announced the release of T-Cell Memory, available on its website in hardcover and eBook formats. (cshlpress.com)

9. Examine and explain structure, functions and components of cellular membranes, including transport of molecules and ions across membranes and the importance of such transport in cell homeostasis and neuronal signaling. (setur.fo)
form adjustments in cells maintenance and morphogenesis of cells integrity in homeostasis. (aboutsciencenow.info)

CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells . (wikidoc.org)
CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst , a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation . (wikidoc.org)

CXCR-4 is an alpha- chemokine receptor specific for stromal-derived-factor-1 ( SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes . (wikidoc.org)
Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells . (wikidoc.org)

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction. (kyoto-u.ac.jp)
Peripheral blood stem cell mobilization is very important in hematopoietic stem cell transplantation (as a recent alternative to transplantation of surgically harvested bone marrow ) and is currently performed using drugs such as G-CSF . (wikidoc.org)
It is a very efficient inducer of hematopoietic stem cell mobilization in animal and human studies. (wikidoc.org)
The lab also is using the telomerase null mice to explore the essential role of telomerase stem cell viability. (hopkinsmedicine.org)
People with this disease die of bone marrow failure, likely due to stem cell loss. (hopkinsmedicine.org)
From a research, medical, and business standpoint, mesenchymal stem cell (MSC)-based therapies are fascinating. (biomedcentral.com)

Using yeast and mammalian neuronal cells we find that Hsp90 and its co-chaperone Sti1 have the capacity to alter TDP-43 misfolding, inclusion formation, aggregation, and cellular toxicity. (bvsalud.org)

CXCR4 mutant mice have aberrant neuronal distribution. (wikidoc.org)
Another statement showed the preadipocyte- and endothelial cell-derived stromal-derived element-1 (CXCL12), mediated early infiltration of CD4+ T lymphocytes in obesity, which preceded the increase of macrophages in adipose cells of mice on HFD (101). (exposed-skin-care.net)
Indeed, the principal adipocytes isolated from obese mice could induce antigen-specific Compact disc4+ T cell activation (58). (exposed-skin-care.net)
We sought to identify PKA phosphorylation sites in PLIN5 and assess their functional relevance in cultured cells and the livers of mice. (uci.edu)

J Cell Biol (2010) 188 (3): 429-441. (silverchair.com)
J Cell Biol (2013) 203 (3): 381-383. (rupress.org)

The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)

The inhibition of NAMPT is usually shown to induce cell death and reduce osteoclastogenesis in MM [10,11]. (forgetmenotinitiative.org)

An LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells. (genscript.com)
The manifestation of is usually shown to impact lysosomal size, granule size, and autophagy in human cells [12]. (forgetmenotinitiative.org)

This led us to additional research the features of these genetics in myeloma cell development and success by using little interfering RNA (siRNA) strategy. (forgetmenotinitiative.org)

Anatomy45

Organisms16

Diseases3

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes56

Disciplines and Occupations1

Information Science4

Differentiation12

Proteins20

Migration13

Single-molecule2

Endothelial cells4

Protein16

Mechanisms9

Proliferation7

Biology5

Gene8

Motility2

Apoptosis3

Tissues11

Microenvironment3

MRNA1

Structures4

Extracellular vesicles3

Molecular6

Cellular processes1

Cytoskeleton1

Mutations2

Processes2

Physiological1

Embryonic2

Replication1

Substrates1

Genes2

Neurons1

Pathways3

Exosome2

Mitochondrial1

Tumor2

Ligand1

Mechanism2

Laboratory1

Homeostasis2

Receptors2

Receptor2

Stem cell6

Yeast1

Mice4

Biol2

Stromal cells1

Induce1

Granule2

Development1