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  • large subunit
  • Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. (ebi.ac.uk)
  • In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. (ebi.ac.uk)
  • The ribosome of E. coli has about 22 proteins in the small subunit (labelled S1 to S22) and 33 proteins in the large subunit (somewhat counter-intuitively called L1 to L36). (wikipedia.org)
  • Recent ' de novo' proteomics experiments where the authors characterized in vivo ribosome-assembly intermediates and associated assembly factors from wild-type Escherichia coli cells using a general quantitative mass spectrometry (qMS) approach have confirmed the presence of all the known small and large subunit components and have identified a total of 21 known and potentially new ribosome-assembly-factors that co-localise with various ribosomal particles. (wikipedia.org)
  • L10 is thought to be an exchangeable ribosomal protein ( 34 ) that may be added to the large subunit in a late cytoplasmic assembly step ( 13 ). (asm.org)
  • nucleic acid
  • However, these proteins all have an amino-terminal domain containing four repeats of Cx 2 C, reminiscent of zinc-binding proteins, implicated in nucleic acid binding or protein oligomerization. (asm.org)
  • The K homology (KH) domain was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. An evolutionarily conserved sequence of around 70 amino acids, the KH domain is present in a wide variety of nucleic acid-binding proteins. (embl-heidelberg.de)
  • sequence
  • A number of eukaryotic and archaeal ribosomal proteins have been grouped based on sequence similarities [ PMID: 7662106 ]. (ebi.ac.uk)
  • Amino acid sequence of the ribosomal protein HS23 from the halophilic Haloarcula marismortui and homology studies to other ribosomal proteins. (ebi.ac.uk)
  • The Nmd3 protein sequence does not contain readily recognizable motifs of known function. (asm.org)
  • Sequence conservation suggests that fragile X mental retardation results from perturbation of RNA binding by the FMR1 protein. (embl-heidelberg.de)
  • Sequence analysis of the FMR1 protein has suggested that RNA binding is related to the presence of two K-homologous (KH) modules and an RGG box. (embl-heidelberg.de)
  • However, no attempt has been so far made to map the RNA-binding sites along the protein sequence and to identify possible differential RNA-sequence specificity. (embl-heidelberg.de)
  • Encodes a member of a family of small, secreted, cysteine rich proteins with sequence similarity to SCR (S locus cysteine-rich protein). (gifu-u.ac.jp)
  • Sec incorporation at the UGA/Sec codon is dependent on a stem-loop structure, the Selenocysteine Insertion Sequence (SECIS) element, which is found in the 3' UTR of eukaryotic selenoprotein mRNAs. (biomedcentral.com)