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  • gene
  • MicroRNAs (miRNAs) are small, highly conserved noncoding RNAs molecules, consisting of 18-25 nucleotides that regulate gene expression by binding to complementary binding sites within the 3′untranslated region (3′UTR) of target mRNAs. (hindawi.com)
  • MiRNAs are a class of small, highly conserved, and noncoding RNAs that regulate gene expression at posttranscriptional level by binding to the 3′ untranslated region (UTR) of target mRNAs. (hindawi.com)
  • Such complex regions could be fragile and play a mechanistic role in the amplification of the ERBB2 gene in breast tumors, because repeated sequences are known to initiate gene amplification in model systems. (biomedcentral.com)
  • Amplification of the ERBB2 gene in breast tumors is potentially initiated by a complex region that has unusual genomic features and thus requires rigorous, labor-intensive investigation. (biomedcentral.com)
  • The selective increase accompanies the overexpression of a particular gene within the genomic region that confers a growth advantage to the cell. (biomedcentral.com)
  • found
  • These structures could be found even in low-density regions, which is consistent with the current model of structure formation by gravitational instability. (sciencemag.org)