• Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. (wikipedia.org)
  • Etoposide is used as a form of chemotherapy for cancers such as Kaposi's sarcoma, Ewing's sarcoma, lung cancer, testicular cancer, lymphoma, nonlymphocytic leukemia, and glioblastoma multiforme. (wikipedia.org)
  • This is a case report of a 77-year-old Spanish male patient with localized SCC of the colon, who presented a pathological complete response in the surgical specimen after neoadjuvant chemotherapy with cisplatin and etoposide. (mdpi.com)
  • Standard management in the UK for high-risk stage 1 nonseminoma germ cell tumours of the testis (NSGCTT) is two cycles of adjuvant bleomycin, etoposide (360 mg/m 2 ), and cisplatin (BE 360 P) chemotherapy, or surveillance. (nih.gov)
  • In a phase II trial reported in JAMA Oncology , Locke J. Bryan, MD , and colleagues found that the combination of pembrolizumab with ICE chemotherapy (a regimen including ifosfamide, carboplatin, and etoposide) produced a high rate of complete response in patients with relapsed or refractory classical Hodgkin lymphoma who were candidates for autologous stem cell transplantation (SCT). (ascopost.com)
  • Rapid emergence of acquired resistance to standard platinum-etoposide chemotherapy is common and improved therapies are required for this recalcitrant tumour. (diagenode.com)
  • Chang, AY 1995, ' Introduction to ifosfamide/carboplatin/etoposide chemotherapy ', Seminars in oncology , vol. 22, no. 3 SUPPL. (johnshopkins.edu)
  • Chemotherapy doses were cisplatin 20 mg/m 2 and ifosfamide 1,200 mg/m 2 on days 1 to 3 and etoposide 40 mg/m 2 administered orally days 1 through 14. (psu.edu)
  • First-line therapy in ES-SCLC currently consists of chemotherapy, combining a platinum drug with either etoposide or irinotecan as a possible alternative. (ersjournals.com)
  • The first-line treatment of ES-SCLC currently consists of chemotherapy with a platinum derivative and etoposide, a combination that was first reported to be effective in the treatment of SCLC in 1985 8 , 9 . (ersjournals.com)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • Background and importance Etoposide is widely used in paediatric chemotherapy treatment, although hypersensitivity can be severe and treatment limiting. (bmj.com)
  • Impact on survival of addition of etoposide to primary chemotherapy in diffuse large B-cell lymphoma: a Swedish Lymphoma Registry study. (lu.se)
  • OBJECTIVES: I. Determine the efficacy of prolonged oral etoposide (VP-16) in patients with advanced ovarian epithelial or cervical cancer. (knowcancer.com)
  • Purpose: The combination of cisplatin, ifosfamide, and oral etoposide (PlEo) given concurrently with accelerated hyperfractionated thoracic radiation was studied in patients with limited small-cell lung cancer in a phase II trial to assess response, survival, and toxicity. (psu.edu)
  • A few years ago, we performed a phase II trial with the FLEP regimen, in which fluorouracil (5-FU) and leucovorin are combined with etoposide and cisplatin (Platinol). (cancernetwork.com)
  • In 1989, Preusser et al[3] reported a 57% response rate with the FLEP regimen-5-FU, leucovorin, etoposide, and cisplatin (Platinol). (cancernetwork.com)
  • The FLEP regimen we used consisted of leucovorin 300 mg/m 2 /day, followed by etoposide 100 mg/m 2 /day, 5-FU 500 mg/m 2 /day, and cisplatin 30 mg/m 2 /day, all given on days 1 through 3 and repeated every 28 days. (cancernetwork.com)
  • There were 24 patients that could be evaluated for efficacy of this combination regimen of Irinotecan and Etoposide. (addon.life)
  • We are offering optimum quality Etoposide Injection , which is used in combination with other medications to treat cancer of the testicles. (kdiamexim.com)
  • Due to its excellent quality and long shelf life, the offered Etoposide Injection is extremely valued by the clients. (kdiamexim.com)
  • Scholars@Duke publication: Dose-intense cyclophosphamide and etoposide for patients with refractory or high-risk non-Hodgkin's lymphoma. (duke.edu)
  • A retrospective review was performed on the toxicity and response to one cycle of dose-intense cyclophosphamide/etoposide, followed by consolidation in patients with refractory or previously untreated, high-risk non-Hodgkin's lymphoma (NHL). (duke.edu)
  • Fifty-five patients with refractory NHL and 13 with untreated, high-risk NHL were administered one cycle of daily cyclophosphamide 1.5 g/m2 intravenously on days 1-4 and etoposide 300 mg/m2 intravenously every 12 hours on days 1-3. (duke.edu)
  • A Phase II Study of Irinotecan and Etoposide as Treatment for Refractory Metastatic Breast Cancer. (addon.life)
  • Both Irinotecan and Etoposide are natural, plant-derived compounds that are modulators of topoisomerase (TOP) enzyme isoforms. (addon.life)
  • Irinotecan is a TOP1 and Etoposide a TOP2 modulator. (addon.life)
  • tell your doctor and pharmacist if you are allergic to etoposide, any other medications, or any of the ingredients in etoposide capsules. (medlineplus.gov)
  • Here, we report on seven patients with recurrent medulloblastoma, most heavily pretreated with a variety of chemotherapeutic agents, including parenteral etoposide (VP-16), who showed responses to the administration of repeated courses of low-dose oral VP-16. (elsevierpure.com)
  • This study aimed to assess the efficacy and safety of apatinib combined with etoposide in patients with recurrent platinum-resistant EOC. (jcancer.org)
  • The efficacy of apatinib combined with etoposide is encouraging in patients with platinum-resistant EOC. (jcancer.org)
  • Etoposide is in the topoisomerase inhibitor family of medication. (wikipedia.org)
  • Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme, which is an enzyme that aids in relaxing negative or positive supercoils in DNA. (wikipedia.org)
  • We have shown that colorectal cancer cell lines defective in DNA MMR exhibit an increased sensitivity to both camptothecin, a topoisomerase I inhibitor, and etoposide, a topoisomerase II inhibitor. (aacrjournals.org)
  • Etoposide is a glycosidic derivative of podophyllotoxin that exerts a cytotoxic effect by stabilizing the normally transient covalent intermediates formed between the DNA substrate and topoisomerase II. (medscape.com)
  • According to IMpower133 and CASPIAN, anti-PD-L1 blockades combined with etoposide and platinum (EP) were the conventional first-line therapy for extensive-stage small-cell lung cancer ( ES-SCLC). (physiciansweekly.com)
  • Etoposide / Etoposide is used for Small Cell Lung Cancer, Acute Leukemia, Bladder Cancer, Spread Of Cancer Cells, Cancer Of Testicles and other conditions. (actizapharma.com)
  • Etoposide is used to treat certain forms of lung cancer (such as small cell lung cancer). (oceanpharmaproducts.com)
  • Therapeutic effectiveness of anlotinib combined with etoposide in extensive-stage small-cell lung cancer: a single-arm, phase II trial. (bvsalud.org)
  • Etoposide / Etoposide improves the patient's condition by performing the following functions like Inhibiting the tumor cells from dividing, Inhibiting the tumor cells from dividing.The following is a list of possible side-effects that may occur in medicines that contain Etoposide / Etoposide. (actizapharma.com)
  • Etoposide does not influence phenotype of this sub-population of melanoma cells, while a combined treatment with Etoposide and Bevacizumab significantly abolished P1 sphere-forming ability, an effect associated with apoptosis of this subset of cells. (oncotarget.com)
  • Hypoxic melanoma cells sorted for VEGF-R2/CD133 positivity also undergo apoptosis when exposed to Etoposide and Bevacizumab. (oncotarget.com)
  • When Etoposide and Bevacizumab-treated hypoxic cells were injected intravenously into immunodeficient mice revealed a reduced capacity to induce lung colonies, which also appear with a longer latency period. (oncotarget.com)
  • Hence, our study indicates that a combined exposure to Etoposide and Bevacizumab targets melanoma cells endowed with stem-like properties and might be considered a novel approach to treat cancer-initiating cells. (oncotarget.com)
  • One cycle comprising bleomycin 30000 IU on days 1, 8, and 15, etoposide 165 mg/m 2 on days 1-3, and cisplatin 50 mg/m 2 on days 1-2, plus antibacterial and granulocyte colony stimulating factor prophylaxis. (nih.gov)
  • It is used in form of its salt etoposide phosphate. (wikipedia.org)
  • Etoposide is also sometimes used to treat certain types of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed). (medlineplus.gov)
  • We have reviewed a total of 33 patients with recurrent platinum-resistant EOC from July 2017 to July 2018, who were regularly treated with apatinib and etoposide until disease progression or unacceptable toxic effects occurred. (jcancer.org)
  • Instead Klose Training is low CBD content, while high THC options a a mixed format course 75 hours Dec 21 2018 etoposide RealSelf members say the cost 200 on average but each treatment session of Emsculpt costs about 1 000 and a series of four initial sessions results so you might end up paying more. (annamariadadomo.com)
  • After successful primary etoposide -based therapy , anlotinib was administered at 12 mg/day on days 1 to 14 of 21-day cycles until disease progression or consent withdrawal. (bvsalud.org)
  • At the date of the review finished, 15 of 33 (45.5%) patients remained on the combined treatment of apatinib and etoposide, while the other 18 (54.5%) had discontinued. (jcancer.org)
  • Etoposide may also be used for purposes not listed in this medication guide. (exportersindia.com)
  • Etoposide (Lastet (50 mg)) is an anti-cancer agent, prescribed for lung cancer and testicular cancer. (medindia.net)
  • Conclusion: Relative to conventional etoposide/cisplatin and concurrent AHTRT, chemoradiation with PlEo produced similar median and 2-year survival rates and a higher rate of acute esophageal toxicity. (psu.edu)
  • I was a 40+ pack year smoker until my dx in 01/07, at which time I quit preparatory to undergoing concurrent radiation and cisplatin/etoposide therapy. (lungevity.org)
  • Material and methods A retrospective observational study was conducted in paediatric patients treated with etoposide from June 2013 to September 2020. (bmj.com)
  • The six year old about school with your down on the ground and allows her ampicilina existence of both substances, just like flavones, flavonoids or terpenes, therefore their upside down underneath etoposide a seems to be unneeded. (annamariadadomo.com)
  • There are conflicting data in the literature regarding the incidence of etoposide hypersensitivity reactions in adults and children. (bmj.com)
  • Dr. Kagan investigated the interaction between dietary antioxidants, vitamins C and E, BHT and BHA, and etoposide VP-16, a widely used phenolic antitumor drug. (aicr.org)
  • and etoposide 100 mg/m2 IV on day 1 and then 200 mg/m2/day orally on days 2 and 3. (cancernetwork.com)
  • You should not become pregnant or breast-feed while you are taking etoposide. (medlineplus.gov)
  • If you become pregnant while taking etoposide, call your doctor. (medlineplus.gov)
  • Etoposide was first synthesized in 1966 and U.S. Food and Drug Administration approval was granted in 1983. (wikipedia.org)
  • Emergency Central , emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109244/11.0/etoposide. (unboundmedicine.com)
  • Grapefruit can affect the removal of etoposide from your body, which may affect how etoposide works. (rapid-medico.com)
  • In summary, UFT/leucovorin/etoposide is effective and moderately toxic in patients with advanced gastric cancer. (cancernetwork.com)
  • Etoposide can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
  • apalutamide will decrease the level or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • enzalutamide will decrease the level or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • ivosidenib will decrease the level or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • Many other medications may also interact with etoposide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)