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  • targeting vascular
  • The primary objective of these investigations was to determine the ocular biodistribution of bevasiranib, a small interfering RNA (siRNA) targeting vascular endothelial growth factor A (VEGF-A), following a single intravitreal injection to rabbit eyes. (molvis.org)
  • Ophthalmology
  • Consultation and screening for early detection to diagnose and treat ocular changes from cancer treatment can be promoted with close communication and collaboration between the primary team and ophthalmology. (oncologynurseadvisor.com)
  • An internationally recognized expert in pediatric ophthalmology, Dr. Bhola has over 15 years experience specializing in the complete array of pediatric vision conditions and eye diseases. (choc.org)
  • This pain is generally exacerbated with extraocular movements, and occurs in the vast majority of patients with typical ON.2 Patients with features atypical of ON, such as those that suggest other etiologies (i.e. abrupt onset of vision loss suggestive of a vascular etiology), warrant ophthalmology evaluation. (clevelandclinic.org)
  • diseases
  • This is different from "sensory defect nystagmus," which is caused by inherited ocular diseases including albinism, achromatopsia, Leber congenital amaurosis, congenital cataract, and anterior segment dysgenesis. (molvis.org)
  • Dr. Bhola's research interests are focused on diseases resulting in irreversible vision loss in pediatric population such as amblyopia, strabismus, retinopathy of prematurity and pediatric glaucoma. (choc.org)
  • tissues
  • The right eye of each rabbit was collected whole, and the left eye was dissected to isolate five ocular tissues. (molvis.org)
  • As expected, the highest concentrations were found in the vitreous, and vitreous levels steadily decreased over time, while concentrations of radioactivity in the other ocular tissues increased to maximum values between 24 h and 72 h after dosing. (molvis.org)
  • 6 7 In uveitis, the cytokine levels significantly increase in ocular tissues and initiate distinct intracellular signaling cascades that lead to both acute physiological effects and long-term changes in inflammatory gene expression. (arvojournals.org)
  • photophobia
  • A 79-year-old woman was referred to our institution with a 1-year history of tearing, blurry vision, pain, photophobia, and redness in her right eye. (springeropen.com)
  • defect
  • BACKGROUND/AIMS Although human ocular toxocariasis causes severe vision defect, little is known about its aetiology, diagnosis, and treatment. (bmj.com)
  • The etiology of infantile nystagmus is not clear and usually occurs without sensory defect. (molvis.org)
  • chronic
  • Open-angle, chronic glaucoma tends to progress at a slower rate and patients may not notice they have lost vision until the disease has progressed significantly. (healthdigezt.com)
  • occur
  • Ocular disease has been estimated to occur in about 2 percent of postnatally infected individuals. (aao.org)
  • manifestation
  • It is less common to find optic neuritis associated with sarcoidosis, particularly as the sole ocular manifestation. (aaopt.org)
  • Ocular lesions are the most common manifestation in congenital infections, followed by neurologic deficits, CNS calcifications, microcephaly and hydrocephalus. (aao.org)
  • tissue
  • It was used to confirm the presence of intact bevasiranib in ocular tissue following a single intravitreal injection of the non-radiolabelled siRNA to rabbit eyes. (molvis.org)
  • Neovascular glaucoma is a potentially devastating ocular consequence of pathologic neovascularization of intraocular tissue. (modernmedicine.com)
  • edema
  • Author Response: The "Ocular Glymphatic System": An Important Missing Piece in the Puzzle of Optic Disc Edema in Astronauts? (arvojournals.org)
  • 10 The finding that CSF pressure did not go up under microgravity conditions further challenges the role of high ICP in astronauts, 11 and the etiology of disc edema in astronauts remains unknown. (arvojournals.org)
  • glaucoma
  • Past ocular history included open-angle glaucoma initially well-controlled with topical therapy alone but later exacerbated by an inflammatory/corticosteroid-induced component in the right eye. (springeropen.com)
  • treatment
  • Knowledge of the etiology of ocular toxicity can result in closely monitoring and educating patients at risk to promote well-being and vision, and anticipating treatment-related toxicity, which may be minimized or prevented by holding or reducing the drug dose. (oncologynurseadvisor.com)
  • Once lost, vision cannot normally be recovered, so treatment is aimed at preventing further loss. (healthdigezt.com)
  • As far as we know, there have been no previous reports published on ophthalmic treatment and vision care among ring chromosome 15 patients. (hindawi.com)