• The purpose of this study was to identify genetic variants associated with corneal biomechanics, and assess their relation to other ocular traits. (arvojournals.org)
  • 5x10 -8 ) variants were used as genetic instruments for Mendelian Randomisation to determine causal relationships between corneal biomechanics and other ocular phenotypes. (arvojournals.org)
  • The overlapping and correlated genetic factors between corneal biomechanics and ocular disease indicate that these results may provide additional insight into the genetic aetiology of POAG and FECD. (arvojournals.org)
  • Ocular abnormalities include keratitis resulting in corneal opacification and vascularization. (orpha.net)
  • It is characterized by well demarcated granular shaped opacities in central anterior stroma and as the disease progresses, extrusion of the deposits results in ocular pain due to corneal epithelial erosion. (bvsalud.org)
  • BACKGROUND: This report presents a unique case that illustrates the importance of ocular history and photo documentation of ophthalmologic pathology when waivers are granted.CASE REPORT: A United States Navy pilot applicant was granted a waiver for a corneal scar of unknown etiology. (bvsalud.org)
  • Wernicke-Korsakoff syndrome (WKS) can manifest with CNS symptoms such as gait changes, altered mental status, and ocular abnormalities. (nih.gov)
  • [2] In addition, up to 45% of astronauts flying missions greater than 30 days demonstrate ocular abnormalities through fundus examination and orbital and brain imaging [7] with or without the presence of subjective symptoms. (aao.org)
  • 1 Treatment options are often chosen on the basis of these presumed ocular abnormalities despite the fact that previous literature indicates that objective ocular physical findings do not correlate well with DE symptoms. (bmj.com)
  • It can be due to refractive error, binocular fusion abnormalities, or neuromuscular anomalies of ocular movements. (nih.gov)
  • Pterygium is a common ocular lesion whose exact etiology is a point of contention. (scialert.net)
  • Therefore, SANS represents a nomenclatural modification to reflect the relative uncertainty of the exact etiology & pathogenesis. (aao.org)
  • [5] Although the exact etiology of SANS is still unknown it is believed that cephalad fluid shifts to the head, neck and orbits occur in microgravity environments due to impaired gravity assisted lymphatic, CSF and vascular drainage. (aao.org)
  • Results from previous studies indicate that these measures may be clinically informative for ocular diseases. (arvojournals.org)
  • Most of these loci are novel, but several overlapped with known genetic risk factors for other ocular diseases. (arvojournals.org)
  • Most chronic ocular diseases, with the possible exception of diabetic retinopathy and primary open-angle glaucoma, appear to be associated with smoking. (nih.gov)
  • This necessitates the investigation of past experimental approaches in their attempt to correlate oxidative stress and ocular diseases in humans in both the epithelial cells plus the capsule (LECs/capsule) and in the aqueous humor (AH). (molvis.org)
  • Primary glaucoma in dogs includes a large group of ocular diseases that share a common end stage and idiopathic etiology. (slu.se)
  • However, the development of the pedigree dog in its numerous shapes and sizes has provided today's clinician with a wide range of ocular diseases to treat. (vin.com)
  • Benefiting from blended learning opportunities, you will learn about paediatric ophthalmology, strabismus (ocular misalignment), ocular motility disorders, and other eye and vision health issues and diseases. (ucl.ac.uk)
  • There was no other ocular pathology in the affected eye. (bmj.com)
  • Ocular Oncology and Pathology provides a selection of topical clinical and basic research articles covering the etiology, pathology, diagnostic techniques, imaging features, and advances in medical and surgical treatment of ophthalmic cancers. (karger.com)
  • In addition to original research, Ocular Oncology and Pathology features timely reviews on contemporary topics, novel-insight case reports, and letters to ensure that the readers remain up to date with recent advances. (karger.com)
  • Previously unpublished original scientific work with emphasis on ocular oncology or pathology. (karger.com)
  • Ocular Pathology: What is a pinguecula? (missionforvisionusa.org)
  • Ocular Pathology: What is sebaceous carcinoma? (missionforvisionusa.org)
  • The slow rate of change of protein carbonyls strongly suggests a long-term implication of OS in ocular disease pathogenesis. (molvis.org)
  • I. Etiology, pathogenesis, and subtype classification. (karger.com)
  • There are well-known associations between systemic arterial hypertension and a variety of ocular disorders that were previously considered to be primarily manifestations of arterial hypertension. (nih.gov)
  • These studies suggest that several of the ocular or optic nerve head ischemic or ocular vascular disorders previously thought to be manifestations of arterial hypertension may, in fact, be due to a combination of systemic arterial hypertension and hypotension, with arterial hypertension acting as a predisposing factor and arterial hypotension actually producing the disorders. (nih.gov)
  • Cataract can be inherited as an isolated trait, in association with other ocular anomalies, or as part of systemic syndromes. (molvis.org)
  • Results Despite similar ocular surface findings, patients in the high NOP group had very different systemic (non-ocular) profiles with higher overall pain intensity ratings, higher frequency of comorbid chronic centralised pain conditions, lower quality-of-life indices and more abnormal mental health scores than those in the low NOP group. (bmj.com)
  • Pseudoexfoliation (PXF) syndrome is a systemic and ocular condition in which hyaline material of unknown etiology is deposited onto structures in the eye's anterior segment. (crstoday.com)
  • Strabismus is defined as acquired if the deviation is noticed after 6 months of age, following a presumed normal ocular alignment. (nih.gov)
  • In two subgroups, individuals with 'purely' acquired CVI and with 'purely' genetic CVI, the ocular variables (such as strabismus, pale optic disc and visual field defects) were compared. (medscape.com)
  • Symptoms are conjunctival hyperemia and ocular discharge and, depending on the etiology, discomfort and itching. (msdmanuals.com)
  • Ocular coloboma is a developmental structural defect of the eye that often occurs as complex ocular anomalies. (altmetric.com)
  • Thus, we decided to perform an ocular examination on all the animals in order to determine the incidence of cataract in the colony, describe the type of cataract, its progression and attempt to identify its possible cause. (vin.com)
  • T, p.R111C) in the IPO13 gene in a consanguineous family with ocular coloboma, microphthalmia, and cataract by a combination of whole-exome sequencing and homozygosity mapping. (altmetric.com)
  • Altogether, our findings demonstrate, for the first time, a new role of IPO13 in eye morphogenesis and that loss of function of IPO13 could lead to ocular coloboma, microphthalmia, and cataract in humans and zebrafish. (altmetric.com)
  • Therefore, it is strongly recommended that when a patient is at risk for ocular or optic nerve head ischemic or ocular vascular disorders, the ophthalmologist should talk to the treating physician about the potential risks of intensive arterial hypotensive therapy, particularly that administered in the evening or at bedtime. (nih.gov)
  • Other common ocular disorders, such as retinal ischemia, anterior ischemic optic neuropathy, and Graves ophthalmopathy, are also significantly linked to this harmful habit. (nih.gov)
  • Conclusions Consistent with a chronic overlapping pain condition, patients with DE disease with more severe NOP symptoms report more frequent and severe non-ocular functional comorbid pain disorders. (bmj.com)
  • Dry eye disease (DED) represents a heterogeneous and multifactorial group of disorders that affects the tears and ocular surface and results in discomfort and unpleasant visual phenomena, and in some cases, damage to the ocular surface. (bmj.com)
  • Moreover, the findings of the present study establish the use of protein carbonyls (together with a methodology for their more accurate quantification, which overcomes serious unreliability problems of past methods) as an age accumulative marker of OS damage, for future studies that investigate long-term OS involvement in pseudoexfoliative ocular disorders. (molvis.org)
  • This pain is generally exacerbated with extraocular movements, and occurs in the vast majority of patients with typical ON.2 Patients with features atypical of ON, such as those that suggest other etiologies (i.e. abrupt onset of vision loss suggestive of a vascular etiology), warrant ophthalmology evaluation. (clevelandclinic.org)
  • Objective To study chronic pain and mental health profiles in patients with dry eye (DE) symptoms, comparing those with high and low levels of neuropathic ocular pain (NOP) complaints. (bmj.com)
  • Rosacea is a common chronic cutaneous disorder of unknown etiology which occurs most commonly in middle-aged individuals. (karger.com)
  • The ocular discomfort may worsen to the point of becoming disabling, especially as smaller segments of the plaque loosen and become partially mobile. (medscape.com)
  • The uveitis specialist may be confronted by a small, localized area of inflammation in a single tissue in a non-sight-threatening location, or widespread blinding inflammation involving almost all ocular tissues. (dovepress.com)
  • Both eyes were white with no evidence of local infection, inflammation, or ocular surface trauma. (bmj.com)
  • Morpholino-oligonucleotide-induced knockdown of ipo13 in zebrafish caused dose-dependent microphthalmia and coloboma, which is highly similar to the ocular phenotypes in the patient. (altmetric.com)
  • Notably, these ocular phenotypes in ipo13-deficient zebrafish could be rescued remarkably by full-length ipo13 mRNA, suggesting that the phenotypes observed in zebrafish were due to insufficient ipo13 function. (altmetric.com)
  • DED is generally classified based on its presumed aetiology, including aqueous deficiency and evaporative dry eye (DE). (bmj.com)
  • Dermal and ocular exposure might result in local irritation or burn injury. (cdc.gov)
  • The pain that occurs with optic neuritis is usually ocular, retroocular, periorbital, or a frontal headache. (clevelandclinic.org)
  • Ocular trauma often occurs in the young and active, and has economic as well as health implications. (cehjournal.org)
  • Acute angle closure glaucoma, a medical emergency due to the risk of impending permanent vision loss, is characterized by sudden ocular pain, seeing halos around lights, red eye, very high intraocular pressure, nausea and vomiting, and suddenly decreased vision. (wikipedia.org)
  • there are some people, however, with a higher susceptibility to develop glaucoma due to some risk factors which include: Ocular hypertension is often wrongly considered a cause, but actually it is a risk factor. (wikipedia.org)
  • Ocular hypertension (increased pressure within the eye) is the most important risk factor for glaucoma, but only about 50% of people with primary open-angle glaucoma actually have elevated ocular pressure. (wikipedia.org)
  • Ocular hypertension-an intraocular pressure above the traditional threshold of 21 mmHg (2.8 kPa) or even above 24 mmHg (3.2 kPa)-is not necessarily a pathological condition, but it increases the risk of developing glaucoma. (wikipedia.org)
  • The disease is characterized by sudden onset of ocular pain, swelling of the eyelids, a foreign body sensation or irritation, epiphora (excessive tearing), eye discharge, and photophobia. (cdc.gov)
  • The most frequent clinical manifestations of infections were as classically described: patients had sudden onset of ocular pain, foreign body sensation, irritation, epiphora, photophobia, and subconjunctival hemorrhage. (cdc.gov)
  • The age of onset was dependent on etiology. (bmj.com)
  • Mutations in the gene encoding its blood transporter, named RBP4, have been associated with two rare conditions: recessive degeneration of retina and dominant malformations of ocular globe. (bmj.com)
  • This article is a review of the literature detailing specific occupational chemical injur ies as well as a review of common occupational chemical injur ies in the United States focusing on pulmonary, ocular , and burn injur ies. (cdc.gov)
  • Spaceflight associated Neuro-Ocular Syndrome (SANS)-formerly called visual impairment and intracranial pressure (VIIP) syndrome [1] -is a constellation of findings and symptoms that have been found in astronauts who have undergone long duration space flight (LDSF) missions in microgravity environments (e.g. (aao.org)
  • An evaluation was performed consisting of questionnaires regarding DE symptoms, NOP complaints (burning, sensitivity to wind, light and cold/hot temperatures) and pain elsewhere in the body (non-ocular). (bmj.com)
  • The discrepancy between symptoms and signs of disease may be partially explained by another, less-well-studied, component of DE, namely the presence of neuropathic ocular pain (NOP). (bmj.com)
  • Aim To describe a cohort of patients with irreversible unilateral bullous keratopathy (BK) of undetermined aetiology. (bmj.com)
  • The severity of an ocular burn is directly correlated with the duration of exposure and the causative agent. (medscape.com)
  • Burning of the face, excluding the eyes and ocular adnexa, is usually caused by thermal, electrical or chemical exposure. (icdexplained.com)
  • Many of them are also poisonous to ocular tissues, affecting the eye mainly through ischemic or oxidative mechanisms. (nih.gov)
  • Ocular examinations were performed under subdued illumination. (vin.com)
  • Results of ocular histopathologic findings were available for five animals that died during that period. (vin.com)
  • We conclude that CVI can be part of a genetic syndrome and that abnormal ocular findings are present more frequently in acquired forms of CVI. (medscape.com)
  • These cases demonstrate an ocular manifestation of COVID-19 infection which was previously unknown. (bmj.com)
  • The etiology is unknown, however, has been reported to be induced by drugs as a possible trigger of the disease. (bvsalud.org)
  • This was followed by a comprehensive ocular surface examination. (bmj.com)
  • Over a 1-year period, 75 mouse lemurs (45 males, 30 females) between 7 months and more than 10 years of age, underwent an ocular examination. (vin.com)
  • The National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea identified four subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous and ocular. (karger.com)
  • An earlier study by Khan et al stated that criminally negligent attitudes, lack of protective devices and severe aggression, were the cause of much ocular trauma in the North West Frontier Province of Pakistan. (cehjournal.org)
  • Ocular squamous cell carcinoma and melanoma are common. (orpha.net)
  • Cognitive impairment treatment directed at etiology, neuropsychological evaluation. (cdc.gov)
  • Ocular injury in Turbat, a rural area in Baluchistan, Pakistan, presents a great challenge and emphasises the need to educate the community on the prevention of eye injuries. (cehjournal.org)
  • However, ocular prophylaxis with those agents does prevent gonococcal ophthalmia and should be continued for that reason (see Prevention of Ophthalmia Neonatorum). (cdc.gov)
  • This section is organized by etiology which was largely not understood at that time. (aao.org)
  • However, its genetic etiology remains largely unexplored. (altmetric.com)
  • The formation of scar tissue is characteristic and can result in blindness if it involves the ocular conjunctiva. (bvsalud.org)
  • Ocular tropism is not limited to these serotypes, and other enteroviruses, e.g., echovirus 7 and 11, coxsackievirus B1 and B2, and non-enteroviruses (adenoviruses), can also cause conjunctivitis ( 1 ). (cdc.gov)
  • Neonatal Conjunctivitis Neonatal conjunctivitis is watery or purulent ocular drainage due to a chemical irritant or a pathogenic organism. (msdmanuals.com)
  • Ophthalmia Neonatorum Caused by C. trachomatis A chlamydial etiology should be considered for all infants with conjunctivitis through 30 days of age. (cdc.gov)
  • Ocular exudate from infants being evaluated for chlamydial conjunctivitis should also be tested for N. gonorrhoeae. (cdc.gov)
  • [ 1 ] Ocular burn injuries are classified by etiologic agents as either chemical injuries (eg, those caused by acid or alkali) or radiant energy injuries (eg, those caused by heat, electricity or ultraviolet [UV] radiation). (medscape.com)
  • Air gun pellets, the cause of 4.8% of our ocular injuries, were mainly due to the careless use of weapons, especially amongst youngsters. (cehjournal.org)
  • however genetic factors play an important role in its etiology. (molvis.org)
  • Neonatal ocular prophylaxis with silver nitrate solution or antibiotic ointments is ineffective in preventing perinatal transmission of chlamydial infection from mother to infant. (cdc.gov)
  • Although few occupational chemical injur ies are reported each year, the severity of these injur ies increases their importance to occupational health nurses who intervene to prevent these injur ies by understanding their nature and etiology. (cdc.gov)
  • The case can be confirmed if laboratory testing was not performed because either a predominant amount of clinical and nonspecific laboratory evidence of a particular chemical was present or the etiology of the agent is known with 100% certainty. (cdc.gov)
  • Almost 150 years have lapsed since this judgment on ocular disease in veterinary medicine was delivered, and most of it remains true to this day. (vin.com)
  • All patients who attended the outpatient department with ocular injury were included in the study. (cehjournal.org)
  • A total of 105 patients with ocular injury were seen, 93 males and 12 females. (cehjournal.org)
  • [5] Due to limitations in sample sizes, the inherent complexity in characterizing SANS-defining signs, and analysis outcomes demonstrating lack of sufficient evidence to pinpoint a single well-evidenced etiology for SANS, it is likely that SANS represents a multi-factorial origin with key clinical highlights from multiple hypothesized theories. (aao.org)