Etiology of acute hepatic failure fulminant hepatic. Medical search. Frequent questions

The clinical picture, encephalopathy and laboratory results indicated fulminant hepatic failure, rhabdomyolysis and multi-system organ failure. (gastrores.org)
FHF is currently defined as hyperacute (encephalopathy appearing within 7 days of the onset of jaundice), acute (encephalopathy appearing between 8 and 28 days) or subacute (encephalopathy appearing between 5 and 12 weeks). (uandes.cl)
Factors that are valuable in assessing the likelihood of spontaneous recovery are age, etiology, degree of encephalopathy, prothrombin time and serum bilirubin. (uandes.cl)
The word diachysis derives from the Greek word, διάχυσησ, which means "Diffusion" The word dialysis derives from the Greek word, διάλυσις, which means "Dissolution" In hyperacute and acute liver failure, the clinical picture develops rapidly with progressive encephalopathy and multiorgan dysfunction such as hyperdynamic circulation, coagulopathy, acute kidney injury and respiratory insufficiency, severe metabolic alterations, and cerebral edema that can lead to brain death. (wikipedia.org)
Both techniques can produce, in fulminant hepatic failure (FHF), an improvement of hepatic encephalopathy grade and biochemical parameters. (wikipedia.org)
Hepatic encephalopathy (HE) continues to hepatic failure [4]. (who.int)
People can develop confusion related to liver disease or hepatic encephalopathy (HE). (medscape.com)
While there are more than 40 definitions of acute liver failure in use, many of themodern definitions recognize the distinct disease phenotypes and seek to quantify the interval between the onset of symptoms and the development of encephalopathy. (emdocs.net)
6-8 Presently, the definition of ALF includes the following features: international normalized ratio (INR) at least 1.5, neurologic dysfunction with any degree of hepatic encephalopathy, no preexisting cirrhosis, and disease course of 26 weeks or less (Table 2). (emdocs.net)
33 Hepatic encephalopathy is classified based on severity, ranging from grade 1 to grade 4. (emdocs.net)
Hepatic encephalopathy (HE). (patient.info)
Particular care should be given to identifying hepatic encephalopathy: see the separate Hepatic Encephalopathy article. (patient.info)
The acute syndrome presents with rapidly progressive severe upper abdominal pain , yellow discoloration of the skin and whites of the eyes , liver enlargement , enlargement of the spleen , fluid accumulation within the peritoneal cavity , elevated liver enzymes , and eventually encephalopathy . (wikipedia.org)
The fulminant syndrome presents early with encephalopathy and ascites. (wikipedia.org)
Common signs and symptoms may stem from decreased hepatic synthetic function (eg, coagulopathy), portal hypertension (eg, variceal bleeding), or decreased detoxification capabilities of the liver (eg, hepatic encephalopathy). (medscape.com)
The symptoms of hepatic encephalopathy may range from mild to severe and may be observed in as many as 70% of patients with cirrhosis. (medscape.com)
Findings on physical examination in hepatic encephalopathy include asterixis and fetor hepaticus. (medscape.com)
An elevated arterial or free venous serum ammonia level is the classic laboratory abnormality reported in patients with hepatic encephalopathy. (medscape.com)
Computed tomography (CT) scanning and MRI studies of the brain may be important in ruling out intracranial lesions when the diagnosis of hepatic encephalopathy is in question. (medscape.com)
MARS appears to improve bilirubinemia, hepatic encephalopathy, renal function, and systemic hemodynamics [ 5 ]. (accjournal.org)

Hepatic toxicity: Monitor for jaundice or signs of liver failure. (nih.gov)
Acute and subacute forms: Characterized by rapid development of abdominal pain, ascites (which can cause abdominal distention), hepatomegaly, jaundice, and renal failure. (medscape.com)
Liver disease can include recurrent jaundice, simple acute self-limited hepatitis-like illness, autoimmune-type hepatitis, fulminant hepatic failure, or chronic liver disease. (nih.gov)
Acute fatty liver of pregnancy or pre-eclampsia - see the separate Jaundice in Pregnancy article. (patient.info)
We conducted a descriptive study from April to October 2015 in 10 tertiary care hospitals throughout Pakistan to determine maternal and fetal morbidity and mortality in HEV-positive pregnant women with acute jaundice or raised liver function tests. (who.int)

Fulminant hepatic failure (FHF) is an acute and eventually fatal illness, caused by a severe hepatocyte damage with massive necrosis. (uandes.cl)
The safety and efficacy of the BAL were evaluated in a prospective, randomized, controlled, multicenter trial in patients with severe acute liver failure. (elsevierpure.com)
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. (lookformedical.com)
Acute liver failure is the clinical manifestation of sudden and severe hepatic injury, and has a variety of underlying etiologies, including drug toxicity, viral infections, autoimmune and genetic disorders, thrombosis, malignancy, heat injury, and ischemia. (emdocs.net)
He owns the absolute priority in the development and the introduction into the clinical practice of Russian clinics of modern methods of correction and maintaining homeostasis, including albumin dialysis, combined plasma filtration and adsorption, selective hemoperfusion, etc. at extremely severe contingent of patients of different age groups having multiple organ failure and septic complications after cardiac surgery. (oaepublish.com)
The potential of new extracorporeal molecular technologies allows their successful use in severe cardiac and respiratory failure, acute kidney injury and hepatic dysfunction and in complex therapy for severe infections and sepsis and extreme metabolic violations. (oaepublish.com)
COVID-19 ( coronavirus disease-2019 ) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), a strain of coronavirus . (radiopaedia.org)
The official name of the illness is COVID-19 (a shortening of COronaVIrus Disease-2019) 15 and it is caused by the "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2) 16,22,46 . (radiopaedia.org)
The official virus name is similar to SARS-CoV-1, the virus strain that caused epidemic severe acute respiratory syndrome (SARS) in 2002-2004, potentially causing confusion 38 . (radiopaedia.org)
This phenomenon was demonstrated decades ago when acute hepatitis D (hepatitis D virus [HDV] or delta) superinfection of patients with chronic hepatitis B was shown to result in severe and progressive disease [ 6 ]. (uptodatefree.ir)
What has emerged during the past 1 year is that, apart from its potentially fatal respiratory presentation from which the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) derives its name, it presents with a myriad of gastrointestinal (GI) and liver manifestations. (xiahepublishing.com)
Severe clinical presentations include acute decompensation and acute-on-chronic liver failure in a patient with chronic liver disease, leading to high mortality. (xiahepublishing.com)
Since then, the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), responsible for COVID-19, has evolved into a pandemic, involving all continents to date (i.e. 31 st January 2021). (xiahepublishing.com)
In patients with heart failure who have hyponatremia (serum sodium less than 130 mEq/L ) or moderate to severe renal impairment (creatinine clearance less than or equal to 30 mL/min or serum creatinine greater than 3 mg/dL), therapy with PRINIVIL should be initiated at a dose of 2.5 mg once a day under close medical supervision. (wikidoc.org)
Severe acute alcohol-associated hepatitis that is nonresponsive to medical therapy has an extremely high mortality. (stanford.edu)
HA593 trade name] is not recommended for patients with moderate or severe hepatic impairment because there are insufficient data to determine whether dose adjustment is necessary. (who.int)

[ 1 ] Liver disease such as acute viral hepatitis can occur in pregnancy, and pregnancy may occur in a patient with underlying chronic liver disease, including patients with cirrhosis and portal hypertension, and patients who have undergone liver transplantation. (medscape.com)
In the United States, acetaminophen toxicity has replaced viral hepatitis as the most common cause of acute liver failure. (medscape.com)
Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C. (lookformedical.com)
As an example, hepatitis A and B vaccines have reduced the incidence of acute viral hepatitis [ 1 ]. (uptodatefree.ir)
Data on the impact of acute viral hepatitis A and B, influenza, and pneumococcal infection on other liver diseases are sparse. (uptodatefree.ir)
Acute viral hepatitis, regardless of etiology, may have deleterious consequences when occurring as a superinfection in patients with pre-existing chronic viral hepatitis or the HBV carrier state. (uptodatefree.ir)
In a subsequent study of acute hepatitis in Taiwan, acute liver failure was observed in only 3.2 percent of 157 patients with acute viral hepatitis of varying etiologies [ 7 ]. (uptodatefree.ir)
This pattern are different from those of massive and submassive necroses found in ordinary fulminant viral hepatitis. (scielo.br)
Morula-like cells" were more frequently found in HDV acute superinfection, as well as in HAV/HBV acute coinfection and acute HCV infection, and less often in other forms of viral hepatitis. (scielo.br)
Hepatitis A virus (HAV) is a common cause of acute viral hepatitis worldwide, but donor-derived transmission to organ recipients has been reported in the literature only twice previously. (cdc.gov)

Aflatoxin poisoning may result in hemorrhagic liver necrosis, steatosis, bile duct proliferation and subsequent organ failure, with a mortality rate of close to 25% and may be higher [ 1 , 2 ]. (gastrores.org)
We present a patient with toxemia of pregnancy and the HELLP syndrome [hemolysis (H), elevated liver enzymes (EL), and a low platelet count (LP)] resulting in massive hepatic necrosis. (symptoma.com)
In these cases, fatty degeneration of the hepatic parenchyma and patterns of centrilobular necrosis with hemorrhage are typical. (medscape.com)
26-28 Initially renal injury is prerenal in etiology secondary to hypovolemia, but acute tubular necrosis rapidly develops due to ongoing ischemia of renal tubules. (emdocs.net)

Patients with fulminant/subfulminant hepatic failure and primary nonfunction following liver transplantation were included. (elsevierpure.com)
Conclusions: This is the first prospective, randomized, controlled trial of an extracorporeal liver support system, demonstrating safety and improved survival in patients with fulminant/subfulminant hepatic failure. (elsevierpure.com)
Fulminant and subfulminant liver failure: definitions and causes. (intramed.net)

Pathologic findings in liver biopsy are (1) high-grade venous congestion and centrilobular liver cell atrophy, and, possibly, (2) thrombi within the terminal hepatic venules. (medscape.com)
Pressure equalization occurs in the sinusoids, along with the nutrient and O 2 gradient from portal tracts to terminal hepatic venules. (basicmedicalkey.com)

Dosage Adjustment in Patients with Myocardial Infarction with Renal Impairment: In acute myocardial infarction, treatment with PRINIVIL should be initiated with caution in patients with evidence of renal dysfunction, defined as serum creatinine concentration exceeding 2 mg/dL. (wikidoc.org)

On the other hand, a patient with a chronic hepatic disease can suffer acute decompensation of liver function following a precipitating event such as variceal bleeding, sepsis and excessive alcohol intake among others that can lead to a condition referred to as acute-on-chronic liver failure (ACLF). (wikipedia.org)
Hepatic failure occurs when the liver loses the ability to regenerate or repair, so that decompensation occurs. (patient.info)
Multiple episodes of reactivation or sustained reactivation can cause progressive hepatic damage and even hepatic decompensation. (biomedcentral.com)

Terms and Abbreviations Used in This Publication Acute hepatitis C Newly acquired symptomatic hepatitis C virus (HCV) infection. (cdc.gov)
detectable in persons with acute, chronic, and resolved infection. (cdc.gov)
Hepatitis refers to the inflammation of the liver processes nutrients, filters the blood , and fights infections, When the liver is inflamed or damaged, its function can be affected, Many people with hepatitis do not have symptoms and do not know they are infected, when symptoms occur with an acute infection, they can appear anytime from 2 weeks to 6 months after exposure. (online-sciences.com)
In the case presented here, adenotonsillectomy was performed during influenza infection , and sevoflurane was administered, after which acute fulminant hepatitis developed. (bvsalud.org)
Viral and clinical factors associated with the fulminant course of hepatitis A infection. (intramed.net)
However, development of an acute insult, such as infection or bleeding, in preexisting chronic liver disease can lead to development of ACLF, which has been elegantly described by Bajaj and colleagues in the most recent ACG guidelines on ACLF . (medscape.com)
[ 1 ] Globally, the incidence varies and viral infection accounts for the majority of cases of liver failure. (patient.info)
Furthermore, in patients with chronic liver disease or in recipients of liver transplants, the superimposition of another acute disease (hepatitis virus superinfection, influenza, and pneumococcal infection) may result in higher morbidity and mortality than in individuals without pre-existing liver disease. (uptodatefree.ir)
Two patients (18.2%) had acute HAV and HBV infection (IgM anti-HAV, HBsAg, IgM anti HBc). (scielo.br)
One (9.1%) had acute HAV infection alone (IgM anti-HAV). (scielo.br)
One (9.1%) had acute HBV and HCV infection (HBsAg, IgM anti-HBc, anti-HCV). (scielo.br)
Finally, one (9.1%) patient had acute HCV infection alone (Anti-HCV). (scielo.br)
The recognition of the importance of nutritional support, prompt diagnosis and treatment of infection, and advances in management of the multisystem complications of both chronic liver disease and acute liver failure have contributed to improved pretransplant survival of these children and improved condition at time of transplantation. (musculoskeletalkey.com)

Most patients who overdose on acetaminophen will initially be asymptomatic, as clinical symptoms of end-organ toxicity do not manifest until 24-48 hours after an acute ingestion. (medscape.com)
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure. (intramed.net)
1982. Acute inhalation toxicity of ammonia in rats with variable exposure periods. (cdc.gov)

Lisinopril is indicated to reduce signs and symptoms of heart failure in patients who are not responding adequately to diuretics and digitalis. (pillintrip.com)
Avid expression of the angiotensin-converting enzyme-2 (ACE-2) receptor throughout the gastrointestinal (GI) tract, including gastric, small intestinal and colonic mucosal cells, vascular endothelial cells, cholangiocytes and smooth muscle cells is the reason for the common occurrence of GI symptoms and hepatic manifestations. (xiahepublishing.com)
For patients who develop symptoms of heart failure, see DOSAGE AND ADMINISTRATION, Heart Failure. (wikidoc.org)
Acute transfusion reactions present as adverse signs or symptoms during or within 24 hours of a blood transfusion. (passmed.uk)

Hepatitis of Unknown Etiology. (cdc.gov)
unknown etiology in 6 patients. (who.int)

The liver diseases unique to pregnancy include hyperemesis gravidarum, acute fatty liver of pregnancy (AFLP), intrahepatic cholestasis of pregnancy (ICP), and hemolysis and elevated liver enzymes and low platelets (HELLP) syndrome. (medscape.com)
acute fatty liver of pregnancy (AFLP) for microvesicular steatosis detection by oil red O stain (from sections of liver biopsies at any stage of processing prior to xylene clearing, cut onto charged slides). (basicmedicalkey.com)
Hepatic ultrasonography, magnetic resonance imaging (MRI), and computed tomography (CT) are all utilized in detecting fatty infiltration in the liver. (termedia.pl)
Evaluation and management of all kinds of liver and hepatobiliary disorders like cirrhosis of liver, chronic hepatitis B and C, fatty liver, fulminant liver failure, gall stones etc. (kokilabenhospital.com)

Clinical DDx: Hepatic veno-occlusive disease. (symptoma.com)
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment. (lookformedical.com)
Although acute liver failure (ALF) is a rare clinical presentation in the ED, it carries a high mortality, morbidity, and resource cost. (emdocs.net)
The manifestation, timing, and severity of ALF's clinical features vary according to its underlying etiology, and a high index of suspicion is required to make an early diagnosis. (emdocs.net)
12,13 The clinical course of ALF follows that of multiple organ failure. (emdocs.net)
See Etiology and Clinical Presentation. (medscape.com)
While the primary indication and role of LT is to increase survival in patients with life-limiting acute or chronic liver conditions, the overall excellent survival outcomes realized today have allowed for expanded consideration of LT in certain clinical situations to improve quality of life of children suffering debilitating complications or side effects related to their liver disease. (musculoskeletalkey.com)

Budd-Chiari syndrome is an uncommon condition induced by thrombotic or nonthrombotic obstruction of the hepatic venous outflow and is characterized by hepatomegaly, ascites, and abdominal pain. (medscape.com)
A 30-year-old G0P0 woman presents to the emergency room for acute onset abdominal pain and nausea. (medbullets.com)

Severity of hepatotoxicity after a single acute overdose is predicted by serum. (msdmanuals.com)

with cirrhosis [2], and met-enkephalin to be elevated in plasma in acute liver disease [3]. (who.int)
Patients may progress to cirrhosis and show the signs of liver failure . (wikipedia.org)
Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and conversion of the normal liver architecture into structurally abnormal nodules. (medscape.com)

Acute Myocardial Infarction (MI): Give 5 mg within 24 hours of MI. (nih.gov)
Cardiogenic shock (pump failure): principal alterations, including scarring of necrotic myocardium and its features, post-ischemic ventricular aneurysm, cerebral complications of myocardial infarction. (unibo.it)
Lisinopril is indicated for the reduction of mortality in treatment of hemodynamically stable patients within 24 hours of acute myocardial infarction. (pillintrip.com)

The venous return is via the left, right, and middle hepatic veins which join to form the inferior vena cava as it enters the heart at the right atrium. (basicmedicalkey.com)

Population-based surveillance for unexplained death and critical illness possibly due to infectious causes (UNEX) was conducted in four U.S. Emerging Infections Program sites (population 7.7 million) from May 1, 1995, to December 31, 1998, to define the incidence, epidemiologic features, and etiology of this syndrome. (cdc.gov)
Conversely, in the USA and much of Europe, the incidence of virally associated liver failure has declined substantially, with most cases now arising from drug-induced liver injury, frequently from acetaminophen or idiosyncratic drug reactions. (emdocs.net)

23-25 Likewise, acute renal failure and hepatorenal syndrome are important complications of ALF and are primarily a result of the hemodynamic alterations in ALF. (emdocs.net)
Acute restrictive diseases: diffuse alveolar damage (respiratory distress syndrome of adult and infant). (unibo.it)
The prognosis is poor in patients with Budd-Chiari syndrome who remain untreated, with death resulting from progressive liver failure in 3 months to 3 years from the time of the diagnosis. (medscape.com)
Overt Budd-Chiari syndrome generally requires the occlusion of at least 2 hepatic veins. (medscape.com)
[2] The syndrome can be fulminant , acute, chronic, or asymptomatic. (wikipedia.org)
Primary Budd-Chiari syndrome occurs due to thrombosis of the hepatic vein. (wikipedia.org)
[2] Inherited disorders of hypercoagulability may lead to thrombosis of the hepatic vein and Budd-Chiari syndrome. (wikipedia.org)
Secondary Budd-Chiari syndrome, which is very rare compared to the primary variant, is due to compression of the hepatic vein by an outside structure (such as a tumor or polycystic kidney disease ). (wikipedia.org)
Autosomal recessive keratitis-ichthyosis-deafness syndrome (KIDAR) is characterized by neonatal-onset ichthyotic erythroderma and profound sensorineural deafness, with failure to thrive and developmental delay in childhood. (beds.ac.uk)
BACKGROUND: The SARS-CoV-2 pandemic and corresponding acute respiratory syndrome have affected all populations and led to millions of deaths worldwide. (stanfordchildrens.org)

Оцінка пацієнта з порушенням функції печінки History and physical examination often suggest a cause of potential liver disorders and narrow the scope of testing for hepatic and biliary disorders. (msdmanuals.com)
Liver transplantation (LT) has become the standard of care for children with end-stage or metabolic liver disease, acute liver failure, and unresectable liver tumors, with most common indication being biliary atresia. (musculoskeletalkey.com)

This leads to increased portal vein and hepatic sinusoid pressures as the blood flow stagnates. (wikipedia.org)

It can lead to life-threatening complications, such as cerebral edema and multiorgan failure. (medscape.com)

How do you distinguish ALF from acute-on-chronic liver failure (ACLF) in a patient with chronic liver disease? (medscape.com)

Obstruction of large- or small-caliber veins leads to hepatic congestion as blood flows into, but not out of, the liver. (medscape.com)
[1] [2] The condition is caused by occlusion of the hepatic veins (usually due to a blood clot ) that drain the liver . (wikipedia.org)
Hepatic veins labeled at center top. (wikipedia.org)

The treatment of liver failure encompasses symptomatic supportive care as a medical treatment and liver transplantation (LT) as a surgical treatment. (accjournal.org)

Renal replacement therapy (RRT) is a routine method for intensive care patients with acute kidney injury (AKI). (oaepublish.com)
Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). (pillintrip.com)
Three years ago in June 2013, our patient with no relevant medical history presented with worsening fatigue, and was diagnosed with kappa-light chain MM. At the time of diagnosis, he was anemic (8.4 g/dL), hypercalcemic (14.4 mg/dL), thrombocytopenic (88,000/μL), and had acute kidney injury (BUN 52 mg/dL and creatinine 5.7 mg/dL). (thejh.org)

The results of blood sample analyses are most remarkable for severely increased levels of hepatic transaminases [9] [10]. (symptoma.com)

In contrast, acute liver failure was seen in 20.3 percent of 177 acute hepatitis patients among hepatitis B surface antigen (HBsAg) carriers. (uptodatefree.ir)

It occurs uncommonly as a coinfection with acute hepatitis B or as. (msdmanuals.com)
If this occurs rapidly in a patient with no previous liver disease it is termed acute liver failure. (patient.info)

Alternate diagnoses were ruled out and a presumptive diagnosis of acute aflatoxicosis was made. (gastrores.org)

The use of hepatic support systems, extracorporeal liver support and auxiliary liver transplantation are innovative therapies. (uandes.cl)
A bioartificial liver device (BAL) is an artificial extracorporeal liver support (ELS) system for an individual who is suffering from acute liver failure (ALF) or acute-on-chronic liver failure (ACLF). (wikipedia.org)

The mechanism for the synergistic effect of alcohol and hepatitis C virus is not fully understood, but it has been attributed to the effects of alcohol on viral replication and the immune system, hepatic iron content and hepatic regeneration. (aafp.org)

Occlusion of a single hepatic vein is usually silent. (medscape.com)

However, as liver failure progresses rapidly and exhibits a varying course, it is difficult to make early decisions regarding LT in practice. (accjournal.org)

Data were analyzed with and without accounting for the following confounding factors: liver transplantation, time to transplant, disease etiology, disease severity, and treatment site. (elsevierpure.com)
The results of treatment, particularly in children, considering their anatomical and physiological features, are related to the severity and progression of organ failure, the indications that are found, the choice of method, and the timely initiation of blood purification. (oaepublish.com)

Classic acute hepatitis but the icteric stage is prolonged 8-29, weeks with manifestations of cholestasis, More with HAV. (online-sciences.com)
With newer variants of COVID-19, which can spread faster than the original strain, the data on hepatic manifestations needs to be updated to keep a step ahead of the virus. (xiahepublishing.com)
Fig. 1 GI and hepatic manifestations of COVID-19. (xiahepublishing.com)

Hepatocytes are damaged early, with sparing of the hepatic sinusoids. (medscape.com)
Microscopically, the hepatic cords are lined by reticulin fibers and separated by sinusoids. (basicmedicalkey.com)

The molecular adsorbent recirculating system (MARS) is a hepatic replacement system that supports excretory liver function in patients with liver failure. (accjournal.org)

Acute Fulminant Hepatic Failure Caused by Sevoflurane Linked to Influenza A. (bvsalud.org)
CLASSIFICATION OF DISEASES AND INJURIES I. INFECTIOUS AND PARASITIC DISEASES (001-139) Includes: diseases generally recognized as communicable or transmissible as well as a few diseases of unknown but possibly infectious origin Excludes: acute respiratory infections (460-466) influenza (487. (cdc.gov)

Wilson disease is a disorder of copper metabolism that, when untreated, can present with hepatic, neurologic, or psychiatric disturbances - or a combination of these - in individuals ages three years to older than 70 years. (nih.gov)
Wilson disease is an autosomal recessive disorder characterized by dramatic build-up of intracellular hepatic copper with subsequent hepatic and neurologic abnormalities. (nih.gov)

Anatomy5

Organisms3

Diseases31

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Psychiatry and Psychology1

Phenomena and Processes7

Information Science1

Named Groups1

Health Care5

Encephalopathy20

Jaundice5

Severe16

Viral hepatitis10

Necrosis4

Subfulminant3

Terminal hepatic venules2

Dysfunction1

Decompensation3

Infection13

Toxicity3

Symptoms4

Unknown etiology2

Fatty4

Clinical7

Abdominal pain2

Serum1

Cirrhosis3

Myocardial3

Inferior vena1

Incidence2

Syndrome10

Biliary2

Increased portal vein1

Complications1

Chronic liver d1

Veins3

Symptomatic1

Kidney3

Transaminases1

Hepatitis B surface antigen1

Occurs2

Diagnosis of acute1

Extracorporeal2

Regeneration1

Occlusion1

Rapidly1

Severity2

Manifestations3

Sinusoids2

Liver function1

Influenza2

Neurologic2