• Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). (wikipedia.org)
  • HPA-axis dysfunction may explain the reported risk indication of abdominal obesity to cardiovascular disease (CVD), type 2 diabetes and stroke. (wikipedia.org)
  • According to the 2005 IDF criteria, subsequently revised in 2009, abdominal obesity is identified as the waist circumference of ≥80 cm in women and ≥94 cm in men. (hindawi.com)
  • Abdominal obesity is the major disorder constituting a base for the development of metabolic syndrome. (hindawi.com)
  • Evidence from the conducted studies has revealed that abdominal obesity (assessed based on the waist circumference) plays a very important role in the development of metabolic disorders and in the assessment of cardiovascular risk. (hindawi.com)
  • Due to the limitations of BMI methodology, current reports by the World Health Organization and other organizations suggest combining the measurements of BMI and abdominal obesity [ 11 ]. (hindawi.com)
  • Methods: Metabolic syndrome is ≥3 of the following: hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, hypertension, abdominal obesity, and high serum glucose. (natap.org)
  • 26 120 180 ] Body mass index (BMI) has been widely used to indicate the level of obesity, though recent studies have found that abdominal or visceral adiposity (vs subcutaneous), as reflected in the waist-to-hip ratio or waist circumference, is a strong criteria for predicting the risk of developing metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). (surgicalneurologyint.com)
  • In this context, the relatively few large epidemiologic cohorts that have conducted detailed baseline assessments of abdominal fat distribution in combination with prospective evaluations of outcomes such as incident diabetes can provide novel insights into the natural history of the obesity-diabetes relationship. (diabetesjournals.org)
  • This agglomeration of abnormalities has been referred to as the metabolic syndrome which can be identified by the presence of three of the five following variables: abdominal obesity, elevated triglyceride concentrations, low HDL-cholesterol levels, increased blood pressure and elevated fasting glucose. (researchgate.net)
  • Post-mortem analyses of coronary arteries have indicated that obesity (associated with a high accumulation of abdominal fat measured at autopsy) was predictive of earlier and greater extent of large vessels atherosclerosis as well as increase of coronary fatty streaks. (researchgate.net)
  • Metabolic syndrome linked to abdominal obesity is also predictive of recurrent coronary events both in post-myocardial infarction patients and among coronary artery disease men who underwent a revascularization procedures. (researchgate.net)
  • It is suggested that until the epidemic progression of obesity is stopped and obesity prevented or at least properly managed, cardiologists will be confronted to an evolving contribution of risk factors where smoking, hypercholesterolemia and hypertension may be relatively less prevalent but at the expense of a much greater contribution of abdominal obesity and related features of the metabolic syndrome. (researchgate.net)
  • The aim of this study was to determine the prevalence of abdominal obesity and its associated factors among adolescents, independent of confounders. (bvsalud.org)
  • The association of abdominal obesity and independent variables was assessed using the chi-square test and the magnitude of associations was verified using Binary Logistic Regression in an unadjusted model and adjusted for confounders (gender, age, socioeconomic status, physical activity and sedentary behaviour). (bvsalud.org)
  • The abdominal obesity prevalence was 17.5% (CI = 15.4%-19.6%), and was higher in boys than in girls. (bvsalud.org)
  • Adolescents with abdominal obesity had higher values of body weight, height, body mass index and sedentary behaviour compared to eutrophic individuals. (bvsalud.org)
  • Being male increased the risk of abdominal obesity by 36% in adolescents. (bvsalud.org)
  • Abdominal obesity was significantly associated with gender and high levels of sedentary behaviour, regardless of confounding factors. (bvsalud.org)
  • The high prevalence of CAN in patients newly diagnosed with T2D suggests that its pathophysiology is rooted in an earlier stage of metabolic derangement, possibly being prediabetes. (encyclopedia.pub)
  • Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. (merckmanuals.com)
  • Polycystic ovarian syndrome (PCOS) is a reproductive metabolic disorder affecting nearly 20% females, globally. (ijpsr.com)
  • Polycystic ovarian syndrome, (PCOS) earlier known as the Stein Leventhal syndrome, is a multisystem endocrine disorder with reproductive and metabolic consequences 1 . (ijpsr.com)
  • Polycystic ovary syndrome is a clinical syndrome typically characterized by anovulation or oligo-ovulation, signs of androgen excess (eg, hirsutism, acne), and multiple ovarian cysts in the ovaries. (merckmanuals.com)
  • Polycystic ovary syndrome has several significant potential complications. (merckmanuals.com)
  • Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders among women of fertile age. (biomedcentral.com)
  • Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder, with a prevalence of 4-20% depending on the diagnostic criteria used, among reproductive-aged women [ 1 ]. (biomedcentral.com)
  • In women of reproductive age, polycystic ovary syndrome (PCOS) constitutes the most frequent endocrine disorder. (beds.ac.uk)
  • Characterized by a series of manifestations of hyperandrogenemia, persistent anovulation, and ovarian polycystic changes ( 1 ), polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders that affects 5 to 10% of women of reproductive age ( 2 ). (frontiersin.org)
  • Polycystic ovary syndrome (PCOS) is an ovarian disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. (nutrikalp.com)
  • All of the above-mentioned disorders contribute to metabolic syndrome and are related to the development of type 2 diabetes and ischaemic heart disease. (hindawi.com)
  • Metabolic and bariatric surgery is the surgical alteration of the stomach, intestine, or both to cause weight loss in patients with obesity-related metabolic disorders and their sequellae. (msdmanuals.com)
  • 35 kg/m2 regardless of comorbidities and those with a BMI 30 to 34.5 kg/m2 with metabolic disorders. (msdmanuals.com)
  • 2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): Indications for metabolic and bariatric surgery. (msdmanuals.com)
  • Our data suggest gender specific interactions between the diet's fatty acid source, the adipocyte-secreted proteins and metabolic disorders. (biomedcentral.com)
  • Thus, HFD-inducing metabolic disorders act via PPARγ to induce different levels of systemic homeostatic remodelling. (biomedcentral.com)
  • Appreciating the pathogenesis of HFD-induced metabolic disorders requires a thorough knowledge of adipose tissue physiology and the regulation of adipokines secretion and action including the role of gender in response to these parameters. (biomedcentral.com)
  • The non-alcoholic fatty pancreas can develop due to an unhealthy diet, lack of physical activity, and other lifestyle factors that contribute to obesity and metabolic disorders. (fitnesshacks.org)
  • Obesity is also associated with infertility and menstrual irregularities, incontinence, and psychological disorders such as depression. (symptoma.com)
  • Metabolic Dysfunction-Associated Liver Disease (MASLD) Steatotic liver disease is due to excessive accumulation of lipid in hepatocytes. (msdmanuals.com)
  • Centrilobular localization of steatosis results from decreased energy stores caused by relative hypoxia and a shift in lipid metabolism, along with a shift in the redox reaction as a result of preferential oxidation of alcohol in the central zone. (medscape.com)
  • Acute respiratory distress, metabolic acidosis, and death after rapid infusion of intravenous lipid emulsions have been reported. (drugs.com)
  • Low hepatic ATP, hyperuricemia, and hepatic lipid accumulation reported in metabolic syndrome (MetS) patients may reflect insufficient hepatic O 2 delivery, potentially accounting for the sympathetic overdrive associated with MetS. (surgicalneurologyint.com)
  • Obesity Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
  • Obesity is a multifactorial chronic disease that cannot be addressed by simply promoting better diets and more physical activity. (springermedizin.at)
  • Collectively, these observations regarding distinct subsets of metabolically-compromised individuals (see Fig. 1 ) reflect the highly complex and multifactorial aetiology of T2D in obese and non-obese individuals. (biomedcentral.com)
  • Characterized as a chronic disease with a multifactorial etiology, environmental factors and a genetic predisposition appear to be the main cofactors 1 . (bvsalud.org)
  • Higher levels of dietary and serum omega-3 PUFAs, particularly long-chain omega PUFAs (DPA and DHA), might have beneficial effects on metabolic parameters and body composition among PCOS patients. (frontiersin.org)
  • The higher affinity of both TBG and TBPA for T4 partially explains the higher serum levels, slower metabolic clearance, and longer half-life of T4 compared to T3. (nih.gov)
  • Hepatorenal syndrome is diagnosed when a creatinine clearance rate of less than 40 mL/min is present or when a serum creatinine level of greater than 1.5 mg/dL, a urine volume of less than 500 mL/day, and a urine sodium level of less than 10 mEq/L are present. (medscape.com)
  • Hence, further long term, controlled studies are required to understand the exact pathogenesis and metabolic consequences both in obese and non-obese PCOS women. (ijpsr.com)
  • Though numerous studies are being done in line with the etiology of PCOS, still the mechanism of pathogenesis and its metabolic impact remains variable and inconclusive. (ijpsr.com)
  • Furthermore, the independent association of systemic adipokine levels with knee osteoarthritis severity supports a role for adipose-associated inflammation in the molecular pathogenesis of obesity-induced osteoarthritis. (biomedcentral.com)
  • Under chronic hyperinsulinemia, FA oxidation progressively decreases with a consequent alteration in glucose transport, and/or phosphorylation pathways associated with normal glucose uptake ( 5 ). (frontiersin.org)
  • PCOS can also be accompanied by obesity because central obesity could exaggerate IR and lead to hyperinsulinemia ( 7 ). (frontiersin.org)
  • Research shows that Western diet habits are a factor in development of metabolic syndrome, with high consumption of food that is not biochemically suited to humans. (wikipedia.org)
  • First, high viral load did not predict development of metabolic syndrome. (natap.org)
  • The aim of this study was to investigate the impact of baseline skeletal muscle mass and changes in skeletal muscle mass over time on the development of metabolic syndrome in a large population-based 7-year cohort study. (biomedcentral.com)
  • We excluded participants with diabetes, metabolic syndrome, chronic diseases, and those who had changed food habits in the previous 3 months. (frontiersin.org)
  • Metabolic syndrome can lead to several serious and chronic complications, including type-2 diabetes, cardiovascular diseases, stroke, kidney disease and nonalcoholic fatty liver disease. (wikipedia.org)
  • citation needed] Recent research indicates prolonged chronic stress can contribute to metabolic syndrome by disrupting the hormonal balance of the hypothalamic-pituitary-adrenal axis (HPA-axis). (wikipedia.org)
  • In contrast, the relation between increasing viral load and metabolic syndrome does not seem to be mediated by general inflammation caused by chronic infection for 2 reasons. (natap.org)
  • Chronic stress is associated with increased risk of glucose intolerance and cardiovascular diseases, albeit through undefined mechanisms. (biomedcentral.com)
  • With the aim of gaining insights into the latter, this study examined the metabolic profile of young adult male rats that were exposed to chronic unpredictable stress. (biomedcentral.com)
  • Epidemiological studies show that chronic stress increases the risk of diabetes and metabolic syndrome [ 2 ]. (biomedcentral.com)
  • As a consequence, there has also been a marked increase in the prevalence of type 2 diabetes all over the world and this chronic metabolic disease is now considered as a coronary heart disease risk equivalent. (researchgate.net)
  • Obesity and overweight affect, worldwide, over 1.7 billion people and is associated with premature mortality, chronic diseases and increase in health costs. (bvsalud.org)
  • Among women in reproductive age, the obese rural population also found vulnerable to PCOS, indicates the role of lifestyle factors in this syndrome. (ijpsr.com)
  • Both non-obese and obese PCOS women found vulnerable to the same metabolic consequences. (ijpsr.com)
  • In that regard, this review tries to summarize the existing mechanistic evidence and metabolic consequences of PCOS and the possible avenues for future research. (ijpsr.com)
  • PCOS is usually defined as a clinical syndrome, not by the presence of ovarian cysts. (merckmanuals.com)
  • According to a study, phenotypes A, B, and C are endocrine-metabolic syndromes, while phenotype D is non-hyperandrogenic PCOS which represents evidence of both oligo-anovulation and ovarian cysts [ 5 ]. (biomedcentral.com)
  • This strong overlap of risk factors for both worse PCOS cardio-metabolic manifestations and severe COVID-19 should be highlighted for the clinical practice, particularly since women with PCOS often receive fragmented care from multiple healthcare services. (beds.ac.uk)
  • The etiology of PCOS is not yet clear, but genetic, environmental and lifestyle factors may contribute to its development ( 9 , 10 ). (frontiersin.org)
  • Obesity tends to reduce early LH levels and GnRH stimulation levels in women with PCOS although their responses remain elevated when compared to age- and weight-matched control women. (nutrikalp.com)
  • Since most of the diagnostic criteria support the idea that PCOS is an ovarian disorder, it is the main target that causes the syndrome. (nutrikalp.com)
  • Ovarian steroidogenesis is disturbed in a syndrome with increased circulating androgen levels that is frequently noted in women with PCOS stigmata. (nutrikalp.com)
  • ABSTRACT The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. (who.int)
  • From the abstract: ' In this Review, we discuss advances in the genetics of obesity from the past decade-with emphasis on developments from the past 5 years-with a focus on metabolic consequences, and their potential implications for precision management of the disease. (cdc.gov)
  • Obesity is commonly characterized as the accumulation of body fat that results when energy intake exceeds energy expenditure, although individuals respond differently to this imbalance due to genetic predisposition. (springermedizin.at)
  • This has resonance because ectopic fat accumulation appears to represent a central component of disease progression regardless of whether obesity is also part of the equation. (biomedcentral.com)
  • Fatty replacement occurs when pancreatic cells that secrete enzymes (acinar cells) are replaced by adipocytes, while fatty infiltration refers to the accumulation of adipocytes due to obesity. (fitnesshacks.org)
  • Our results suggest that HIV itself, treatment, and host factors affect the risk of metabolic syndrome in HIV disease. (natap.org)
  • Moreover, overnutrition overwhelms inherent mitochondrial capacity for scavenging excess ROS produced by metabolic processes promoting further upregulation of proinflammatory processes through NF-κB pathways [30]. (encyclopedia.pub)
  • This syndrome involves anovulation or ovulatory dysfunction and androgen excess of unclear etiology. (merckmanuals.com)
  • Obesity Obesity is excess body weight, defined as a body mass index (BMI) of ≥ 30 kg/m 2 . (merckmanuals.com)
  • By creating a bigger pool of fat cells to help clear excess glucose from the blood, toxicity from hyperglycemia is reduced, at least for a time. (perfecthealthdiet.com)
  • The ovary contains numerous small preantral follicles due to continuous processes and increased central stroma due to thecal hyperplasia and excess stroma from irregular gonadotropin exposure. (nutrikalp.com)
  • In the Southern region the prevalence of excess weight was 56.8% for males and 51.6% in females as well as being the region with the highest percentage of obesity: 15.9% of men and 19.6% of women. (bvsalud.org)
  • Regardless of the etiology of Cushing's disease or Cushing's syndrome, the clinical manifestations are caused almost entirely by excessive cortisol production in the zona fasciculata of the adrenal gland. (pediagenosis.com)
  • The term MetS, or originally Syndrome X, was proposed to foster a coherent clinical approach to management and therapeutic intervention. (surgicalneurologyint.com)
  • These clinical observations regarding the detrimental health effects of central or upper body obesity were subsequently reinforced by the results of large prospective epidemiological studies of diabetes incidence, in which fat patterning of subjects was estimated using body surface measurements, specifically waist and hip circumferences and skinfold thicknesses ( 2 - 5 ). (diabetesjournals.org)
  • We are actively understanding the biology of GDF15 as it has become an important therapeutic target for metabolic disease and cancer cachexia with clinical trials ongoing. (upenn.edu)
  • This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
  • Replication studies identify several genetic variants in Arabs with obesity-linked diabetes. (who.int)
  • Evidence from genome-wide association studies highlight the importance of genetic and epigenetic factors in the development of obesity and how they in turn affect the transcriptome, metabolites, microbiomes, and proteomes. (springermedizin.at)
  • It further described as a convergence syndrome with a variety of genetic and environmental abnormalities that leads to brain damage (Alzheimer's, 2015). (nursingpaper.com)
  • Albert Salehi's group The etiology of metabolic syndrome and type 2 diabetes is complex and involves the interaction between both genetic and environmental factors including nutritional state with consequent metabolic signals. (lu.se)
  • Daniel Agardh's group Our researchThe overall purpose of our research is to uncover the genetic and environmental etiology of three autoimmune diseases - celiac disease, type 1 diabetes, and autoimmune thyroiditis. (lu.se)
  • We present a 17 year-old woman, with a previous genetic diagnosis of Prader-Willi syndrome and BMI of 74 Kg/m(2), that was admitted in anasarca, with marked cyanosis, dyspnea and oliguria. (symptoma.com)
  • The etiology of this disease is complex and multifaceted, and numerous genetic and environment risk factors have been identified that modify disease incidence and severity. (biomedcentral.com)
  • This study uses a cohort sample of 12,644 to 13,832 mother-child pairs from the UK Born in Bradford Study to examine the associations between maternal metabolic syndrome classification (MetS) and child development outcomes at age 5, using cord blood markers as candidate mediators. (biomedcentral.com)
  • Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. (biomedcentral.com)
  • 180 ] While obesity is a risk factor for MetS, the fact that not all obese patients develop MetS or T2DM[ 25 106 186 196 203 230 266 ] suggests that adiposity may not be etiologic. (surgicalneurologyint.com)
  • Gaps exist in our information about diabetes and obesity in Arabpopulations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. (who.int)
  • Close readers of our book may have noticed that a combination of carb and fat toxins is, we believe, the most common cause of metabolic syndrome, diabetes, and obesity. (perfecthealthdiet.com)
  • Type 2 diabetes and obesity epidemics are in effect in the United States and the two pathologies are linked. (biomedcentral.com)
  • Head: Karin Stenkula My research group is focused on experimental cell biology research within the diabetes and obesity field. (lu.se)
  • Integrating multi-omics approaches will enable a paradigm shift from the one size fits all approach towards precision obesity management, i.e. (1) precision prevention of the onset of obesity, (2) precision medicine and tailored treatment of obesity, and (3) precision risk reduction and prevention of secondary diseases related to obesity. (springermedizin.at)
  • Thyroid hormones, including Levothyroxine sodium tablets, USP, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. (nih.gov)
  • The Intra-oral Alimentary Satiety Device can be considered a safe and effective method which, together with a hypocaloric diet, shows satisfactory results, thus proving to be an important auxiliary option in the treatment of obesity. (bvsalud.org)
  • Epidemiologic investigations have consistently shown an independent increased risk for diabetes associated with overweight and obesity, with clear dose response patterning across categories of increasing body mass. (diabetesjournals.org)
  • We calculated the racial/ethnic-specific percentages of gestational diabetes mellitus (GDM) attributable to overweight and obesity. (cdc.gov)
  • Using logistic regression, we estimated the magnitude of the association between prepregnancy body mass index and GDM and calculated the percentages of GDM attributable to overweight and obesity overall and by race/ethnicity. (cdc.gov)
  • The adjusted percentages of GDM deliveries attributable to overweight and obesity were 17.8% among Asians/Pacific Islander, 41.2% among White, 44.2% among Hispanic, 51.2% among Black, and 57.8% among American Indian women. (cdc.gov)
  • Elevated prepregnancy body mass index contributed to GDM in all racial/ethnic groups, which suggests that decreasing overweight and obesity among women of reproductive age could reduce GDM, associated delivery complications, and future risk of diabetes in both the mother and offspring. (cdc.gov)
  • Hence, many effects of nutrition on the development and progression of cancer lack 'specificity' in their association, and such alimentary cues also affect the risk of developing metabolic syndrome, a prelude to arteriosclerosis and neurodegeneration ( Fig. 1 ). (nature.com)
  • Available evidence clearly indicates a rapid progression in the prevalence of obesity worldwide. (researchgate.net)
  • In this narrative review, we consider a number of explanations that have been forwarded regarding the pathological progression to type 2 diabetes both with and without the concurrent influence of overweight/obesity. (biomedcentral.com)
  • The epidemiology of obstructive sleep apnoea (OSA)/hypopnoea syndrome (OSAHS) has been described in a significant number of studies. (ersjournals.com)
  • This is especially true of patients who may be at high risk for additional complications, e.g. those with metabolic syndrome, diabetes, or cardiac, cerebrovascular or other neurological diseases. (ersjournals.com)
  • Weight problems with symptoms of associated complications are the major features of morbid obesity . (symptoma.com)
  • However, ART is restricted by adverse drug reactions, resulting in medication non-ad- treatment barriers such as complex dosing, drug-drug in- herence, treatment failure and poor response rate of pa- teractions, toxicities and metabolic complications. (bvsalud.org)
  • 0.91) had a higher incidence of metabolic syndrome/diabetes than those in the low quotient group (25 vs. 8% p = 0.04). (frontiersin.org)
  • Objective: To determine the incidence and risk factors for metabolic syndrome in HIV-infected adults in the Nutrition for Healthy Living (NFHL) study (2000-2003) and prevalence relative to the findings of the National Health and Nutrition Examination Survey (NHANES) (1999-2002). (natap.org)
  • The incidence of metabolic syndrome in the NFHL study was higher with increasing viral load, higher BMI, higher trunk-to-limb fat ratio, and Kaletra (lopinavir/ritonavir) or didanosine (ddI) use and lower among college-educated persons. (natap.org)
  • Hence, this study aims to recognize various risk factors including metabolic components and blood parameters to predict the possible incidence of the disease. (biomedcentral.com)
  • A further longitudinal study is needed to elucidate the casual relationship between low muscle mass and metabolic syndrome incidence across the full age range of the population, beyond the sarcopenia context. (biomedcentral.com)
  • Interestingly, metabolic inflammatory processes are evident in the cardiovascular, neuronal, and neurovascular systems, indicating their possible involvement in the etiology of cardiac autonomic dysfunction in the metabolic syndrome [33-35]. (encyclopedia.pub)
  • 2. Single cell multiomics to understand metabolic and cardiac biology and disease. (upenn.edu)
  • Funded with several NIH and DOD grants, we are currently applying single-cell multiomics to understand metabolic and cardiac biology and disease. (upenn.edu)
  • Hence, different factors in the etiology of the disease are shown to contribute differentially to CAN manifestations. (encyclopedia.pub)
  • Most of the metabolic abnormalities defining metabolic syndrome are observed in HIV. (natap.org)
  • Obesity is increasing rapidly on a global scale and is associated with comorbidities that require expensive medical care and limit the life span,[ 4 180 ] including increased risk of all cause and cardiovascular disease mortality. (surgicalneurologyint.com)
  • Morbid obesity is associated with a number of comorbidities that enhance the risk of mortality. (symptoma.com)
  • A subset of these patients has concurrent symptoms of excessive daytime sleepiness attributable to their nocturnal breathing disorder and is classified as having obstructive sleep apnoea/hypopnoea syndrome (4-5% of the middle-aged population). (ersjournals.com)
  • In moderate-to-severe obstructive sleep apnoea/hypopnoea syndrome, treatment with continuous positive airway pressure has been shown to be effective. (ersjournals.com)
  • Select Asian subgroups, such as Vietnamese (13.0%), Asian Indian (14.0%), and Filipino (14.2%), had the highest GDM prevalence, but the lowest percentage attributable to obesity. (cdc.gov)
  • Background: Metabolic syndrome increases the risk of cardiovascular outcomes and type II diabetes. (natap.org)
  • These results indicate that diet-induced obesity increases the risk of symptomatic features of osteoarthritis through changes in musculoskeletal function and pain-related behaviors. (biomedcentral.com)
  • however, there is currently no comprehensive explanation for why obesity increases the risk of osteoarthritis at different sites throughout the body. (biomedcentral.com)
  • The syndrome is thought to be caused by an underlying disorder of energy utilization and storage. (wikipedia.org)
  • Other therapies have been associated with improvements in metabolic profiles, such as increases in HDL cholesterol (nevirapine and nelfinavir).33 In our cohort, lopinavir/ritonavir users had a higher risk of developing metabolic syndrome. (natap.org)
  • Assessment of metabolic syndrome was done by International Diabetic Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. (biomedcentral.com)
  • It is also used for obesity, altitude sickness, aging skin, high levels of cholesterol or other fats in the blood, and many other purposes, but there is no good scientific evidence to support many of these other uses. (medlineplus.gov)
  • The purpose of this review is to provide an overview of the different types of omics data: genomics, epigenomics, transcriptomics, proteomics, metabolomics and illustrate how a multi-omics approach can be fundamental for the implementation of precision obesity management. (springermedizin.at)
  • Finally, we propose a vision for the future of precision obesity management. (cdc.gov)
  • The mechanisms of the complex pathways of metabolic syndrome are under investigation. (wikipedia.org)
  • In addition, different cell types exhibit preference for specific metabolic pathways (fatty acid oxidation/FAO, glycolysis or oxidative phosphorylation/OxPhos). (upenn.edu)
  • [ 1 ] Tripodi et al reported that in nonalcoholic fatty liver disease (NAFLD), a procoagulant imbalance progresses from steatosis to metabolic cirrhosis, which may be caused by an increase in factor VIII and a reduction of protein C. (medscape.com)
  • The condition most commonly associated with fatty liver disease is metabolic syndrome. (medscape.com)
  • Metabolic syndrome is associated with the risk of developing cardiovascular disease and type 2 diabetes. (wikipedia.org)
  • Although ddI use has not been shown to cause metabolic changes, the increased risk of metabolic syndrome among our ddI users may reflect the effect of previous treatments on individuals or may be related to greater disease severity. (natap.org)
  • Here we discuss the molecular mechanisms through which alimentary cues modulate metabolic, microbial and neuroendocrine circuitries and thus affect the probability of developing premalignant lesions that progress to clinically manifested disease and the response to therapeutic intervention. (nature.com)
  • The global outbreak of the new disease (COVID-19) caused by the novel severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) has reached pandemic status in March 2020 [ 1 , 2 ]. (beds.ac.uk)
  • This form of Cushing's syndrome can be very difficult to differentiate from Cushing's disease in the early stages of each, and the clinician needs to be aware of the various pathophysiological mechanisms involved in excessive ACTH production. (pediagenosis.com)
  • Worldwide, 6.3 to 33% of the general populations are estimated to suffer from the disease with even higher prevalence in the group sharing metabolic co-morbidities. (biomedcentral.com)
  • Acute coronary syndrome (ACS) is a cardiovascular disease, which describes any condition characterized by signs and symptoms of sudden myocardial ischaemia and reduction in blood flow to the heart [ 1 ]. (hindawi.com)
  • d) Single-cell multiomics to understand cell-type specific metabolic changes in heart disease. (upenn.edu)
  • AIDS-like syndrome: AIDS-like disease (illness) (syndrome) ARC AIDS-related complex Pre-AIDS AIDS-related conditions Prodromal-AIDS 3. (cdc.gov)
  • This provides theoretical support for early diagnosis and prevention of metabolic syndrome in the Xinjiang Kazakh population and may provide evidence for people living in Kazakhstan and Uzbekistan. (researchsquare.com)
  • Morbid obesity or clinically severe obesity is a condition characterized by body mass index (BMI) over 40 kg/m2, and involves serious health consequences. (symptoma.com)
  • Obesity is thus a worldwide healthcare problem increasing morbid-mortality [ 2 ]. (biomedcentral.com)
  • This review makes the case for the hepatorenal reflex causing sympathetic overdrive and metabolic syndrome in response to exaggerated splanchnic oxygen consumption from excessive eating. (surgicalneurologyint.com)
  • Hirsutism and Hypertrichosis Hirsutism is the excessive growth of thick or dark hair in women in locations that are more typical of male hair growth patterns (eg, mustache, beard, central chest, shoulders, lower abdomen. (merckmanuals.com)
  • Cushing's syndrome is directly caused by excessive amounts of glucocorticoids and their effects on numerous organ systems. (pediagenosis.com)
  • When faced with a patient with excessive ACTH production, the clinician must perform a thorough evaluation, including history, physical examination, and laboratory and radiological testing, to determine the etiology. (pediagenosis.com)
  • Interestingly, comparisons between type 1 and type 2 diabetic individuals further confirm the fact that CAN processes in T2D start earlier than the onset of overt metabolic impairment [2]. (encyclopedia.pub)
  • We hypothesized that a respiratory quotient might predict metabolic syndrome and type 2 diabetes onset. (frontiersin.org)
  • Two individuals developed type 2 diabetes and 10 metabolic syndrome after 1 year. (frontiersin.org)
  • There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. (who.int)
  • When applied to obesity prevention and management, each omics type could potentially help to detect specific biomarkers in people with risk profiles and guide healthcare professionals and decision makers in developing individualized treatment plans according to the needs of the individual before the onset of obesity. (springermedizin.at)
  • Obesity is perhaps the longest studied and best described risk factor for type 2 diabetes. (diabetesjournals.org)
  • Both states are commonly accompanied by the presence of type 2 diabetes, metabolic syndrome, and obesity. (fitnesshacks.org)
  • 1 - 4 Offspring of mothers with GDM are at increased risk for metabolic syndrome and type 2 diabetes in adulthood. (cdc.gov)
  • Secondly, even those public health initiatives that are directed towards obesity prevention and management show little evidence of success and efficacy at the population level. (springermedizin.at)