• The company gave away the rights of Cardioxane, Savene, Totect and Ethyol (amifostine), as Clinigen shifts its pharmaceutical strategy. (pharmaceutical-technology.com)
  • ZUHL, Germany-Amifostine (Ethyol) used as cytoprotective therapy can reduce the occurrence of xero-stomia, loss of taste, and fibrosis associated with radiochemotherapy for head and neck cancer. (cancernetwork.com)
  • The purpose of the study was to draw upan experimental model of hepatic veno-occlusive disease (VOD) induced by dactinomycin (ACT) and to investigate the possible hepatoprotective effects of Ethyol (amifostine). (viamedica.pl)
  • Those products, Cardioxane®, Savene®, Totect® and Ethyol®, address side effects patients may experience when treated with other cancer therapies. (appliedclinicaltrialsonline.com)
  • SR has been involved in the identification of several FDA approved oncology drugs (lomustine, carmustine, dacarbazine, fludarabine, and clofarabine) and one cytoprotective agent (Ethyol). (uab.edu)
  • The first three drugs use dexrazoxane to treat cardiotoxicity caused by cancer drugs while Ethyol is used to correct the effects of cancer treatment with cisplatin or radiation. (pharmaceutical-technology.com)
  • It is marketed by Clinigen Group under the trade name Ethyol. (wikipedia.org)
  • Ethyol® is a radiation protector and the only drug that has been approved by the FDA for xerostomia (dry mouth) in patients receiving radiation therapy for cancers of the head and neck. (pceiva.org)
  • ETHYOL is contraindicated in patients with known hypersensitivity to aminothiol compounds. (nih.gov)
  • It is marketed by Clinigen Group under the trade name Ethyol. (wikipedia.org)
  • In the randomized ovarian cancer study, ETHYOL had no detectable effect on the antitumor efficacy of cisplatin-cyclophosphamide chemotherapy. (nih.gov)
  • 14. Exploration of platinum-based dose-intensive chemotherapy strategies with amifostine (Ethyol). (nih.gov)
  • Selected analyses of the effects of ETHYOL in reducing the cumulative renal toxicity of cisplatin in the randomized ovarian cancer study are provided in TABLES 1 and 2, below. (nih.gov)
  • Embryo-Fetal Toxicity: ETHYOL can cause fetal harm. (nih.gov)
  • 19. Amifostine (Ethyol): pharmacokinetic and pharmacodynamic effects in vivo. (nih.gov)
  • ETHYOL is the trihydrate form of amifostine and is supplied as a sterile lyophilized powder requiring reconstitution for intravenous infusion. (nih.gov)
  • ETHYOL is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite. (nih.gov)
  • The ability of ETHYOL to differentially protect normal tissues is attributed to the higher capillary alkaline phosphatase activity, higher pH and better vascularity of normal tissues relative to tumor tissue, which results in a more rapid generation of the active thiol metabolite as well as a higher rate constant for uptake into cells. (nih.gov)
  • ETHYOL is rapidly metabolized to an active free thiol metabolite. (nih.gov)
  • Measurable levels of the free thiol metabolite have been found in bone marrow cells 5-8 minutes after intravenous infusion of ETHYOL. (nih.gov)
  • WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure. (adooq.com)
  • A randomized controlled trial compared six cycles of cyclophosphamide 1000 mg/m 2 , and cisplatin 100 mg/m 2 with or without ETHYOL pretreatment at 910 mg/m 2 , in two successive cohorts of 121 patients with advanced ovarian cancer. (nih.gov)
  • Subgroup analyses suggested that the effect of ETHYOL was present in patients who had received nephrotoxic antibiotics, or who had preexisting diabetes or hypertension (and thus may have been at increased risk for significant nephrotoxicity), as well as in patients who lacked these risks. (nih.gov)
  • Hypotension and Cardiovascular Events: Patients who are hypotensive or dehydrated should not receive ETHYOL. (nih.gov)
  • Do not administer ETHYOL to hypotensive patients who are taking antihypertensive therapy that cannot be stopped for 24 hours prior to ETHYOL administration. (nih.gov)
  • After a 10-second bolus dose of 150 mg/m 2 of ETHYOL, renal excretion of the parent drug and its two metabolites was low during the hour following drug administration, averaging 0.69%, 2.64% and 2.22% of the administered dose for the parent, thiol and disulfide, respectively. (nih.gov)
  • The recommended dose of ETHYOL is 200 mg/m2 administered once daily as a 3-minute i.v. infusion, starting 15-30 minutes PRIOR to standard fraction radiation therapy (1.8-2.0 Gy). (biotechinvest.net)
  • Hello, I'm trying to collect information on amifostene (ethyol) use during radiation. (cancer.org)
  • Amifostine (ETHYOL) protects rats from mucositis resulting from fractionated or hyperfractionated radiation exposure. (bvsalud.org)
  • If interruption of antihypertensive therapy is possible, interrupt antihypertensive therapy 24 hours prior to ETHYOL administration. (nih.gov)
  • Less than 10% of ETHYOL remains in the plasma 6 minutes after drug administration. (nih.gov)