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  • Peptides
  • In addition to their LRR domains, these leucine-rich repeat immune (LRIM) proteins share several structural features including signal peptides, patterns of cysteine residues, and coiled-coil domains. (biomedcentral.com)
  • Granule
  • Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes. (diva-portal.org)
  • In patients with FHL-2, PRF1 mutations induce a complete or partial reduction of the synthesis of the perforin protein, resulting in impairment of the granule-mediated cytotoxic machinery of NK and T cells. (haematologica.org)
  • Taken together, these reports suggest F-actin remodeling as a key factor in insulin granule priming and mobilization through the F-actin web, but the underlying molecular mechanism and key signaling pathways involved in this process remain largely unknown. (diabetesjournals.org)
  • Using the RBL-2H3 rat mast cell line, we investigated whether granule secretion involves components of the soluble N -ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery. (jimmunol.org)
  • superfamily
  • These key components of the secretory pathway belong to a superfamily of proteins which share a SNARE motif composed of 60 to 70 amino acids arranged in heptad repeats. (springer.com)
  • ABSTRACT
  • Abstract : Many prominent biological processes are driven by protein assembling between membranes. (ens.fr)
  • membranes
  • Our observations indicate a decisive role of the tryptophan moiety of SybII in keeping the vesicles in the release-ready state and support a model wherein tryptophan-mediated protein-lipid interactions assist in bridging the apposing membranes before fusion. (jneurosci.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • lipid
  • Although BDNF can control transcription and protein synthesis, it still remains open to question whether BDNF regulates lipid biosynthesis. (jneurosci.org)
  • Consistent with this notion, BDNF raised the level of the lipid raft marker protein caveolin-2 in rafts. (jneurosci.org)
  • Remarkably, BDNF increased the levels of presynaptic proteins in lipid rafts, but not in nonrafts. (jneurosci.org)
  • Yet the most probable route of SNARE-mediated membrane fusion comprises a series of events that requires not only protein-protein but also protein-lipid interactions. (jneurosci.org)
  • Lipid Regulated Intramolecular Conformational Dynamics of SNARE-Protein Ykt6. (nih.gov)
  • Eukaryotic cells contain multiple membrane-bound compartments between which proteins and lipid molecules are continually shuttled via membrane-bound vesicular carriers. (springer.com)
  • Despite the constant flux of proteins and lipid through these compartments their functional and composition integrity is maintained. (springer.com)
  • neurons
  • Among neurotrophins, brain-derived neurotrophic factor (BDNF) is highly expressed in brain and mediates multiple effects on CNS neurons ( Bibel and Barde, 2000 ). (jneurosci.org)
  • Chromogranin A is an acid 48 kDa glycoproteins proteins localized to the matrix of large dense core vesicles of neurons and neuroendocrine cells. (springer.com)
  • The asymmetric distribution of membrane proteins in different cell surface domains is a feature common to many types of polarized cells, including epithelia, neurons, and immune cells ( Yamada and Nelson, 2007 ). (rupress.org)
  • overexpression
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • gene
  • The SGR2 (At1g31480) gene encodes a phospholipase A1-like protein localized to the vacuolar membrane, although its biochemical function is not yet known. (pnas.org)
  • biological
  • They range from 30 nm to several micrometers in diameter, and ferry biological cargos such as proteins, lipids, RNAs and DNAs for local and distant intercellular communications. (springer.com)
  • Brain-derived neurotrophic factor (BDNF) exerts multiple biological functions in the CNS. (jneurosci.org)
  • Controlling the metal stress is known to activate a multigene response resulting in the changes in various proteins, which directly affects almost all biological processes in a living cell. (chemweb.com)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • BoNTs
  • There are seven immunologically unique BoNT serotypes (A-G). The Centers for Disease Control classifies BoNTs as 'Category A' select agents and are the most lethal protein toxins for humans. (mdpi.com)
  • BoNTs are di-chain proteins comprised of an N -terminal zinc metalloprotease Light Chain (LC) and a C-terminal Heavy Chain (HC) which includes the translocation and receptor binding domains. (mdpi.com)
  • mutant
  • Although malformation of the SCO during gestation leads to ventricular dilation and aqueductal stenosis before birth (FIGURE 1, B AND C ⇓ ) ( 32 , 80 ), the involvement of specific factors has been slowly elucidated over the past decade through the analysis of mutant mouse models. (physiology.org)
  • secretion
  • Absorption and secretion of peptide and protein cargoes across single-cell thick mucosal and endothelial barriers occurs by active endocytic and vesicular trafficking that connects one side of the epithelial or endothelial cell (the lumen) with the other (the serosa or blood). (readbyqxmd.com)
  • Eventually, a number of proteins were identified that regulated cell aggregation, islet cell-type segregation, architectural organization within islets of Langerhans, and state of differentiation, cell growth, and hormone secretion ( 9 - 16 ). (diabetesjournals.org)
  • Genes
  • The identification and characterisation of genes related to LRIM1 and APL1C revealed putatively novel innate immune factors and furthered the understanding of their likely molecular functions. (biomedcentral.com)
  • This is the first report linking membrane trafficking proteins to dystroglycanopathy and suggests that these genes should be considered in the diagnostic evaluation of patients with congenital muscular dystrophy and dystroglycanopathy. (biomedcentral.com)