To fight MDR and XDR tuberculosis, three new antitubercular drugs, bedaquiline (BDQ), delamanid, and pretomanid were approved for use in clinical setting. (frontiersin.org)
The following agents are leprostatic agents: acedapsone clofazimine dapsone desoxyfructo-serotonin diucifon ethionamide rifampicin rifapentine sulfameter thalidomide Leprosy is a chronic infectious disease caused by Mycobacterium leprae. (wikipedia.org)
NTM are also naturally resistant to many antibiotics, specifically anti-tuberculosis (anti-TB) drugs. (bvsalud.org)
Multidrug-resistant tuberculosis (MDR-TB) is also on the rise, especially in large cities, in those previously treated with antitubercular drugs, or in those who failed to follow or complete a drug regimen. (nurseslabs.com)
Minocycline1
Community-acquired MRSA has responded to a number of other antibiotics, including doxycycline, clindamycin, minocycline, and TMP/sulfamethoxazole. (conduent.com)
Drugs3
Disrupting the mycolic acid pathway with the help of effective treatment is a great task and proven therapy by the drugs like isoniazid, ethionamide, isoxyl, thiacteazone, and triclosan. (microbenotes.com)
The currently recommended NTM treatments rely on the extended indications of existing drugs, which underlines the difficulties of new antibiotic discovery against NTM. (bvsalud.org)
Background: Fluoroquinolone (FQ) antibiotics are among the most potent second-line antitubercular drugs these days. (bvsalud.org)
Fluoroquinolone1
Long-acting rifamycin derivatives and potent fluoroquinolone antibiotics have been studied, and they lead the way for improved regimens against active and latent TB. (medscape.com)
Considering the range of chemical reactions involved in the biosynthetic pathways of Mtb , information related to the biotransformation of antitubercular compounds would provide opportunities for the development of new chemical tools to study successful TB infections while also highlighting potential areas for drug discovery, host-directed therapy, dose optimization and elucidation of mechanisms of action. (nature.com)
To a certain extent, anti-NTM drug development depends on using already available antibiotics and compounds. (bvsalud.org)
Here, we aimed to review new antibiotics or compounds with good antibacterial activity against NTM, focusing on their mechanisms of action, in vitro and in vivo antibacterial activities. (bvsalud.org)
Targets1
The increasing accessibility of whole-genome sequencing across research and clinical settings has improved our ability to predict antibacterial susceptibility, to track epidemics at the level of individual outbreaks and wider historical trends, to query the efficacy of the bacille Calmette-Guérin (BCG) vaccine, and to uncover targets for novel antitubercular therapeutics. (jci.org)
Finally, we also constructed a data sheet including the mutations associated with BDQ resistance that could be useful for the early detection of BDQ-resistance in MDR/XDR patients with the purpose of a better management of antibiotic resistance in clinical settings. (frontiersin.org)
Infectious disease1
The Centers for Disease Control and Prevention (CDC) recommends that clinicians reserve linezolid for more severe infections after consultation with an infectious disease specialist or for those patients who have not responded to other antibiotics. (conduent.com)
Synthesis1
It is a weak antitubercular drug and it inhibits bacteria by mycolic acid cyclopropane synthesis. (microbenotes.com)
RESISTANCE3
Up to 10 per cent of patients who had their mycobacterial infection tested for resistance to second- or later-line drugs had isolates with resistance-conferring variants to at least one antibiotic (103/1000 for ethionamide), which was not detected by pDST. (inahta.org)
However, from South Australian data, none of the 5/75 (6.7%) patients whose infection had ethionamide resistance-conferring variants would be considered for this treatment (as they were all likely to respond to at least three first-line drugs). (inahta.org)
TB resistance is a great concern in the antibiotic resistance pandemic due to the high risk of death, as patients can remain infected for months or years and also because of the difficulty of the treatment. (scirp.org)