• Aly HA, Khafagy RM (2014) Tau reverses endosulfan-induced oxidative stress and apoptosis in adult rat testis. (springer.com)
  • Das J, Ghosh J, Manna P, Sil PC (2012a) Tau protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis. (springer.com)
  • The present study aimed to evaluate the possible beneficial effects of betaine on oxidative stress and memory deficits induced by intrahippocampal injection of amyloid beta (Aß) in an AD model. (bvsalud.org)
  • Conclusion and implications: The current findings showed that oral administration of betaine could prevent Aß-induced impairment of memory possibly through suppression of oxidative stress in the hippocampus area of rats. (bvsalud.org)
  • The effects of ginseng oligosaccharides (GSOs) on neuronal oxidative injury induced by glutamate (GLU) and the molecular mechanisms involved were investigated. (sdbonline.org)
  • Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
  • These findings indicate that GSOs protect against GLU-induced neuronal oxidative damage through Nrf2/HO-1 activation. (sdbonline.org)
  • MMPs are involved in the number of pathologies that destroy the CNS and reduction in the level of endogenous antioxidants like α-tocopherol, vitamin E with ethanol, promotes oxidative stress by generating free radicals and lipid peroxidation. (benthamscience.com)
  • The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)
  • The pathologic effect of AGEs is caused by its ability in inducing oxidative stress and inflammation through binding with the receptor on the cell surface and body protein cross-linking, thus altering the cell structure and function. (hindawi.com)
  • 2019). Ethanol and cannabinoids interact to alter behavior in a zebrafish fetal alcohol spectrum disorder model. (nccu.edu)
  • Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder (FASD), a prevalent, preventable pediatric disorder. (biomedcentral.com)
  • A program that helps youth and families in Waterloo region deal with fetal alcohol spectrum disorder is receiving provincial attention. (blogspot.com)
  • FAS is a syndrome that falls under a larger group of conditions known as Fetal Alcohol Spectrum Disorder (FASD). (aao.org)
  • Golding said this research, which was funded by a Medical Research Grant from the W.M. Keck Foundation and the NIH National Institute on Alcohol Abuse and Alcoholism, reveals a potential blind spot in the current diagnostic criteria for FAS, the most severe form of Fetal Alcohol Spectrum Disorder (FASD), which requires documentation of maternal alcohol use during pregnancy. (neurosciencenews.com)
  • Our group previously reported that arsenic (As) exposure induced apoptosis in hippocampus neurons. (springer.com)
  • The aim of the present study was to clarify the protective capacity of taurine (Tau) on As-induced neuronal apoptosis and the related mechanism in mouse hippocampus. (springer.com)
  • The results indicated that Tau supplement markedly ameliorates As-induced apoptosis by mitochondria-related pathway in mouse hippocampus. (springer.com)
  • Das J, Ghosh J, Manna P, Sil PC (2010) Protective role of Tau against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. (springer.com)
  • Gao X, Yang X, Zhang B (2011) Neuroprotection of Tau against bilirubin-induced elevation of apoptosis and intracellular free calcium ion in vivo. (springer.com)
  • Leon R, Wu H, Jin Y, Wei J, Buddhala C, Hu WJ (2009) Protective function of Tau in glutamate-induced apoptosis in cultured neurons. (springer.com)
  • Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)
  • Long-term behavioral impairment following acute embryonic ethanol exposure in zebrafish. (nccu.edu)
  • Use with ethanol causes additive psychomotor impairment. (nih.gov)
  • Using a brain injury model, we also found that stem cell grafts prevented injury-induced cognitive impairment (memory loss) by secreting trophic factors to protect injured nerve cells. (utmb.edu)
  • Acute and chronic neurologic disorders associated with the various neurologic effects of ETHANOL. (edu.au)
  • Acute behavioural comparisons of toluene and ethanol in human subjects. (cdc.gov)
  • These studies are employing genetic and molecular approaches to examine ocular, forebrain, and hindbrain development in response to ethanol exposure, and the subsequent changes in agrin, Fgf or Shh signaling. (nccu.edu)
  • We found substantial genetic variation in gene expression in response to ethanol with extensive sexual dimorphism. (biomedcentral.com)
  • In this brief overview, medications used to treat insomnia such as hypnotics, sedatives, medications inducing sedation as a side effect, medications directed at the sleep-associated circadian neuroendocrine system, and agents utilized in treating insomnia-inducing sleep diagnoses such as restless leg syndrome are discussed. (springer.com)
  • Medications for treating insomnia are classified as hypnotics, sedatives, medications inducing sedation as a side effect, medications directed at the sleep-associated circadian neuroendocrine system, and agents utilized in treating insomnia-inducing sleep diagnoses such as restless leg syndrome (RLS) (Curry et al. (springer.com)
  • Propofol (2,6-diisopropylphenol) is an intravenous anesthetic widely used in surgery or intensive care units to induce and maintain anesthesia as well as sedation [ 2 ]. (degruyter.com)
  • With wide safety margins and few contraindications, the benzodiazepines most commonly used by dentists are diazepam, as a mild sedation-inducing anxiolytic, midazolam, to induce sleep and amnesia, and alprazolam, lorazepam, and triazolam, each with their appropriate properties and preferred dosages. (bvsalud.org)
  • Chang CY, Shen CY, Kang CK, Sher YP, Sheu WH, Chang CC, Lee TH (2014) Tau protects HK-2 cells from oxidized LDL-induced cytotoxicity via the ROS-mediated mitochondrial and p53-related apoptotic pathways. (springer.com)
  • Ataxia (from Greek α- [a negative prefix] + -τάξις [order] = "lack of order") is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in eye movements, that indicates dysfunction of parts of the nervous system that coordinate movement, such as the cerebellum. (wikipedia.org)
  • Overall, esketamine mitigates propofol-induced cognitive dysfunction and brain injury in rats by activating mBDNF/TrkB/PI3K signaling. (degruyter.com)
  • The major emphasis of the laboratory is the investigation of the role of agrin in fetal alcohol spectrum disorders (FASD) and how agrin function via Fgfs and Shh is a target of embryonal ethanol and cannabinoid exposure in zebrafish. (nccu.edu)
  • A goal of Dr. Cole's laboratory is to correlate these molecular changes, as a consequence of embryonic ethanol exposure, to behavioral changes in juvenile and adult zebrafish. (nccu.edu)
  • Molecular and morphological changes in zebrafish following transient ethanol exposure during defined developmental stages. (nccu.edu)
  • Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf and Sonic hedgehog function. (nccu.edu)
  • Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish. (nccu.edu)
  • Exposure to many neurotoxicants can affect multiple sensory systems. (cdc.gov)
  • We reared DGRP lines which showed extreme upregulation or downregulation of snoRNA expression during developmental alcohol exposure on standard or ethanol supplemented medium and demonstrated that developmental exposure to ethanol has genotype-specific effects on adult locomotor activity and sleep. (biomedcentral.com)
  • There is significant and sex-specific natural genetic variation in the transcriptional response to developmental exposure to ethanol in Drosophila that comprises networks of genes affecting nervous system development and ethanol metabolism as well as networks of regulatory non-coding RNAs. (biomedcentral.com)
  • 2020). Ethanol and cannabinoids regulate zebrafish GABAergic neuron development and behavior in a sonic hedgehog and fibroblast growth factor dependent mechanism. (nccu.edu)
  • Although the first half of sleep after alcohol intake looks good on the EEG, the result of the assessment regarding the autonomic nerve system shows that drinking leads to insomnia rather than good sleep. (eurekalert.org)
  • Kava kava is an herbal remedy for treatment of anxiety, insomnia, and related nervous disorders. (healthyplace.com)
  • Several studies have found that kava may be useful in the treatment of anxiety, insomnia, and related nervous disorders. (healthyplace.com)
  • Except in individuals whose insomnia is secondary to circadian disturbance, mood disorder/depression and/or restless leg syndrome , there is minimal evidence supporting the efficacy of other medications used to treat insomnia despite their widespread use. (springer.com)
  • These are the agents that should be exclusively classified as hypnotics and utilized to induce sleep when medications are required to treat the complaint of insomnia. (springer.com)
  • Chronic insomnia is significantly associated with a decrease in quality of life measures, the exacerbation of co-morbid diagnoses, and an increased likely-hood for developing mood disorders / de[ression (Sateia et al. (springer.com)
  • 2017 ). While there are dozens of insomnia-associated sleep diagnoses, any medical or psychiatric disorder or environmental stress that produces nighttime discomfort is likely to induce insomnia. (springer.com)
  • Sleep hygiene refers to environmental factors, dietary approaches, drugs, and a lack of required sleep facilitating approaches that can induce insomnia. (springer.com)
  • Insomnia inducing drugs include caffeine, nicotine, weight loss preparations, and activating agents of both prescription and abuse. (springer.com)
  • High-performance liquid chromatography with a diode-array detector (HPLC-DAD) revealed a range of bioactive molecules (i.e., gallic acid, quercetine, luteolin) in the pomegranate juice that may have neuroprotective value for the nervous disorders caused by Al intoxication. (researchgate.net)
  • We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. (uth.edu)
  • 2017). Comparison of molecular marker expression in early zebrafish brain development following chronic ethanol or morpholino treatment. (nccu.edu)
  • Background: Alcoholic neuropathy is a chronic disorder caused by the excessive consumption of alcohol. (benthamscience.com)
  • Swales, m, heard, hl, and williams, mg: Linehans dialectical behavior therapy for borderline personality disorder, alcoholism or drug carrier, which allows for processing of basic principles of medical toxicology ical illness. (revivemedicalny.com)
  • Substance use disorders generally involve behavior patterns in which people continue to use a substance (for example, a recreational drug) despite having problems caused by its use. (msdmanuals.com)
  • Brain, mind, immunologic system and other relevant physiological functions are deeply influenced by a primitive structure and to deeply understand the meaning of this complex system inside us make possible to better explain today Human behavior and physiology and other process" [1]. (heraldopenaccess.us)
  • The Al deposition in the brain caused neural degeneration and decreased cell density inducing a state of anxiety, depression, and a deficit of learning and memory. (researchgate.net)
  • To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. (uth.edu)
  • It is most often prescribed to treat the symptoms associated with generalized anxiety disorder (GAD), such as tension, dizziness, fear, pounding heartbeat, and other symptoms people might feel.It is considered to be less sedating than other drugs that treat anxiety symptoms. (arlen.com.br)
  • Buspirone is used to treat certain anxiety disorders or to relieve the symptoms of anxiety. (arlen.com.br)
  • Buspar (buspirone) is an anti-anxiety drug used to treat anxiety and it may improve symptoms of depression in patients with generalized anxiety disorder. (arlen.com.br)
  • A recent study shows that CBD, or cannabidiol, is successful at reducing anxiety that's related to other disorders including PTSD, GAD, PD, OCD, and SAD. (austinchronicle.com)
  • Many of the patients suffered psychiatric disorders, including anxiety disorders, depression and suicide attempts, and 80.9% took other psychoactive drugs. (who.int)
  • Although there are several studies monitoring HRV during sleep, as far as I know there is no report describing the effects of alcohol on autonomic nervous system during sleep using this parameter. (eurekalert.org)
  • It is also one of the neurotransmitters in the autonomic nervous system, occupying an important role in the sympathetic and parasympathetic parts, and is the only neurotransmitter used in the motor part of the somatic nervous system. (stayfitlonger.com)
  • The attention deficit hyperactivity disorder (ADHD) is a condition that can be characterized by the lack of attention, impulsivity and hyperactivity. (usp.br)
  • Atomoxetine is a selective norepinephrine reuptake inhibitor indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD). (nih.gov)
  • Anatomically are involved cortexes, basal ganglia and thalamus but also other system like amygdala) Dopaminergic-Mesolimbic pathway in example Dopamine is involved in many physiological functions like emotion, pleasure, movement (extra pyramidal), Breast feeding, involved in depression or schizophrenia, prolactin regulation, nausea and vomiting and other. (heraldopenaccess.us)
  • The purpose of the present study was to determine the neuroprotective potential of pomegranate juice on Al induced neurotoxicity. (researchgate.net)
  • pomegranate juice on Al induced neurotoxicity. (researchgate.net)
  • As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. (degruyter.com)
  • It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of propofol. (degruyter.com)
  • However, its effect on propofol-induced neurotoxicity and the underlying mechanism remain unclear. (degruyter.com)
  • Therefore, a better understanding of the mechanism underlying propofol-induced neurotoxicity is favorable for eliminating the side effects of propofol. (degruyter.com)
  • Therefore, in the present study, the effects of rotenone-induced PD on female mice as well as their fetuses and curcumin supplementation on the cerebral tissue of both female mice and their resulted fetuses were studied. (bvsalud.org)
  • METHODS: The rotenone was injected subcutaneously to induce PD model of female mice. (bvsalud.org)
  • NIH R21 AA025400, P.I., "Gene-ethanol interactions in a zebrafish multi-binge FASD model," $405,079 total costs. (nccu.edu)
  • FAS/FASD is the most common preventable pediatric disorder, often diagnostically confounded with autism spectrum disorder [ 8 ]. (biomedcentral.com)
  • Sedatives and sleep-inducing drugs intensify codeine phosphate effects. (herbapol.pl)
  • Sedatives and other medications used off-label for sedative side-effects are a contributing factor to drug induced hypersomnolence, a factor in more than 30% of motor accident deaths. (springer.com)
  • The binding of glucagon for -adrenergic antagonist-poisoned patients with parenchymal disorders of the situation, the diagnosis of hard-metal disease include upper respiratory tract injury) chlorine isocyanates low water solubility oxides of nitrogen ing material fluorinated resins hydrogen uoride fire-retardant hydrogen chloride, carbon tetrachloride, ethanol, effects side child abilify acetaminophen, paranitrophenol, aniline, and n-nitrosomethylamine, cyp2e1 actively produces free radicals and causes increased metabolic rate and reduces stool output. (revivemedicalny.com)
  • It may intensify effects of other opioid drugs on respiratory center and the effects of ethanol. (herbapol.pl)
  • However, after application of the product containing codeine the following undesired effects may occur: nausea, vomiting, constipations, dryness in the mouth, sleep disorders and allergic reactions, e.g. dermal lesions. (herbapol.pl)
  • In conclusion, the antinociceptive effects of T. catigua extract seem to be mainly associated with the activation of dopaminergic system and, to a lesser extent, through interaction with opioid pathway. (hindawi.com)
  • The authors have also evaluated the effects of extracts made from the plants present in the product Catuama, T. catigua, P. cupana , P. olacoides and Z. officinalis , and verified that T. catigua had the higher antinociceptive effect on the acetic acid-induced nociception [ 3 ]. (hindawi.com)
  • Sagawa added that it is important for clinicians who are treating physical and psychological disorders related to alcohol to consider the disturbing effects on sleep's restorative effects that habitual drinking can have. (eurekalert.org)
  • Long-term treatment with statins may have adverse effects: affection of muscles or peripheral nervous system. (nel.edu)
  • Opioid analgesics present a wide array of serious and nonserious risks, including adverse effects, opioid use disorders, and overdose mortality. (naturalmedicinejournal.com)
  • The benefits of most sources of acetylcholine can be multifaceted and not directly related to acetylcholine synthesis and effects on brain activity, so we will limit ourselves to benefits related to the cholinergic system and effects on the nervous system. (stayfitlonger.com)
  • on the other hand, the salt of sibutramine monohydrate, which has a pharmacological mechanism of action similar in these systems of central neurotransmission, have not had their use tested in a model of ADHD. (usp.br)
  • Alcohol crosses the placenta and, although there are many hypotheses, the exact mechanism by which alcohol induces CNS and structural changes is still unclear [4] . (aao.org)
  • 2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. (uth.edu)
  • The results showed that Tau treatment induced the decrease of TUNEL-positive cells, prohibited the disturbance of Bcl-2 and Bax expression, and inhibited Cyt C release and caspase-8 and caspase-3 activation significantly. (springer.com)
  • Li B, Shi Y, Shu J, Gao J, Wu P and Tang S-J, 2013 Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type1 (HIV-1) envelope glycoprotein 120 (gp 120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (caMKII) and c-JUN N-terminal kinase (JNK) signaling pathways. (utmb.edu)
  • Liu Z, Liu Y, Gao R, Li H, Dunn T, Wu P, Smith GR, Sarkar PS and Fang X, 2014 Ethanol Suppresses PGC-1α Expression by Interfering with the cAMP-CREB Pathway in Neuronal Cells. (utmb.edu)
  • Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)
  • A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment. (uth.edu)
  • We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. (uth.edu)
  • ABSTRACT All psychiatric and general medical male patients referred to 2 hospitals in Basra, Iraq from September 2000 to April 200l were screened using the Alcohol Use Disorder Identification Test. (who.int)
  • Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis. (nih.gov)
  • Fifty psychiatric outpatients diagnosed with schizophrenia or schizoaffective disorder and on treatment with clozapine or olanzapine were studied during 8 years. (nel.edu)
  • Data have been collected using the Mortality Information System and were analyzed by the TabWin program. (bvsalud.org)
  • More recently, our group has shown that Catuama also produces a prominent reduction of the mechanical hypersensitivity induced by LPS in rats [ 4 ]. (hindawi.com)
  • Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance. (nih.gov)
  • It is not recommended to apply in case of respiratory system diseases with accompanying retention of thick secretion inside bronchial tree and difficulties with expectoration. (herbapol.pl)
  • Because of ethanol content, the syrup should not be applied in individuals with alcoholism and in patients with liver diseases or epilepsy. (herbapol.pl)
  • Many subjects habitually drink alcohol, and if the reduction of parasympathetic nerve activity during sleep chronically occurred, negative health consequences may be much larger and may induce various diseases. (eurekalert.org)
  • Human neural stem cells can be used to study how the human nervous system is developed, how neural diseases damage the system and how to use stem cells to repair the injured or degenerated brain and spinal cord. (utmb.edu)
  • The cutaneous porphyrias are dermatologic diseases that may or may not involve the liver and nervous system. (medscape.com)
  • Course of Psychiatric Disorders in Pregnancy Dilemmas in Pharmacologic Management. (benzo.org.uk)
  • Ames D, Chiu E. Drugs Used for Psychiatric Disorders. (benzo.org.uk)
  • The CANTAB was derived from laboratory research and has proved useful in defining the nature of neurobehavioral deficits in a variety of adult clinical disorders (Fray, Robbins & Sahakian, 1996). (cdc.gov)
  • The possible involvement of the dopaminergic system in the actions of T. catigua extract was substantiated by data showing the potentiation of apomorphine-induced hypothermia and by the prevention of haloperidol-induced catalepsy. (hindawi.com)
  • These studies are currently focusing on elucidating the mechanisms by which agrin modulates the function of heparin-binding growth factors and morphogens, such as fibroblast growth factors (Fgfs) and sonic hedgehog (Shh), during zebrafish nervous system development. (nccu.edu)
  • By speeding up the nervous system, stimulant medications can increase blood pressure and speed up the heartbeat. (webmd.com)
  • Normally, during physiologic nocturnal sleep in humans, the parasympathetic nervous system, responsible for 'rest-and-digest' activities, is dominant over the sympathetic nervous system, responsible for stimulating activities. (eurekalert.org)
  • Alcohol Use Alcohol (ethanol) is a depressant (it slows down brain and nervous system functioning). (msdmanuals.com)
  • Functional genomic studies were performed using HepG2 cells and induced pluripotent stem cell (iPSC)-derived brain organoids. (elsevierpure.com)
  • Finally, we demonstrated that ethanol significantly induced FGF21, dopamine, norepinephrine, and epinephrine concentrations in iPSC-derived brain organoids. (elsevierpure.com)
  • The present review will examine evidence revealing that astrocytes respond to dopamine and modulate information processing in the primary brain regions implicated in the mesolimbic dopamine system. (nature.com)
  • The functioning of the brain and the entire nervous system is a complex process involving dozens of neurotransmitters, each of which has a specific action. (stayfitlonger.com)
  • Against the backdrop of modern brain and nervous system stress, let us ask ourselves: do we need neurotransmitters? (stayfitlonger.com)
  • Herein, we investigated the role of esketamine in propofol-induced brain injury. (degruyter.com)
  • A rat model of propofol-induced brain injury was established with or without the treatment of esketamine. (degruyter.com)
  • However, whether esketamine has an effect on propofol-induced brain injury has not been investigated. (degruyter.com)
  • Such studies will allow us to improve the efficacy of stem cell therapy for various neurological disorders, including spinal cord injury, brain trauma and Lou Gehrig's disease (amyotrophic lateral sclerosis or ALS). (utmb.edu)
  • If this happens to you, stop taking Sonata and talk with your doctor about another treatment for your sleep disorder. (rxlist.com)
  • Alternative medicine includes well-established treatment systems such as homeopathy, traditional chinese medicine, and ayurvedic medicine, as well as more-recent, fad-driven treatments. (w8mdspa.com)
  • In the zebrafish embryos, Ingham's group identified a Dhh gene and the Shh gene as active in the notochord, a structure in chordate embryos, in the floor plate, a structure that in vertebrate embryos develops into the nervous system. (asu.edu)
  • Osei-Owusu P, Scrogin KE: Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage. (arlen.com.br)
  • Also, the low-frequency/high-frequency ratio that is considered an index of the balance between the sympathetic and parasympathetic systems was increased. (eurekalert.org)
  • We used 96 sequenced, wild-derived inbred lines from the Drosophila melanogaster Genetic Reference Panel (DGRP) to profile genome-wide transcript abundances in young adult flies that developed on ethanol-supplemented medium or standard culture medium. (biomedcentral.com)
  • These nervous system dysfunctions occur in several different patterns, with different results and different possible causes. (wikipedia.org)