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  • genes
  • The interaction of the genes that make beta-3 and SERT has been of substantial clinical interest as they have been implicated in cardiovascular disease and autism. (bio-medicine.org)
  • Cells
  • Estrogen receptor beta induces antiinflammatory and antitumorigenic networks in colon cancer cells. (uh.edu)
  • 2011). Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G(2)/M checkpoint signaling. (uh.edu)
  • Role of gambogic acid and NaI(131) in A549/DDP cells. (abcam.com)
  • Although stimulated in both Ishikawa(+) and Ishikawa(-) cells by DDT and its congeners, AP-1 activation was more pronounced in the estrogen-unresponsive Ishikawa(-) cells. (thefreelibrary.com)
  • For instance, IKK2 is found to be mainly responsible for phosphorylating serine 536 in monocytes and macrophages, or in CD40 receptor binding in hepatic stellate cells. (wikipedia.org)
  • The mating factor peptide may bind to a cell surface receptor on other yeast cells and induce them to prepare for mating. (wikipedia.org)
  • mice
  • They found that mice deficient in only the estrogen receptor ER-beta had reduced recovery from auditory trauma, and that treatment with ER-beta-binding drugs protected mice from auditory damage. (bio-medicine.org)
  • MPA failed to induce mammary carcinomas or significant morphologic changes in the mammary glands of C57BL/6 mice. (biomedcentral.com)
  • Tissue
  • Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific regulation. (novapublishers.com)
  • Tissue distribution and quantitative analysis of ERα and ERβ messenger ribonucleic acid in the wild-type and ERα knockou t mouse. (novapublishers.com)
  • interacts
  • The authors therefore suggested that the demonstration that SERT interacts with integrin beta-3 provides a possible mechanistic basis for these recent genetic associations. (bio-medicine.org)
  • bind
  • 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) is thought to bind directly to mouse CAR, thus inducing its translocation into the nucleus. (wikipedia.org)
  • Within tissues, IGFBP-3 can bind IGF-1 and IGF-2 released by many cell types, and block their access to the IGF-1 receptor (IGF1R), which is activated by both IGFs. (wikipedia.org)
  • Kinase
  • Alternatively, PP2A might be activated through another pathway including the epidermal growth factor receptor (EGFR) and the receptor for activated C kinase 1 (RACK1). (wikipedia.org)
  • integrin
  • There are also, however, other pathways that are activated by this interaction such as the pathways c-Kit-induced Rac activation and β1-integrin. (wikipedia.org)
  • variants
  • A second project is focusing on variants of ERβ1 the ERβ2, ERβ4 and ERβ5 which have a truncated c-terminal domain preventing normal receptor function (see figure 2). (uh.edu)