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  • mediates
  • However, advances in radioisotope chemistry and detection techniques for tritium, facilitated the identification of a receptor protein that mediates the diverse actions of estrogen without metabolic alteration of the hormone itself. (aacrjournals.org)
  • The uterus of female ERKO mice is hypoplastic, suggesting that ERα mediates mitosis and differentiation in the uterus in response to estrogen stimulation. (wikipedia.org)
  • naturally occurrin
  • The next step of a drug discovery project is to identify environmental substances that may have an effect in humans similar to an effect produced by a naturally occurring estrogen. (osc.edu)
  • tissue
  • Estrogen stimulation of ERα is known to stimulate cell proliferation in breast tissue. (wikipedia.org)
  • The discovery in 1987 that the SERMs tamoxifen and raloxifene, then thought to be antiestrogens because of antagonist effects in breast tissue, showed estrogenic effects in preventing bone loss in ovariectomized rats had a great effect on our understanding of the function of estrogen receptors and nuclear receptors in general. (wikipedia.org)
  • Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue. (wikipedia.org)