AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth CareGeographicals
EstrogensReceptors, EstrogenEstrogen Receptor alphaEstrogen Receptor betaEstrogens, Conjugated (USP)EstradiolWomen's HealthWomenEstrogens, CatecholOvariectomySelective Estrogen Receptor ModulatorsEstrogens, Non-SteroidalPostmenopauseTamoxifenBreast NeoplasmsPregnant WomenPregnancyBattered WomenEstradiol CongenersReceptors, ProgesteroneMenopauseAromataseUterusDiethylstilbestrolWomen's Health ServicesWomen's RightsSex FactorsPremenopauseEstroneProgesteroneProgestinsSex CharacteristicsRisk FactorsCohort StudiesAge FactorsWomen, WorkingEthinyl EstradiolQuestionnairesPhytoestrogensCase-Control StudiesCross-Sectional StudiesTime FactorsPhysicians, WomenAromatase InhibitorsVaginaUnited StatesHydroxyestronesNeoplasms, Hormone-DependentParityAntineoplastic Agents, HormonalMedroxyprogesterone AcetateTestosteronePregnancy Complications, InfectiousBody Mass IndexFollow-Up StudiesIncidenceRNA, MessengerEndometriumPregnancy OutcomeLogistic ModelsIsoflavonesUterine Cervical NeoplasmsMenstruationMammographyBreastPostpartum PeriodOsteoporosis, PostmenopausalPrenatal CareBone DensityImmunohistochemistryInfertility, FemaleVaginal SmearsSocioeconomic FactorsOdds RatioVitellogeninsMass ScreeningEuropean Continental Ancestry GroupCell Line, TumorAndrogensCervix UteriContraceptives, OralRisk AssessmentObesityRiskEndometrial NeoplasmsCastrationNafoxidineRetrospective StudiesBenzhydryl CompoundsDietTreatment OutcomePhenolsAgingGonadal Steroid HormonesDose-Response Relationship, DrugInfant, NewbornAnalysis of VarianceContraceptives, Oral, HormonalEndometriosisPolycystic Ovary Syndrome
MenopausePostmenopausal womenDeficiencyHormonesProgestinEstradiolReceptors0.625Dosage forms of estrogensPremarinEndometrial CancerHormonalVaginaEstroneMenopausal hormone therapyForms of estrogenType of estrogenUterusEffects of estrogenTherapyReceptor-Positive Breast CancerPost-menopausal womenPubertyBreast cancerTissues in the bodySymptomsReproductiveRisksTumorsOvaries removedIncreased riskSyntheticWomen's Health IniCancersOralPremenopausal womenPregnantPerimenopausalLevel of estrogenUrineHormone estrogenMedicationsLevelsConcentrationsTestosteroneLibidoAdditionallyMalesDeficientAffect estrogenYearsHumansFindingsInsufficiencySexual dysfunctionOrally
Menopause53
Postmenopausal women15
  • Among the older postmenopausal women studied as part of the Women's Health Initiative (WHI), an orally administered conjugated estrogen supplement was found to be associated with an increased risk of dangerous blood clotting. (wikipedia.org)
  • New results from a substudy of the Women's Health Initiative (WHI) Estrogen-Alone Trial show that younger postmenopausal women who take estrogen-alone hormone therapy have significantly less buildup of calcium plaque in their arteries compared to their peers who did not take hormone therapy. (nih.gov)
  • Conducting a clinical trial that would start any form of hormone therapy on postmenopausal women at a younger age and follow them for decades - when they would be more likely to have heart attacks - is not feasible. (nih.gov)
  • We cannot assume that any possible short-term, cardiovascular benefit from hormone therapy to postmenopausal women in their fifties would extend into older ages if they were to continue using hormones," Rossouw cautioned. (nih.gov)
  • The WHI is a major, 15-year research program designed to address the most frequent causes of death, disability, and poor quality of life in postmenopausal women: cardiovascular disease, cancer, and osteoporosis. (nih.gov)
  • The principal findings from the WHI hormone therapy trials, which studied 27,347 postmenopausal women on estrogen-alone or estrogen plus progestin, found that the overall risks of hormone therapy outweigh the benefits. (nih.gov)
  • Among the identified risks and benefits of hormone-replacement therapy, the effects of treatment on cognitive function in postmenopausal women have proved difficult to define. (jneurosci.org)
  • Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding. (medicinenet.com)
  • The Women's Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis ( DVT ) in postmenopausal women (50 to 79 years of age) during 7.1 years of treatment with daily oral conjugated estrogens (CE) [0.625 mg]-alone, relative to placebo. (medicinenet.com)
  • The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with daily CE (0.625 mg)-alone, relative to placebo. (medicinenet.com)
  • It is unknown whether this finding applies to younger postmenopausal women. (medicinenet.com)
  • The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo. (nih.gov)
  • The prevalence of vasomotor symptoms is 14-51% in premenopausal women, 35-50% in perimenopausal women, a 30-80% in postmenopausal women. (medscape.com)
  • Proinflammatory cytokines are primary mediators of bone loss in postmenopausal women due to the decreased estrogen production. (usda.gov)
  • Based on a number of pharmacoepidemiologic studies, conjugated estrogen was believed to decrease heart disease and stroke in postmenopausal women. (cmaj.ca)
Deficiency8
  • These effects appear to become most prominent during times of estrogen deficiency, such as the menopausal transition. (medscape.com)
  • Many symptoms are attributed to estrogen deficiency and they vary in intensity among women. (medscape.com)
  • The effect of circulating oestrogen deficiency on sleep regulation and locomotor activity was investigated in aromatase cytochrome P450 deficient mice (ArKO) and wild-type (WT) controls. (ox.ac.uk)
  • After SD, the rebound of sleep and SWA was similar between the genotypes, suggesting that oestrogen deficiency does not affect the mechanisms maintaining the homeostatic balance between the amount of sleep and its intensity. (ox.ac.uk)
  • But decreasing estrogen levels do not signal a deficiency, as the estrogen-marketing lobby would have us believe. (medicalxpress.com)
  • The language of estrogen deficiency and hormone or estrogen "replacement" still dominates the medical literature even 17 years after a huge randomized study called the Women's Health Initiative (WHI) showed taking a combination of estrogen-progestin caused more harm than benefit (two-thirds of the women were over 60). (medicalxpress.com)
  • We investigated whether alpha-1 antitrypsin (AAT), a multifunctional protein with proteinase inhibitor and anti-inflammatory activities, mitigates bone loss induced by estrogen deficiency, a state with increased production of proinflammatory cytokines. (usda.gov)
  • To determine whether AAT mitigates bone loss induced by estrogen deficiency, thirty-eight female C57BL/6J mice (7-wk-old), were either ovariectomized or sham-operated. (usda.gov)
Hormones6
Progestin6
  • Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer . (medicinenet.com)
  • Estrogen therapy, with or without a progestogen (progesterone and progestin), has long been prescribed to treat menopausal symptoms. (medscape.com)
  • The treatment may consist solely of estrogen (estrogen replacement therapy, or ERT), or it may involve a combination of estrogen and progestin, a synthetic form of progesterone. (medicalnewstoday.com)
  • Giving menopausual women estrogen alone-without progesterone or its synthetic knock-off progestin-led to increased rates of endometrial cancer in the 1970s. (medicalxpress.com)
  • Estrogen, whether on its own or combined with progesterone/progestin , can treat vasomotor symptoms. (medicalxpress.com)
  • Although progesterone has not been tested in a large controlled trial, progesterone also doesn't seem to cause the blood clots, heart disease or breast cancer associated with estrogen or estrogen-progestin menopausal hormone therapy. (medicalxpress.com)
Estradiol12
  • Examples of estrogens include bioidentical estradiol, natural conjugated estrogens, synthetic steroidal estrogens like ethinylestradiol, and synthetic nonsteroidal estrogens like diethylstilbestrol. (wikipedia.org)
  • Estrogens are agonists of the estrogen receptors, the biological targets of endogenous estrogens like estradiol. (wikipedia.org)
  • Most combined oral contraceptives contain ethinylestradiol or its prodrug mestranol as the estrogen component, but a few contain estradiol or estradiol valerate. (wikipedia.org)
  • Contraceptive patches and vaginal rings contain ethinylestradiol as the estrogen component, while combined injectable contraceptives contain estradiol or more typically an estradiol ester. (wikipedia.org)
  • Compared to estradiol, conjugated equine estrogen was associated with an 8% increased risk of developing high blood pressure. (news-medical.net)
  • Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level. (nih.gov)
  • The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secrets 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. (nih.gov)
  • In order of potency, naturally occurring estrogens are 17 (beta)-estradiol (E2), estrone (E1), and estriol (E3). (medscape.com)
  • Both males and females produce estradiol, and it is the most common type of estrogen in females during their reproductive years. (medicalnewstoday.com)
  • MI was induced by occlusion of the left anterior descending artery in young adult male and female Wistar rats or in ovariectomized (OVX) female rats without and with estrogen (17β-estradiol, E2) replacement. (menopause.org.au)
  • In young females, an estradiol level below the premenopausal reference range indicates hypogonadism . (medscape.com)
  • Absent or irregular menstrual periods in the setting of normal or high estradiol levels indicate possible polycystic ovarian syndrome, androgen-producing tumors, or estrogen-producing tumors. (medscape.com)
Receptors7
  • Two types of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and the estrogen G protein-coupled receptor GPR30 , which is a G protein-coupled. (absoluteastronomy.com)
  • That's because only the female cells express estrogen receptors, which estrogen needs to bind to. (huffpost.com)
  • Both MC and HPTE have been shown to have weak estrogenic and antiandrogenic activities through estrogen and androgen receptors, respectively. (cdc.gov)
  • Most patients had positive estrogen and progesterone receptors. (who.int)
  • Estrogen receptors in the vagina, pelvic floor, bladder, and urethra are no longer being nourished by estrogen. (medscape.com)
  • 91.6 %), poorly differentiated with positive estrogen and progesterone receptors. (bvsalud.org)
  • carcinoma of non-special type, poorly differentiated and positive estrogen and progesterone receptors. (bvsalud.org)
0.6253
  • Before the specific dangers of conjugated estrogens were well understood, standard therapy was 0.625 mg/day of conjugated estrogens (such as Premarin). (wikipedia.org)
  • Participants were randomly assigned to either 0.625 milligrams per day of conjugated equine estrogens (Premarin™) or placebo (inactive pill). (nih.gov)
  • ESTRATEST® H.S. (Half-Strength) Tablets: Each light green, capsule shaped, sugar-coated oral tablet contains: 0.625 mg of Esterified Estrogens, USP and 1.25 mg of Methyltestosterone, USP. (theodora.com)
Dosage forms of estrogens2
  • In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and other dosage forms of estrogens. (medicinenet.com)
  • Other doses of conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. (nih.gov)
Premarin7
Endometrial Cancer2
Hormonal8
  • An estrogen (E) is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy, and as part of feminizing hormone therapy for transgender women. (wikipedia.org)
  • Unlike other medications like progestins and anabolic steroids, estrogens do not have other hormonal activities. (wikipedia.org)
  • Estrogens are available widely throughout the world and are used in most forms of hormonal birth control and in all menopausal hormone therapy regimens. (wikipedia.org)
  • Oral contraceptives in premenopausal women have been shown to give a relative risk of 2.5, which suggests an altered hormonal axis as a possible contributory factor. (medscape.com)
  • But there are downsides to estrogen-based hormonal therapy. (medicalxpress.com)
  • Her team's study looked at the effects of a constant, consistent level of estrogen, comparable to what women taking hormone replacement therapy or some forms of hormonal birth control would experience. (huffpost.com)
  • Primary hormonal therapy has increasingly become a popular option in women with estrogen receptor (ER)-positive breast tumors. (medpagetoday.com)
  • Hormonal testing revealed strong estrogen receptor (ER) positivity, with 51%-100% of cells staining positive. (medscape.com)
Vagina8
  • The female sex hormone oestrogen has a key role to play, because it supports the blood supply to the vagina, vulva and cervix. (healthspan.co.uk)
  • Oestrogen also helps to keep the vaginal wall lubricated, and as levels decline the vagina can become dry and irritated, which may make sex uncomfortable or painful, and therefore less desirable. (healthspan.co.uk)
  • In the vagina, estrogen maintains the thickness of the vaginal wall and promotes lubrication. (medicalnewstoday.com)
  • The vagina is an estrogen-responsive organ. (sfaf.org)
  • You can apply the estrogen with a cream, a tablet that dissolves in the vagina, or with a ring that you place in the vagina that stays there. (sfaf.org)
  • The urethra is also estrogen-responsive, so trans guys on testosterone likely have an increased risk for UTIs, especially if they're having penis-in-vagina or penis-in-frontal genital opening sex. (sfaf.org)
  • A. Many women have problems with vaginal discharge or pain or irritation of the vulva and vagina. (harvard.edu)
  • Sexual dysfunction in women includes pain during intercourse, involuntary painful contractions (spasms) of the muscles around the vagina (vaginismus), lack of interest in sex (low libido), and problems with arousal or orgasm. (msdmanuals.com)
Estrone3
  • Esterified estrogens is a mixture of the sodium salts of the sulfate esters of the estrogenic substances, principally estrone, that are of the type excreted by pregnant mares. (nih.gov)
  • Esterified estrogens contain not less than 75 percent and not more than 85 percent of sodium estrone sulfate, and not less than 6 percent and not more than 15 percent of sodium equilin sulfate, in such proportion that the total of these two components is not less than 90 percent, all percentages being calculated on the basis of the total esterified estrogens content. (nih.gov)
  • Esterified Estrogens contain not less than 75.0 percent and not more than 85.0 percent of sodium estrone sulfate, and not less than 6.0 percent and not more than 15.0 percent of sodium equilin sulfate, in such proportion that the total of these two components is not less than 90.0 percent. (theodora.com)
Menopausal hormone therapy1
  • When a woman stops menopausal hormone therapy, she often experiences rapidly worsening vasomotor symptoms. (medicalxpress.com)
Forms of estrogen1
  • It is a weaker form of estrogen and one that the body can convert to other forms of estrogen, as necessary. (medicalnewstoday.com)
Type of estrogen2
  • We chose to dive deeper into factors associated with hormone therapy, such as the route of administration (oral vs. non-oral) and type of estrogen, and how they may affect blood pressure. (news-medical.net)
  • and conjugated equine estrogen, an animal-derived form of estrogen and the oldest type of estrogen therapy. (news-medical.net)
Uterus3
Effects of estrogen3
  • The animal model established here should enable progress toward defining the neurobiological mechanisms that mediate the beneficial effects of estrogen on age-related cognitive decline in primates. (jneurosci.org)
  • Part 2 examined the effects of estrogen on DHEA by analyzing the relationship between DHEA and age in young females on and off oral contraceptives (OCs) and PM females on and off estrogen or hormone replacement therapy (ERT/HRT). (tamu.edu)
  • The investigators also looked at the direct effects of estrogen on neurons, using what Lahiri called a "UTI in a dish. (technologynetworks.com)
Therapy28
  • There are, however, risks associated with conjugated estrogen therapy. (wikipedia.org)
  • These new results offer some reassurance to younger women who have had a hysterectomy and who would like to use hormone therapy on a short-term basis to ease menopausal symptoms," noted Elizabeth G. Nabel, M.D., NHLBI director. (nih.gov)
  • The new findings are from an ancillary study of 1064 women who were 50-59 years of age at the start of the WHI hormone therapy clinical trial. (nih.gov)
  • We already know that starting hormone therapy in older women increases their risk of heart disease. (nih.gov)
  • It remains unclear, however, whether vaginal estrogen therapy can affect breast cancer recurrence or mortality in this patient population. (medscape.com)
  • The research team wanted to determine whether the risk for breast cancer-specific mortality was higher in women who used vaginal estrogen therapy vs those who did not use hormone replacement therapy . (medscape.com)
  • After a breast cancer diagnosis, 5% of women used vaginal estrogen therapy and 2% received systemic hormone replacement therapy. (medscape.com)
  • Cite this: Vaginal Estrogen Therapy Safe for Women With Breast Cancer - Medscape - Nov 03, 2023. (medscape.com)
  • Women ages 45 years and older taking estrogen hormone therapy in pill form were more likely to develop high blood pressure than those using transdermal (topical, applied to the skin) or vaginal formulations, according to new research published today in Hypertension , a peer-reviewed American Heart Association journal. (news-medical.net)
  • The authors of this study noted that while high blood pressure is a modifiable risk factor for cardiovascular disease, the potential effects of different types of hormone therapy on blood pressure in menopausal women remain uncertain. (news-medical.net)
  • We know that post-menopausal women have increased risk of high blood pressure when compared to pre-menopausal women, furthermore, previous studies have shown that specific types of hormone therapy have been associated with higher rates of heart disease,' Kalenga said. (news-medical.net)
  • This study involved a large group of over 112,000 women, ages 45 years and older, who filled at least two consecutive prescriptions (a six-month cycle) for estrogen-only hormone therapy, as identified from health administrative data in Alberta, Canada between 2008 and 2019. (news-medical.net)
  • First, researchers investigated the relationship between route of estrogen-only hormone therapy administration and risk of developing high blood pressure at least one year after starting the treatment. (news-medical.net)
  • For this study, the researchers reviewed medical records of individuals taking estrogen-only hormone therapy. (news-medical.net)
  • Women taking oral estrogen therapy had a 14% higher risk of developing high blood pressure compared to those using transdermal estrogen and a 19% higher risk of developing high blood pressure compared to those using vaginal estrogen creams or suppositories. (news-medical.net)
  • According to Kalenga, the study's findings suggest that if menopausal woman take hormone therapy, there are different types of estrogen that may have lower cardiovascular risks. (news-medical.net)
  • Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia . (medicinenet.com)
  • Both men and women often turn to hormone replacement therapy to combat the loss. (articlecity.com)
  • These are lures to get women to ask for estrogen or hormone "replacement" therapy. (medicalxpress.com)
  • About a quarter of women find they can't stop therapy because the withdrawal symptoms are so severe . (medicalxpress.com)
  • Plus, since researchers were only working with cells, not living human beings, they can't even say for sure whether women taking birth control or hormone therapy have increased flu resistance. (huffpost.com)
  • Estrogen's flu-fighting potential could be especially crucial for older, post-menopausal women who are considering taking hormone replacement therapy. (huffpost.com)
  • Although the NCCN guidelines allow for the use of lumpectomy plus endocrine therapy without breast irradiation in women age 70 or older with small (T1), clinically node-negative ER-positive breast cancer, the decision should be personalized given the wide variation of comorbidities in this age group and the long-term follow-up data from CALGB 9343. (medpagetoday.com)
  • The oldest group is also less likely to have adjuvant therapy than women in their 60s and 70s. (medpagetoday.com)
  • Consider estrogen therapy only for women at significant risk of osteoporosis. (nih.gov)
  • Investigators from Cedars-Sinai, working with laboratory mice, have been able to prevent symptoms of the condition with estrogen, which is commonly used for hormone replacement therapy. (technologynetworks.com)
  • Treatment of sexual problems in women varies by cause but may include education about sexual function, medications, pelvic physical therapy, or psychotherapy or sex therapy. (msdmanuals.com)
  • the consumption of animal fat and protein (7) and alcohol (8), nonbreastfeeding (9), and use of oral contraceptives (10) and estrogen replacement therapy (11) have all been suggested. (cdc.gov)
Receptor-Positive Breast Cancer2
  • In this video, Drs. Jame Abraham, Erin Roesch, and Azka Ali discuss the management of a patient with de novo metastatic estrogen receptor-positive breast cancer. (ascopost.com)
  • Chemotherapy refusal and subsequent survival in healthy older women with high genomic risk estrogen receptor-positive breast cancer. (cdc.gov)
Post-menopausal women2
  • Previous studies have also found that post-menopausal women with heart disease have a greater risk of depression than younger women and men of all ages. (menopause.org.au)
  • post-menopausal women with a higher serum FSH (≥78.3 IU/L) had higher serum TC and LDL-C levels than those with relatively lower FSH levels (40-78.3 IU/L), and ovariectomized mice had higher serum FSH and lipid levels and reduced hepatic LDL receptor expression. (nature.com)
Puberty2
  • Estrous cycles start after puberty in sexually mature females and are interrupted by anestrous phases or pregnancies. (absoluteastronomy.com)
  • Lichen sclerosus can occur in males or females of any age, but it more commonly affects prepubertal or perimenopausal females or males between puberty and age 60 years. (medscape.com)
Breast cancer30
  • Other side effects of estrogens include an increased risk of blood clots, cardiovascular disease, and, when combined with most progestogens, breast cancer. (wikipedia.org)
  • Women with breast cancer who use vaginal estrogen therapies, such as tablets or creams, do not face an increased risk for breast cancer-specific mortality, which can provide some reassurance to patients and providers that vaginal estrogen therapies are safe in this population. (medscape.com)
  • To investigate, the researchers used UK cancer registries to identify women aged 40-79 years who were diagnosed with breast cancer in Scotland and Wales, gathering data on cancer stage, grade, treatment, presence of anemia , among other factors. (medscape.com)
  • About 14,000 fewer women were diagnosed with the disease than had been expected, researchers reported Thursday at the San Antonio Breast Cancer Symposium. (pravda.ru)
  • Breast cancer is the most common major cancer in American women and the second leading cause of cancer deaths in women. (pravda.ru)
  • Breast cancer in older patients is most likely to present with clinically palpable masses. (medpagetoday.com)
  • The risk of breast cancer increases as women age, yet despite the higher prevalence of breast cancer in the older age group, older women are under-represented in clinical trials. (medpagetoday.com)
  • Most studies show that women in their 80s who present with breast cancer are more likely to have clinically palpable disease than younger patients are. (medpagetoday.com)
  • Retrospective data reveal that women older than 80 are significantly less likely to undergo surgery compared with women in their 60s and 70s, and this lower rate of surgery translates into lower-than-expected rates of overall survival as well as breast cancer-specific survival. (medpagetoday.com)
  • Breast cancer surgery is relatively low risk for most women, including women older than 80. (medpagetoday.com)
  • In 1986, breast cancer (International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) 174) was the underlying cause of death for 40,534 women in the United States. (cdc.gov)
  • Breast cancer accounted for 32% of diagnosed cancers and 20% of cancer deaths among women (1). (cdc.gov)
  • Breast cancer incidence and mortality in the United States and worldwide have increased in cohorts of women born since 1900, for reasons not well understood (3,4). (cdc.gov)
  • 54% of deaths from breast cancer in the United States in 1986 occurred in women greater than or equal to 65 years of age (2). (cdc.gov)
  • Age-adjusted rates of breast cancer mortality were 12% higher in black women than in white women (5). (cdc.gov)
  • and survival in women diagnosed with 'regional' or 'distant' breast cancer is substantially lower. (cdc.gov)
  • Based on this study, at least 19% of breast cancer deaths among women in the United States can be estimated to be attributable to nonuse of mammography (Table 2). (cdc.gov)
  • Men also die from breast cancer (ICD-9-CM 175), but at less than 1/100th the rate among women (2). (cdc.gov)
  • Breast cancer is the most frequent cancer among wom- but not in limited-resource settings with weak health en worldwide, affecting 2.1 million women annually and systems (4) . (who.int)
  • These campaigns provide free mammography high breast cancer incidence, accounting for almost 37% tests for women 40 years and older with no family of cancer cases in females and 20% of all cancer cases (3) . (who.int)
  • A prospective study of weight gain in women diagnosed with early-stage invasive breast cancer, ductal carcinoma in situ, and women without breast cancer. (cdc.gov)
  • Self-reported barriers to screening breast MRI among women at high risk for breast cancer. (cdc.gov)
  • Changes in methylation-based aging in women who do and do not develop breast cancer. (cdc.gov)
  • Breast cancer risk factors in Iranian women: a systematic review and meta-analysis of matched case-control studies. (cdc.gov)
  • Breast Breast cancer is among the first three cancers diagnosed in women worldwide. (bvsalud.org)
  • To identify the epidemiological and clinical characteristics of patients under or equal to 40 years old, epidemiológica de diagnosed with breast cancer in a tertiary hospital specialized in women's care. (bvsalud.org)
  • Information was collected from 60 clinical records of patients diagnosed with breast cancer with an age less than iguales a 40 años con or equal to 40 years old, between January 2019 and December 2020. (bvsalud.org)
  • Women aged less than or characterization of patients equal to 40 years old, with breast cancer, are patients from urban areas, overweight, with one to four children and no family under or equal to 40 years history of breast cancer, with initial clinical presentation in locally advanced stages, with a diagnosis of invasive breast old with breast cancer. (bvsalud.org)
  • of women diagnosed with breast cancer is about 90 % in developed countries3. (bvsalud.org)
  • It is among the first three have decreased breast cancer mortality in cancers diagnosed in women in both devel- all age groups, nevertheless for women oped and developing countries1,2. (bvsalud.org)
Tissues in the body1
  • Estrogens have widespread effects on many tissues in the body. (medicinenet.com)
Symptoms6
  • Does that mean menopausal women with vasomotor symptoms such as hot flashes and night sweats must just suffer? (medicalxpress.com)
  • 5 Huybrechts and coauthors point out that, "in the absence of randomized controlled trials, pharmacoepidemiologic studies using large databases are the best option available for defining the comparative safety of the psychopharmacologic treatment regimens used to manage behavioral symptoms in older adults with illnesses causing dementia. (cmaj.ca)
  • So, we showed that there are at least two ways that estrogen helps reduce symptoms of delirium. (technologynetworks.com)
  • Lower urinary tract symptoms (LUTS) in older adults are very common. (medscape.com)
  • According to the EPIC study, the largest population-based survey to assess LUTS in five countries, storage symptoms, including any type of incontinence, reported a prevalence of 10.4% in men over age 60 years and 19.3% of women over 60 years. (medscape.com)
  • In addition, voiding symptoms in general were noted in 37.2% of men and 24.6% of women over 60 years of age (Irwin et al. (medscape.com)
Reproductive6
  • Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. (nih.gov)
  • Estrogen is a hormone that plays a role in both the male and female reproductive systems. (medicalnewstoday.com)
  • In females, it contributes to reproductive and breast health, among other functions. (medicalnewstoday.com)
  • However, most people know it for its role alongside progesterone in female sexual and reproductive health. (medicalnewstoday.com)
  • Like estrogen, progesterone plays a vital role in female reproductive health. (shokuikuaustralia.com)
  • Despite their demographic significance, women considered older than reproductive age are excluded from most investments in global public health. (countercurrents.org)
Risks5
  • In a study by the NIH, esterified estrogens were not proven to pose the same risks to health as conjugated estrogens. (wikipedia.org)
  • Although our findings lend support to the theory that estrogen may slow early stages of plaque build-up in the coronary arteries, estrogen has complex effects and other known risks," said JoAnn Manson, M.D., chief of Preventive Medicine at Harvard's Brigham and Women's Hospital and lead author of the paper. (nih.gov)
  • The results are consistent with our earlier findings that younger women treated with estrogen had a trend toward fewer heart attacks but, for an individual woman, it remains uncertain whether the benefits of estrogen would outweigh the risks. (nih.gov)
  • Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. (nih.gov)
  • But health risks related to the loss of estrogen increase as you get older. (webmd.com)
Tumors3
  • The decline was biggest for tumors whose growth is fueled by estrogen the type most affected by hormone use. (pravda.ru)
  • In fact, when both factors were combined older women with estrogen-positive tumors the drop was 12 percent. (pravda.ru)
  • Similarly, another study found that in older patients, tumors were more likely to be found by clinical breast examination and less often by radiologic procedures. (medpagetoday.com)
Ovaries removed1
  • A third to half of all women who have their ovaries removed report a drop in sexual desire after the procedure, write Glenn Braunstein, MD, and colleagues. (foxnews.com)
Increased risk1
Synthetic2
  • Estrogens have contraceptive effects and are used in combination with progestins (synthetic progestogens) in birth control to prevent pregnancy in women. (wikipedia.org)
  • There is no evidence that the use of "natural" estrogens results in a different endometrial risk profile than synthetic estrogens at equivalent estrogen doses. (nih.gov)
Women's Health Ini1
  • Heart attacks are uncommon among younger women, and the more relevant question is about long-term benefit as women grow older," noted Jacques Rossouw, M.D., chief of the NHLBI Women's Health Initiative Branch. (nih.gov)
Cancers3
  • Research shows women need a break from the high demands of estrogen, which stimulates cellular growth and poses a risk for cancers. (medicalxpress.com)
  • For example, a retrospective review of 354 patients older than 70 found that among the patients older than 80, only 38% of breast cancers were detected mammographically. (medpagetoday.com)
  • 1995. Organochlorine compounds and estrogen-related cancers in women. (cdc.gov)
Oral1
  • ESTRATEST® Tablets: Each dark green, capsule shaped, sugar-coated oral tablet contains: 1.25 mg of Esterified Estrogens, USP and 2.5 mg of Methyltestosterone, USP. (theodora.com)
Premenopausal women1
  • or premenopausal women not undergoing the procedure for the time control group. (mayo.edu)
Pregnant6
  • Conjugated estrogens are a mixture of several different estrogens (estrogen salts) derived from natural sources and blended to approximate the composition of estrogens in the urine of pregnant horses. (medicinenet.com)
  • Estrogens should not be given to pregnant women due to the risk of harm to a fetus. (medicinenet.com)
  • HELP SCREEN SHOULD READ: Gestational diabetes is a form of diabetes or high blood sugar found in pregnant women. (cdc.gov)
  • Menopausal women cannot become pregnant and, beyond that, many are pleased to be free of unpredictable and sometimes flooding blood flow that one-third of women experience in perimenopause. (medicalxpress.com)
  • ABSTRACT A study in Riyadh, Saudi Arabia investigated the prevalence of gestational diabetes mellitus (GDM) and its predictors in a high-parity group of pregnant women (n = 633, 50.1% grand multiparas). (who.int)
  • To isolate TI cells, 24-25 day-old female Sprague-Dawley rats were injected (s.c.) with 20 I.U. of pregnant mare serum gonadotropin. (cdc.gov)
Perimenopausal1
  • It is important for women to know that many perimenopausal miseries are because estrogen is too high and extremely variable, not because it is low or deficient. (medicalxpress.com)
Level of estrogen1
  • Furthermore, we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX) mice, in which a normal level of estrogen (E2) was maintained by exogenous supplementation. (nature.com)
Urine1
  • The physical examination should include a pelvic examination for females and prostate examination for males, abdominal examination, urinalysis, urine culture (if appropriate), and measurement of post-void residual (PVR), along with a uroflow (Rosier et al. (medscape.com)
Hormone estrogen3
  • Additionally, the research team showed the hormone estrogen normally helps protect against this chemical modification of complement C3. (medicalnewstoday.com)
  • The women were also taking the female sex hormone estrogen. (foxnews.com)
  • The female hormone estrogen is linked with lupus. (uhhospitals.org)
Medications2
  • In a large cohort study, older outpatients with dementia in whom an antidepressant was initiated had a risk of death about half as high as those treated with an antipsychotic (and about one-third lower than those who were not receiving any psychotropic medications). (cmaj.ca)
  • When prescribing solely for the treatment of postmenopausal osteoporosis, first consider the use of non-estrogen medications. (nih.gov)
Levels22
  • Those who had taken estrogen were 30 to 40 percent less likely to have measurable levels of coronary artery calcium compared to those on placebo. (nih.gov)
  • Conversely, drugs such as erythromycin , ketoconazole , itraconazole , and ritonavir may reduce the elimination of estrogens by the liver and lead to increased levels of estrogens in the blood. (medicinenet.com)
  • Grapefruit juice also may increase levels of estrogen by increasing the absorption of estrogens from the intestine. (medicinenet.com)
  • Increased levels of estrogens in the blood may result in more estrogen-related side effects. (medicinenet.com)
  • In this article, we look at estrogen in more detail, including how it works, what happens when the levels fluctuate, and medical uses. (medicalnewstoday.com)
  • Estrogen levels vary among individuals. (medicalnewstoday.com)
  • Learn more about high estrogen levels and low estrogen levels here. (medicalnewstoday.com)
  • Males with low estrogen levels may have excess belly fat and low libido. (medicalnewstoday.com)
  • If a person has low levels of estrogen, a doctor may prescribe supplements or medication. (medicalnewstoday.com)
  • While testosterone is often labelled as the quintessential "male" hormone, both men and women have it circulating in their bodies, with significantly higher levels in men. (shokuikuaustralia.com)
  • Low testosterone levels can impact libido, mood, and body composition in both sexes, while excessive testosterone can disrupt blood sugar balance in women and lead to lethargy and muscle weakness in both genders. (shokuikuaustralia.com)
  • In the last 1 to 2 years of this stage, estrogen levels fall faster. (webmd.com)
  • When your ovaries prematurely stop releasing eggs, for unknown reasons, your levels of estrogen and progesterone change. (webmd.com)
  • However, the group receiving estrogen showed no depression--their levels were on par with the control females with ovaries--and no increase in inflammation in brain areas involved in mood and pleasure. (menopause.org.au)
  • First, epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels, even after adjustment by considering the effects of serum estrogen. (nature.com)
  • Young children tend to have higher ceruloplasmin blood levels than older children and adults. (healthline.com)
  • What I found in my research, by contrast, was that estrogen levels are often elevated and unpredictable in perimenopause . (medicalxpress.com)
  • In other words, the brain gets used to higher estrogen levels and reacts to the decrease by releasing the stress hormone norepinephrine, which causes altered temperature responses. (medicalxpress.com)
  • But women who are not on such treatments have estrogen levels that cycle up and down. (huffpost.com)
  • The estrogen levels you get from one of these methods are so low that there's no risk that they will counteract or reverse the effects of gender-affirming testosterone. (sfaf.org)
  • When they treated the mice with estrogen, levels of IL-6 in the blood and delirium-like behavior were greatly reduced. (technologynetworks.com)
  • It can cause hot flashes, vaginal dryness, and irritability as estrogen levels fall. (medlineplus.gov)
Concentrations4
  • DHEA concentrations were significantly higher in young males than young females even after accounting for age. (tamu.edu)
  • For part 2, DHEA concentrations were significantly higher in young females off OCs compared with young females on OCs, and significantly higher in PM women off ERT/HRT than those on ERTHRT. (tamu.edu)
  • The data also suggest that estrogen treatment (OCs and ERT/HRT) suppresses DHEA concentrations in premenopausal and PM females, and that DHEA declines with age in PM females regardless of estrogen treatment. (tamu.edu)
  • Table 1 summarizes normal concentrations of the various estrogens. (medscape.com)
Testosterone14
Libido3
  • WebMD Medical News: "FDA Rejects Libido Drug for Women. (foxnews.com)
  • It has also been found to improve skin health and libido in older women. (shokuikuaustralia.com)
  • Sexual Interest/Arousal Disorder Sexual interest/arousal disorder in women is lack of or decreased interest in sexual activity (low libido) and sexual thoughts and/or lack of response to sexual stimulation. (msdmanuals.com)
Additionally2
  • Additionally, researchers evaluated the formulation of estrogen used and the risk of developing high blood pressure. (news-medical.net)
  • Additionally, the adrenal glands manufacture DHEA and pregnenolone in both men and women. (shokuikuaustralia.com)
Males4
  • The objective of part 1 was to determine the relationship between DHEA, body mass index (BMI), and age in young males, young females, and postmenopausal (PM) females. (tamu.edu)
  • From these findings, we conclude that there is an inverse relationship between DHEA and age for young males, young females off OCs, and PM females, no ERT/HRT. (tamu.edu)
  • In contrast, the menopausal females displayed higher rates of depression-like behavior than all of the males studied. (menopause.org.au)
  • The team is also working to understand the different effects of delirium on females versus males, which was not a topic of this study. (technologynetworks.com)
Deficient3
  • Sleep and rest regulation in young and old oestrogen-deficient female mice. (ox.ac.uk)
  • In mice deficient of oestrogen, the total amount of sleep per 24 h was the same as in WT controls. (ox.ac.uk)
  • The results indicate that despite the pronounced redistribution of sleep and motor activity in oestrogen deficient mice, the basic homeostatic mechanisms of sleep regulation in ArKO mice remain intact. (ox.ac.uk)
Affect estrogen1
  • Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism and decrease or increase the estrogen plasma concentration. (nih.gov)
Years20
  • In February 2006, WHI researchers reported that among the women in the estrogen-alone trial who were 50-59 years of age at study entry, women in the estrogen group had a non-significant trend towards lower rates of heart attacks compared to the placebo group, and significantly fewer women in the estrogen group required procedures to re-open clogged arteries. (nih.gov)
  • There was no suggestion of cardiovascular benefit in women who were 60 years or older. (nih.gov)
  • Currently between the ages of 21- 45 years old. (mayo.edu)
  • After accounting for age, a stronger association was seen among women younger than 70 years of age compared to women older than 70. (news-medical.net)
  • and (3) PM females older than 40 years not receiving ERT/HRT. (tamu.edu)
  • [ 1 ] Most women have hot flashes for 6 months to 2 years. (medscape.com)
  • However, one study group reported that 26% of women had hot flashes for 6-10 years and that 10% had them for more than 10 years. (medscape.com)
  • The women were 24-70 years old. (foxnews.com)
  • One in four Mexican-American women and about one in six white women over 50 years old have osteoporosis. (womenshealth.gov)
  • Error message: 'It is unlikely that SPs aged 60 years or older will still be menstruating. (cdc.gov)
  • For example, the normal range for children between 7 months old and 3 years old is 31 to 90 mg/dL. (healthline.com)
  • However, in this study, tests for dementia given to persons older than 30 years showed some performance decline from 40 to 45 years. (medscape.com)
  • AD is responsible for the sharp decline in survival in persons with DS older than 45 years. (medscape.com)
  • Women in this region also outlive men by an average of at least 4 years. (countercurrents.org)
  • Currently, there are 90.8 men for every 100 women above 60 years, and 69.5 men for every 100 women over the age of 80. (countercurrents.org)
  • The probability of GDM for a parous woman increased from 2% to 21% when age increased from 20 to 40 years. (who.int)
  • However, greater than 60% of U.S. women greater than or equal to 40 years of age report never having had a mammogram (19), and many of the women who have had mammograms have not fully complied with recommended screening intervals. (cdc.gov)
  • In women younger than 40 years old it occupies the first place in incidence. (bvsalud.org)
  • 40 years old. (bvsalud.org)
  • The highest number of cases was found in cáncer de mama women between 39 and 40 years old (18.3 % each). (bvsalud.org)
Humans1
  • A variety of different estrogens have been marketed for clinical use in humans or use in veterinary medicine, although only a handful of these are widely used. (wikipedia.org)
Findings5
  • These results agree with previous findings in young men, but differ from previous findings in obese young females. (tamu.edu)
  • Our findings demonstrate that sex and estrogens influence neuroinflammation and depression-like behavior in rats with [heart failure] post [heart attack]," the researchers wrote. (menopause.org.au)
  • A new study had important findings for women, but all we heard about was "man flu. (huffpost.com)
  • Only when a large randomized controlled trial was finally conducted was it found that these findings were confounded by the social class of estrogen users. (cmaj.ca)
  • Findings of the study, as shared by Dr Peng, clearly indicate that sexuality is a lifelong need and sexual activity remains an important aspect of life among older men and women. (countercurrents.org)
Insufficiency1
  • The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen. (nature.com)
Sexual dysfunction3
Orally1
  • We know estrogens ingested orally are metabolized through the liver, and this is associated with an increase in factors that can lead to higher blood pressure. (news-medical.net)