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Receptors, ProgesteroneEstrogensReceptors, EstrogenEstrogen Receptor alphaEstradiolPromegestoneEstrogen Receptor betaMifepristoneBreast NeoplasmsProgestinsNorpregnadienesProgesteroneProgesterone CongenersOviductsUterusGonanesOvariectomyHormone AntagonistsEndometriumEstrogens, Conjugated (USP)ImmunohistochemistryTamoxifenPregnancyCorpus LuteumReceptor, erbB-2Receptors, EstradiolEstrusMenstrual CycleLuteinizing HormoneOvaryMedroxyprogesterone AcetateLuteal PhaseSelective Estrogen Receptor ModulatorsMyometriumPregnancy, AnimalUterine NeoplasmsRNA, MessengerCarcinoma, Ductal, BreastCastrationOvulationTumor Markers, BiologicalGonadal Steroid HormonesMedroxyprogesteroneEstrogens, CatecholKi-67 AntigenDiethylstilbestrolEstrogens, Non-SteroidalEstrenesEndometrial NeoplasmsAromataseNeoplasms, Hormone-DependentEstroneHydroxyprogesteronesEstrous CycleGranulosa CellsLeiomyomaSteroidsMammary Glands, AnimalPostmenopauseCytosolChickensLuteal CellsChorionic GonadotropinReceptors, AndrogenPseudopregnancyPrognosisFollicle Stimulating HormoneNorethindroneAntineoplastic Agents, HormonalBreastProlactinOvarian FollicleReceptors, SteroidReverse Transcriptase Polymerase Chain ReactionProgesterone-Binding GlobulinDinoprostMenopauseEstrogen AntagonistsPregnenedionesEstradiol Congeners20-alpha-DihydroprogesteroneCell Line, TumorMenstruationImmunoenzyme TechniquesGene Expression RegulationTestosteroneTranscription, GeneticReceptors, GlucocorticoidTime FactorsCell NucleusEmbryo ImplantationGene Expression Regulation, NeoplasticFollicular PhaseDeciduaSheepContraceptive Agents, FemaleCarcinoma, LobularDiestrusLabor, ObstetricLuteolysis
HER2TamoxifenTumorCORRELATION BETWEEN ESTROGEN RECEPTORHormonal receptors statusExpress estrogenPatientsCancers in womenOvariectomyProteinsHER2NEUProteinAdjuvantPostmenopausalHypothalamusEstradiolSignalingHormone estrogen1994RatsOvarianExpressionCompoundsPositive breast cancerSteroidSelectivePrognosticPathologyTreatmentsCellsStatusHumanNuclearGeneWomenEvaluationOutcomesTreatmentNegativeCarcinomaInvolvesCancerAssociationsStudyGrowth
HER216
  • MammaPrint/BluePrint subtyping classified patients into four molecular subgroups: Luminal A, Luminal B, HER2 (human epidermal growth factor receptor 2), and Basal type. (nih.gov)
  • The study aimed to evaluate the correlation of prognostic factors such as age, BMI, ER, PR, HER2 receptor status in-patients with carcinoma of breast to study the correlation between hormonal receptors status and other prognostic factors with lymphovascular invasion in carcinoma breast. (worldwidejournals.org)
  • Triple-positive breast cancer is a type of breast cancer that tests positive for estrogen receptors, progesterone receptors, and high levels of HER2 protein. (medicalnewstoday.com)
  • Some types of breast cancer cells use estrogen and progesterone as well as a protein called HER2 to grow. (medicalnewstoday.com)
  • Knowing whether cancer cells have estrogen or progesterone receptors, and the level of HER2 protein, can help determine the best course of treatment. (medicalnewstoday.com)
  • These features mean that treating triple-positive breast cancer can involve using hormone therapy and drugs to target hormone receptors and HER2. (medicalnewstoday.com)
  • Around 10% of all breast cancers are hormone receptor-positive and HER2-positive. (medicalnewstoday.com)
  • To diagnose triple-positive breast cancer, doctors will test a biopsy sample for hormone receptors and HER2 levels. (medicalnewstoday.com)
  • An IHC test can find out if cancer cells have hormone receptors or high levels of HER2. (medicalnewstoday.com)
  • According to a 2018 article , treating triple-positive breast cancer may include using hormone therapy to target hormone receptors, either on its own or alongside drugs to target HER2. (medicalnewstoday.com)
  • Cells that are negative for estrogen receptor, progesterone receptor and HER2. (clevelandclinic.org)
  • Triple-negative breast tumors are estrogen receptor-, progesterone receptor-, and HER2 / neu -negative. (snmjournals.org)
  • Although they account for only 10%-17% of all breast carcinomas ( 1 - 8 ), tumors are often high grade and patients are relatively young and have a reduced breast cancer-specific survival, compared with patients with estrogen receptor- or HER2 / neu -expressing tumors ( 2 , 9 ). (snmjournals.org)
  • TNBC test negative for both the estrogen and progesterone receptors and the cell surface receptor Her2, hence its name. (sciencedaily.com)
  • this may be in part because they have a higher rate of triple-negative breast cancer (negative for estrogen and progesterone receptors and human epidermal growth factor receptor [HER2] oncogene), which has a poorer prognosis than other types. (msdmanuals.com)
  • The hormone receptor-positive and HER2 over-expression subtypes were found to be associated with a reduced risk of disease relapse, while only PR positivity was associated with a decreased risk of mortality. (bvsalud.org)
Tamoxifen4
  • Purpose: This study aimed to analyze the efficacy and prognostic significance of adjuvant tamoxifen in breast cancer patients with various hormone receptor statuses. (tmu.edu.tw)
  • Tamoxifen attaches to the hormone receptors in the breast cancer cells, stopping them from accessing the hormones they need to multiply. (medicalnewstoday.com)
  • Arimidex may not work as well if taken with tamoxifen or an estrogen medication. (rxlist.com)
  • Purpose: Endocrine therapies, such as tamoxifen, are commonly given to most patients with estrogen receptor (ERa) ^ positive breast carcinoma but are not indicated for persons with ERa-negative cancer. (lu.se)
Tumor3
  • Tumor cells that have many of these receptors on their surfaces are said to be estrogen- or progesterone-receptor positive. (cancercare.org)
  • More importantly, we demonstrated that USP19 catalytic activity is important for the control of tumor cell migration and invasion, and that its molecular mechanism of action involves LRP6, a Wnt co-receptor. (nature.com)
  • Mixture analysis using principal components suggested co-exposures to multiple airborne heavy metals may drive associations with tumor receptor status. (cdc.gov)
CORRELATION BETWEEN ESTROGEN RECEPTOR1
  • The correlation between estrogen receptor (ER)/progesterone receptor (PR) phenotypes and clinical characteristics was investigated, and the survival rate was assessed after 5-year follow-up. (tmu.edu.tw)
Hormonal receptors status2
Express estrogen1
  • The cells express estrogen/progesterone-receptors. (wikipedia.org)
Patients3
  • From this study, we conclude that Positive receptor status (ER, PR and, HER2NEU) is found in the majority of the women with normal BMI and negative receptor status is associated with obese patients. (worldwidejournals.org)
  • Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
  • Most patients had positive estrogen and progesterone receptors. (who.int)
Cancers in women2
  • About 70 percent of all breast cancers in women have receptors that attach to estrogen and/or progesterone. (medlineplus.gov)
  • 1995. Organochlorine compounds and estrogen-related cancers in women. (cdc.gov)
Ovariectomy3
  • We investigated the effect of ovariectomy (OVX) and hormonal treatment for 10 weeks by estradiol and progesterone on muscarinic M 4 receptor subtype in different brain areas of female rats. (uaeu.ac.ae)
  • Ovariectomy up-regulated M 4 receptors in the dentate gyrus, CA1, CA3, frontal cortex and hypothalamus whereas the estrogen treatment restored M 4 binding to that of the sham group. (uaeu.ac.ae)
  • Progesterone treatment had no effect on the ovariectomy-induced up-regulation of M 4 receptors. (uaeu.ac.ae)
Proteins3
  • Receptors are proteins that attach to certain substances. (medlineplus.gov)
  • Estrogen and progesterone receptors are proteins in cells that attach to the hormones estrogen and progesterone to allow the cells to grow. (medicalnewstoday.com)
  • On binding of insulinlike growth factors to the receptor, adaptor proteins, such as insulin-receptor substrate-1 (IRS-1) and IRS-2, are recruited to the phosphorylation site of the cytoplasmic domain ( 19 - 21 ). (snmjournals.org)
HER2NEU1
Protein4
  • The purpose of this study was to determine the ontogeny of cellular changes in the expression of estrogen receptors (ERα, ERβ), G protein-coupled estrogen receptor 1 (GPER1), and progesterone receptors (PRs) in endometriosis using a mouse model. (springer.com)
  • Kolkova Z, Noskova V, Ehinger A, Hansson S, Casslén B. G protein-coupled estrogen receptor 1 (GPER, GPR 30) in normal human endometrium and early pregnancy decidua. (springer.com)
  • Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study. (springer.com)
  • Historically, melatonin has been considered an endocrine hormone released from the epithalamic pineal gland, which then acts on specific G-protein-coupled melatonin receptors in target tissues of both adults and the fetus ( 1 , 2 ). (frontiersin.org)
Adjuvant1
  • ARIMIDEX is indicated for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer . (rxlist.com)
Postmenopausal2
  • The effect of estrogen on the hippocampal muscarinic M 4 receptor subtype is a novel finding and may have functional significance for cholinergic receptors especially in relation to postmenopausal memory problems and neurodegenerative disease like Alzheimer's disease. (uaeu.ac.ae)
  • ARIMIDEX is indicated for the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer. (rxlist.com)
Hypothalamus3
  • The negative and positive feedback actions of estrogen and progesterone on the hypothalamus may be mediated in part by the endogenous opiate system. (illinois.edu)
  • Receptor quantification in the hippocampus, frontal cortex, parietal cortex, amygdala and hypothalamus was done by receptor autoradiography using a selective ligand for muscarinic M 4 receptors. (uaeu.ac.ae)
  • Receptor quantification in the hippocampus, frontal cortex, parietal cortex, amygdala and hypothalamus was done by receptor autoradiography using a selective ligand for muscarinic M4 receptors. (uaeu.ac.ae)
Estradiol1
Signaling3
  • Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in the neural control of fertility in animal models and humans. (jneurosci.org)
  • In particular, it has been demonstrated that USP19 regulates LRP6 stability, a co-receptor of the Wnt signaling cascade 22 . (nature.com)
  • Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage. (cdc.gov)
Hormone estrogen1
19941
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
Rats3
  • Using auto radiographic techniques, we measured the density of naloxone- binding sites at various times of the day in intact proestrous, ovariectomized, or ovariectomized rats treated with estrogen or estrogen plus progesterone. (illinois.edu)
  • Estrogen treatment restored the exploratory behavior of the ovariectomized rats to that of the sham group whereas the progesterone-treated rats were less alert to the surrounding when compared to the sham and estrogen supplemented rats. (uaeu.ac.ae)
  • have shown that injection of kisspeptin antisera into the vicinity of the GnRH neuron cell bodies prevents the LH surge in both proestrous and ovariectomized estrogen-treated (OVX+E) rats. (jneurosci.org)
Ovarian1
Expression5
  • However, controversies exist regarding the status of the steroid hormone receptor expression in endometriotic tissues. (springer.com)
  • The expression of all these receptors also deferred between two lesions from the same animal. (springer.com)
  • We propose that the variable outcomes in hormonal therapy for endometriosis could be possibly due to heterogeneity in the expression of steroid hormone receptors in the ectopic endometrium. (springer.com)
  • For example, with regard to targets, the reported affinities of the two known human melatonin receptors (in both cell expression systems and ex vivo ) are in the nanomolar range [cf. ( 7 )], whereas many if not most experimental protocols have employed very pharmacological concentrations to achieve significant effects. (frontiersin.org)
  • Therefore, patient selection for IGF-1R-targeted therapy may be based on receptor expression. (snmjournals.org)
Compounds1
  • Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. (cdc.gov)
Positive breast cancer1
Steroid2
  • This steroid induced suppression of opiate receptors appears to have important physiological repercussions and provides a basis for the steroid-induced differential sensitivity to exogenous opiates that has been observed previously. (illinois.edu)
  • First, we set out to determine whether kisspeptin neurons in mice expressed the appropriate receptors required for gonadal steroid positive feedback, and whether they were activated at the time of the LH surge, as had been found previously in the rat. (jneurosci.org)
Selective1
  • Paterni I, Granchi C, Katzenellenbogen JA, Minutolo F. Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential. (springer.com)
Prognostic1
Pathology1
  • Demographic and pathology characteristics, cancer stage at diagnosis and presence of receptors were extracted and ana- lysed. (who.int)
Treatments1
  • If your hormone receptor status shows you have one or both of these receptors on your cancer cells, you may respond well to certain types of treatments. (medlineplus.gov)
Cells10
  • ER/PR tests will show whether there are ER and/or PR receptors on your breast cancer cells. (medlineplus.gov)
  • This type happens when the cancer cells don't have the right hormonal receptors. (webmd.com)
  • Tumors take in estrogen through structures on the surfaces of their cells. (cancercare.org)
  • Normal breast cells have these receptors. (medicalnewstoday.com)
  • Some breast cancer cells also have estrogen and progesterone receptors. (medicalnewstoday.com)
  • If breast cancer cells have estrogen receptors, they are ER-positive. (medicalnewstoday.com)
  • A doctor may use an immunohistochemistry (IHC) test to check cancer cells for estrogen and progesterone receptors. (medicalnewstoday.com)
  • About 50% of the proliferating epithelial cells showed positive nuclear labeling for estrogen and progesterone receptors, and approximately one-third were positive for Ki-67. (scielo.br)
  • More recently, melatonin has been reported to be synthesized in small amounts by a wide variety of animal cells and tissues as well as diverse organisms, including all kingdoms of living organisms [cf. ( 3 , 4 )], where it presumably has local paracrine and autocrine actions, some of which are probably independent of specific melatonin receptors ( 5 ). (frontiersin.org)
  • 1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
Status5
  • Test results are frequently referred to as the hormone receptor status. (medlineplus.gov)
  • Knowing your hormone receptor status will help your health care provider decide how to treat it. (medlineplus.gov)
  • receptor status. (mindunwindart.com)
  • Positive receptor status (ER, PR) is associated with decreased lymphovascular invasion and negative receptor status is associated with increased lymphovascular invasion. (worldwidejournals.org)
  • What Is My Hormone Receptor Status? (cancercare.org)
Human1
  • The IGF-1R is a transmembrane receptor expressed in many human cancers, including 36% of all triple-negative breast carcinomas ( 11 ). (snmjournals.org)
Nuclear1
Gene1
  • They also express the immediate early gene c-FOS, a molecular marker indicative of intense neural activation, at the time of the OVX+E±progesterone-evoked LH surge. (jneurosci.org)
Women1
  • Breast cancer is the most frequent cancer among wom- but not in limited-resource settings with weak health en worldwide, affecting 2.1 million women annually and systems (4) . (who.int)
Evaluation1
  • Aberrations in the progesterone pathway and the Th1/Th2 cytokine dichotomy - An evaluation of RPL predisposition in the northeast Indian population. (cdc.gov)
Outcomes1
  • 1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
Treatment4
  • Estrogen receptor/progesterone receptor (ER/PR) tests are used to help guide breast cancer treatment. (medlineplus.gov)
  • Treatment with estrogen decreased and treatment with estrogen plus progesterone decreased even more the densities of naloxone-binding sites. (illinois.edu)
  • The insulinlike growth factor 1 receptor (IGF-1R) is a new target for the treatment of breast cancer. (snmjournals.org)
  • A potential new target for the treatment of triple-negative breast cancer is the insulinlike growth factor 1 receptor (IGF-1R). (snmjournals.org)
Negative1
  • estrogen receptor-negative/progesterone receptor-negative) 7 years prior presents to a primary care clinic with painful constipation. (medscape.com)
Carcinoma3
  • Estrogens play an important role for the development and Authors' Affiliations: Departments of 1Oncology and 2Theoretical Physics, Lund progression of breast carcinoma. (lu.se)
  • carcinoma of non-special type, poorly differentiated and positive estrogen and progesterone receptors. (bvsalud.org)
  • con presentación clínica inicial en etapas localmente avanzadas, con diagnóstico de carcinoma de mama invasivo de tipo no especial, pobremente diferenciado y receptores para estrógeno y progesterona positivos. (bvsalud.org)
Involves1
  • To determine whether this desensitization to opiates involves receptor down-regulation, we measured the density of naloxone-binding sites in hypothalamic regions regulating gonadotropin release and/or sexual behavior. (illinois.edu)
Cancer6
Associations1
Study1
  • LVVB: study conception, nivel especializado en la atención de la mujer. (bvsalud.org)
Growth1
  • Two different growing patterns of sphenoid wing meningioma have been described: meningioma en masse, forming a nodular space-occupying lesion, and meningioma en plaque, which is flat and demonstrates a carpet-like growth pattern. (medscape.com)