• Testosterone
  • All of the different forms of estrogen are synthesized from androgens, specifically testosterone and androstenedione, by the enzyme aromatase. (wikipedia.org)
  • COMT
  • Furthermore, Catechol-O-methyltransferase ( COMT ) catalyzes the methylation of 2-Hydroxyestradiol and 4-Hydroxyestradiol to 2-Methoxyestradiol and 4-Metoxyestradiol , respectively [ 4 ]. (bio-rad.com)
  • Androgens
  • Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue. (wikipedia.org)
  • Quantitatively, estrogens circulate at lower levels than androgens in both men and women. (wikipedia.org)