• also known as salicylic acid methyl ester , oil of wintergreen , betula oil, methyl-2-hydroxybenzoate) is a natural product of many species of plants . (wikidoc.org)
  • Exogenous application of SA and some other chemicals including: polyacrylic acid, acetyl salicylic acid, 2, 6-dichloroisonicotinic acid, methyl salicylate, jasmonic acid and jasmonic methyl ester, benzothiadiazole derivatives, DL-B-aminobutyric acid and oxalic acid, can induce accumulation of pathogenensis-related proteins and lead to reduced incidence of several diseases on many crops (Gozzo, 2003). (scialert.net)
  • It is the methyl ester of salicylic acid. (shantichemicals.com)
  • Synonyms : 2-Hydroxybenzoic acid methyl ester Oil of wintergreen Wintergreen oil Methyl 2-hydroxybenzoate Formula : C8H8O3 Molecular weight : 152.15 g/mol CAS-No. They will give you further instructions. (innovation-arg.com)
  • Phenyl Salicylate exists as white crystals with a melting point of 41°-43° C. It is very slightly soluble in water and freely soluble in alcohol. (nih.gov)
  • Aspirin (acetylsalicylic acid or ASA) is prepared by the esterification of the phenolic hydroxyl group of salicylic acid with the acetyl group from acetic anhydride or acetyl chloride. (wikipedia.org)
  • In this reaction, the hydroxyl group of salicylic acid reacts with acetic anhydride to form an ester, resulting in the production of aspirin. (infinitylearn.com)
  • Salicylic acid has long been a key starting material for making acetylsalicylic acid (aspirin). (wikipedia.org)
  • Even in a worst-case use scenario in which one was using multiple salicylic acid containing topical products, the aggregate plasma concentration of salicylicic acid was well below what was permissible for acetylsalicylic acid (aspirin). (wikipedia.org)
  • Chemmically aspirin is acetylsalicylic acid, and ester formed between acetic acid and the -OH group of salicylic acid. (chemicalforums.com)
  • Along with serving as a vital, lively metabolite of aspirin acetylsalicylic acid, which acts partly as a prodrug to salicylic acid, it might be finest identified for its use as a key ingredient in topical anti-acne merchandise. (mcafeemarketcap.com)
  • Additionally, salicylic acid is a key precursor in the synthesis of aspirin (acetylsalicylic acid) and other pharmaceutical compounds. (infinitylearn.com)
  • Answer: Salicylic acid is a key starting material in the synthesis of aspirin (acetylsalicylic acid). (infinitylearn.com)
  • [8] In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. (everipedia.org)
  • [2] Numerous plants produce methyl salicylate in very small amounts. (wikidoc.org)
  • 204-317-7 For the full text of the H-Statements and R-Phrases mentioned … Wintergreenplants which are botanically referred to as gaultheria procumbens are the oneswhich produce methyl salicylate in significant amounts and they can always berecognized by a rather characteristic scent. (innovation-arg.com)
  • Since oral aspirin (which produces much higher salicylic acid plasma concentrations than dermal salicylic acid applications) poses no significant adverse pregnancy outcomes in terms of frequency of stillbirth, birth defects or developmental delay, use of salicylic acid containing cosmetics is safe for pregnant women. (wikipedia.org)
  • because aspirin is a memeber of salicylates, esters of salicyclic acid. (chemicalforums.com)
  • In this process, salicylic acid reacts with acetic anhydride in the presence of a catalyst, such as sulfuric acid, to form aspirin and acetic acid. (infinitylearn.com)
  • Reviewed by: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Accidental overdose from aspirin is very uncommon in the paediatric population, but methyl salicylate overdose is associated with significant toxicity even with very small ingestions. (innovation-arg.com)
  • Following gavage administration, blood level of radioactivity reached a peak at 30 minutes at which time blood concentration of salicylate was 106 μg/ml. (europa.eu)
  • Absorption following topical administration was slower, with peak blood level of radioactivity reached after 2 hours contact, and blood concentration of salicylate 8 μg/ml. (europa.eu)
  • Medicinal products Methyl salicylate has anti-inflammatory properties and is still used, A study in 4 human volunteers (Wolowich, 2003) gave a mean time to maximum serum concentration of salicylate of 2.4 hours, confirming the slower absorption in humans reported by Davison … The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. (innovation-arg.com)
  • Commercial vendors prepare sodium salicylate by treating sodium phenolate (the sodium salt of phenol) with carbon dioxide at high pressure (100 atm) and high temperature (115 °C) - a method known as the Kolbe-Schmitt reaction. (wikipedia.org)
  • Made by the action of phosphorus oxy-chloride on a mixture of phenol and salicylic acid. (nih.gov)
  • Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage. (drugbank.com)
  • This impact on pores and skin cells additionally makes salicylic acid a lively ingredient in several shampoos meant to deal with dandruff. (mcafeemarketcap.com)
  • Answer: Salicylic acid is used as an active ingredient in many acne treatment products. (infinitylearn.com)
  • Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. (drugbank.com)
  • Octyl salicylate is used to augment the UVB protection in a sunscreen. (drugbank.com)
  • Salicylic acid is sparingly soluble in water but dissolves readily in organic solvents like ethanol and ether. (infinitylearn.com)
  • If high concentrations of salicylic ointment are used topically, high levels of salicylic acid can enter the blood, requiring hemodialysis to avoid further complications. (wikipedia.org)
  • Foliar applications of salicylic acid with two concentrations of 200 and 400 μM were tested against fungal pathogen. (scialert.net)
  • Answer: Although the use of low-concentration household salicylic acid products is usually considered safe, salicylic acid can cause mild chemical burns at high concentrations. (infinitylearn.com)
  • Plasma analysis in rats showed rapid hydrolysis to free salicylate for MeS, NaS and ASA, resulting in comparable plasma concentrations of salicylate at 60 minutes post dosing, with no measurable parent compound. (europa.eu)
  • Salicylic acid is used as a food preservative, a bactericide, and an antiseptic. (wikipedia.org)
  • Methyl Salicylate exhibits excellent antiseptic property. (ayurvedicoils.com)
  • Methyl salicylate shows anti-inflammatory activity. (ayurvedicoils.com)
  • When methyl salicylate cataplasm is tied to the rat paws, it produces anti-inflammatory activity existing for 72 hours after its topical application. (ayurvedicoils.com)
  • The plasma half-life for salicylate is 2 to 3 hr in low doses and about 12 hr at usual anti-inflammatory doses. (contemplation.biz)
  • [6] It has proven fatal to small children in doses as small as 4 mL. [7] A 17 year-old cross-country runner at Notre Dame Academy on Staten Island, died April 3, 2007, after her body absorbed high levels of methyl salicylate through excessive use of topical muscle-pain relief products. (wikidoc.org)
  • Methyl Salicylate used in the topical application is one of the medicinal rubefacient that redden the skin by dilating the blood capillaries and thus increasing the blood circulation naturally. (ayurvedicoils.com)
  • The topical salicylic acid (for the skin) is used to treat acne, dandruff, seborrhea, or psoriasis and to remove cotton, calluses, and warts. (infinitylearn.com)
  • Methyl salicylate serves as an analgesic to relieve pain in joint and muscles. (ayurvedicoils.com)
  • According to the study 'Involvement of Transient Receptor Potential Vanilloid Subtype 1 in Analgesic Action of Methyl salicylate', it was found that Methyl salicylate inhibits human transient receptor potential vanilloid subtype1 (TRVP1) and this inhibitory property of methyl salicylate may partly contribute to the analgesic effect of Methyl salicylate . (ayurvedicoils.com)
  • For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments. (contemplation.biz)
  • Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenine dinucleotide and noncompetitively with UDPG. (wikipedia.org)
  • When applied topically, methyl salicylate is thought to penetrate the skin and underlying tissues where it reversibly inhibits cyclooxygenase enzyme and locally and peripherally prevents the production of inflammatory mediators such as prostaglandin and thromboxane A2. (contemplation.biz)
  • Other derivatives include methyl salicylate used as a liniment to soothe joint and muscle pain and choline salicylate used topically to relieve the pain of mouth ulcers. (wikipedia.org)
  • Ointments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. (contemplation.biz)
  • Sodium salicylate is a useful phosphor in the vacuum ultraviolet spectral range, with nearly flat quantum efficiency for wavelengths between 10 and 100 nm. (wikipedia.org)
  • Methyl salicylate relieve musculoskeletal pain in the muscles, joints, and tendons by causing irritation and reddening of the skin due to dilated capillaries and increased blood flow. (contemplation.biz)
  • Leading Manufacturers, Wholesaler and Trader of Camphor Powder, Isoborneol Flakes, Isoborneol Powder, Methyl Salicylate and Thymol Crystals from Sambhal. (shantichemicals.com)
  • Overall it can be concluded that all the salicylates share a common metabolic profile following initial ester hydrolysis to free salicylate. (europa.eu)
  • These results indicate that following absorption, the initial metabolic step for all these salicylates (MeS, NaS and ASA) is hydrolysis to free salicylate. (europa.eu)
  • Methyl salicylate is an organic compound present mainly in Wintergreen oil obtained from Gaultheria procumbens. (ayurvedicoils.com)
  • Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. (contemplation.biz)
  • Oil-free formula is built with our serum technology, powered by good-for-skin ingredients: Clinique's dark spot-fighting molecule UP302, three kinds of vitamin C, salicylic acid, and hyaluronic acid. (lasoo.com.au)
  • No single study on methyl salicylate (MeS) covers all the endpoints of basic toxicokinetics (absorption, distribution, metabolism and elimination). (europa.eu)
  • Absorption of MeS in humans was somewhat slower than for ASA, with total salicylate plasma concentration at 90 minutes approximately half that from ASA (Davison, 1961). (europa.eu)
  • After absorption, methyl salicylate is distributed throughout most body tissues and most transcellular fluids, primarily by pH dependent passive processes. (contemplation.biz)
  • Salicylic Acid is a beta hydroxy acid that happens as a pure compound in plants. (mcafeemarketcap.com)
  • Salicylic acid from Latin salix, willow tree is a lipophilic monohydroxybenzoic acid, phenolic acid, and beta-hydroxy acid BHA. (mcafeemarketcap.com)
  • Salicylic Acid: A beta hydroxy acid (BHA) that exfoliates and helps to unclog pores, beneficial for acne-prone skin. (bryghtenup.com)
  • The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis. (wikipedia.org)
  • Salicylic acid is an organic compound with the formula HOC6H4COOH. (wikipedia.org)
  • Infused with salicylic acid and bifidus, it fosters a breathable scalp and delivers a hydrating formula that preserves the scalp barrier while remaining lightweight for both the scalp and lengths. (cloud10beauty.com)
  • Methyl salicylate is an organic compound with the formula C₆H₄. (shantichemicals.com)
  • Salicylic acid is a white crystalline organic compound with the chemical formula C₇H₆O₃. (infinitylearn.com)
  • Enhanced with Salicylic Acid to remove dulling dead skin cells, this unique formula helps smooth uneven skin tone and texture to reveal fresher, more youthful-looking skin. (beautyloops.com)
  • A fragrance carved with hefty chunks of cashmeran, sandalwood, musk and patchouli, reinforced with salicylates and incense, softened with heliotrope, colored with a violet accord. (blogspot.com)
  • Industrial uses impacting the benzyl salicylate price trend primarily include self-care and personal care products, flavouring and fragrance agents, UV absorber in cosmetics, fixation in the floral perfumes, and solvents. (lookmagazines.com)
  • Methyl salicylate is used for its distinctive and appealing fragrance in perfumery. (ayurvedicoils.com)
  • Conjugation with glycine forms salicyluric acid and conjugation with glucuronic forms ester or acyl and ether or phenolic glucuronide, which are the three main metabolites. (contemplation.biz)
  • citation needed] Salicylic acid, when applied to the skin surface, works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. (wikipedia.org)
  • Salicylic acid treats acne by inflicting pores and skin cells to slough off extra readily, stopping pores from clogging up. (mcafeemarketcap.com)
  • The use of straight salicylic solution might trigger hyperpigmentation on unpretreated pores and skin for those with darker pores and skin varieties Fitzpatrick phototypes IV, V, VI, in addition to the lack of use of a broad-spectrum sunblock. (mcafeemarketcap.com)
  • Salicylic acid possesses keratolytic properties, making it effective in exfoliating the skin and unclogging pores. (infinitylearn.com)
  • Aside from its toxicity, methyl salicylate may be used by plants as a pheromone to warn other plants of pathogens such as tobacco mosaic virus . (wikidoc.org)
  • Definition: Salicylate toxicity is characterized by a constellation of symptoms caused by acute or chronic overdose of salicylate containing compounds. (innovation-arg.com)
  • Hyperpnea is an early finding of toxicity, as salicylates can act directly on the medullary respiratory center leading to hyperventilation leading to a respiratory alkalosis. (innovation-arg.com)
  • Methyl salicylate is easily characterized by a high degree of toxicity. (innovation-arg.com)
  • Salicylic acid as a medication is commonly used to remove the outer layer of the skin. (wikipedia.org)
  • Commercial methyl salicylate is now synthesized, but in the past, it was commonly distilled from the twigs of Sweet Birch ( Betula lenta ) and Eastern Teaberry ( Gaultheria procumbens ). (wikidoc.org)
  • One of the most commonly used chemicals inducers is Salicylic Acid (SA), which appear to mimic the systemic effects of localized infection (Kessmann et al . (scialert.net)
  • Salicylic acid can react with alcohols to form esters, a process commonly used in the synthesis of salicylates, such as methyl salicylate. (infinitylearn.com)
  • Methyl salicylate appears as a colorless to yellowish or reddish liquid, which is clear and viscous in nature. (ayurvedicoils.com)
  • Methyl salicylate (C8H8O3, MW 152.15) occurs as a colorless, yellowish, or reddish liquid with the characteristic odor and taste of wintergreen. (contemplation.biz)
  • Salicylate may competitively inhibit prostaglandin formation. (wikipedia.org)
  • Aloe vera extracts are rich in nutrients and according to the World Health Organization , is considered to be the most biologically active of the Aloe species - with 75 active constituents (including vitamins, minerals, saccharides, amino acids, anthraquinones, enzymes, lignin, saponins, and salicylic acids). (satorichemist.com)
  • The necessity of SA for the expression of SAR in tobacco was shown in experiments with the salicylate hydroxylase (nahG) transgene, which converts salicylate into catechol (Gaffney et al . (scialert.net)
  • The valuation of the oil is best determined by acetylation, which converts the alcoholic constituents into acetic esters, and saponification of the acetylated oil, when from 92 to 98 per cent. (henriettes-herb.com)
  • Below are symptoms of a methyl salicylate overdose in different parts of the body. (innovation-arg.com)
  • Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. (contemplation.biz)
  • an aldehyde, santalal, C 15 H 24 O, yielding santalenic acid on oxidation (which crystallises in thin laminae, melting at 76°), is also present, together with small quantities of esters and free acid. (henriettes-herb.com)
  • Toxic ingestions of salicylates typically occur with doses of approximately 150 mg/kg body weight. (innovation-arg.com)
  • The half-life of salicylate may be as long as 15 to 30 hr at high therapeutic doses or when there is intoxication. (contemplation.biz)