Protein StabilityEnzyme StabilityDrug StabilityProtein DenaturationThermodynamicsProtein FoldingModels, MolecularRNA StabilityMutationProteinsProtein ConformationMolecular Sequence DataAmino Acid SequenceUbiquitinationProtein Structure, TertiaryCircular DichroismProteasome Endopeptidase ComplexTemperatureProteolysisProtein Structure, SecondaryProtein BindingUbiquitinGuanidineProtein EngineeringAmino Acid SubstitutionMutagenesis, Site-DirectedProtein UnfoldingCell LineUbiquitin-Protein LigasesCalorimetry, Differential ScanningHot TemperatureHalf-LifeKineticsProtein Processing, Post-TranslationalUreaHEK293 CellsHydrogen BondingRNA, MessengerMuramidaseSolventsBase SequencePhosphorylationHydrogen-Ion ConcentrationBinding SitesRecombinant ProteinsEscherichia coliTransition TemperatureMutation, MissenseModels, ChemicalStatic ElectricityStructure-Activity RelationshipCell Line, TumorMutant ProteinsAmino Acid MotifsNuclear ProteinsTranscription, GeneticDNA-Binding ProteinsHydrophobic and Hydrophilic InteractionsTranscription FactorsRecombinant Fusion ProteinsLeupeptinsSpectrometry, FluorescenceCrystallography, X-RayGene Expression RegulationBacterial ProteinsSignal TransductionComputer SimulationTumor Suppressor Protein p53Models, BiologicalProto-Oncogene Proteins c-mdm2HeLa CellsCOS CellsSequence AlignmentTransfectionSequence Homology, Amino AcidAmino AcidsSaltsPoint MutationProteasome InhibitorsLysineProtein Structure, QuaternarySumoylationSerinePlasmidsSolubilityF-Box ProteinsImmunoprecipitationMultiprotein ComplexesRNA, Small InterferingEntropyProtein MultimerizationTumor Suppressor ProteinsSolutionsDimerizationTime FactorsBlotting, WesternRibonucleasesSequence Analysis, ProteinCarrier ProteinsCalorimetry