• The Barrett True K No History (BTKNH) formula, which also incorporates measured posterior corneal curvature, performed similarly to BTK in both groups. (bvsalud.org)
  • The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
  • The cornea does so by having an organization consisting of three tissue layers: the epithelium, stroma, and endothelium. (molvis.org)
  • Experimental mice, i.e., wild-type, Col5a1 f/f and Kera-Cre/Col5a1 f/f ( Col5a1 ∆st/∆st , collagen V null in the corneal stroma) mice in a C57BL/6J genetic background, were subjected to a lamellar keratectomy, and treated with or without UMSC (10 4 cells/cornea) transplantation via an intrastromal injection or a fibrin plug. (molvis.org)
  • UMSC transplantation was successful in recovering some corneal transparency in injured corneas of wild-type, Col5a1 f/f and Col5a1 ∆st/∆st mice. (molvis.org)
  • Currently, 12.7 million patients are waiting for corneal transplantation, one of the major treatments for severe Glaucoma, while only 1 in 70 of the needs are covered because of the limited corneal donor. (ncsu.edu)
  • Failure to prevent the progression of many of the diseases that lead to the need for medical products of human origin, such as trachoma causing corneal blindness and diabetes resulting in kidney failure, means that the growth in demand for these products continues to outpace the increase in their availability. (who.int)
  • The production of collagen V by transplanted UMSCs may account for the regeneration of corneal transparency, as exemplified by better collagen fiber organization, as revealed with SHG signals. (molvis.org)
  • She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
  • Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. (hindawi.com)
  • Medical products of human origin are defined as substances that are derived wholly or in part from the human body and intended for clinical application.1 Source components in the human body range from organs, tissues, blood, cells and gametes to breast milk, hair, nails, urine and faeces. (who.int)
  • Nevertheless, the available guidance is somewhat fragmented and generally oriented towards a number of specific products (e.g. blood and organs/tissues/cells). (who.int)
  • Professors Yang Zhang and Jessica M. Gluck are working together to develop a rapid nanoscopic imaging platform to study and validate the nanoscopic functions of biomedical textiles-incorporated tissue-engineered constructs to serve as artificial cornea. (ncsu.edu)
  • Essential safety mechanisms include appropriate donor screening and testing, techniques that inactivate pathogens or render them less pathogenic, and adequate traceability of medical products of human origin, so that sentinel events of disease transmission can be promptly investigated and linked to specific products, source individuals and recipients, enabling the development of new risk containment and mitigation strategies, including rapid product recalls. (who.int)
  • The corneal stroma is composed of primarily collagen fibrils, small leucine-rich proteoglycans (SLRPs), as well as sparsely distributed cells called keratocytes. (molvis.org)
  • The purpose of this study is to examine the therapeutic efficacy of human umbilical cord mesenchymal stem/stromal cells (UMSCs) in treating congenital and acquired corneal opacity associated with the loss of collagen V. (molvis.org)
  • The complementary use of AOSLO to characterize morphology of these cells provides clues to their activation status and potential role in tissue maintenance and repair. (stanford.edu)
  • Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)
  • Our results highlight the remarkablepotential use of BC-Ppy scaffolds as a cardiac patch in tissue regenerativetherapies. (ibecbarcelona.eu)
  • The demand for medical products of human origin is growing with the emergence of new therapeutic applications, improved access to health care in some regions, and changing demographics of potential donor and recipient populations, such as ageing and increased burdens of chronic diseases. (who.int)
  • 8 nm).Ppy NPs effectively augment the conductivity, surface roughness, andthickness of BC composites despite reducing scaffolds' transparency.BC-Ppy composites were flexible (up to 10 mM Ppy), maintained theirintricate 3D extracellular matrix-like mesh structure in all Ppy concentrationstested, and displayed electrical conductivities in the range of nativecardiac tissue. (ibecbarcelona.eu)
  • An excessive level of ROS damages many cellular and tissue components. (hindawi.com)
  • In addition, expression of limbal epithelial and corneal stromal proteins such as ATP-binding cassette sub-family G member 2 (ABCG2), tumour protein p63 (p63), paired box 6 (Pax6), cytokeratin 3 (AE5), cytokeratin 10, and keratocan sulfate were evaluated either by immunofluorecence staining or reverse transcription polymerase chain reaction. (molvis.org)
  • 1] As corneal edema progresses and worsens, first stromal and then intercellular epithelial edema develops. (medscape.com)
  • During the initial 14 days, Slc4a11 expression, corneal thickness (CT), stromal [lactate], Na+-K+ ATPase activity, mitochondrial superoxide levels, expression of lactate transporters, and activity of key kinases were assessed. (bvsalud.org)
  • However, the most important influence on corneal deturgescence is the presence of an active metabolic pump in the endothelium. (medscape.com)
  • PURPOSE: Inducible Slc4a11 KO leads to corneal edema by disruption of the pump and barrier functions of the corneal endothelium (CE). (bvsalud.org)
  • Pseudophakic bullous keratopathy (PBK) and aphakic bullous keratopathy (ABK) refer to the development of irreversible corneal edema as a complication of cataract surgery. (medscape.com)
  • This collaborative effort will be extended in the future to retinal disease, corneal disease and cataract. (nih.gov)
  • The corneal stroma is unique in having a homogeneous distribution of fibrils with small diameter (25-30 nm) that are regularly packed within lamellae and this arrangement minimizes light scattering permitting transparency. (molvis.org)
  • Osmotic forces and the electrolyte balance within the corneal stroma also tend to draw water into the cornea. (medscape.com)
  • when the cell density reaches a critically low level of about 300-500 cells/mm2, corneal edema develops. (medscape.com)
  • The US Food and Drug Administration (FDA) premarket approval studies for intraocular lenses performed from 1978-1982 found an incidence of postoperative corneal edema of 0.06% for posterior chamber lenses, 1.2% for anterior chamber lenses, and 1.5% for iris fixated lenses. (medscape.com)
  • This dystrophy does predispose to the development of corneal edema (see Pathophysiology, Causes, Histologic Findings). (medscape.com)
  • Fuchs corneal dystrophy, a known predisposing factor in the development of postoperative corneal edema, occurs approximately 3 times more frequently in women than in men. (medscape.com)
  • The incorporation of exogenous lactate into cardiac tissues is a regenerative strategy that is rapidly gaining attention. (ibecbarcelona.eu)
  • Surgical trauma, inflammation, and corneal dystrophies can accelerate this normal aging loss. (medscape.com)
  • HN - 2011 MH - Abdominal Wound Closure Techniques UI - D058107 MN - E4.987.100 MS - Methods to repair breaks in abdominal tissues caused by trauma or to close surgical incisions during abdominal surgery. (nih.gov)
  • Patients of Northern European descent do have an increased incidence of Fuchs corneal dystrophy. (medscape.com)
  • Approximately 90% of patients undergoing this procedure maintain a clear corneal graft. (medscape.com)
  • The next question is: since Cord Blood cells can become Nerve Growth Factor, will using Cord Blood drops work better or as well as NGF, especially in patients who have corneal neuropathy? (drcremers.com)
  • An excessive level of ROS damages many cellular and tissue components. (hindawi.com)