Essential for embryonic. Medical search. Frequent questions

Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells. (ca.gov)
Here, we profile the DNA methylome, transcriptome, and global occupancy of histone modifications (H3K4me1, H3K4me3, H3K27me3, and H3K27ac) in a series of mouse embryonic stem cells (mESCs) with varying DNA methylation levels to study the effects of DNA methylation on deposition of histone modifications. (ca.gov)

The embryonic phase of development is complete by the end of the 10th menstrual or gestational week (this corresponds to 12 weeks following the onset of the last normal menstrual period). (medscape.com)
Despite the massive reduction of Dio1 and Sepp1 mRNAs, significantly more corresponding protein was detected in primary hepatocytes lacking Secisbp2 than in cells lacking tRNA[Ser]Sec. Regarding selenoprotein expression, compensatory nuclear factor, erythroid-derived, like 2 (Nrf2)-dependent gene expression, or embryonic development, phenotypes were always milder in Secisbp2-deficient than in tRNA[Ser]Sec-deficient mice. (nih.gov)
Embryonic development or embryogenesis is the process by which the embryo is formed and develops. (news-medical.net)
Although these tumors can originate during embryonic development, they aren't embryos, and they are not a person's "twin. (livescience.com)
Here, through oocyte-specific conditional knockout of SMC2, a core component of the condensin complex, we showed that SMC2 is essential for the production of healthy eggs and early embryo development. (authorea.com)
In more than 130 types of mammals where this takes place, the process occurs at the blastocyst stage of embryonic development, and is characterized by a dramatic reduction or complete cessation of mitotic activity, arresting most often in the G0 or G1 phase of division. (wikipedia.org)
This work together with our previous work about the effects of prenatal alcohol exposure on embryonic development, reveals a genotype-specific effects of environmental factors. (helsinki.fi)
This screen is capable of analyzing the expression of 48 genes simultaneously across dozens of different samples, and our gene list covers all three germ layers that arise during normal embryonic development, the trophectoderm, and epigenetic regulators of chromatin status. (utexas.edu)
This zone, in which stem cells are retained after embryonic development for the production of new cells, exerts a tight control over many crucial tasks such as growth promotion and the recreation of essential biochemical and physical cues for neural cell differentiation. (sciencedaily.com)
Our group provided evidence that supplementing beef cows with a lipid source rich in omega-6 fatty acids during the early embryonic period increased pregnancy success by promoting conceptus development, establishment and maintenance of the pregnancy," Cooke said. (farmprogress.com)
The three genes, HESX1 , OTX2 , and SOX2 , all play important roles in embryonic development. (medlineplus.gov)
FGFs are essential for early embryonic development, organ formation, and angiogenesis. (rcsb.org)
This includes, 1) how small RNAs regulate gene expression in the male germline to support spermatogenesis and fertility, 2) how small RNAs are packaged into mature sperm, 3) how RNAs transmitted during fertilization are able to regulate early embryonic gene expression and development, and 4) how this regulation can alter developmental programs to produce a non-genetically inherited phenotype. (upenn.edu)
During embryonic development, the programmed death of certain cells plays an essential role in shaping organs and allowing proper growth. (phys.org)
EZH2, a methyltransferase catalyzing H3K27me3, has been abundantly studied in human and mouse embryonic development. (hindawi.com)
These results validated a different transcript in pigs and characterized its expression profile in fetal tissues of different gestation stages, which indicated that EZH2 played important roles during porcine embryonic development. (hindawi.com)
In the early embryonic development, abnormal expression of EZH2 impaired embryo growth and pluripotency maintenance [ 7 , 8 ]. (hindawi.com)
Thus, the appropriate expression level of the EZH2 gene is important for embryonic development. (hindawi.com)
In pigs, several studies have focused on its function in early embryonic development regulation and in SCNT efficiency improvement [ 8 , 14 - 16 ]. (hindawi.com)
However, the transcript and expression status of the EZH2 gene during porcine embryonic development remains unknown. (hindawi.com)
Subsequently, we detected the expression of EZH2 on mRNA level and protein level in two different embryonic development stages (65-dpc and 90-dpc) via qRT-PCR and western blots. (hindawi.com)
Our study is aimed at providing information for understanding the biological function of EZH2 in porcine embryonic development. (hindawi.com)
To provide a general introduction to the mechanisms used in both plants and animals to produce and position, during embryonic development, the many different cell types required to create a functional adult organism. (manchester.ac.uk)
Maternal control of development and establishment of the major embryonic axes. (manchester.ac.uk)
In most organisms maternal information is deposited in the egg which is essential for the establishment of anterior-posterior (head-tail), dorsal-ventral (front-back) and left-right axes of the embryo during the very earliest stages of development. (manchester.ac.uk)
H4K16ac has an instructive function in the germline and is indispensable for embryonic development later on. (mpg.de)
In view of these rather inconsistent findings, it appeared necessary, not to immediately further examine the effect of carbaryl on the reproductive system of the adult organism, but rather to ascertain the role of this agent on critical stages in the embryological development of this system during the period of primordial germ cell (PGC) migration and mid-way in embryonic development following sex differentiation. (cdc.gov)
In addition, this study will also examine the status of both male and female gonads near the mid-embryonic stage (12 days of incubation) to determine whether any adverse effects on the development and sexual differentiation of the gonad can be induced following a longer term exposure to carbaryl. (cdc.gov)
We explore the method on three circuits for haematopoiesis and embryonic stem cell development for commitment and reprogramming scenarios and illustrate how the method can be used to determine sequential steps for onsets of external factors, essential for efficient reprogramming. (lu.se)
The Wnt signaling pathway is highly conserved and crucial during embryonic development. (lu.se)
This insight has revolutionised research in ecology and evolution, ranging topics from embryonic development to thermal adaptation and fitness in the wild. (lu.se)
However, molecular genetic studies have shown that some genes on the inactivated X chromosome (or chromosomes) remain functional, and these few are essential to normal female development. (msdmanuals.com)
We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)
Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)

Specifically within placental embryonic diapause, this cessation is led by the intentional failure of the blastocyst to implant in the uterine wall, which is an essential component in developmental progression in these species. (wikipedia.org)
21, 2023 Despite being an essential developmental process, the understanding of human embryonic genome activation is limited, owing to the lack of in vitro cell models and ethical concerns. (sciencedaily.com)
The slow-conducting SA and AV nodes take developmental origin from the slow-conducting embryonic inflow tract and atrioventricular canal region. (medscape.com)

We have reported that retrograde application of embryonic endothelial progenitor cells (eEPCs) provides rapid paracrine protection against ischemia-reperfusion injury. (elsevierpure.com)
PLA 70/30 was more amorphous, degraded faster and, crucially, released significant amounts of L-lactate, which is essential for the maintenance and differentiation of neural progenitor cells. (sciencedaily.com)

Here, we demonstrate that the deletion of both Spred-1 and Spred-2 resulted in embryonic lethality at embryonic days 12.5 to 15.5 with marked subcutaneous hemorrhage, edema, and dilated lymphatic vessels filled with erythrocytes. (elsevierpure.com)
Embryonic lethality of mutant mice deficient in the p116 gene. (nih.gov)

Mei, J., Huang, X. & Zhang, P. Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. (nature.com)

Collectively, our data show that DNA methylation is essential and instructive for deposition of specific histone modifications across regulatory regions, which together influences gene expression patterns in mESCs. (ca.gov)

In placental embryonic diapause, the blastocyst does not immediately implant in the uterus after sexual reproduction has resulted in the zygote, but rather remains in this non-dividing state of dormancy until conditions allow for attachment to the uterine wall to proceed as normal. (wikipedia.org)
Other studies have demonstrated, inversely, the lack of involvement of more common regulators of the cell cycle such as p53 within the placental model of embryonic diapause. (wikipedia.org)
In vitro fertilization affects the regulatory region of genes essential for placental and embryonic growth, as well as the birth weight. (helsinki.fi)

Linear eukaryotic chromosomes contain specialized protective structures at the chromosome ends, called telomeres, which are essential for maintaining genome stability. (ubc.ca)
Here, we have generated a CHMP2B-mutated human embryonic stem cell line using genome editing with the purpose to create a human in vitro FTD disease model. (lu.se)

One of the genes mutated in patients is CHMP2B, which encodes a protein found in a complex important for maturation of late endosomes, an essential process for recycling membrane proteins through the endolysosomal system. (lu.se)

Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
We proposed to use the classical embryonic stem cell-based gene-targeting technology to generate rat models mimicking human heart failure, diabetes and neurodegenerative diseases. (ca.gov)
4) Generated a motor neuron reporter human embryonic stem cell line. (ca.gov)
These stem cells as well as human embryonic stem cells were then used to generate cerebral cortex cells. (scitechdaily.com)
Omega-6 fatty acids have long been touted as essential fatty acids in human health and are typically derived from vegetable oils, seeds and nuts. (farmprogress.com)
Here we show that human shugoshin 2 (SGO2), an essential protector of meiotic cohesin with unknown functions in the soma 6 , 7 , is turned into a separase inhibitor upon association with SAC-activated MAD2. (nature.com)
First, Oleaga's team transfected a line of human embryonic kidney cells with the mature form of PCSK9 and furin vectors to test where PCSK9_55 was formed. (asbmb.org)
however, we present a new co-culture system in which neurons and astrocytes are independently generated from human embryonic stem cells and combined in co-cultures. (lu.se)
Clinical research had demonstrated the therapeutic benefits of interventions using adult stem cells rather than embryonic cells, a direction that guaranteed respect for human dignity, even at the embryonic stage. (who.int)

The lab utilizes a combination of state-of-the-art genomic, molecular biology, and assisted reproduction techniques across multiple model systems including mice, embryonic stem cells, and C. elegans to understand these questions. (upenn.edu)
Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice. (nature.com)

The embryonic stem cell-based gene-targeting technology was used for the generation of these rat models. (ca.gov)
Using the small animal model embryonic stem cell-based gene-targeting technology that we developed, we will create small animal models for heart failure, diabetes and neurodegenerative diseases. (ca.gov)
The papers made fantastic claims about embryonic stem cell research studies that turned out to be false. (lifenews.com)
In handling fraudulent stem-cell research articles, journal editors went above and beyond existing procedures to try and verify the findings, but in today's competitive publishing environment, more stringent, less trusting safeguards are now essential,' the committe said, according to a Science statement LifeNews.com obtained. (lifenews.com)
Prior to September 11, the defining moment of the Bush presidency had been the president's decision to limit embryonic stem-cell research. (breakpoint.org)
Along the same lines, a writer in the Baltimore Chronicle accused "opponents of embryonic stem-cell research" of "prolonging the suffering of millions. (breakpoint.org)
He labeled the president, and other opponents of embryonic stem-cell research, as an "obstacle to hope for a scientific breakthrough, a miracle. (breakpoint.org)
Reeve, who was left paralyzed after being thrown from a horse a decade ago, was a tireless advocate of embryonic stem-cell research. (breakpoint.org)
Second, the policy applies only to research using federal money for embryonic stem-cell research. (breakpoint.org)

The α-tocopherol transfer protein is essential for vertebrate embryogenesis. (oregonstate.edu)

Madin-Darby canine kidney (MDCK) cells were maintained in Eagle's minimal essential medium (MEM) containing 5% newborn calf serum (NCS). (cdc.gov)
The researchers engineered the embryonic kidney cells to express a recombinant PCSK9_55. (asbmb.org)

Regulation of the cell cycle as it relates to embryonic diapause has been linked to the dacapo gene in the fruit fly, responsible for inhibiting the formation of cyclin E-cdk2 complexes necessary for DNA synthesis. (wikipedia.org)
Taken together, our results demonstrate that precise regulation of TRF1 levels is essential for telomere resolution and mitotic segregation. (ubc.ca)

Organisms which undergo embryonic diapause are able to synchronize the birth of offspring to the most favorable conditions for reproductive success, irrespective of when mating took place. (wikipedia.org)
In organisms which are capable of embryonic diapause, in non-ideal reproductive conditions, there is a cessation of cellular division which prevents the embryo from growing and maturing, delaying the maturation of the embryo until conditions are ideal enough to promote the survival of the offspring, and in some cases, the mother. (wikipedia.org)
Proper segregation of replicated chromosomes is essential for cell division in all organisms. (ubc.ca)

Lacking a prodomain sequence that is essential to PCSK9 secretion, this form's abundant intracellular expression and retention were unsurprising. (asbmb.org)

An Indiana woman's brain tumor turned out to contain hair, bone and teeth, and has been dubbed her "embryonic twin" - but experts say that such tumors are not actually twins, nor are they embryos. (livescience.com)

Several genetically modified rats that are essential for the generation of rat disease models mentioned above have been generated. (ca.gov)
We are still in the process of generating the remaining genetically modified rats that are also essential for the production of the three rat disease models. (ca.gov)
However, according to the Lyon hypothesis, 1 of the 2 X chromosomes in each female somatic cell is inactivated genetically early in embryonic life (on or about day 16). (msdmanuals.com)

Understanding of the molecular and ionic mechanisms underlying cardiac conduction is essential for the appreciation of the pathogenesis of conduction abnormalities in structurally normal and altered hearts. (medscape.com)

Thus, Xfoxi1a is an essential regulator of ventral specification of the early head ectoderm during gastrulation. (biologists.com)
Reinaldo Cooke is leading a Texas A&M AgriLife project that will feed omega-6 and omega 3 fatty acids to beef cattle to determine what role they may play in managing early embryonic loss. (farmprogress.com)
Utilizing omega-6 fatty acids as a management strategy to mitigate early embryonic loss, a major cause of reproductive and economic losses to the U.S. beef industry, is the focus of a new Texas A&M AgriLife Research-led project. (farmprogress.com)
Most pregnancy losses occur during the first 28 days of gestation, he said, and these losses are classified as early embryonic loss. (farmprogress.com)
We need to provide biological support to nutritional interventions that minimize early embryonic loss," he said. (farmprogress.com)

Conversely, we found that Yap1 is essential for proper ES cell differentiation. (utexas.edu)
The hallmark of embryonic stem (ES) cells is their ability for self-renewal (capability of unlimited cell division without the loss of pluripotency) as well as for differentiation into all cell types of the adult organism. (uni-muenchen.de)

In the study conducted by University of Helsinki, Helsinki University Hospital and University of Tartu, the researchers looked for mechanisms how the IVF can alter the embryonic growth. (helsinki.fi)

First, we introduced targeted genetic mutations into rat embryonic stem cells. (ca.gov)
Next, we produced rats from these gene-targeted embryonic stem cells. (ca.gov)
Mouse embryonic stem (ES) cells are pluripotent cells, meaning that they can give rise to all tissues in the body. (utexas.edu)
The papers claimed the team created patient specific embryonic stem cells that would overcome the problems of a patient's immune system rejecting the cells in treatments. (lifenews.com)
The president's policy affects only embryonic stem cells. (breakpoint.org)
And the federal policy doesn't prohibit the use of all embryonic stem cells. (breakpoint.org)
Thus, the PeBoW-complex seems to be an essential factor for the rapid proliferation of ES cells and might therefore also be involved in self-renewal. (uni-muenchen.de)

Results showed that exposure to belladonna mother tincture at higher concentration (5, 10 %) cause embryonic malformation including pericardial edema, increase in body length, eye width and heart rate, while decrease hatching rate with no effect on mortality. (ijpsonline.com)

Embryonic diapause (delayed implantation in mammals) is a reproductive strategy used by a number of animal species across different biological classes. (wikipedia.org)
Embryonic diapause is a relatively widespread phenomenon outside of mammals, with known occurrence in the reproductive cycles of many insects, nematodes, fish, and other non-mammalian vertebrates. (wikipedia.org)

Condensin plays an essential role in chromatin configuration. (authorea.com)

The proper methylation status of histones is essential for appropriate cell lineage and organogenesis. (hindawi.com)

Kuzdere T, Flury V, Schalch T , Iesmantavicius V, Hess D, Bühler M. Differential phosphorylation of Clr4SUV39H by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis. (le.ac.uk)

As Kass points out, there are enough of these lines "for years of essential basic research. (breakpoint.org)

A plant goes to great lengths to produce each seed and fill it with high concentrations of vitamins, minerals, proteins, essential oils and dormant enzymes. (organic.org)

The orderly migration of PGCs from their extra-embryonic origin in all vertebrates to the developing gonadal anlagen is essential to insure the future fertility of the species. (cdc.gov)

Some groups only have one species that undergoes embryonic diapause, such as the roe deer in the order Artiodactyla. (wikipedia.org)

The seed is an embryonic plant itself and the origin of nutrition. (organic.org)

Hormones relating to the failed implantation also contribute to the embryonic arrest. (wikipedia.org)
Underdevelopment of the pituitary can lead to a shortage (deficiency) of many essential hormones. (medlineplus.gov)

Stay up to date on the latest science news by signing up for our Essentials newsletter. (livescience.com)

He agreed with the previous speaker, in relation to the transplantation of organs from non-heartbeating donors, that it was essential to ensure that the cessation of vital functions was truly irreversible and certified by valid criteria. (who.int)

Mouse embryonic stem2

Development34

Developmental3

Progenitor cells2

Lethality2

Fibroblasts1

Gene expression1

Placental3

Genome2

Genes1

Human9

Mice2

Stem cell9

Embryogenesis1

Kidney2

Regulation2

Organisms3

Expression1

Tumors1

Genetically3

Molecular1

Early5

Differentiation2

Mechanisms1

Cells7

Edema1

Reproductive2

Chromatin1

Lineage1

Methylation1

Research1

Proteins1

Migration1

Species1

Origin1

Hormones2

News1

Organs1