Esophagogastric junction cancer. Medical search. Frequent questions

The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer. (jnccn.org)
Gulam A. Manji, MD, PhD, of Columbia University Medical Center, discusses phase II results on perioperative combination chemotherapy and pembrolizumab in patients with resectable gastric cancer. (ascopost.com)
Gastric cancer still remains a major cause of cancer-related deaths globally. (frontiersin.org)
Approximately one-third of patients with gastric cancer undergoes an avoidable lymph node dissection. (frontiersin.org)
Many of the recent treatment updates in the management of gastric cancer have a major influence on both surgical and oncological approaches. (frontiersin.org)
The concept of sentinel node biopsy and utilization of the Maruyama Computer Program are significant components of stage-adapted gastric cancer surgery. (frontiersin.org)
Our goal is to review the available surgical strategies for gastric cancer, with a primary focus on lymphadenectomy. (frontiersin.org)
According to the recent GLOBOCAN 2020 estimation ( 1 ), gastric cancer is the fifth most common cancer worldwide. (frontiersin.org)
The diagnosis of gastric cancer is frequently made at an advanced stage, resulting in a high mortality rate. (frontiersin.org)
Economic development has contributed to the global reduction in the prevalence of H. pylori, a major factor for gastric cancer, as well as eradication therapy. (frontiersin.org)
There is a well-known positive association between gastroesophageal reflux disease (GERD) and proximal gastric cancer ( 3 ). (frontiersin.org)
Moreover, in Western societies, there has been a gradual decrease in the incidence of the distal, intestinal type of gastric cancer, and an increase in the proximal, diffuse type ( 4 ). (frontiersin.org)
In 2014 the Cancer Genome Atlas Research Network identified and published four molecular subtypes of gastric cancer: Epstein-Barr virus positive, microsatellite unstable tumors, genomically stable, and chromosomally unstable tumors ( 5 ). (frontiersin.org)
Regardless of the scientific and technological advancement, the development of a multimodal treatment approach using resection (surgical or endoscopic) is still the foundation of curative management in gastric cancer ( 7 ). (frontiersin.org)
Generally, clinically staged T1N + M0 and T2-T4aN(any)M0 gastric cancer requires surgical resection with adequate lymphadenectomy, together with perioperative or adjuvant chemotherapy. (frontiersin.org)
Journal Article] Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells. (nii.ac.jp)
Guidelines for the management of oesophageal and gastric cancer. (helsedirektoratet.no)
A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer. (helsedirektoratet.no)
Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. (helsedirektoratet.no)
Special interest radiology improves the perceived preoperative stage of gastric cancer. (helsedirektoratet.no)
Laparoscopic versus open gastrectomy for gastric cancer. (helsedirektoratet.no)
At the time of diagnosis of gastric cancer approximately one third of patients already have metastases. (unige.ch)
Further randomized trials investigate the benefit of antibodies and immune checkpoint inhibitors in locoregional and advanced metastatic gastric cancer with promising results. (unige.ch)
A reason for the reported difference in the incidence and time trend of EGJ adenocarcinoma among the three countries may be explained by two distinct etiologies: one arising from chronic gastritis similar to distal gastric cancer, and the other related to gastroesophageal reflux disease similar to esophageal adenocarcinoma including Barrett's adenocarcinoma. (elsevierpure.com)
The National Cancer Institute (NCI) estimates 24,590 new cases and 10,720 deaths from gastric cancer in the United States in 2015. (southcarolinablues.com)
About 29% to 35% of gastric cancer cases have regional spread to lymph nodes or metastasis to distant sites. (southcarolinablues.com)
Boku, Narikazu 2018-03-29 00:00:00 Purpose We conducted a systematic review and meta-analysis on survival impact of post-progression chemotherapy (post- Cx) after first-line chemotherapy (1st-Cx) and after second-line chemotherapy (2nd-Cx), and survival benefit of third-line chemotherapy (3rd-Cx) for advanced gastric cancer (AGC). (deepdyve.com)
In this context first results for check point inhibitors active in esophageal and gastric cancer were presented. (springermedizin.at)
First phase II results with regorafenib emphasize a potential role for TKI's in gastric cancer. (springermedizin.at)
Zurück zum Zitat Wöll E. Perioperative therapy in gastric cancer. (springermedizin.at)
The registry is based on the protocols of the Japanese Gastric Cancer Association [21]. (gavinpublishers.com)
Background Metastatic gastric cancer and cancer of the esophagogastric junction (GC/EGJ) is an aggressive disease with poor prognosis. (gencat.cat)
Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis. (cdc.gov)

Adenocarcinoma of the esophagogastric junction (AEG) is increasing worldwide. (biomedcentral.com)
However, the resulting gastroesophageal reflux disease caused by the eradication of Helicobacter pylori (among various other factors) might potentially lead to an increase in the incidence of adenocarcinoma of the esophagogastric junction (AEG) worldwide [ 5 ]. (biomedcentral.com)

Guideline] NCCN Clinical Practice Guidelines in Oncology: Esophageal and Esophagogastric Junction Cancers. (medscape.com)

This international, multicenter, randomized, double-blind phase III study intends to recruit 680 patients who have received radical gastrectomy (R0 resection, D2 or more extended lymphadenectomy) with postoperative pathological stage II or III (AJCC Cancer Staging Manual, 8th Edition) gastric or EGJ adenocarcinoma to evaluate the efficacy and safety of JS001 combined with postoperative adjuvant chemotherapy versus placebo combined with postoperative adjuvant chemotherapy. (centerwatch.com)
it is a sign that the cancer has progressed beyond the point at which surgical resection remains possible. (medscape.com)
It has been more than 140 years since Theodor Billroth's (1829-1894) first successful gastric resection for cancer in 1881. (frontiersin.org)
The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction - a phase III trial of the German AIO/CAO-V/CAOGI. (helsedirektoratet.no)
Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial. (helsedirektoratet.no)
Patients with oligometastatic gastric and esophagogastric junction cancer are randomized after chemotherapy to either undergo resection followed by adjuvant chemotherapy or to undergo definitive chemotherapy. (unige.ch)
Exposures: Esophageal resection for cancer of the esophagus and gastroesophageal junction. (elsevierpure.com)
Primary DCF therapy for patients with unresectable esophageal cancer resulted in conversion surgery for 41.7% (20/48) of patients, in which R0 resection was achieved in 19 patients (39.6%) [ 5 ]. (biomedcentral.com)

Cancer Metastasis Rev. 2006 Jun;25(2):269-77. (nih.gov)
Cancer Metastasis Rev. 2006. (nih.gov)
Our purpose was to determine whether clinical stages based on the 8th edition American Joint Committee on Cancer Tumor-Node-Metastasis staging system could guide treatment decision. (springer.com)
Increasing evidence has shown that tumor heterogeneity is a result of the hierarchical organization of cancer stem cells (CSCs), which are strongly associated with tumor relapse and metastasis. (nii.ac.jp)
Iwase H, Indo T, Shimada M, Tsuzuki T, Nakarai K, Kaida S, Doi R, Okeya M and Kato E: Esophageal cancer with colonic metastasis successfully treated by chemoradiotherapy followed by chemotherapy with S-1 and cisplatin. (spandidos-publications.com)

Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial. (helsedirektoratet.no)
Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. (helsedirektoratet.no)
Pathological response to neoadjuvant 5-FU, oxaliplatin, and docetaxel (FLOT) versus epirubicin, cisplatin, and 5-FU (ECF) in patients with locally advanced, resectable gastric/esophagogastric junction (EGJ) cancer: Data from the phase II part of the FLOT4 phase III study of the AIO. (springermedizin.at)

In a Japanese case-control study reported in JAMA Oncology, Momozawa et al found that germline BRCA1/2 pathogenic variants were associated with an increased risk of biliary tract, esophageal, and gastric cancers, in addition to an increased risk of cancers that have well-established associations. (ascopost.com)
As reported in Nature by Yelena Y. Janjigian, MD, of the Gastrointestinal Oncology Service at Memorial Sloan Kettering Cancer Center, and colleagues, the first interim analysis of the phase III KEYNOTE-811 trial has shown a significantly higher objective response rate with the addition of. (ascopost.com)
The retrospective study included 145 patients with esophageal cancer who presented to Van Training and Research Hospital Medical Oncology outpatient clinic between January 2015 and September 2020. (researchsquare.com)
Shitara K] Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan. (gencat.cat)

An understanding of the factors that influence survival for patients with localized esophageal cancer has evolved concomitantly with these changes in epidemiology. (jnccn.org)
Delays in surgery for esophageal cancer did not appear to have much impact on patients' relative survival for early-stage cancer compared with patients who had surgery early, but they did reduce the relative survival rate by almost half for patients with more advanced disease, according to an. (ascopost.com)
When used alone, chemotherapy is not an effective treatment for esophageal cancer or long-term survival. (epnet.com)
Induction therapy does not improve survival for clinical stage T2N0 esophageal cancer. (springer.com)
A propensity-matched analysis comparing survival after primary minimally invasive esophagectomy followed by adjuvant therapy to neoadjuvant therapy for esophagogastric adenocarcinoma. (springer.com)
Metabolic response has been seen to correlate with the histopathologic response, and the 3-year survival is far better in responders than in nonresponders (70% vs. 35%, respectively, in a study of esophageal junction adenocarcinoma). (medscape.com)
When cancer is caught in its early stages treatments and survival rates are greatly improved. (hoacny.com)
Journal Article] MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival. (nii.ac.jp)
Journal Article] Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma. (nii.ac.jp)
Esophageal cancer is usually diagnosed at an advanced stage, resulting in poor survival. (spandidos-publications.com)
The aim of this study was to evaluate the relationship between the monocyte count assessed at diagnosis and disease-free survival and prognosis in patients with esophageal cancer. (researchsquare.com)
Our findings showed that monocyte count is a prognostic factor affecting disease-free survival in patients with esophageal cancer, regardless of histological subtype. (researchsquare.com)
Significant parameters used in the determination of the prognosis and survival of esophageal cancer include tumor stage, surgical margin, and metastatic lymph node status. (researchsquare.com)
In the present study, we aimed to investigate whether the monocyte count measured at the time of diagnosis can be used as a new prognostic biomarker in predicting disease-free survival in patients with esophageal cancer. (researchsquare.com)
Due to its later manifestation and generally less favorable characteristics, EGJ cancer has a worse prognosis, with a lower 5-year, overall and disease-free survival [18,19]. (gavinpublishers.com)
It is imperative that cancer organizations and funding agencies provide funding and resources that will in turn lead to cutting- edge developments in understanding esophageal cancer and decrease the incidence and improve the survival for patients with esophageal cancer. (amegroups.com)
Therefore, myelosuppression and gastrointestinal side effects caused by preoperative DCF therapy may worsen postoperative infections leading to life-threatening diseases in high-risk patients with esophageal cancer and may reduce long-term survival benefits by increasing the incidence of postoperative infections. (biomedcentral.com)

Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
Trastuzumab with chemotherapy is recommended as first-line therapy for patients with HER2-positive advanced or metastatic cancer, confirmed by immunohistochemistry and, if needed, by fluorescence in situ hybridization for IHC 2+. (jnccn.org)
Chemotherapy and targeted therapy are used to treat esophageal cancer. (epnet.com)
Chemotherapy uses drugs to kill cancer cells. (epnet.com)
Chemotherapy for esophageal cancer is most often used in combination with radiation therapy (called chemoradiation). (epnet.com)
Chemotherapy for esophageal cancer may given before or after surgery . (epnet.com)
Chemotherapy regimens for esophageal cancer have been found to work better when drugs are combined. (epnet.com)
Unlike chemotherapy, targeted therapy drugs attack cancer cells without harming healthy cells. (epnet.com)
Trastuzumab, when used with chemotherapy, may help stop tumor growth in cancers with an excess amount of HER2. (epnet.com)
Cancer chemotherapy and pharmacology, 65 (6), 1009-1021. (helsedirektoratet.no)
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. (helsedirektoratet.no)
Background/Aim: Impact of second-line chemotherapy in unresectable advanced/recurrent gastric/esophagogastric junction cancer (AGC) remains unclear. (iiarjournals.org)
Ramucirumab is considered MEDICALLY NECESSARY as a single agent or in combination with paclitaxel for the treatment of individuals with advanced (non-resectable) or metastatic esophageal, gastric, or gastroesophageal junction adenocarcinoma with disease progression that occurs during or after fluoropyrimidine- or platinum-containing chemotherapy. (southcarolinablues.com)
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial.Lancet 376: 687-697, 2010. (springermedizin.at)
Patients and Methods: This study included 168 patients who underwent curative surgery followed by perioperative adjuvant chemotherapy for esophageal cancer between 2005 and 2018. (iiarjournals.org)
To evaluate the use of early assessment of chemotherapy responsiveness by positron emission tomography (PET) imaging to tailor therapy in patients with esophageal and esophagogastric junction adenocarcinoma. (unc.edu)
Is 6 Months the Optimal Duration of Adjuvant Chemotherapy for Pancreatic Cancer? (cancerdiagnosisprognosis.org)
Recently the therapeutic treatment for advanced, stage T2-T4 gastro-oesophageal junction cancer and those adjacent to the regional lymph nodes involves neoadjuvant chemotherapy with subsequent surgical intervention. (akjournals.com)

Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
Journal Article] MicroRNA MIR21 and T Cells in Colorectal Cancer. (nii.ac.jp)

Oesophageal and gastric (OG) cancer are global health problems with poor prognosis. (cancercentrum.se)

Esophagectomy remains the "keystone of curative treatment for esophageal cancer," Van der Wilks explained. (medscape.com)
Esophagectomy with perioperative adjuvant treatment is the standard treatment for resectable esophageal cancer ( 3 , 4 ). (iiarjournals.org)
Objective: To develop and validate a risk prediction model of death within 90 days after esophagectomy for cancer using the International Esodata Study Group (IESG) database, the largest existing prospective, multicenter cohort reporting standardized postoperative outcomes. (elsevierpure.com)

Neoadjuvant oncological treatment for gastro-oesophageal junction cancer previously consisted of the intravenous administration of epirubicin, cisplatin and fluorouracil (ECF) or epirubicin, cisplatin and capecitabine (ECX) combination (Group I). In the course of the new protocol (FLOT-, F: 5-FU, L: leucovorin, O: oxaliplatin, T: docetaxel), patients were included with resectable gastro-oesophageal junction cancer who had a clinical-stage cT2 or higher nodal positive cN+ disease (Group II). (akjournals.com)

abstract = "Esophagogastric junction (EGJ) adenocarcinoma has been on the increase in Western countries. (elsevierpure.com)

The Society of Thoracic Surgeons practice guidelines on the role of multimodality treatment for cancer of the esophagus and gastroesophageal junction. (medscape.com)

Oesophageal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. (medscape.com)
The clinical spectrum of esophageal cancer has changed dramatically over the past couple of decades. (jnccn.org)
Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study. (springer.com)
MADRID - More than one third of patients with locally advanced esophageal cancer who have a complete clinical response to neoadjuvant chemoradiotherapy may be able to safely avoid major surgery, findings from the Dutch SANO-trial suggest. (medscape.com)
We suggest that an international collaborative study using the same definition of EGJ adenocarcinoma may be helpful not only for clarifying the characteristics of these cancers but also for improving the clinical outcome of these patients. (elsevierpure.com)
We evaluated the clinical impact of the preoperative platelet-to-lymphocyte ratio (PLR) in patients with resectable esophageal cancer who received curative treatment. (iiarjournals.org)
Conclusion: The PLR had a clinical impact on the long-term oncological outcomes of patients with esophageal cancer treated with curative intent. (iiarjournals.org)
A listing of 8 Head and Neck Cancer clinical trials in Wisconsin actively recruiting volunteers for paid trials and research studies in various therapeutic areas. (policylab.us)
Knowing the relevance of this issue and the contradictions present in the literature, it is necessary to search for a better understanding of the clinical and epidemiological differences between cardia and gastric antral cancer. (gavinpublishers.com)
Antireflux surgery and chemoprevention by proton pump inhibitors nonsteroidal anti-inflammatory drugs selective cyclooxygenase-2 inhibitors green tea retinoic acid and thioproline showed preventive effects on the development of Barrett's adenocarcinoma in rodent models but it remains controversial whether antireflux surgery could regress BE and prevent esophageal cancer in clinical observation. (techblessing.com)

For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)
IMRT has been compared with 3-dimensional conformal radiotherapy (3D-CRT) for the treatment of stomach, hepatobiliary, and pancreatic cancers. (bcbsnd.com)

Adenocarcinoma of the gastroesophageal junction (GEJ or GE junction, a specific part of the esophagus where the esophagus and stomach meet) is a specific subset of esophagus cancers . (medicinenet.com)
Adenocarcinoma of the GE junction describes cancers that arise either in the lower esophagus or upper stomach, very close to the GE junction. (medicinenet.com)
Esophageal cancer is cancer arising from the esophagus-the food pipe that runs between the throat and the stomach. (wikipedia.org)
It is most often used to treat cancers where the stomach and esophagus meet. (epnet.com)
OAGB, as all Omega-loop surgical strategies, is characterized by the direct anastomosis of the biliopancreatic loop to the stomach, instead of interposing an alimentary loop as in the Roux-en-Y procedures. (nature.com)
Biweekly fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) for patients with metastatic adenocarcinoma of the stomach or esophagogastric junction: a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie. (helsedirektoratet.no)
Gastroesophageal junction adenocarcinoma, a form of cancer that is located in the region where the esophagus joins the stomach, is also rare, but equally lethal. (southcarolinablues.com)
Esophageal and Esophagogastric Junction Cancers (Excluding the proximal 5 cm of the stomach) V.2.2013. (medscape.com)
A Case of Secondary Achalasia due to Recurrence of Stomach Cancer. (whocc.org.cn)
For correct diagnosis and treatment, explorolaparotomy was performed and it was diagnosed as secondary achalasia due to recurrence of stomach cancer. (whocc.org.cn)

Squamous cell cancer of the esophagus is related to the use of alcohol and tobacco products, both smoke and smokeless. (medicinenet.com)
In the past, squamous cell cancer was the most common worldwide, but that has changed. (medicinenet.com)
Adenocarcinoma is more common than squamous cell cancer in western countries, including the U.S. The reason for this change has yet to be determined. (medicinenet.com)
Small localized squamous-cell cancers may be treated with surgery alone with the hope of a cure. (wikipedia.org)
Until the 1970s, the most common type of esophageal cancer in the United States was squamous cell carcinoma, which has smoking and alcohol consumption as risk factors. (medscape.com)
Garg N, Stoehr C, Zhao YS, Rojas H and Hsueh CT: Metastatic squamous cell carcinoma of colon from esophageal cancer. (spandidos-publications.com)

For staging information, see Esophageal Cancer Staging . (medscape.com)

First-line treatment (in combination with erlotinib) of metastatic non-small cell lung cancer in patients whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations. (southcarolinablues.com)
Conventionally, proximal tumors (Esophagogastric Junction (EGJ)) are distinguished from distal tumors. (gavinpublishers.com)
Proximal and distal adenocarcinomas are known to have different behaviors and manifestations, but the literature shows discrepant data on such aspects in this type of cancer, especially regarding proximal tumors [4]. (gavinpublishers.com)
For tumors of the gastroesophageal junction, the letter U was associated with the word cardia (II or III). (gavinpublishers.com)

Sentinel lymph node mapping with GI cancer. (nih.gov)
For patients with resectable locoregional cancer, the guidelines recommend gastrectomy with a D1+ or a modified D2 lymph node dissection (performed by experienced surgeons in high-volume centers). (jnccn.org)

Niknejad M, Distal esophageal cancer. (radiopaedia.org)

After 30 weeks of follow-up, Wistar rats operated on RYGB, OAGB with a short BPL (15 cm, OAGB-15), or a long BPL (35 cm, OAGB-35), and unoperated rats exhibit no cases of esogastric cancer, metaplasia, dysplasia, or Barrett's esophagus. (nature.com)

EAC is a highly lethal cancer that can arise from Barrett's oesophagus, a relatively common, pre-cancerous metaplastic condition that affects around 1.6% of the US population 7 . (nature.com)

For individuals who have gastrointestinal (GI) tract cancers who receive IMRT, the evidence includes nonrandomized comparative studies, retrospective series, and a systematic review. (bcbsnd.com)

A complaint of dysphagia in an adult should always prompt an endoscopy to help rule out the presence of esophageal cancer. (medscape.com)
This first edition book on 'Esophageal Cancer' which contains a diverse range of articles taken from AME journals and include authors with expertise in molecular biology, diagnosis and treatment, therapeutic endoscopy, surgery, radiotherapy and medical treatment, and prognosis. (amegroups.com)

Inflammation plays a pivotal role in cancer development and prognosis. (researchsquare.com)

Despite an overall decline in its incidence in recent decades, gastric adenocarcinoma remains the fourth most common type of cancer and the second or third leading cause of cancer-related deaths worldwide. (gavinpublishers.com)

There has been a shift in the type of esophageal cancer that is now prevalent in the United States and Western Europe. (medicinenet.com)

AJCC Cancer Staging Manual. (cancer.gov)

Difficulty swallowing and cough are symptoms of esophageal cancer. (medicinenet.com)

Zev Wainberg, MD, of the University of California, Los Angeles Medical Center, discusses preliminary data on the safety and efficacy of TTX-030, an anti-CD39 antibody, in combination with budigalimab and FOLFOX for the first-line treatment of locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma. (ascopost.com)
To compare active surveillance with standard surgery, the team conducted a phase 3 noninferiority stepped-wedge cluster randomized trial involving patients with locally advanced esophageal cancer. (medscape.com)

Using whole-genome sequencing to contrast genomic alterations in patients with stable Barrett's esophagus compared to patients whose Barrett's progressed to esophageal adenocarcinoma, Paulson et al reported that DNA changes presaging esophageal cancer can be spotted years before cancer develops. (ascopost.com)
In the Cambridge cohorts, the frequency of ecDNA increased between Barrett's-oesophagus-associated early-stage (24%) and late-stage (43%) EAC, suggesting that ecDNA is formed during cancer progression. (nature.com)
The Chemoprevention for Barrett's Esophagus Trial (CBET) a phase IIb multicenter randomized double-masked study using celecoxib in patients with Barrett's dysplasia failed to prove to prevent progression of dysplasia to cancer. (techblessing.com)

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. (medscape.com)
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. (spandidos-publications.com)
10 ] reported a reduced incidence (25.5%) of grades 3 and 4 neutropenia and no cases of FN in a phase I/II trial of biweekly DCF (bDCF) regimen for metastatic esophageal cancer without a decrease in antitumor activity of the standard DCF therapy. (biomedcentral.com)

We precisely defined Siewert type based on pathological mapping and macroscopic measurements of the distance between the tumour epicentre and the esophagogastric junction. (biomedcentral.com)

At present, it is unclear whether ecDNA is a later manifestation of genomic instability, or whether it can be an early event in the transition from dysplasia to cancer. (nature.com)
Our findings show that ecDNA can develop early in the transition from high-grade dysplasia to cancer, and that ecDNAs progressively form and evolve under positive selection. (nature.com)
However, the relative paucity of pre-cancer-to-cancer longitudinal studies, together with the challenges of interpreting clonality in the face of non-Mendelian genetics, have made it difficult to determine whether ecDNAs arise early in tumorigenesis and contribute to the transformation of dysplasia into cancer. (nature.com)
at the proliferative zone progresses to dysplasia and finally adenocarcinoma and exogenous carcinogen is not necessary for cancer development. (techblessing.com)

Shaheen O, Ghibour A and Alsaid B: Esophageal cancer metastases to unexpected sites: A systematic review. (spandidos-publications.com)
Ai D, Zhu H, Ren W, Chen Y, Liu Q, Deng J, Ye J, Fan J and Zhao K: Patterns of distant organ metastases in esophageal cancer: A population-based study. (spandidos-publications.com)

Consequences of Refusing Surgery for Esophageal Cancer: A National Cancer Database Analysis. (medscape.com)
Surgery alone versus chemoradiotherapy followed by surgery for stage I and II esophageal cancer: final analysis of randomized controlled phase III trial FFCD 9901. (springer.com)
Characteristics and correlates of increasing use of surgery in Taiwanese cancer patients' last month of life, 2001-2010. (springer.com)
This study compared the long-term consequences of two common forms of bariatric surgery: one-anastomosis gastric bypass (OAGB) and Roux-en-Y Gastric Bypass (RYGB) in a preclinical rat model. (nature.com)
Can Some Patients With Esophageal Cancer Avoid Surgery? (medscape.com)
These data suggest that this model can help in the decision-making process when esophageal cancer surgery is being considered and in informed consent. (elsevierpure.com)

Aetna considers percutaneous ethanol injection (PEI) medically necessary for the treatment of hepatocellular cancers (HCC) without extra-hepatic spread. (aetna.com)

Current targeted therapy options for esophageal cancer include trastuzumab and ramucirumab. (epnet.com)

The treatment of localized esophageal cancer mandates a multidisciplinary approach, with treatment tailored to disease extent, location, histology, and an accurate assessment of pretreatment staging. (jnccn.org)
Cancer of the esophagus and esophagogastric junction: an eighth edition staging primer. (springer.com)
Accuracy of hydro-multidetector row CT in the local T staging of oesophageal cancer compared to postoperative histopathological results. (helsedirektoratet.no)
The TNM classification for the staging of esophageal cancer is provided below. (medscape.com)
SEER Summary Staging Manual-2000: Codes and Coding Instructions**, National Cancer Institute, NIH Pub. (cancer.gov)

Lung cancer is the leading cause of death from cancer in the United States and worldwide, with advanced NSCLC representing the majority of these cases (Garon, 2014). (southcarolinablues.com)
The NCI estimates 224,210 new cases and 159,260 deaths from lung cancer (NSCLC and SCLC combined) in the United States in 2014. (southcarolinablues.com)
It has been estimated that only 16% of all individuals with lung cancer will survive 5 years or more following diagnosis. (southcarolinablues.com)
Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer. (cdc.gov)

Preoperative chemoradiotherapy for esophageal or junctional cancer. (springer.com)

Multicenter phase 2: Capecitabine (CAP) + oxaliplatin (OX) + bevacizumab (BEV) + trastuzumab (TRAS) for patients (pts) with metastatic esophagogastric cancer (MEGCA). (springermedizin.at)

Anatomy11

Organisms1

Diseases17

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes3

Information Science2

Health Care3

Gastric Cancer33

Adenocarcinoma of the esophagogastric junction2

NCCN Clinical Practice Guidelines in1

Resection8

Metastasis5

Resectable gastric3

Oncology4

Survival17

Chemotherapy20

Colorectal cancer2

Oesophageal and gastric1

Esophagectomy3

Gastro-oesophageal jun1

Abstract1

Esophagus and gastroesophageal junction1

Clinical10

Pancreatic4

Stomach10

Squamous cell6

Esophageal Cancer Staging1

Tumors4

Lymph2

Distal1

Metaplasia1

Lethal1

Retrospective1

Endoscopy2

Prognosis1

Cause of cancer-related dea1

Type of esophageal cancer1

AJCC Cancer Staging Manual1

Symptoms of esophageal cancer1

Locally advanced2

Barrett's3

Incidence3

Tumour1

Dysplasia4

Metastases2

Surgery6

Hepatocellular1

Ramucirumab1

Staging5

Lung Cancer4

Chemoradiotherapy1

Trastuzumab1