Esophagogastric junction adenocarcinoma patients. Medical search. Frequent questions

The latter procedure, along with peritoneal lavage is recommended for stage IB-III patients before surgical resection ( 9 ). (frontiersin.org)
The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction - a phase III trial of the German AIO/CAO-V/CAOGI. (helsedirektoratet.no)
Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial. (helsedirektoratet.no)
In Hong Kong and Malaysia, many EGJ adenocarcinomas have been detected at a stage not amenable to endoscopic resection. (elsevierpure.com)
This international, multicenter, randomized, double-blind phase III study intends to recruit 680 patients who have received radical gastrectomy (R0 resection, D2 or more extended lymphadenectomy) with postoperative pathological stage II or III (AJCC Cancer Staging Manual, 8th Edition) gastric or EGJ adenocarcinoma to evaluate the efficacy and safety of JS001 combined with postoperative adjuvant chemotherapy versus placebo combined with postoperative adjuvant chemotherapy. (centerwatch.com)
Can multimodal treatment with tumor resection and metastasectomy combined with perioperative chemotherapy, increase the chances of survival in oligometastatic patients? (unige.ch)
The Dutch D1/D2 trial reported an increased median survival for a subgroup of patients with single metastasis who underwent resection. (unige.ch)
Multimodal treatment with resection doubled the median survival of oligometastatic patients in the German AIO-FLOT 3 study and as a consequence, the AIO-FLOT 5 (RENAISSANCE) trial was designed. (unige.ch)
Patients with oligometastatic gastric and esophagogastric junction cancer are randomized after chemotherapy to either undergo resection followed by adjuvant chemotherapy or to undergo definitive chemotherapy. (unige.ch)
The results of the ongoing randomized trials will show if oligometastatic patients benefit from a multimodal treatment with resection. (unige.ch)
Among the 53 patients, 3 patients underwent combined portal vein resection and reconstruction (end-to-end anastomosis). (bvsalud.org)
During the operation, 5 patients (9.43%) had transection of the middle colonic artery and underwent resection of part of the transverse mesocolon due to invasion of the transverse mesocolon by tumours. (bvsalud.org)
We compared the results of the randomly assigned nine patients from earlier ECF/ECX protocol (Group I). We analyzed the effect of the different neoadjuvant therapy on tumor regression, and evaluated the types of possible side effects, type of surgery, and the oncological radicality of surgical procedures (number of removed regional lymph nodes, resection margins). (akjournals.com)
In patients with small, discrete nodules or areas of dysplasia in whom disease appears limited to the mucosa or submucosa as assessed by endoscopic ultrasonography, endoscopic mucosal resection should be considered as a diagnostic/staging tool. (medscape.com)
In February 2022, the dosing of the first patient was completed in the Phase III clinical trial of TUOYI ® in combination with standard chemotherapy as the adjuvant treatment after radical resection of gastric or esophagogastric junction adenocarcinoma (JUPITER-15 study, NCT05180734). (cambodiatribune.com)
Outcomes were poor overall for patients with BM, but patients who underwent neurosurgical resection had improved survival. (elsevierpure.com)
The CGEO procedure has advantages for gastric tube reconstruction and side-to-side overlap anastomosis of the esophagus to gastric remnant and is suitable for radical resection of type II esophagogastric junction carcinoma or proximal gastric cancer. (cancerdiagnosisprognosis.org)

Ferguson MK, Durkin A. Long-term survival after esophagectomy for Barrett's adenocarcinoma in endoscopically surveyed and nonsurveyed patients. (medscape.com)
A reason for the reported difference in the incidence and time trend of EGJ adenocarcinoma among the three countries may be explained by two distinct etiologies: one arising from chronic gastritis similar to distal gastric cancer, and the other related to gastroesophageal reflux disease similar to esophageal adenocarcinoma including Barrett's adenocarcinoma. (elsevierpure.com)
Using whole-genome sequencing to contrast genomic alterations in patients with stable Barrett's esophagus compared to patients whose Barrett's progressed to esophageal adenocarcinoma, Paulson et al reported that DNA changes presaging esophageal cancer can be spotted years before cancer develops. (ascopost.com)
despite their increased risk of tumor formation, most patients who have Barrett's esophagus die of other causes. (pharmaceuticalintelligence.com)
Barrett's esophagus describes abnormal dysplasia and is thought to perhaps be a precursor to the development of further cell mutations and adenocarcinoma. (medicinenet.com)
Adenocarcinoma arises from glandular cells present in the lower third of the esophagus, often where they have already transformed to intestinal cell type (a condition known as Barrett's esophagus). (wikipedia.org)
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. (cdc.gov)
Antireflux surgery and chemoprevention by proton pump inhibitors nonsteroidal anti-inflammatory drugs selective cyclooxygenase-2 inhibitors green tea retinoic acid and thioproline showed preventive effects on the development of Barrett's adenocarcinoma in rodent models but it remains controversial whether antireflux surgery could regress BE and prevent esophageal cancer in clinical observation. (techblessing.com)
The Chemoprevention for Barrett's Esophagus Trial (CBET) a phase IIb multicenter randomized double-masked study using celecoxib in patients with Barrett's dysplasia failed to prove to prevent progression of dysplasia to cancer. (techblessing.com)

Guideline] NCCN Clinical Practice Guidelines in Oncology: Esophageal and Esophagogastric Junction Cancers. (medscape.com)

Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. (helsedirektoratet.no)
A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer. (helsedirektoratet.no)
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. (helsedirektoratet.no)
To evaluate the use of early assessment of chemotherapy responsiveness by positron emission tomography (PET) imaging to tailor therapy in patients with esophageal and esophagogastric junction adenocarcinoma. (unc.edu)
The effect of post-Cx% on survival outcomes adjusted for the types of chemotherapy and patient characteristics was evaluated by meta-regression. (deepdyve.com)
Patients meeting the inclusion criteria will be 1:1 randomized into JS001-chemotherapy group and placebo-chemotherapy group. (centerwatch.com)
In the phase III RATIONALE-302 trial reported in the Journal of Clinical Oncology, Shen et al found that the anti-PD-1 antibody tislelizumab significantly improved overall survival vs chemotherapy in the second-line treatment of patients with advanced or metastatic esophageal squamous cell. (ascopost.com)
Gulam A. Manji, MD, PhD, of Columbia University Medical Center, discusses phase II results on perioperative combination chemotherapy and pembrolizumab in patients with resectable gastric cancer. (ascopost.com)
The clear definition of the oligometastatic state, assessment of the response to neoadjuvant chemotherapy and realistic estimation of the R0 resectability will be useful for patient selection. (unige.ch)
Standardized treatment includes primary surgery with the objective to perform an optimal cytoreduction followed by chemotherapy Treatment must be individualized according to each patient. (bvsalud.org)
Recently the therapeutic treatment for advanced, stage T2-T4 gastro-oesophageal junction cancer and those adjacent to the regional lymph nodes involves neoadjuvant chemotherapy with subsequent surgical intervention. (akjournals.com)
Both Keytruda (pembrolizumab) and Opdivo (nivolumab) are being considered for a first-line therapy designation in combination with chemotherapy for patients with advanced or metastatic Esophageal Cancer. (ecan.org)
Opdivo (nivolumab) is being considered for approval as first-line therapy for patients with metastatic or advanced Esophageal Cancer in combination with fluoropyrimidine- (5 FU) and platinum-containing chemotherapy. (ecan.org)
Researchers assigned patients to nivolumab plus chemotherapy (FOLFOX), nivolumab plus ipilimumab (Yervoy) an anti-CTLA-4 monoclonal antibody, or chemotherapy alone. (ecan.org)
The nivolumab-chemotherapy regimen significantly improved overall survival and progression-free survival among patients whose tumors expressed programmed death ligand-1 (PD-L1 - the checkpoint target of Opdivo) with a combined positive score of 5 or higher. (ecan.org)
The FDA will decide on the efficacy of Keytruda (pembrolizumab), another PD-LI inhibitor, in combination with chemotherapy in patients with previously untreated advanced esophageal squamous cell carcinoma, esophageal adenocarcinoma, or esophagogastric junction adenocarcinoma. (ecan.org)
The application for approval is based upon the Keynote-590 study which found that overall survival was improved for all patients who received Keytruda with chemotherapy rather than chemotherapy alone. (ecan.org)
Patients with a PD-L1 combined positive score of 10 or more experienced the greatest benefit from the addition of Keytruda to their chemotherapy. (ecan.org)
The FRESCO-2 study was a multi-regional clinical trial conducted in the U.S., Europe, Japan and Australia that investigated fruquintinib plus best supportive care ("BSC") vs placebo plus BSC in patients with metastatic CRC who had progressed on standard chemotherapy and relevant biologic agents and who had progressed on, or were intolerant to, TAS-102 and/or regorafenib. (hutch-med.com)
Neoadjuvant chemotherapy for resectable oesophageal and junctional adenocarcinoma: results from the UK Medical Research Council randomised OEO5 trial (ISRCTN 01852072). (springermedizin.at)
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial.Lancet 376: 687-697, 2010. (springermedizin.at)
A potential alternative for adenocarcinoma tumors at the gastroesophageal junction is perioperative chemotherapy. (cancernetwork.com)
DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy. (cdc.gov)
During the past decade perioperative chemotherapy, pre- or postoperative radio-chemotherapy, and, in Asian populations, adjuvant chemotherapy have been shown to improve the outcome of patients with advanced GC and GEJ cancers suited for surgery. (docksci.com)
The introduction of trastuzumab in combination with platinum/ﬂuoropyrimidine-based chemotherapy for patients with HER2-positive disease has marked a turning point. (docksci.com)

Cancers originating in the esophagus or esophagogastric junction constitute a major global health problem. (jnccn.org)
Duodenum or jejunum is definitely anastomosed with blind end of esophagus or esophagogastric junction. (techblessing.com)

Here, we show that MUC16 expression is associated with disease progression, basal-like and squamous tumor subtypes, increased tumor metastasis, and short-term survival of PDAC patients. (unc.edu)
The surgical treatment of adenocarcinoma of the esophagogastric junction surgical treatment (AGEJ) is still controversial, particularly concerning to survival and postoperative complications. (usp.br)
Systemic therapy can provide palliation, improved survival, and enhanced quality of life in patients with locally advanced or metastatic disease. (jnccn.org)
Delays in surgery for esophageal cancer did not appear to have much impact on patients' relative survival for early-stage cancer compared with patients who had surgery early, but they did reduce the relative survival rate by almost half for patients with more advanced disease, according to an. (ascopost.com)
The aim of this study was to evaluate the relationship between the monocyte count assessed at diagnosis and disease-free survival and prognosis in patients with esophageal cancer. (researchsquare.com)
Disease-free survival was 17.3 months (95% CI: 8.4-26.2) in patients with a monocyte count ≥515/μL as opposed to 38.5 months (95% CI: 28. (researchsquare.com)
Our findings showed that monocyte count is a prognostic factor affecting disease-free survival in patients with esophageal cancer, regardless of histological subtype. (researchsquare.com)
In the present study, we aimed to investigate whether the monocyte count measured at the time of diagnosis can be used as a new prognostic biomarker in predicting disease-free survival in patients with esophageal cancer. (researchsquare.com)
The current results provide the first clinical evidence that CCRT coupled with IGRT is associated with better overall survival when compared with CCRT without IGRT in NOL-ESCC patients. (oncotarget.com)
Aim: In this study, we aimed to present our 10-year experience regarding clinicopathology characteristics and overall survival of 69 patients with adenocarcinomas of esophag ogastric junction (AEJs). (selcukmedj.org)
Even in patients who do respond, the duration of response is often short, and their survival is quite limited. (canjhealthtechnol.ca)
Evidence from 1 phase III, randomized, double-blind, placebo-controlled trial demonstrated that treatment with pembrolizumab plus cisplatin and 5-fluorouracil (5-FU) resulted in added survival benefit when used for the first-line treatment of patients with locally advanced unresectable or metastatic adenocarcinoma or squamous cell carcinoma of the esophagus or advanced or metastatic Siewert type I adenocarcinoma of the EGJ. (canjhealthtechnol.ca)
When compared to patients who did not receive Opdivo, progression-free survival was doubled and the risk of recurrence or death was reduced by 31% in the group that received Opdivo. (ecan.org)
The clinicopathologic data, short-term survival prognosis, and results of patients in the hand-sewn anastomosis ( n =20) and the overlap anastomosis ( n =30) groups were analyzed. (biomedcentral.com)
After 2 years, researchers found no significant differences in overall and disease-free survival between patients on active surveillance and those who received surgery either immediately following neoadjuvant chemoradiotherapy or who switched from active surveillance to surgery. (medscape.com)
Overall, patients who underwent active surveillance had "noninferior overall survival at 2 years," said Berend J. Van der Wilk, PhD candidate, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands, who presented the findings at the European Society for Medical Oncology (ESMO) Annual Meeting 2023 on October 20. (medscape.com)
The potential pitfalls of an active surveillance approach is that patients may develop unresectable tumor regrowths, "possibly resulting in inferior overall survival. (medscape.com)
Long-term survival is poor except for patients with local disease. (msdmanuals.com)

The Society of Thoracic Surgeons practice guidelines on the role of multimodality treatment for cancer of the esophagus and gastroesophageal junction. (medscape.com)
A single-institution retrospective review identified 583 patients treated from January 1997 to January 2016 for stages I through IV cancer of the esophagus and esophagogastric junction (follow-up, ≥3 months). (elsevierpure.com)
The CROSS trial, conducted in the Netherlands, reported a pathologic response rate of almost 50% for patients with squamous cell cancer of the esophagus who received chemoradiation. (cancernetwork.com)

Zev Wainberg, MD, of the University of California, Los Angeles Medical Center, discusses preliminary data on the safety and efficacy of TTX-030, an anti-CD39 antibody, in combination with budigalimab and FOLFOX for the first-line treatment of locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma. (ascopost.com)

Liquid biopsy: The genomic alterations of solid cancers can be identified by evaluating circulating tumor DNA (ctDNA) in the blood This procedure is used more in patients who cannot undergo traditional biopsy, but can also be performed in other patients to gather more evidence for management. (medscape.com)
Bleeding - Patients may experience bleeding from the tumor leading to iron deficiency anemia. (medscape.com)
Esophageal cancers are histologically classified as squamous cell carcinoma (SCC) or adenocarcinoma, which differ in their etiology, pathology, tumor location, therapeutics, and prognosis. (jnccn.org)
The random stratification factors include adjuvant chemotherapeutic regimens (XELOX versus SOX) and tumor anatomical sites (gastric adenocarcinoma versus gastroesophageal junction adenocarcinoma). (centerwatch.com)
Accumulating evidence shows that in addition to the characteristics of the tumor, the immune response of the patient is also highly important for determining the prognosis. (researchsquare.com)
After 24 months of interventional treatment, the preoperative sCD28 level was lower in patients with recurrent tumor recurrence than in patients without recurrence ( t=2.843, P=0.007). (bvsalud.org)
and a type III tumor is a proximal gastric cancer extending upwards to the gastroesophageal junction. (cancernetwork.com)
A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation. (cdc.gov)

Lymph node metastasis is an important clinical issue in AEG patients. (biomedcentral.com)
Aberrant expression of CA125/MUC16 is associated with pancreatic ductal adenocarcinoma (PDAC) progression and metastasis. (unc.edu)
We investigated whether the incidence of brain metastasis (BM) from primary esophageal and esophagogastric cancer is increasing. (elsevierpure.com)

However, it is important to note that in both cases patients were suffering from chronic reflux before and after the surgery. (nature.com)

A total of 117 patients who underwent curative surgery for AEG, classified as Siewert type I or II, at our institute between 2000 and 2016 were included in this study. (biomedcentral.com)
Material and Methods: Retrospective comparisons were made between the preoperative blood parameters (NLR, PLR, and SII) and clinicopathological features of 133 patients who underwent surgery for a localized laryngeal lesions between 01.03.2010-31.06.2021. (kbb-bbc.org.tr)
Objective:To study the retrocolonic approach for laparoscopic pancreaticoduodenec-tomy (LPD).Methods:The clinical data of 53 patients who underwent LPD using the retrocolonic approach at the Second Hospital of Hebei Medical University from January 2019 to December 2021 were analyzed retrospectively. (bvsalud.org)
Case Report: In June 2022, two patients with Siewert type II carcinoma of esophagogastric junction underwent laparoscopic proximal gastrectomies, using a novel esophagogastrostomy technique of Conical remnant GastroEsophageal side-Overlap fundoplication (CGEO). (cancerdiagnosisprognosis.org)
The clinical data of 50 patients who underwent totally laparoscopic total gastrectomy, with an average follow-up time of 12 months, were collected. (biomedcentral.com)
Therefore, we recorded the number of patients who underwent TLTG with hand-sewn anastomosis and with overlap anastomosis from January 2017 to January 2020. (biomedcentral.com)
Clinical and pathological data of 50 patients who underwent TLTG in the Third Affiliated Hospital of Harbin Medical University from January 2017 to January 2020 were collected. (biomedcentral.com)
Overall, 198 patients underwent active surveillance, and 111 patients underwent standard surgery. (medscape.com)

Targeted therapies including trastuzumab, nivolumab, ipilimumab, and pembrolizumab have produced encouraging results in clinical trials for the treatment of patients with locally advanced or metastatic disease. (jnccn.org)
Keytruda should only be covered to treat adult patients who have not received previous treatment for advanced or metastatic esophageal or EGJ cancer and who have good performance status. (canjhealthtechnol.ca)
This application is based on the results of the Checkmate-649 study which included patients with previously untreated, non-HER2-positive advanced or metastatic gastroesophageal junction cancer or esophageal adenocarcinoma. (ecan.org)
The FDA approved Keytruda for the treatment of patients with recurrent locally advanced or metastatic squamous cell carcinoma of the esophagus whose tumors express PD-L1 with a score of 10 or higher after they have experienced disease progression on one or more prior lines of systemic therapy. (ecan.org)

Multidisciplinary team management is essential for all patients with locally advanced esophageal or esophagogastric junction cancers. (jnccn.org)
This selection from the NCCN Guidelines for Esophageal and Esophagogastric Junction Cancers focuses on the management of recurrent or metastatic disease. (jnccn.org)
Over 95% of gastric cancers are adenocarcinomas, which are typically classified based on anatomic location and histologic type. (jnccn.org)
We suggest that an international collaborative study using the same definition of EGJ adenocarcinoma may be helpful not only for clarifying the characteristics of these cancers but also for improving the clinical outcome of these patients. (elsevierpure.com)
Although cancers of the stomach ( gastric cancer ) have been steadily declining over the last 50 years, studies show the incidence of a cancer affecting the esophagus (esophageal adenocarcinoma) has risen by about 600% over the past few decades. (pharmaceuticalintelligence.com)
Adenocarcinoma of the gastroesophageal junction (GEJ or GE junction, a specific part of the esophagus where the esophagus and stomach meet) is a specific subset of esophagus cancers . (medicinenet.com)
Adenocarcinoma of the GE junction describes cancers that arise either in the lower esophagus or upper stomach, very close to the GE junction. (medicinenet.com)
First, what are the mainstay adjuvant and neoadjuvant therapy options for patients diagnosed with esophageal cancers? (cancernetwork.com)
In general, most patients who develop squamous cell cancers have comorbidities, since this is a cancer related to smoking and drinking. (cancernetwork.com)
Abstract Gastroesophageal cancers comprising gastric cancer (GC), and cancers of the distal oesophagus and gastroesophageal junction (GEJ) are a global health threat. (docksci.com)
1. Introduction Cancers of the stomach (GC), the gastroesophageal junction (GEJ) and the distal oesophagus are the second ⇑ Corresponding author at: Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. (docksci.com)

During regular endoscopic follow-up, multilevel circumferential biopsies should document the evolution of the histologic changes in the lower esophagus and at the gastroesophageal junction of these patients. (pharmaceuticalintelligence.com)

In patients with locally advanced (T3/T4) adenocarcinoma of the esophagogastric junction infiltrating the anatomic cardia or Siewart type III esophagogastric tumors, laparoscopy is recommended to improve the accuracy of staging. (medscape.com)
Patients with obstructing tumors are at increased risk for perforation during staging EUS. (medscape.com)
Conventionally, proximal tumors (Esophagogastric Junction (EGJ)) are distinguished from distal tumors. (gavinpublishers.com)
Proximal and distal adenocarcinomas are known to have different behaviors and manifestations, but the literature shows discrepant data on such aspects in this type of cancer, especially regarding proximal tumors [4]. (gavinpublishers.com)
For tumors of the gastroesophageal junction, the letter U was associated with the word cardia (II or III). (gavinpublishers.com)
With duodenoesophageal reflux 50 of tumors were adenocarcinoma in contrast to 100% squamous differentiation of tumors in rats given the carcinogens with esophagogastroplasty which was supposed to induce gastric reflux alone or no operation. (techblessing.com)

We precisely defined Siewert type based on pathological mapping and macroscopic measurements of the distance between the tumour epicentre and the esophagogastric junction. (biomedcentral.com)

It still is unclear if medicine or surgery provides the best quality of life and the best protection against the development of dysplasia and the possible progression toward adenocarcinoma formation when intestinal metaplasia is present in the esophagus. (pharmaceuticalintelligence.com)
3 Adenocarcinoma induced by Duodenoesophageal Reflux Only We were the first to statement development of columnar epithelial metaplasia and mucinous adenocarcinoma as Gimap5 well as squamous cell carcinoma using a rodent duodeno-forestomach or duodeno-glandular-forestomach reflux model to put duodenal juice into the esophagus without exogenous carcinogens [2]. (techblessing.com)

OAGB, as all Omega-loop surgical strategies, is characterized by the direct anastomosis of the biliopancreatic loop to the stomach, instead of interposing an alimentary loop as in the Roux-en-Y procedures. (nature.com)
Results of surgical therapy in esophagogastric junction adenocarcinoma. (pakmedinet.com)
In instances of upper gastric cancer or partial esophagogastric junction cancer, total gastrectomy is the standard surgical intervention ( Zhonghua Wei Chang Wai Ke Za Zhi 24(5) (2021)">3 ). (cancerdiagnosisprognosis.org)

MADRID - More than one third of patients with locally advanced esophageal cancer who have a complete clinical response to neoadjuvant chemoradiotherapy may be able to safely avoid major surgery, findings from the Dutch SANO-trial suggest. (medscape.com)
To compare active surveillance with standard surgery, the team conducted a phase 3 noninferiority stepped-wedge cluster randomized trial involving patients with locally advanced esophageal cancer. (medscape.com)

Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial. (helsedirektoratet.no)
Neoadjuvant oncological treatment for gastro-oesophageal junction cancer previously consisted of the intravenous administration of epirubicin, cisplatin and fluorouracil (ECF) or epirubicin, cisplatin and capecitabine (ECX) combination (Group I). In the course of the new protocol (FLOT-, F: 5-FU, L: leucovorin, O: oxaliplatin, T: docetaxel), patients were included with resectable gastro-oesophageal junction cancer who had a clinical-stage cT2 or higher nodal positive cN+ disease (Group II). (akjournals.com)
Pathological response to neoadjuvant 5-FU, oxaliplatin, and docetaxel (FLOT) versus epirubicin, cisplatin, and 5-FU (ECF) in patients with locally advanced, resectable gastric/esophagogastric junction (EGJ) cancer: Data from the phase II part of the FLOT4 phase III study of the AIO. (springermedizin.at)

Comparative effectiveness of image-guided radiotherapy for non-operated localized esophageal squamous cell carcinoma patients receiving concurrent. (oncotarget.com)
Although concurrent chemoradiotherapy (CCRT) coupled with image-guided radiotherapy (IGRT) is associated with a theoretical benefit in non-operated localized esophageal squamous cell carcinoma (NOL-ESCC) patients, there is currently no clinical evidence to support this. (oncotarget.com)
The two main sub-types of the disease are esophageal squamous-cell carcinoma (often abbreviated to ESCC), which is more common in the developing world, and esophageal adenocarcinoma (EAC), which is more common in the developed world. (wikipedia.org)

However, the resulting gastroesophageal reflux disease caused by the eradication of Helicobacter pylori (among various other factors) might potentially lead to an increase in the incidence of adenocarcinoma of the esophagogastric junction (AEG) worldwide [ 5 ]. (biomedcentral.com)
Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. (medscape.com)
Over the past four decades, the incidence of adenocarcinoma at the esophagogastric junction has increased significantly ( J Gastroenterol Hepatol 23(11) (2008)">1 , Ann Surg 263(1) (2016)">2 ). (cancerdiagnosisprognosis.org)

We retrospectively analysed 117 consecutive AEG patients (Siewert type I or II) who received a lymphadenectomy between 2000 and 2016. (biomedcentral.com)
The patients were divided into two groups as Siewert Type II and Siewert Type III. (selcukmedj.org)
Yalkin O, Iflazoglu N, Uzunoglu MY, Turhan EI, Nalbant M. Analysis of 69 Cases of Adenocarcinoma of the Esophagogastric Junction (Siewert Type II/III): 10- Year Single Center Experience. (selcukmedj.org)
Conclusion: CGEO is a feasible and safe reconstructive esophagogastrostomy procedure following laparoscopic proximal gastrectomy for Siewert type II esophagogastric junction carcinoma. (cancerdiagnosisprognosis.org)
Patient 1 was a 71-year-old man diagnosed with cancer (Siewert type II) of the esophagogastric junction, staged preoperatively as T3N0M0. (cancerdiagnosisprognosis.org)
Patient 2 was an 82-year-old man diagnosed with cancer (Siewert type II) of the esophagogastric junction. (cancerdiagnosisprognosis.org)

Palliative management, which may include systemic therapy, chemoradiation, and/or best supportive care, is recommended for all patients with unresectable or metastatic cancer. (jnccn.org)
As reported in the Journal of Clinical Oncology by Maron et al, a retrospective study found that use of EGFR inhibitor therapy was associated with benefit in patients with unresectable or metastatic EGFR-amplified gastroesophageal adenocarcinoma. (ascopost.com)

If approved, this would mean that for the first time, Esophageal Cancer patients would not have to experience disease progression on other treatments before getting the chance to receive immunotherapy. (ecan.org)
The AspECT (Aspirin Esomeprazole Chemoprevention Trial) a large multicenter phase III randomized trial to evaluate the effects of esomeprazole and/or aspirin on the rate of progression to high-grade dysplasia or adenocarcinoma in patients with BE is now ongoing. (techblessing.com)

Regarding the histological origin there are two types: the squamous cell carcinoma and the adenocarcinoma. (gavinpublishers.com)
Weight loss is often an initial sign in cases of squamous-cell carcinoma, though not usually in cases of adenocarcinoma. (wikipedia.org)
The two main types (i.e. squamous-cell carcinoma and adenocarcinoma) have distinct sets of risk factors. (wikipedia.org)
Among patients with BM, the primary histology was adenocarcinoma in 21 and squamous cell carcinoma in 1 (P = 0.30). (elsevierpure.com)
In the United States, by far the more common is adenocarcinoma, but we also see squamous cell carcinoma about 25% of the time. (cancernetwork.com)

Biweekly fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) for patients with metastatic adenocarcinoma of the stomach or esophagogastric junction: a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie. (helsedirektoratet.no)
The National Comprehensive Cancer Network (NCCN) guidelines and Memorial Sloan Kettering's internal guidelines both split the esophagus and the stomach at the gastroesophageal junction. (cancernetwork.com)
Although proximal gastrectomy allows for retention of distal stomach function, the anatomy of the esophagogastric junction is destroyed, and the capacity to prevent reflux is lost. (cancerdiagnosisprognosis.org)
Adenocarcinomas of the distal stomach are dominant in Eastern Europe, Asia and South America. (docksci.com)

Second-line and subsequent therapy may involve single agents (eg, taxanes) or molecular therapy, such as ramucirumab to target vascular endothelial growth factor (VEGF) receptor or trastuzumab for metastatic adenocarcinoma that overexpresses HER2. (medscape.com)
The implementation of biomarker testing, especially analysis of HER2 status, microsatellite instability status, and the expression of programmed death-ligand 1, has had a significant impact on clinical practice and patient care. (jnccn.org)
CADTH recommends that Keytruda should be reimbursed by public drug plans for the treatment of esophageal or human epidermal growth factor receptor 2 (HER2)-negative esophagogastric junction (EGJ) cancer that cannot be removed by surgery or is metastatic, if certain conditions are met. (canjhealthtechnol.ca)

Cardia adenocarcinoma is shown to affect male patients at a disproportionally higher rate [5]. (gavinpublishers.com)
The relationship with hormonal factors is curious, since there seems to be an association between higher concentrations of Dehydroepiandrosterone (DHEA), circulating estradiol and free estradiol and lower risks of cardia adenocarcinoma in men [6-9]. (gavinpublishers.com)
To conduct a comparative analysis of the clinical behavior of both cardia and antral adenocarcinomas. (gavinpublishers.com)

Based on public list prices, Keytruda is not considered cost-effective at a willingness-to-pay threshold of $50,000 per quality-adjusted life-year (QALY) for patients included in the indication approved by Health Canada, relative to cisplatin plus 5-FU. (canjhealthtechnol.ca)
Given all the evidence, pERC concluded that pembrolizumab plus cisplatin and 5-FU met some of the needs identified by patients because it provides an additional treatment option with improved OS and a manageable safety profile. (canjhealthtechnol.ca)
Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial. (springermedizin.at)
Untreated metastatic diffuse gastric adenocarcinoma (DGAC): Randomized phase III study of S-1 and cisplatin vs. 5-FU and cisplatin (the DIGEST trial). (springermedizin.at)

With regard to adjuvant and neoadjuvant treatment of esophageal and gastroesophageal adenocarcinomas, we very much continue to administer preoperative chemoradiation. (cancernetwork.com)
Patients received neoadjuvant chemoradiotherapy with carboplatin and paclitaxel for 5 weeks. (medscape.com)

Background In people with lower-extremity peripheral artery disease, the effects of exercise on patient-reported outcomes remain unclear. (unc.edu)
Image-guided radiotherapy (IGRT) is an advanced radiotherapy technology with great potential to improve patient outcomes via improved radiotherapy delivery [ 7 ]. (oncotarget.com)
Further comprehensive multicenter studies with larger series and long-term studies are needed to provide contribution to the existing evidence on outcomes of patients w ith AEJs. (selcukmedj.org)
We are very happy to see the positive outcomes of the FRESCO-2 study which offers a potential new treatment for patients with advanced metastatic colorectal cancer, where the unmet need is very high and patients have limited treatment options," said Dr Marek Kania, Executive Vice President, Managing Director and Chief Medical Officer of HUTCHMED International. (hutch-med.com)
Pharmacogenomic assessment of outcomes of pemetrexed-treated patients with adenocarcinoma of the lung. (cdc.gov)
Van der Wilk said those strong outcomes create some uncertainty as to whether all patients need standard surgery after chemoradiotherapy. (medscape.com)

JS001/placebo will be given for up to 17 cycles after surgery, until intolerable toxicity, disease recurrence, patient's withdrawal of consent, investigator's judgment that the patient needs to be withdrawn from the study treatment, or death, whichever comes first. (centerwatch.com)
Patients who have reflux disease are not necessarily symptomatic. (pharmaceuticalintelligence.com)
It should be performed only if the patient shows no evidence of M1 disease. (medscape.com)
Adenocarcinoma involves the lower third of the esophagus and is thought to be related to gastro- esophageal reflux disease ( GERD ). (medicinenet.com)
Input from patient groups indicated that patients desire new effective therapies that prolong OS, improve quality of life (QoL), reduce disease symptoms, and have tolerable side effects. (canjhealthtechnol.ca)
Esophageal Cancer patients who undergo esophagectomy but fail to achieve a pathologic complete response are at substantial risk for recurrence of their disease. (ecan.org)
On the other hand, the adenocarcinoma seems to be related to obesity, H. pylori infection, reflux disease and also to alcohol [15,16]. (gavinpublishers.com)
BMdeveloped in 12 who were initially treated for locally advanced disease and in 10 stage IV patients who presented with distant metastases. (elsevierpure.com)
The goals of pharmacotherapy are to prevent complications and to reduce morbidity in patients with gastroesophageal reflux disease (GERD). (medscape.com)
Additional H2 blocker therapy has been reported to be useful in patients with severe disease (particularly those with Barrett esophagus) who have nocturnal acid breakthrough. (medscape.com)

By meeting the primary endpoint of OS with a secondary endpoint of PFS, fruquintinib provides a significant potential new option for our refractory colorectal cancer patients. (hutch-med.com)
Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma. (cdc.gov)
Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma. (cdc.gov)

Adenocarcinoma occurs in the distal esophagus. (msdmanuals.com)

NGS: When limited tissue is available for testing or if the patient cannot undergo traditional biopsy, the use of limited molecular diagnostic panels may quickly exhaust the sample. (medscape.com)

Postoperative complications (dynamic ileus, abdominal infection, and pancreatic leakage) occurred in three patients (15%) in the hand-sewn anastomosis group and in four patients (13.3%) in the overlap anastomosis group (anastomotic leakage, anastomotic bleeding, dynamic ileus, and duodenal stump leakage). (biomedcentral.com)
MTHFR C677T polymorphism in chronic pancreatitis and pancreatic adenocarcinoma. (cdc.gov)

Multicenter phase 2: Capecitabine (CAP) + oxaliplatin (OX) + bevacizumab (BEV) + trastuzumab (TRAS) for patients (pts) with metastatic esophagogastric cancer (MEGCA). (springermedizin.at)

Background: There is currently no universally-accepted, ideal method of esophagogastric reconstruction to address reflux esophagitis and anastomotic complications of esophagogastrostomy after proximal gastrectomy. (cancerdiagnosisprognosis.org)

The Checkmate-577 study provided Opdivo (nivolumab) to Esophageal Cancer patients who had undergone chemoradiation and esophagectomy but did not achieve a pathologic complete response. (ecan.org)
The number of Esophageal Cancer patients who achieve a pathologic complete response after esophagectomy is relatively low. (ecan.org)
An FDA decision is expected by May 20th on this application for treating patients who have undergone esophagectomy with Opdivo. (ecan.org)

at the proliferative zone progresses to dysplasia and finally adenocarcinoma and exogenous carcinogen is not necessary for cancer development. (techblessing.com)

[ 70 ] In a study that compared the role of CT, EUS, and EUS-FNA for preoperative nodal staging in 125 patients with esophageal cancer, EUS-FNA was more sensitive than CT (83% vs. 29%) and more accurate than CT (87% vs. 51%) or EUS (87% vs. 74%) for nodal staging. (medscape.com)
The standard of care for esophageal adenocarcinoma remains preoperative chemoradiation. (cancernetwork.com)

In contrast to esophageal adenocarcinoma, which usually affects the lower esophagus, esophageal SCC is more likely to localize at or higher than the tracheal bifurcation. (jnccn.org)

In the present review, we focus on the current clinical situation of EGJ adenocarcinoma in three Asian countries: Japan, Hong Kong, and Malaysia. (elsevierpure.com)
This review also shows that there are several concerns in clinical practice for EGJ adenocarcinoma. (elsevierpure.com)
In other words, Van der Wilk asked, "Should we be willing to follow an active surveillance, organ-sparing strategy for patients with a clinical response? (medscape.com)
More than 300 patients who achieved a complete clinical response 12 weeks after completing chemoradiotherapy were randomly assigned to undergo standard surgery or active surveillance. (medscape.com)
It is demonstrated that duodenal juice rather than gastric juice is essential to develop esophageal adenocarcinoma in not only rodent experiments but also clinical studies. (techblessing.com)

Conclusions:The expression patterns of soluble immune checkpoint molecules varied in patients at different stages of primary liver cancer, suggesting that there were differences in their immune status and sCD28 could be used as a prognostic marker for postoperative recurrence of liver cancer. (bvsalud.org)

Many patients do not respond to available treatment options. (canjhealthtechnol.ca)
The U.S. FDA granted Fast Track Designation for the development of fruquintinib for the treatment of patients with metastatic CRC in June 2020 . (hutch-med.com)
A total of 584 patients were included, of whom 347 started treatment. (cancercentrum.se)
The low proportions of patients starting treatment within the target times indicates a great need for improvement. (cancercentrum.se)

Adenocarcinoma is more common than squamous cell cancer in western countries, including the U.S. The reason for this change has yet to be determined. (medicinenet.com)

Anatomy4

Diseases9

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes2

Resection17

Barrett's9

NCCN Clinical Practice Guidelines in1

Chemotherapy25

Esophagus or esophagogastric junction2

Survival18

Cancer of the es3

Gastric or gastroesophageal junction adenocarcinoma1

Tumor8

Metastasis3

Suffering from c1

Underwent8

Advanced or metastatic4

Cancers11

Endoscopic1

Tumors6

Tumour1

Metaplasia2

Surgical3

Locally advanced esophageal2

Resectable3

Esophageal squamous3

Incidence of adenocarcinoma3

Siewert6

Unresectable or metastatic2

Progression2

Carcinoma5

Stomach4

HER23

Cardia3

Cisplatin4

Neoadjuvant2

Outcomes6

Disease10

Colorectal3

Distal esophagus1

Biopsy1

Pancreatic2

Trastuzumab1

Reflux esophagitis1

Esophagectomy3

Dysplasia1

Preoperative2

Lower esophagus1

Clinical5

Prognostic1

Treatment4

Squamous cell cancer1