Esophageal squamous cell carcinoma. Medical search. Frequent questions

Thrombospondin type 1 domain-containing 7A ( THSD7A ) was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). (hindawi.com)
SCARA5 promoted cell proliferation and migration but inhibited apoptosis in ESCC. (hindawi.com)
Therefore, it is important to explore candidate genes that could have significance to the clinical diagnosis, as well as the treatment of esophageal squamous cell carcinoma (ESCC) at the molecular level [ 4 ]. (hindawi.com)
The benefits of neoadjuvant chemoradiation (NCRT) compared to upfront esophagectomy (UE) in esophageal squamous cell carcinoma (ESCC) is controversial. (springer.com)
Background: The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. (lu.se)
Neoadjuvant chemotherapy (NAC) followed by surgery is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). (biomedcentral.com)
Esophageal squamous cell carcinoma (ESCC) is a malignancy with poor prognosis that requires extensive treatment. (biomedcentral.com)
A retrospective medical chart review was conducted for older patients with locally advanced ESCC who received anticancer therapy between January 2012 and December 2012 at 22 medical centers (including 10 university hospitals and 10 cancer-specific hospitals), participating institutions of the Japanese Esophageal Oncology Group. (biomedcentral.com)
Dysfunction of the Hippo pathway is common in esophageal squamous carcinoma (ESCC). (aging-us.com)
Here, we demonstrated that chaetocin dramatically inhibited the proliferation in ESCC cells by causing cycle arrest in the M phase and activating the caspase-dependent apoptosis signaling pathway in vitro , and we also found that chaetocin induced the accumulation cellular reactive oxygen species (ROS). (aging-us.com)
We further revealed that chaetocin triggered the activation of Hippo pathway in ESCC cells, which is characterized by elevated phosphorylation levels of almost all core proteins in Hippo pathway, such as MST1 (Thr183), MST2 (Thr180), MOB1 (Thr35), LAST1 (Thr1079 and Ser909) and YAP (Ser127), ultimately leading to decreased nuclear translocation of YAP. (aging-us.com)
Moreover, the MST1/2 inhibitor XMU-MP-1 not only partially rescued the inhibitory effect chaetocin-induced proliferation, but also rescued the chaetocin-induced apoptosis in ESCC cells. (aging-us.com)
Esophageal cancer is the eighth most common cancer worldwide and esophageal squamous cell carcinoma (ESCC) is the predominant type in Asia. (hku.hk)
In this chapter, we summarize circulating cancer biomarkers including circulatory proteins, microRNAs, and tumor cells that are found to have elevated level in serum and plasma of ESCC patients when compared to healthy subjects. (hku.hk)
The aim of this study was to identify prognostic long non-coding RNAs (lncRNAs) and develop a multi-lncRNA signature for suvival prediction in esophageal squamous cell carcinoma (ESCC). (researchsquare.com)
Along with the clinical symptoms of early esophageal squamous cell carcinoma are not obvious and can be easily ignored by patients, most ESCC patients are diagnosed in advanced stages. (researchsquare.com)
Although concurrent chemoradiotherapy (CCRT) coupled with image-guided radiotherapy (IGRT) is associated with a theoretical benefit in non-operated localized esophageal squamous cell carcinoma (NOL-ESCC) patients, there is currently no clinical evidence to support this. (oncotarget.com)
This study aims to identify possible genes associated with esophageal squamous cell carcinoma (ESCC) by bioinformatics tool and further explore the function of immunoglobulin heavy chain variable family 4 gene (IGHV4)-28 in the ESCC progression. (highwire.org)
Of the two main histological types, esophageal squamous cell carcinoma (ESCC) is globally predominant, especially in Asia where it accounts for 90% of all EC cases, while esophageal adenocarcinoma (EAC), the incidence of which has promptly increased, is the most common subtype in Western countries. (highwire.org)
Knockdown of IGHV4-28 promoted cell proliferation, migration, and invasion of ESCC cells. (highwire.org)
Merck has announced that it has received approval from the Chinese National Medical Products Administration (NMPA) in China for Keytruda (pembrolizumab) for treating patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC), whose tumors express PD-L1. (ipharmacenter.com)
Esophageal cancer may be due to either esophageal squamous-cell carcinoma (ESCC) or adenocarcinoma (EAC). (wikipedia.org)
Prostaglandin-2 (PGE-2), one of the products of cyclooxygenase-2 (COX-2) induced catalysis, may play a critical role in the carcinogenesis of esophageal squamous cell carcinoma (ESCC). (archivesofmedicalscience.com)
Platinum-based regimens have been routinely used in the clinical treatment of patients with esophageal squamous cell carcinoma (ESCC). (figshare.com)
The sensitivity of ESCC cell lines to cisplatin was related to their activity of Shh signaling. (figshare.com)
Manipulating of Shh expression markedly changed the sensitivity of ESCC cells to platinum. (figshare.com)
Continuous treatment with cisplatin resulted in the activation of Shh signaling and enhanced cancer stem cell-like phenotypes in ESCC cells. (figshare.com)
Treatment with DHA attenuated the cisplatin-induced activation of the Shh pathway in ESCC cells and synergized the inhibitory effect of cisplatin on proliferation, sphere and colony formation of ALDH-positive ESCC cells in vitro and growth of ESCC cell-derived xenograft tumors in vivo. (figshare.com)
Esophageal squamous cell carcinoma (ESCC) has a poor prognosis and is one of the deadliest gastrointestinal malignancies. (biomedcentral.com)
The development of esophageal squamous cell carcinoma (ESCC) progresses a multistage process, collectively known as precursor lesions, also called dysplasia (DYS) and carcinoma in situ (CIS), subsequent invasive lesions and final metastasis. (biomedcentral.com)
To confirm the immunohistochemical results, three proteins, fascin, CK14 and laminin-5γ2, which were overexpressed in ESCC on tissue microarray, were detected in 12 ESCC cell lines by Western blot assay. (biomedcentral.com)
A multistage process has been proposed for the evolution of esophageal squamous cell carcinoma (ESCC), in which normal squamous epithelia undergo a series of histological and genetic progression towards noninvasive precursor lesions, i.e., dysplasia (DYS) and carcinoma in situ (CIS), then towards invasive cancer, and, finally towards deep invasion and metastasis to lymph nodes and other organs. (biomedcentral.com)
Although cDNA microarray has been successfully used to explore the gene expression in ESCC, it is difficult to be used in the precursor lesions due to the difficulty to obtain the dysplastic cells accurately. (biomedcentral.com)
Better understanding of esophageal precancerous lesions (EPL) can inform prevention strategies for esophageal squamous cell carcinoma (ESCC). (figshare.com)
Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due to the paucity of effective targeted therapy. (biomedcentral.com)
ESCC is believed to arise from cancer stem cells (CSCs) that contribute to metastasis and chemoresistance. (biomedcentral.com)
Moreover, the overexpression of LEF1 was observed in esophageal CSCs purified by the magnetic sorting of adherent and spheroidal ESCC cells. (biomedcentral.com)
The increased level of LEF1 in CSCs facilitated the expression of CSC markers, stem cell-like properties, resistance to chemotherapy, and tumorigenicity and increased the percentage of CSCs in ESCC samples. (biomedcentral.com)
Quantification of the association between alcohol drinking and risk of esophageal squamous cell carcinoma (ESCC) is an open issue, particularly among light alcohol drinkers, never-smokers, and Asian populations, in which some high-risk polymorphisms in alcohol metabolizing genes are more prevalent. (unimib.it)
This article investigates the role of Transgelin (TAGLN) in the epithelial-mesenchymal transition (EMT) of esophageal squamous cell carcinomas (ESCC) and its possible mechanism of inhibiting the invasion of these cancers. (figshare.com)

Endoscopic submucosal dissection (ESD) permits removal of esophageal epithelial neoplasms en bloc , but is associated with esophageal stenosis, particularly when ESD involves the entire circumference of the esophageal lumen. (biomedcentral.com)

Until the 1970s, the most common type of esophageal cancer in the United States was squamous cell carcinoma, which has smoking and alcohol consumption as risk factors. (medscape.com)
Squamous cell carcinoma is the most common histological type of esophageal cancer in China. (biomedcentral.com)

Since then, there has been a steep increase in the incidence of esophageal adenocarcinoma, for which the most common predisposing factor is gastroesophageal reflux disease (GERD). (medscape.com)
According to the above explanations, we tried to prepare and formulate a chemotherapeutic drug (gold nanoparticles in aqueous medium using Rhus coriaria L. fruit aqueous extract) for the treatment of several types of esophageal cancer including human esophageal squamous cell carcinoma, human Caucasian esophageal carcinoma, adenocarcinoma of the gastroesophageal junction, and distal esophageal adenocarcinoma. (ac.ir)
To survey the cytotoxicity and anti-esophageal cancer effects of HAuCl4, R. coriaria aqueous extract, and gold nanoparticles, dye compound 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidefor (MTT) assay was used on the human esophageal squamous cell carcinoma (KYSE-270), human Caucasian esophageal carcinoma (OE33), adenocarcinoma of the gastroesophageal junction (ESO26), and distal esophageal adenocarcinoma (FLO-1) cell lines. (ac.ir)
After approving the above results in the clinical trial studies, these gold nanoparticles can be used as a chemotherapeutic drug for the treatment of several types of esophageal cancer such as human esophageal squamous cell carcinoma, human Caucasian esophageal carcinoma, adenocarcinoma of the gastroesophageal junction, and distal esophageal adenocarcinoma. (ac.ir)
Worldwide, squamous cell carcinoma is predominant, while in Western countries, esophageal adenocarcinoma is most prevalent. (medscape.com)
The incidence and mortality of esophageal adenocarcinoma has been rising for several decades, Konda said. (medscape.com)
Barrett's esophagus is a known risk factor for esophageal adenocarcinoma. (medscape.com)
There is general agreement among the guidelines that patients with chronic GERD and multiple other risk factors associated with esophageal adenocarcinoma should undergo upper gastrointestinal endoscopy to screen for Barrett esophagus or esophageal adenocarcinoma. (medscape.com)
The 2019 ASGE guideline found insufficient evidence on the effectiveness of screening for Barrett esophagus, but suggested that if screening endoscopy is performed, it should be done in an at-risk population, defined as individuals with a family history of esophageal adenocarcinoma or Barrett esophagus (high risk) or patients with GERD plus at least 1 other risk factor (moderate risk). (medscape.com)
Squamous cell carcinoma con- geal cancer is endemic in some regions other malignancies were considered as stituted 95% and adenocarcinoma 5% of Islamic Republic of Iran [3,4] and exclusion criteria. (who.int)
The principal histologic types of esophageal cancer are squamous cell carcinoma (SCC) and adenocarcinoma. (medscape.com)
Staging Esophageal Adenocarcinoma. (msdmanuals.com)
Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study. (cdc.gov)

Japanese Classification of Esophageal Cancer, 11th Edition: part I. Esophagus. (spandidos-publications.com)
For patient education information, see the Heartburn and GERD Center , Esophageal Cancer (Cancer of the Esophagus) , and the Esophageal Cancer Directory . (medscape.com)
Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase Ⅲ Multicenter, Randomized, Open-Label Clinical Trial[J]. Clin Oncol, 2018, 36(27): 2796-2803. (med-sci.cn)
Weighing the pros and cons, Konda concluded that EMR is technically easier and adequate in most cases of Barrett's esophagus, while ESD may be preferred in select cases with concern for submucosal carcinoma or nonlifting lesions. (medscape.com)
For patient education information, see the Heartburn and GERD Center and Esophageal Cancer (Cancer of the Esophagus). (medscape.com)
Esophageal Web An esophageal web is a thin mucosal membrane that grows across the lumen of the upper esophagus and may cause dysphagia. (msdmanuals.com)
Clinical features of superficial esophagus squamous cell carcinoma according to alcohol-degrading enzyme ADH1B and ALDH2 genotypes. (cdc.gov)

Esophageal cancer (EC) has been reported as the 8th most common malignancy, as well as the 6th most common cause of cancer deaths in the world [ 1 ]. (hindawi.com)
SCARA5 expression is significantly downregulated in various tumor tissues including liver cancer (LC), rectal cancer, and glioblastoma [ 15 , 16 ] and might affect cell proliferation and invasion abilities by the focal adhesion kinase (FAK) signaling pathway and epithelial-mesenchymal transition (EMT) [ 5 , 17 - 20 ]. (hindawi.com)
This multicenter trial included esophageal cancer patients with clinical T4 disease and/or unresectable regional lymph node metastasis. (nih.gov)
In the updated analyses, median OS and 3-year OS were 13.1 months and 25.9%, respectively, for arm A and 14.4 months and 25.7%, respectively, for arm B. Daily RT plus LDPF chemotherapy did not qualify for further evaluation as a new treatment option for patients with locally advanced unresectable esophageal cancer. (nih.gov)
Multimodality approaches for the curative treatment of esophageal cancer. (springer.com)
Preoperative chemoradiotherapy for esophageal or junctional cancer. (springer.com)
Surgery alone versus chemoradiotherapy followed by surgery for stage I and II esophageal cancer: final analysis of randomized controlled phase III trial FFCD 9901. (springer.com)
Induction therapy does not improve survival for clinical stage T2N0 esophageal cancer. (springer.com)
Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study. (springer.com)
Esophageal cancer is usually diagnosed at an advanced stage, resulting in poor survival. (spandidos-publications.com)
Shaheen O, Ghibour A and Alsaid B: Esophageal cancer metastases to unexpected sites: A systematic review. (spandidos-publications.com)
Ai D, Zhu H, Ren W, Chen Y, Liu Q, Deng J, Ye J, Fan J and Zhao K: Patterns of distant organ metastases in esophageal cancer: A population-based study. (spandidos-publications.com)
Iwase H, Indo T, Shimada M, Tsuzuki T, Nakarai K, Kaida S, Doi R, Okeya M and Kato E: Esophageal cancer with colonic metastasis successfully treated by chemoradiotherapy followed by chemotherapy with S-1 and cisplatin. (spandidos-publications.com)
Garg N, Stoehr C, Zhao YS, Rojas H and Hsueh CT: Metastatic squamous cell carcinoma of colon from esophageal cancer. (spandidos-publications.com)
The nuclei and the silver-stained nucleolar organizer region-associated proteins (AgNORs) in the normal, the dysplastic and the cancer cells of 38 cases of esophageal squamous cell carcinoma were measured by an image analysis system. (ac.be)
The authors suggest that the morphometric study of AgNORs may be valuable in further studies on the change of AgNORs during the progression of the esophageal epithelial lesions towards cancer. (ac.be)
Background/Aim: This study analyzed the outcomes of docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy and DCF plus concurrent radiotherapy (DCF-RT), both followed by conversion surgery, if possible, in patients with cT4b esophageal cancer. (iiarjournals.org)
Patients and Methods: Forty-six patients with cT4b esophageal cancer, including borderline cT4b lesions, were eligible. (iiarjournals.org)
Conclusion: Induction DCF or DCF-RT is promising for the treatment of cT4b esophageal cancer. (iiarjournals.org)
Esophageal cancer is a disease in epidemiologic transition. (medscape.com)
For staging information, see Esophageal Cancer Staging . (medscape.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Esophageal cancer is a major cause of cancer-related mortality worldwide [ 1 ]. (oncotarget.com)
Esophageal cancer (EC) is one of the most lethal carcinomas worldwide and the most common and invasive malignant tumors among gastrointestinal malignancies. (highwire.org)
Keytruda has been approved for five different indications across three different cancers in China and is the first PD-1 inhibitor approved for esophageal cancer. (ipharmacenter.com)
Esophageal cancer is the seventh most common cancer in the world, can be either squamous cell carcinoma or adenocarcinomas. (ipharmacenter.com)
In China, esophageal cancer is the fifth most common cancer and is the fourth leading cancer that causes death. (ipharmacenter.com)
Squamous-cell carcinoma (SCC), also known as epidermoid carcinoma, comprises a number of different types of cancer that begin in squamous cells. (wikipedia.org)
Cutaneous squamous-cell carcinoma is the second most common skin cancer, accounting for over 1 million cases in the United States each year. (wikipedia.org)
When associated with the lung, it is typically a centrally located large-cell cancer (non-small-cell lung cancer). (wikipedia.org)
It often has a paraneoplastic syndrome causing ectopic production of parathyroid hormone-related protein, resulting in hypercalcemia, but paraneoplastic syndrome is more commonly associated with small-cell lung cancer. (wikipedia.org)
Most bladder cancer is transitional cell, but bladder cancer associated with schistosomiasis is often SCC. (wikipedia.org)
SCC well-differentiated, left upper paraspinal back marked for biopsy with adjacent actinic keratosis SCC, left lateral canthus marked for biopsy SCC, left ventral forearm Cancer can be considered a very large and exceptionally heterogeneous family of malignant diseases, with squamous-cell carcinomas comprising one of the largest subsets. (wikipedia.org)
All SCC lesions are thought to begin via the repeated, uncontrolled division of cancer stem cells of epithelial lineage or characteristics. (wikipedia.org)
Accumulation of these cancer cells causes a microscopic focus of abnormal cells that are, at least initially, locally confined within the specific tissue in which the progenitor cell resided. (wikipedia.org)
Background: Expression of activin A is associated with lymph node metastasis and clinical stage in esophageal cancer. (elsevierpure.com)
Moreover, anti-activin-neutralizing antibody-treated squamous cell cancer cell lines inhibited their migration. (elsevierpure.com)
Survival benefit of perioperative chemotherapy for T1-3N0M0 stage esophageal cancer: a SEER database analysis[J]. Thorac Dis, 2021, 13(2): 995-1004. (med-sci.cn)
Clinical Significance of Salvage Esophagectomy for Patients with Esophageal Cancer and Factors of Influencing Long-term Survival[J]. Anticancer Res, 2017, 37(9): 5045-5051. (med-sci.cn)
Six human viruses, including high-risk alpha human papillomaviruses (HPV), hepatitis B (HBV) and C (HCV) viruses, human T-cell lymphotropic virus 1 (HTLV-1), Epstein-Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (HHV-8), have been classified as class 1 carcinogens by the International Agency for Research on Cancer. (biomedcentral.com)
Esophageal cancer is a common disease worldwide, especially in the north of China. (biomedcentral.com)
In contrast, 5-year survival rate of early esophageal cancer is higher than 90% [ 3 ]. (biomedcentral.com)
Here, a cross-sectional epidemiologic study based on the Early Diagnosis and Early Treatment Project of Esophageal Cancer database from 2011 to 2017 was performed to fully investigate and characterize the epidemiology of EPL in rural Huai'an District. (figshare.com)
As mentioned, the gold nanoparticles had significant anti-esophageal cancer effects against the above cancers especially human Caucasian esophageal carcinoma. (ac.ir)
It has also been reported that the Wnt signaling pathway regulates cancer stem cell-like properties and contributes to the tumorigenic properties of many cancers, including breast cancer, esophageal cancer, etc. (biomedcentral.com)
Among 30,221 first primary oral squamous cell carcinoma patients, 6163 (20.4%) patients developed a second primary cancer, 5042 of which were metachronous. (nih.gov)
Can Some Patients With Esophageal Cancer Avoid Surgery? (medscape.com)
MADRID - More than one third of patients with locally advanced esophageal cancer who have a complete clinical response to neoadjuvant chemoradiotherapy may be able to safely avoid major surgery, findings from the Dutch SANO-trial suggest. (medscape.com)
Esophagectomy remains the "keystone of curative treatment for esophageal cancer," Van der Wilks explained. (medscape.com)
To compare active surveillance with standard surgery, the team conducted a phase 3 noninferiority stepped-wedge cluster randomized trial involving patients with locally advanced esophageal cancer. (medscape.com)
Surgeons should perform endoscopic mucosal resection (EMR) for all visible lesions in the presence of neoplasia to make an accurate histopathologic diagnosis of early-stage esophageal cancer, said a physician presenting at the 2022 Gastrointestinal Cancers Symposium. (medscape.com)
Vani Konda, MD, a gastroenterologist with Baylor Scott and White Center for Esophageal Diseases, Dallas, participated in an educational session on approaches for treating localized gastroesophageal cancer. (medscape.com)
The optimal therapy may vary with the esophageal cancer, and the cancer may vary with geography. (medscape.com)
A diagnosis of high-grade dysplasia by biopsy is associated with a 40% risk of prevalent cancer, mostly intramucosal carcinoma. (medscape.com)
ABSTRACT Oesophageal cancer is endemic in some regions of the Islamic Republic of Iran and efforts have been made to find factors that play a role in its prognosis. (who.int)
Elevated ALP in patients with oesophageal cancer may predict lymph node involvement. (who.int)
oesophageal cancer was 63.3 (SD 11.4) mortality worldwide [1,2]. (who.int)
Esophageal cancer is a devastating disease. (medscape.com)
3] Although some patients can be cured, the treatment for esophageal cancer is protracted, diminishes quality of life, and is lethal in a significant number of cases. (medscape.com)
In the United States, esophageal cancer is much less commonly diagnosed. (msdmanuals.com)
A prospective of five cervical cancer screening tests assessed the risk of esophageal squamous cell carcinoma. (who.int)
cancer in the organs and ducts that make and store bile, the liquid made by the liver), renal cell carcinoma (RCC, a type of cancer that begins in the kidneys), breast cancer, and certain other solid tumors. (medlineplus.gov)
It works by helping your immune system to slow or stop the growth of cancer cells. (medlineplus.gov)
Contribution of ZBTB20 Polymorphisms to Esophageal Cancer Risk Among the Chinese Han Population. (cdc.gov)
Identification of clinical prognostic features of esophageal cancer based on m6A regulators. (cdc.gov)
Inactivation of Hippo pathway characterizes a poor-prognosis subtype of esophageal cancer. (cdc.gov)
Characterization of the Immune Infiltration Landscape and Identification of Prognostic Biomarkers for Esophageal Cancer. (cdc.gov)
The Clinical Application Value of the Prognostic Nutritional Index for the Overall Survival Prognosis of Patients with Esophageal Cancer: A Robust Real-World Observational Study in China. (cdc.gov)
Causal relationship between lung diseases and risk of esophageal cancer: insights from Mendelian randomization. (cdc.gov)
Association of VEGF-116G/A Promoter Polymorphism with Esophageal Cancer Risk: A Case-Control study and an Updated Meta-Analysis on Gastrointestinal Tract Cancers. (cdc.gov)
A study by Fogh et al examined the use of induction chemoradiotherapy followed by surgery a strategy that is widely used in treating esophageal cancer. (medscape.com)
In the hope of informing future primary prevention efforts, the ESCCAPE consortium aims to conduct studies to shed light on the etiological epidemiology of oesophageal cancer in this setting, and in particular of the most common histological subtype, oesophageal squamous cell carcinoma. (who.int)
Seventy-four oesophageal resections were performed with a yearly average resection rate of only 5.6%.Conclusions: SCC is still the most prevalent oesophageal cancer (OC) without an increase in the ratio of AC to SCC. (bvsalud.org)
the diagnosis of oesophageal cancer in its premalignant stage would improve the survival. (bvsalud.org)
Oesophageal and gastric (OG) cancer are global health problems with poor prognosis. (cancercentrum.se)
I beskrivningen av förloppet står det att bland annat symtom som nytillkomna sväljsvårigheter ska väcka misstanke om cancer och då ska en snabb remiss skickas för gastroskopi (undersökning där en slang med kamera förs ner i magsäcken). (cancercentrum.se)
SVF startas då en välgrundad misstanke (VGM) uppstår, vilket innebär att det föreligger en betydande risk för cancer. (cancercentrum.se)

Low-dose cisplatin and 5-fluorouracil (LDPF) chemotherapy with daily radiotherapy (RT) is used as an alternative chemoradiotherapy regimen for locally advanced esophageal carcinoma. (nih.gov)
The investigators hypothesize that nivolumab combined with neoadjuvant chemoradiotherapy (CRT) is safe and effective in patients with locally advanced esophageal squamous cell carcinoma (LAESCC). (centerwatch.com)
Patterns of recurrence after oesophagectomy and postoperative chemoradiotherapy versus surgery alone for oesophageal squamous cell carcinoma. (springer.com)
Pre- versus postoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma. (springer.com)
Definitive concurrent chemoradiotherapy (CCRT) is one of the standards of care for localized esophageal SqCC cases beyond the early stage [ 3 ]. (oncotarget.com)

Esophageal carcinoma is a malignant tumor of esophageal mucosa epithelium or gland. (researchsquare.com)
Moreover, nude mice transplanted with IGHV4-28-silencing TE-4 cells showed restrained tumor weight and volume. (highwire.org)
Moreover, we uncovered a novel mechanism by which IL-37 suppressed tumor cell migration via its intracellular mature form (amino acids 46-218). (nature.com)
Intracellular mature form of IL-37, but not its extracellular form, markedly inhibited migration of multiple kinds of tumor cells through inhibiting Rac1 activation. (nature.com)
This activates lymphocytes, which affect tumor cells and healthy cells. (ipharmacenter.com)
This condition is called squamous-cell carcinoma in situ, and it is diagnosed when the tumor has not yet penetrated the basement membrane or other delimiting structure to invade adjacent tissues. (wikipedia.org)
Conclusions: Collectively, these data indicate that continuous high expression of activin A in esophageal carcinoma cells is not related to tumor suppression, but rather to tumor progression in vitro and in vivo. (elsevierpure.com)
En bloc ESD with tumor-free margins was safely achieved in all cases. (biomedcentral.com)
A lesion extending beyond the muscularis mucosa into the submucosa is a submucosal carcinoma, or T1b tumor, Konda said. (medscape.com)

Comparative effectiveness of image-guided radiotherapy for non-operated localized esophageal squamous cell carcinoma patients receiving concurrent. (oncotarget.com)

Comparison of neoadjuvant chemotherapy versus upfront surgery with or without chemotherapy for patients with clinical stage III esophageal squamous cell carcinoma. (springer.com)
Evidence-based recommendations on nivolumab (Opdivo) with fluoropyrimidine- and platinum-based chemotherapy for untreated unresectable advanced, recurrent, or metastatic oesophageal squamous cell carcinoma in adults. (nice.org.uk)

The role of human parvovirus B19 (B19V) infection in malignant and benign lesions such as head and neck squamous cell carcinomas (HNSCCs) and oral mucocele lesions has not been established. (biomedcentral.com)
On the other hand, submucosal carcinoma is rare in the absence of endoscopically visible lesions. (medscape.com)
Methods: A retrospective review of histopathological reports on pre-malignant and malignant oesophageal lesions over three time periods (TP), namely: 2003-4 (TP1), 2008-9 (TP2) and 2013-14 (TP3) was carried out at Inkosi Albert Luthuli Central Hospital, Durban, South Africa.Results: A total of 1341 specimen reports were retrieved. (bvsalud.org)

We retrospectively examined the correlation of serum alkaline phosphatase (ALP) levels with several clinicopathological characteristics of 207 cases of oesophageal carcinoma. (who.int)
EBV-LMPI expression in tumour cells of 10 of 26 cases of oesophageal carcinoma may also be of value in diagnosis and pathogenesis. (bvsalud.org)

Hasegawa H, Oshikiri T, Yasuda T, Sumi Y, Fujino Y, Tominaga M and Kakeji Y: Colonic metastasis after resection of primary esophageal squamous cell carcinoma: report of a case. (spandidos-publications.com)
Because all superficial SCCs involved nearly the entire circumference of the esophageal lumen, complete circular resection was considered necessary in each patient. (biomedcentral.com)
They found the procedure longer, but the en bloc resection was higher in ESD. (medscape.com)

A propensity-matched analysis comparing survival after esophagectomy followed by adjuvant chemoradiation to surgery alone for esophageal squamous cell carcinoma. (springer.com)
All known oncogenic pathogens can promote cell survival and transformation because of their common abilities to cause chronic insults, genetic and epigenetic alterations, deregulated metabolic pathways, and immune escape. (biomedcentral.com)
Instead, ACG guidelines advise that "it is reasonable to cease endoscopic surveillance in patients with an estimated survival of less than 5 years and those who are no longer fit for repeated endoscopy or cannot tolerate endoscopic, surgical, or oncological intervention for esophageal neoplasia. (medscape.com)

[Abstract] Objective To compare the diagnostic efficacy between combined MRI sequences and multi detector-row computed tomography (MDCT) in T staging of esophageal squamous cell carcinoma, so as to provide a reference basis for clinical accurate T staging. (med-sci.cn)

The present study reports a rare case of esophageal squamous cell carcinoma (SCC) with rectal metastasis. (spandidos-publications.com)

A 65‑year‑old man was diagnosed with middle thoracic esophageal SCC with multiple lymph node metastasis. (spandidos-publications.com)
Biopsies were performed and histopathological findings showed SCC, consistent with metastasis from primary esophageal SCC. (spandidos-publications.com)
Shimada Y, Okumura T, Hojo S, Sukegawa K, Nagata T, Hayashi S and Tsukada K: Synchronous asymptomatic colonic metastasis from primary esophageal squamous cell carcinoma. (spandidos-publications.com)
Fang N, Wang YL, Zeng L, Wu ZJ and Liu LL: Colonic metastasis from esophageal squamous cell carcinoma demonstrated with 18F-FDG PET/CT. (spandidos-publications.com)

Primary squamous-cell carcinoma of the thyroid shows an aggressive biological phenotype resulting in poor prognosis for patients. (wikipedia.org)

TP63 staining is the main histological marker for squamous-cell carcinoma. (wikipedia.org)

risk of esophageal squamous cell carcinoma. (who.int)

Methods: To clarify the aggressive behavior of tumors with high activin A expression, we used the β subunit of activin A to establish stable activin βA (Act-βA)- transfected carcinoma cells in two human esophageal carcinoma cell lines, KYSE110 and KYSE140. (elsevierpure.com)

90% of the esophageal cancers in china are squamous cell carcinomas. (ipharmacenter.com)
Most cancers were in stage efforts have been made to find factors oesophageal tumours underwent trans- III, followed by stage II. (who.int)
Stage I, II, and III esophageal cancers are all potentially resectable. (medscape.com)

Epidemiology of Esophageal Squamous Cell Carcinoma[J]. Gastroenterology, 2018, 154(2): 360-373. (med-sci.cn)

In her presentation , she addressed the advantages and disadvantages of EMR and endoscopic submucosal dissection (ESD) for esophageal neoplasia for both diagnosis and treatment. (medscape.com)

The Oesophageal Squamous Cell Carcinoma African Prevention research (ESCCAPE) is a collaborative research effort to investigate the etiological epidemiology of squamous cell carcinoma in Africa. (who.int)

citation needed] Medical history, physical examination and medical imaging may suggest a squamous-cell carcinoma, but a biopsy for histopathology generally establishes the diagnosis. (wikipedia.org)
The diagnosis of squamous cell dysplasia is concordant with previously cited rates. (bvsalud.org)

Upfront surgery and pathological stage-based adjuvant chemoradiation strategy in locally advanced esophageal squamous cell carcinoma. (springer.com)

Chen Mao-huai & Wu Ming-yao , «Morphometric study on AgNORs of esophageal squamous cell carcinoma and paraneoplastic epithelial cells», Acta Stereologica [En ligne], Volume 11 (1992), Number 2 - Dec. 1992, 205-209 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=1952. (ac.be)

We report on 7 consecutive patients with superficial esophageal squamous cell carcinoma (SCC) who underwent wholly circumferential ESD. (biomedcentral.com)

Study on the diagnostic efficacy of combined MRI sequences contrast MDCT in T staging of esophageal squamous cell carcinoma[J]. Chin J Magn Reson Imaging, 2022, 13(4): 43-48. (med-sci.cn)

Squamous cell carcinoma (SqCC) is the most prevalent form, particularly in non-Western countries [ 1 , 2 ]. (oncotarget.com)

Use of oral prednisolone administration may be an effective treatment strategy for reducing post-ESD esophageal stricture after complete circular ESD. (biomedcentral.com)

Then oe-IGHV4-28 or sh-IGHV4-28 was transfected into TE-4 and EC9706 cells to verify the effect on cell proliferation, migration, invasion, and apoptosis rate. (highwire.org)
IGHV4-28 was highly expressed in TE-4 and EC9706 cell lines and overexpression of IGHV4-28 enhanced cell proliferation, invasion, and migration, as well as decreased apoptosis rate. (highwire.org)
We focused our attention on cell growth and tumorigenesis, and proliferation and apoptosis. (elsevierpure.com)
In an in vitro invasion assay and a xenograft analysis, the Act-βA-transfected carcinoma cells showed far higher proliferation in vitro and a higher potency for tumorigenesis in vivo, respectively. (elsevierpure.com)
The effects of Transgelin overexpression and knockdown on the proliferation of Eca-109 and KYSE-150 cells were examined by Transwell chamber, scratch assay, and CCK-8 cell activity assay. (figshare.com)
After overexpression of Transgelin, the invasion and proliferation abilities of Eca-109 and KYSE-150 cells were significantly decreased compared with those of the control group (P (figshare.com)

Materials and Methods Ninty patients with esophageal squamous cell carcinoma confirmed by biopsy in our hospital were prospectively collected. (med-sci.cn)
Methods: 26 archival formalin-fixed paraffin wax embedded tissue blocks of oesphageal carcinoma and 6 of normal oesophagus obtained by endoscopy were studied. (bvsalud.org)

Li L , Jiang H , Li Y , Xiang X , Chu Y , Tang J , Liu K , Huo D , Zhang X , . Chaetocin exhibits anticancer effects in esophageal squamous cell carcinoma via activation of Hippo pathway. (aging-us.com)

Esophageal neoplasia therapy includes tissue-acquiring (lesion removal and histopathologic samples) and non-tissue-acquiring therapies (which include radiofrequency ablation, cryotherapy and hybrid-argon plasma coagulation. (medscape.com)

The expression levels of IGHV4-28 in TE-4 and EC9706 cells were detected by quantitative reverse transcription-PCR (qRT-PCR). (highwire.org)
The expression of Transgelin in Eca-109 and KYSE-150 cells was overexpressed by Transgelin-overexpressing plasmid. (figshare.com)
The targeted Transgelin siRNA and Transgelin-overexpressing plasmid can effectively regulate the expression of Transgelin mRNA and protein in Eca-109 and KYSE-150 cells. (figshare.com)
With the increase of Transgelin expression in Eca-109 and KYSE-150 cells, the expression of E-cadherin increased, while the expression of Vimentin decreased, and the difference was statistically significant (P (figshare.com)
Epstein-Barr virus latent membrane protein expression and cyclin DI cell cyase protein expression in malignant and normal oesophageal tissues to see whether any variation in their expression in these tissues could be of diagnostic or prognostic value. (bvsalud.org)

Conclusions Combined MRI sequences are better than MDCT for T staging of esophageal squamous cell carcinoma. (med-sci.cn)

Three carcinomas in situ are associated with SCCs of the penis:[citation needed] Bowen's disease presents as leukoplakia on the shaft. (wikipedia.org)

Anatomy13

Organisms6

Diseases78

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment61

Psychiatry and Psychology2

Phenomena and Processes43

Disciplines and Occupations1

Information Science5

Named Groups1

Health Care23

Geographicals3

ESCC40

Neoplasms1

Type of esophageal cancer2

Adenocarcinoma13

Esophagus7

Cancer77

Chemoradiotherapy5

Tumor9

Radiotherapy1

Chemotherapy2

Lesions3

Cases of oesophageal carcinoma2

Resection3

Survival3

Clinical1

Study reports a rar1

Metastasis4

Poor prognosis1

Histological1

Risk of esophageal1

Human esophageal1

Cancers3

20181

Endoscopic1

Epidemiology1

Diagnosis2

Locally1

Epithelial cells1

Superficial1

20221

Prevalent1

Treatment1

Proliferation6

Methods2

Anticancer1

Neoplasia1

Expression5

Conclusions1

Situ1