SquamousESCCPrognosisNeoplasmsCancersGastricSeveral histologicalPatientsTumorSurvivalResectionDiagnosisIncidenceMalignancyAbstractTissuesMethodsCarcinomaEndoscopyEndoscopicCarcinomasDysplasiaColorectal adenocarcinomaEighth-most common cancerClinicopathologicalGastrointestinalLUADLung cancerMethylationNeoplasmPrevalentGenesBarrett'sObesityMortality rateEtiologyEsophagusTypeSignificancePathwayLymph
Squamous25
- Esophageal cancer is common worldwide, including in Japan, and its major histological subtype is squamous cell carcinoma. (bvsalud.org)
- The biological and clinical features of these cancers differ from those of esophageal squamous cell carcinoma. (bvsalud.org)
- There are two main histological subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma. (bvsalud.org)
- Oesophageal cancer is group comprising several histological types, chiefly squamous cell (SCC), adenocarcinoma, leiomyosarcoma and other rarer types. (omicsonline.org)
- To explore the pathologic significance of calponin 2 in esophageal squamous cell carcinoma, the expression level of calponin 2 proteins in the tumor tissue of 190 esophageal squamous cell carcinoma patients was examined with immunohistochemistry while the expression level of calponin 2 messenger ribonucleic acid was analyzed by using the data from The Cancer Genome Atlas database. (ijpsonline.com)
- Both the calponin 2 messenger ribonucleic acid and protein level were increasingly expressed in the tumor tissues of esophageal squamous cell carcinoma patients compared with the adjacent non-tumor tissue and correlated negatively with the tumor grade. (ijpsonline.com)
- Calponin 2 was shown to be an independent factor influencing the overall survival of the esophageal squamous cell carcinoma patients. (ijpsonline.com)
- Esophageal Squamous Cell Carcinoma (ESCC) and esophageal adenocarcinoma[ 2 , 3 ]. (ijpsonline.com)
- The two main sub-types of the disease are esophageal squamous-cell carcinoma (often abbreviated to ESCC), which is more common in the developing world, and esophageal adenocarcinoma (EAC), which is more common in the developed world. (wikipedia.org)
- Weight loss is often an initial sign in cases of squamous-cell carcinoma, though not usually in cases of adenocarcinoma. (wikipedia.org)
- The two main types (i.e. squamous-cell carcinoma and adenocarcinoma) have distinct sets of risk factors. (wikipedia.org)
- The two major risk factors for esophageal squamous-cell carcinoma are tobacco (smoking or chewing) and alcohol. (wikipedia.org)
- Moreover, COL14A1 methylation ( COL14A1me) and GPX3 methylation ( GPX3me) levels discriminated adenocarcinomas and squamous cell carcinomas, respectively, from normal samples ( p = 0.002 and p = 0.009, respectively). (biomedcentral.com)
- COL14A1me & ZNF569me accurately identified adenocarcinomas (82.29%) whereas GPX3me & ZNF569me identified squamous cell carcinomas with 81.73% accuracy. (biomedcentral.com)
- This study aims to identify possible genes associated with esophageal squamous cell carcinoma (ESCC) by bioinformatics tool and further explore the function of immunoglobulin heavy chain variable family 4 gene (IGHV4)-28 in the ESCC progression. (highwire.org)
- Of the two main histological types, esophageal squamous cell carcinoma (ESCC) is globally predominant, especially in Asia where it accounts for 90% of all EC cases, while esophageal adenocarcinoma (EAC), the incidence of which has promptly increased, is the most common subtype in Western countries. (highwire.org)
- Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. (biomedcentral.com)
- There are abundant esophageal squamous cell carcinoma (ESCC) cell lines around the world. (biomedcentral.com)
- Currently, it consists of histological subtypes of small lung cancer (SCLC) and non-small lung carcinoma (NSCLC), including adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma [ 4 , 5 ]. (hindawi.com)
- Esophageal Primary Intrahepatic Adenosquamous Carcinoma (IASC) is defined by the coexistence of both squamous and glandular elements in the same lesion histologically. (oncologyradiotherapy.com)
- We retrospectively analyzed the clinical data of 16 patients who underwent resection of synchronous advanced esophageal squamous cell carcinoma (ESCC) and gastric adenocarcinoma from January 2009 to Dec 2021. (biomedcentral.com)
- In this study, we retrospectively analyzed the clinical data of 16 patients who received synchronous resection of advanced esophageal squamous cell carcinoma (ESCC) and gastric adenocarcinoma at our institution, and evaluated the feasibility and efficacy of this treatment modality and analyzed the impacts of different clinical parameters on the overall survival. (biomedcentral.com)
- Esophageal squamous cell carcinoma (ESCC) is a common histologic subtype in China. (spandidos-publications.com)
- Although Barrett's adenocarcinoma is the most rapidly increasing cancer in Western countries, esophageal squamous cell carcinoma (ESCC) remains dominant in East Asia ( 3 ). (spandidos-publications.com)
- Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer [ 2 - 4 ], and the incidence of esophageal adenocarcinoma (EAC) is increasing, especially in Western countries [ 5 ]. (e-ce.org)
ESCC3
- ESCC is the predominant histological type of esophageal cancer worldwide and has worse prognosis than esophageal adenocarcinoma. (bvsalud.org)
- From January 2009 to December 2021, patients who had primary ESCC and gastric adenocarcinoma and received simultaneous radical surgical resection at the Department of Cardiothoracic Surgery in Huashan Hospital were retrospectively enrolled. (biomedcentral.com)
- Esophageal dysplasia, including low-grade intraepithelial neoplasia, high-grade intraepithelial neoplasia (HGIN), and Barrett's esophagus (BE) are the precursor lesions of ESCC and EAC [ 6 , 7 ]. (e-ce.org)
Prognosis8
- The aim of this study was to evaluate the relationship between the monocyte count assessed at diagnosis and disease-free survival and prognosis in patients with esophageal cancer. (researchsquare.com)
- Significant parameters used in the determination of the prognosis and survival of esophageal cancer include tumor stage, surgical margin, and metastatic lymph node status. (researchsquare.com)
- High HMGB1 expression is an independent predictor of poor prognosis in patients with adenocarcinoma of the ampulla of Vater not treated with adjuvant chemotherapy. (biomedcentral.com)
- Notch-1 could be used as a predictable biomarker to be detected in different pathological and histological subtypes in LAD for diagnosis or prognosis. (biomedcentral.com)
- Primary Intrahepatic Adenosquamous Carcinoma (iASC) is a very rare subtype of Cholangiocarcinoma (CCA), with a worse prognosis than adenocarcinoma. (oncologyradiotherapy.com)
- Oesophageal and gastric (OG) cancer are global health problems with poor prognosis. (cancercentrum.se)
- Patients with a high expression of RUNX1 and/or IFNGR2 (HH/H) in the IDH-mutant subtype showed poorer prognosis and significantly increased infiltration of M2 macrophages. (bjbms.org)
- Advanced esophageal cancer is known to have a poor prognosis. (e-ce.org)
Neoplasms4
- Epidemiologically, the majority of esophageal neuroendocrine neoplasms are neuroendocrine carcinoma. (bvsalud.org)
- The early detection of esophageal neoplasms, including esophageal dysplasia and early esophageal cancer, is highly important for the accurate treatment of the disease. (e-ce.org)
- Here, we review the advancement of image-enhanced endoscopy-related technologies and their role in the early identification of esophageal neoplasms. (e-ce.org)
- This review aimed to provide an overview of the current status and advancements of IEE-related technologies for the early detection of esophageal neoplasms. (e-ce.org)
Cancers7
- Although calponin 2 has been reported to play roles in several cancers, whether it takes part in the progression of esophageal cancer still remains unknown. (ijpsonline.com)
- Esophageal Cancer (ESCA), one of the top ten most commonly diagnosed cancers worldwide, has caused 604 000 new diagnosed cases in 2020 and the number will continue to increase in 2021[ 1 ]. (ijpsonline.com)
- NPC is a malignant tumor that occurs in the nasopharyngeal mucosal epithelium and is one of the most common head and neck cancers in China. (itbusinessnet.com)
- Non-small cell lung cancer (NSCLC) accounts for 70%-80% in lung cancer, and among them, lung adenocarcinoma (LAD) accounting for almost half of lung cancers, was one of the most common histologic subtype. (biomedcentral.com)
- The aim of this study was to evaluate the feasibility and efficacy of simultaneous resection of synchronous advanced esophageal and gastric cancers. (biomedcentral.com)
- Thus, surgeons may face the dilemma of patients presenting with simultaneous gastric and esophageal cancers in clinical settings, but there are no established treatment guidelines for these patients. (biomedcentral.com)
- As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
Gastric6
- According to the recent GLOBOCAN 2020 estimation ( 1 ), gastric cancer is the fifth most common cancer worldwide. (frontiersin.org)
- In 2014 the Cancer Genome Atlas Research Network identified and published four molecular subtypes of gastric cancer: Epstein-Barr virus positive, microsatellite unstable tumors, genomically stable, and chromosomally unstable tumors ( 5 ). (frontiersin.org)
- A recent review of cancer statistics in China reported that gastric cancer was the second most common cancer and esophageal cancer was the sixth most common [ 1 ]. (biomedcentral.com)
- reported that about 5.3% of patients with esophageal cancer had synchronous gastric cancer [ 5 ], and the nationwide registry of Japan reported that about 4.3% of patients with esophageal cancer had synchronous gastric cancer [ 6 ]. (biomedcentral.com)
- Synchronous gastric cancer was defined as detection of gastric cancer before surgery based on preoperative esophagogastroduodenoscopy(EGD) that was pathologically proven as adenocarcinoma.Any patient who received simultaneous endoscopic resection for esophageal or gastric cancer was excluded. (biomedcentral.com)
- Patients with early tumors located in the upper gastric cancer and adenocarcinoma infiltrating the dentate line were also excluded. (biomedcentral.com)
Several histological1
- RCC is classified into several histological subtypes such as clear cell renal cell carcinomas, papillary renal cell carcinomas and chromophobe renal cell carcinomas. (biomedcentral.com)
Patients8
- The retrospective study included 145 patients with esophageal cancer who presented to Van Training and Research Hospital Medical Oncology outpatient clinic between January 2015 and September 2020. (researchsquare.com)
- Our findings showed that monocyte count is a prognostic factor affecting disease-free survival in patients with esophageal cancer, regardless of histological subtype. (researchsquare.com)
- In the present study, we aimed to investigate whether the monocyte count measured at the time of diagnosis can be used as a new prognostic biomarker in predicting disease-free survival in patients with esophageal cancer. (researchsquare.com)
- Nivolumab, a human monoclonal immunoglobulin G4 antibody that inhibits programmed cell death protein 1, has recently been identified as a potential treatment for patients with metastatic esophageal cancer based on the results of the ATTRACTION-3 and CheckMate 648 trials. (bvsalud.org)
- The study found two panels of candidate biomarkers for the diagnosis of IBD and the differentiation of IBD subtypes to guide appropriate therapeutic interventions in pediatric patients. (medscape.com)
- Patients with adenocarcinoma of the gallbladder were identified in the Surveillance, Epidemiology, and End Results database from 1973 to 2016. (biomedcentral.com)
- Patients with adenocarcinoma of the ampulla of Vater who underwent R0 resection with pancreaticoduodenectomy between 2001 and 2011 were included in the present multi-institutional study. (biomedcentral.com)
- 3) patients with the same HR-HPV subtype with no CINⅡ and more lesions after treatment with CINⅡ or CIN Ⅲ (CINⅡ/CIN Ⅲ). (bvsalud.org)
Tumor8
- Due to the high mortality rate of esophageal cancer, exploration of new prognostic biomarkers for this tumor is of paramount importance. (researchsquare.com)
- Further, in esophageal cancer tumor tissue, calponin 2 gene was found to co-express with genes associated with tight junction and the expression level of calponin 2 was observed to correlate significantly with the number of infiltrating immune cells. (ijpsonline.com)
- These results supported the idea that calponin 2 is involved in esophageal cancer and may function as a tumor inhibitor probably through modulating cancer cells tight junction and tumor immunity. (ijpsonline.com)
- Prominent symptoms usually do not appear until the cancer has infiltrated over 60% of the circumference of the esophageal tube, by which time the tumor is already in an advanced stage. (wikipedia.org)
- The final common pathway seems to include the endogenous production of inflammatory mediators, such as endotoxin lipopolysaccharide, platelet-activating factor, tumor necrosis factor, and other cytokines, decreased epidermal growth factor, and progressive mucosal damage by free radical production. (medscape.com)
- The tumor located at middle thoracic esophagus, 23-30 cm from the incisor with constrictive lumen and elevated mucosa observed in the esophageal tract (Fig. 1 a). (biomedcentral.com)
- Signet ring cell carcinoma (SRC) is an adenocarcinoma in which more than 50% of the tumor consists of isolated or small groups of malignant cells containing intracytoplasmic mucins [ 1 ]. (biomedcentral.com)
- This finding implied the possible key role of RUNX1 in the differentiation of IDH mutant subtypes as well as in the formation of tumor microenvironment (TME) infiltration signatures by monitoring IFNGR2. (bjbms.org)
Survival2
- the diagnosis of oesophageal cancer in its premalignant stage would improve the survival. (bvsalud.org)
- Despite the improvement in treatment modalities, the 5-year survival of esophageal cancer is between 10% and 25% and the mortality rate is still high due to an advanced stage at diagnosis [ 4 , 8 , 9 ]. (e-ce.org)
Resection2
- Seventy-four oesophageal resections were performed with a yearly average resection rate of only 5.6%.Conclusions: SCC is still the most prevalent oesophageal cancer (OC) without an increase in the ratio of AC to SCC. (bvsalud.org)
- Predicting the depth of the invasion of early esophageal cancer is important to determine a proper candidate lesion for endoscopic resection since the invasion depth has a reliable relationship with the rate of lymph node metastasis [ 11 - 13 ]. (e-ce.org)
Diagnosis4
- Gastro-oesophageal cancer remains a devastating diagnosis for the patient and a challenge for the clinician. (omicsonline.org)
- EBV-LMPI expression in tumour cells of 10 of 26 cases of oesophageal carcinoma may also be of value in diagnosis and pathogenesis. (bvsalud.org)
- According to the International Multidisciplinary Classification of Lung Adenocarcinoma (LAD) by International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) in 2011, the diagnosis of LAD is changing from simple morphology into a comprehensive multidisciplinary classification. (biomedcentral.com)
- The progression of non-invasive diagnosis via image-enhanced endoscopy techniques has been shown to aid the early detection and estimate the depth of invasion of early esophageal cancer and, as a result, may provide additional opportunities for curative treatment. (e-ce.org)
Incidence5
- The incidence of gastro-oesophageal cancer has striking geographical variation as does the gold standard treatment. (omicsonline.org)
- Oesophageal adenocarcinoma is also associated with tobacco use, with a higher incidence in men [ 7 ]. (omicsonline.org)
- A decreasing incidence of oesophageal SCC in SA has been suggested. (bvsalud.org)
- The study aimed to assess whether the incidence of these malignant histopathological subtypes has changed in this setting. (bvsalud.org)
- Introduction: The development of oesophageal carcinoma has been attributed to various environmental factors and its incidence varies regionally. (bvsalud.org)
Malignancy2
- Esophageal cancer (EC) is the seventh most common malignancy globally. (bvsalud.org)
- Esophageal cancer, a malignancy that arises in the esophagus, is one of the most aggressive and rapidly progressing forms of cancer worldwide. (eccafe.org)
Abstract1
- Duitse onderzoekers publiceren in oktober a.s. het abstract van een aantal laboratoriumstudies en dierstudies die ze gedaan hebben met Herceptin als basis aangevuld met gemcitabine en/of docetaxel bij inoperabele en gevorderde alvleesklierkanker . (kanker-actueel.nl)
Tissues2
- Epstein-Barr virus latent membrane protein expression and cyclin DI cell cyase protein expression in malignant and normal oesophageal tissues to see whether any variation in their expression in these tissues could be of diagnostic or prognostic value. (bvsalud.org)
- More interestingly, the expression of Notch-1 protein was often observed to be negative in solid predominant adenocarcinoma (SPA) tissues, but highly expressed in papillary predominant adenocarcinoma (PPA) and micropapillary predominant adenocarcinoma (MPA) tissues. (biomedcentral.com)
Methods1
- Methods: A retrospective review of histopathological reports on pre-malignant and malignant oesophageal lesions over three time periods (TP), namely: 2003-4 (TP1), 2008-9 (TP2) and 2013-14 (TP3) was carried out at Inkosi Albert Luthuli Central Hospital, Durban, South Africa.Results: A total of 1341 specimen reports were retrieved. (bvsalud.org)
Carcinoma2
- Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. (biomedcentral.com)
- Signet ring cell carcinoma (SRC) is a rare histological subtype of gallbladder adenocarcinoma. (biomedcentral.com)
Endoscopy3
- CSEC216 was established from an endoscopic biopsy sample derived from a 45-year-old male patient who underwent esophageal endoscopy in the Cancer Hospital of Shantou University Medical College. (biomedcentral.com)
- White-light endoscopy (WLE) is the standard modality for detecting esophageal neoplastic lesions. (e-ce.org)
- Image-enhanced endoscopy (IEE), including dye-based chromoendoscopy and virtual chromoendoscopy with or without magnifying endoscopy (ME) is a new diagnostic endoscopic technique that has been helpful in the detection of tumors and predicting the depth of invasion of esophageal cancer. (e-ce.org)
Endoscopic1
- However, the endoscopic features of early esophageal neoplastic lesions under WLE are subtle and isochromatic [ 15 , 16 ]. (e-ce.org)
Carcinomas1
- Esophageal cancer (EC) is one of the most lethal carcinomas worldwide and the most common and invasive malignant tumors among gastrointestinal malignancies. (highwire.org)
Dysplasia3
- The protective changes in the lower oesophagus brought about by persistent acid exposure can result in dysplasia, with a 0.5% risk of development of adenocarcinoma per year [ 13 ]. (omicsonline.org)
- The development of this disease is known to occur in recognized histological stages from normal through dysplasia to the malignant stage. (bvsalud.org)
- However, esophageal dysplasia and early esophageal cancer are usually subtle and can be easily missed. (e-ce.org)
Colorectal adenocarcinoma1
- Data queried for this analysis include colorectal adenocarcinoma (2010-2011) from the Surveillance, Epidemiology, and End Results Program (SEER) database. (oncotarget.com)
Eighth-most common cancer1
- As of 2018, esophageal cancer was the eighth-most common cancer globally with 572,000 new cases during the year. (wikipedia.org)
Clinicopathological1
- The aim of this study is to detect the expression of Notch-1 and analyze its clinicopathological or prognostic significance in different histological subtypes of Lung Adenocarcinomas (LADs). (biomedcentral.com)
Gastrointestinal1
- Colon cancer is the most common type of gastrointestinal cancer. (medscape.com)
LUAD3
- However, the underlying functions of STARDs in lung adenocarcinoma (LUAD) have not been clarified yet. (medsci.org)
- Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
- However, we are rarely aware of its diagnostic, progressive and prognostic performance in lung adenocarcinoma (LUAD). (ijbs.com)
Lung cancer1
- Lung cancer is one of the most common diseases and one of the leading causes of cancer-related mortality in the world [ 1 ]. (hindawi.com)
Methylation1
- Thus, promoter methylation of specific genes might be used to discriminate normal from cancerous esophageal cells, enabling the detection of disease at early stages, increasing the likelihood of curative treatment. (biomedcentral.com)
Neoplasm1
- It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer. (lookformedical.com)
Prevalent1
- NPC is one of the most common head and neck malignancies and is highly prevalent in Southeast Asia, North Africa and southern China [ 1 ]. (jcancer.org)
Genes1
- Additionally, recent studies have shown an association between oesophageal SCC and mutations in genes governing enzymes related to aldehyde metabolism [ 9 ]. (omicsonline.org)
Barrett's2
- Interestingly, and perhaps accounting for its geographical distribution, it is associated with obesity, Barrett's oesophagus, and chronic gastro-oesophageal reflux disease, largely diseases of the West [ 11 , 12 ]. (omicsonline.org)
- Adenocarcinoma arises from glandular cells present in the lower third of the esophagus, often where they have already transformed to intestinal cell type (a condition known as Barrett's esophagus). (wikipedia.org)
Obesity1
- The most common causes of the adenocarcinoma type are smoking tobacco, obesity, and acid reflux. (wikipedia.org)
Mortality rate1
- Esophageal cancer is a cancer with a high mortality rate, ranking sixth in cancer-related deaths in the world. (researchsquare.com)
Etiology1
- When examining esophageal cancer etiology, various risk factors have been identified as potential contributors to its pathogenesis. (eccafe.org)
Esophagus1
- Esophageal cancer is cancer arising from the esophagus-the food pipe that runs between the throat and the stomach. (wikipedia.org)
Type1
- SCC remains the commonest type worldwide, although adenocarcinoma is commoner in Western countries [ 6 ]. (omicsonline.org)
Significance1
- The LAST terminology does not support the distinction between these two categories because of poor inter-observer agreement, lack of clinical significance and the common underpinning biology. (cancer.org.au)
Pathway1
- Heme iron can bring about the generation of cancer-causing free radicals such as unstable N-nitroso compounds (NOCs) that induce oxidation and inflammation, a common pathway contributing to cancer risk. (cyclingplantbasedgranny.com)
Lymph1
- Common sites of spread include nearby lymph nodes, the liver, lungs and bone. (wikipedia.org)