• Mouse naive embryonic stem cells have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation structured stem-cell-based embryo models with spatially organized morphogenesis (called SEMs) 3 . (nature.com)
  • Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. (research.com)
  • Epidermal stem cells (ESCs) are specific stem cells derived from the embryonic ectoderm, which can be differentiated into various layers of the skin to activate the state of proliferation and differentiation and the apoptotic state of the epidermis. (aging-us.com)
  • To dissect the dynamic regulation of Runx1 in hematopoietic development, we analyzed its three-dimensional chromatin conformation in mouse embryonic stem cell (ESC) differentiation cultures. (ox.ac.uk)
  • Substrate stiffness affects early differentiation events in embryonic stem cells. (ox.ac.uk)
  • Chemical factors such as soluble growth factors and insoluble components of the extracellular matrix are known to affect the differentiation of murine ESCs. (ox.ac.uk)
  • By growing ESCs on flexible polydimethylsiloxane substrates with varying stiffness, we tested the hypothesis that substrate stiffness can influence ESC differentiation. (ox.ac.uk)
  • Finally, we demonstrated that osteogenic differentiation of ESCs was enhanced on stiff substrates compared to soft substrates, illustrating that the mechanical environment can play a role in both early and terminal ESC differentiation. (ox.ac.uk)
  • Such human fully integrated and complete SEMs recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos, including the epiblast, the hypoblast, the extra-embryonic mesoderm and the trophoblast layer surrounding the latter compartments. (nature.com)
  • These include embryonic disc and bilaminar disc formation, epiblast lumenogenesis, polarized amniogenesis, anterior-posterior symmetry breaking, primordial germ-cell specification, polarized yolk sac with visceral and parietal endoderm formation, extra-embryonic mesoderm expansion that defines a chorionic cavity and a connecting stalk, and a trophoblast-surrounding compartment demonstrating syncytium and lacunae formation. (nature.com)
  • As ESCs differentiate to mesoderm, chromatin accessibility, Runx1 enhancer-promoter (E-P) interactions, and CTCF-CTCF interactions increase in the TAD, along with initiation of Runx1 expression from the P2 promoter. (ox.ac.uk)
  • Embryonic or adult SCs by definition are characterized by their self-renewal and potentiality, peculiarities that allow them to give rise to more SCs and differentiate into various cell lineages under appropriate conditions. (biomedcentral.com)
  • According to their potentiality, embryonic stem cells (ESCs) are classified as totipotent and pluripotent, both of them can differentiate into the three germ lines. (biomedcentral.com)
  • ESCs are obtained from inner cell mass, characterized by unlimited self-renewal and pluripotentiality, which allow them to differentiate into various specialized cells types in a morphologically and functionally way, characteristics that make them attractive for developing differentiated kidney cells (DKCs) [ 9 ]. (biomedcentral.com)
  • Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are potentially unlimited cell sources for cellular therapies due to the unique capacities of PSCs to self-renew indefinitely and differentiate into cells from all three germ lineages (ectoderm, mesoderm, and endoderm) [ 1 ]. (biomedcentral.com)
  • In his study, Pablo Menendez carries out multidisciplinary Progenitor cell and Embryonic stem cell research. (research.com)
  • Pablo Menendez performs multidisciplinary study in Embryonic stem cell and Induced pluripotent stem cell in his work. (research.com)
  • Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter. (research.com)
  • Here we extend those findings to humans using only genetically unmodified human naive embryonic stem cells (cultured in human enhanced naive stem cell medium conditions) 4 . (nature.com)
  • We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)
  • In addition, we found that in the presence of LIF, MDLS could replace feeder cells to maintain the undifferentiated state of OG2-mES cells (Oct4-GFP reporter gene mouse embryonic stem cell line), and the MDLS-expanded OG2-mES cells showed an elevated expression levels of pluripotency markers in vitro. (biomedcentral.com)
  • In 2018, Chinese research scientists produced 29 viable mice offspring from two female mother mice by creating sperm-like structures from haploid embryonic stem cells using gene editing to alter imprinted regions of DNA. (wikipedia.org)
  • The proper copying and repair of DNA to maintain the correct sequence and structure of genomes is critical to the proper function of cells, and repair and replication is frequently disrupted in cancers and targeted by cancer treatments. (birmingham.ac.uk)
  • An organoid is a 3D organization of cells that can recapitulate some of the structure and function of native tissue. (mdpi.com)
  • Much of this process relies on the morphogenesis of the extra-embryonic tissues and the effect this has on the organization of embryonic cells. (nature.com)
  • For instance, in mouse embryos this occurs as early as day 6.5 post fertilization and involves the development of a population of cardiac precursor cells in the lateral posterior epiblast just prior to formation of the primitive streak - a structure which marks the beginning of gastrulation. (mechanobio.info)
  • They are 3-dimensional, complex, multicellular structures that can be derived from patient specific human induced pluripotent stem cells (hiPSCs). (nature.com)
  • Background and purpose: Skin tissue is the natural barrier that protects our body, the damage of which can be repaired by the epidermal stem cells (ESCs). (aging-us.com)
  • In addition, as the specific stem cells for wound repairing, ESCs play a vital role in the repairing and rebuilding of skin and its accessory organs [ 4 , 5 ]. (aging-us.com)
  • In this study, we identify a population of vascular progenitor c-Kit+/Sca-1- cells available in large numbers and derived from immuno-privileged embryonic stem cells (ESCs). (ox.ac.uk)
  • When seeded ex vivo on a decellularised vessel, c-Kit+/Sca-1-derived cells recapitulated the native vessel structure and upon in vivo implantation in the mouse, markedly reduced neointima formation and mortality, restoring functional vascularisation. (ox.ac.uk)
  • Comparative Metabolomic Profiling of Rat Embryonic and Induced Pluripotent Stem Cells. (shengsci.com)
  • Metabolomic profiles of somatic cells, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) reflect their metabolic phenotypes. (shengsci.com)
  • Embryonic stem cells (ESC) are both a potential source of cells for tissue replacement therapies and an accessible tool to model early embryonic development. (ox.ac.uk)
  • Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are widely used in regenerative medicine and experimental models for studying development and diseases because of their pluripotent potential to differentiate into all cell lineages: endoderm, ectoderm, and mesoderm germ layers [ 1 , 2 , 3 ]. (biomedcentral.com)
  • The « Pluripotent Stem Cells » facility proposes training into the culture of embryonic stem cells (ESCs) and induced Pluripotent Stem Cells (iPSCs). (cnrs.fr)
  • The inner cell mass is a source of embryonic stem cells. (texasgateway.org)
  • Brain Organoids (minibrains) from iPSCs and ESCs. (cnrs.fr)
  • Embryo-like models with spatially organized morphogenesis and structure of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (that is, the embryonic disc, the bilaminar disc, the yolk sac, the chorionic sac and the surrounding trophoblast layer) remain lacking 1 , 2 . (nature.com)
  • The structures of animals consist of primary tissues that make up more complex organs and organ systems. (texasgateway.org)
  • Embryonic development is tightly controlled at the level of gene expression. (amegroups.org)
  • Cardiac specification occurs very early on during embryonic development. (mechanobio.info)
  • Ablation of Sox2 in the developing SCN leads to downregulation of circadian neuropeptides as early as embryonic day (E) 15.5, followed by a decrease in the expression of two transcription factors involved in SCN development, Lhx1 and Six6, in neonates. (bvsalud.org)
  • Deletion of promoter-proximal CTCF sites at the sub-TAD boundaries has no obvious effects on E-P interactions but leads to partial loss of domain structure, mildly affects gene expression, and delays hematopoietic development. (ox.ac.uk)
  • The genetic and protein experiments proved the obtention of DKCs that passed through the chronological stages of embryonic kidney development. (biomedcentral.com)
  • Our results indicated that we obtained DKCs from mPSCs, which passed through the chronological stages of embryonic kidney development. (biomedcentral.com)
  • The use of hPSCs provides great opportunities to model and study embryonic and human development. (biomedcentral.com)
  • Which of the following statements about early embryonic stages is FALSE? (texasgateway.org)
  • However, ESCs are easily damaged by external stimuli, such as ultraviolet (UV), which induces DNA damage and oxidative stress in ESCs [ 6 ]. (aging-us.com)
  • Directly determined by the chemical nature of its constituents, the crystal structure of a given material is rigid and rarely can be turned from low symmetry to high symmetry short of external stimuli such as pressure. (scite.ai)
  • Although it is possible to culture structures derived from human blastocysts ex vivo, these cultures do not recapitulate the events and structural organization of the in vivo embryos 6 ( Supplementary Information ). (nature.com)
  • Independently of the gestational periods, the qualitative evaluation showed the initial wash-in phase from the first appearance of the uterine artery to the rapid distribution in embryonic vesicles or placenta to the progressive washout, whilst there was no enhancement of either embryos or fetuses in any bitch. (edu.au)
  • The project will use a combination of embryological, 3D imaging, and genomics approaches including single cell dissection and analyses, 3D-FISH, ATACseq and RNAseq both in embryos (Torres-Padilla lab in Munich) as well as in ESCs through a collaboration with the Chambers lab. (helmholtzresearchschool-epigenetics.org)
  • Methods: ESCs were isolated from neonatal mice. (aging-us.com)
  • This review aims to provide insights into the structure, localization, and function of the mammalian CatSper channel, primarily human and mice. (123dok.net)
  • The way the DNA is structured, wrapped and read is fundamental to how and when the blueprint genes are read. (birmingham.ac.uk)
  • The cytoskeleton is a highly dynamic network of filamentous proteins that enables the active transport of cellular cargo, transduces force, and when assembled into higher-order structures, forms the basis for motile cellular structures that promote cell movement. (mechanobio.info)
  • Thousands of copies of the circular mtDNA are present in most cell types that are packaged by TFAM into higher-order structures called nucleoids1. (regenerativemedicine.net)
  • The tissue model thereby mimics structure and function of human soft tissue with endothelial cell-coated larger vessels for perfusion and micro-vessel networks within the hydrogel-matrix. (regenhu.com)
  • Together, our analysis of gene regulation at a large multi-promoter developmental gene reveals that dynamic sub-TAD chromatin boundaries play a role in establishing TAD structure and coordinated gene expression. (ox.ac.uk)
  • It is conceptualized that biomass accumulated through photosynthesis and other build-up mechanism within volume of secluded structure serve as foundation. (webmedcentral.com)
  • Here, we report that the stem/progenitor cell transcription factor, Sex determining region Y-box 2 (Sox2), is required in the embryonic SCN to control the expression of SCN-enriched neuropeptides and transcription factors. (bvsalud.org)
  • External fertilization most commonly occurs in which type of environment? (texasgateway.org)
  • Thus, a very special character of the pseudocubic structure allows the design of high-performance novel TE materials with the ability to simultaneously optimize electrical and thermal transport properties. (scite.ai)
  • However, external factors abolish the self-repair ability of ESCs by inducing oxidative stress and severe inflammation. (aging-us.com)
  • Which female organ has the same embryonic origin as the penis? (texasgateway.org)
  • Tiếng Việt These external translations are automated and may not be accurate. (edu.au)
  • As a result, Apremilast protected ESCs against IL-1α-induced impairment in capacities of ESCs, this was verified by the elevated expression levels of integrin β1 and Krt19. (aging-us.com)
  • Metabolically inert infrastructure or buoyant force of fluids secludes self gravitating body from external stronger gravitational field and helps to maintain self gravity's free fall condition. (webmedcentral.com)
  • Homeostasis allows an animal to maintain a balance between its internal and external environments. (texasgateway.org)
  • Interleukin-1α (IL-1α) has been identified as an important DNA damage sensor that transmits the genotoxic stress signal to oxidative stress and inflammation, making IL-1α a potential target for the alleviation of injury on ESCs by UV [ 7 ]. (aging-us.com)
  • The researchers led by Kurt Hankenson , D.V.M., Ph.D., a professor of orthopedic surgery at Michigan Medicine, hypothesized for some years that by binding Jagged-1 to a biomaterial structure and delivering it to the site of injury, it could improve healing of the bone. (transhumanist-party.org)
  • The Genome Structure Function section of the Institute of Cancer and Genomic Sciences investigates the fundamentals of the active information database that is our genome, in normal and disease states. (birmingham.ac.uk)
  • It is open to internal and external academics, clinical users, as well to private companies. (cnrs.fr)