• The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. (wikipedia.org)
  • Additionally, EpoR has been implicated in suppressing expression of death receptors Fas, Trail and TNFa that negatively affect erythropoiesis. (wikipedia.org)
  • Objective: The erythropoietin receptor (EpoR) stimulates erythro- cyte proliferation after erythropoietin binding. (edu.au)
  • EpoR belongs to the cytokine receptor superfamily and is also found on macrophages and endothelial cells, which play a role in systemic autoimmune diseases. (edu.au)
  • Because neuroplasticity is regulated by a variety of neurotrophic factors we studied differential effects of haloperidol (HAL, a FGA) and olanzapine (OLZ, a SGA) on temporal expression of erythropoietin (EPO), a potent neuroprotective factor and its receptor (EPOr) in rat brain. (elsevierpure.com)
  • Protection was blocked by the coapplication of a soluble Epo receptor (sEpoR) or an antibody against EpoR (anti-EpoR). (jneurosci.org)
  • Are erythropoietin receptors (EpoR) present on tumors? (cancernetwork.com)
  • Background: Adverse outcomes in breast cancer patients treated with recombinant human erythropoietin (rhEpo) have been linked to the expression of Epo-receptors (EpoR) in cancer cells, although limited data on the clinical significance of these observations are available. (iiarjournals.org)
  • Results: While EpoR levels were not linked to anaemia or inflammation, they were positively associated with progesterone and oestrogen receptor status. (iiarjournals.org)
  • Conclusion: Since EpoR expression is associated with hormone receptor positivity and decreased locoregional disease control, this parameter characterises a specific cancer phenotype rather than being a negative predictor itself. (iiarjournals.org)
  • All resulted in a truncated version of a gene called the erythropoietin receptor (EPOR) gene, and all produced the same outcome--driving the white blood cells to proliferate out of control. (news-medical.net)
  • Erythropoiesis stimulating agents (ESAs) have been reported to activate erythropoietin receptors (EpoR) on cell types, including endothelial, neuronal, renal tubule, and cardiac cells. (lonza.com)
  • These are believed to cause the destruction of RBC precursors and decrease the number of erythropoietin receptors on progenitor cells. (medscape.com)
  • Erythropoietin acts by binding to its cell surface receptor on erythroid progenitor cells to stimulate erythrocyte production. (uzh.ch)
  • Erythropoietin receptor expression in nonhematopoietic tissue, including skeletal muscle progenitor cells, raises the possibility of a role for erythropoietin beyond erythropoiesis. (uzh.ch)
  • Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
  • Another proposed mechanism for anemia of chronic illness deals with cytokines, such as interleukins (IL-1 and IL-6), and tumor necrosis factor (TNF-alpha), which are believed to cause the destruction of RBC precursors and decrease the number of erythropoietin receptors on progenitor cells. (medscape.com)
  • GH-dependent signaling is usually activated by GHR's adoption of the dimerized construction that activates the receptor-associated cytoplasmic tyrosine kinase, Janus kinase 2 (JAK2), and additional kinases and following engagement from the sign transducer and activator of transcription (STAT), sTAT5A/B particularly, ERK, phosphatidylinositol-3 kinase, and additional pathways (18C25). (imacst.com)
  • erythropoietin receptor activator (C.E.R.A.), for the treatment of CKD-associated anemia in patients receiving dialysis in daily clinical practice. (karger.com)
  • Binding of a 30 kDa ligand erythropoietin (Epo), changes the receptor's conformational change, resulting in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e. (wikipedia.org)
  • Another method of inhibit surface area receptor signaling has been antireceptor antibodies that stop either ligand binding or receptor activation (30, 31). (imacst.com)
  • Neuregulin (NRG) 1 contains an epidermal growth factor (EGF)-like signaling domain and serves as a ligand for receptor tyrosine kinases of the ErbB family. (uni-goettingen.de)
  • Screen drug effects on a specific receptor or full panels in agonist or antagonist mode. (indigobiosciences.com)
  • 4. Initiation of treatment with an erythropoiesis-stimulating agent (eg, erythropoietin), a thrombopoietin receptor agonist (eg, eltrombopag), or danazol within 28 days prior to the screening visit. (who.int)
  • 2. Study the cellular and molecular mechanisms by which the cytokine erythropoietin (Epo) protects respiratory motor neurons from injury using a rodent model for amyotrophic lateral sclerosis (ALS). (atsu.edu)
  • The cytokine erythropoietin (Epo) initiates adaptive cellular responses to a variety of mechanical and physiological insults in various non-hematopoietic mammalian tissues including the nervous system. (uni-goettingen.de)
  • Mice with erythropoietin receptor restricted to hematopoietic tissue were used to assess contributions of endogenous erythropoietin to promote skeletal myoblast proliferation and survival and wound healing in a mouse model of cardiotoxin induced muscle injury. (uzh.ch)
  • Skeletal muscle myoblasts also produced endogenous erythropoietin that increased at low O(2). (uzh.ch)
  • Introduction: Erythropoietin (Epo), a hematopoietic growth factor, has long been observed to improve cognition but this effect was attributed to the increase in hemoglobin levels. (uni-goettingen.de)
  • Erythropoietin (Epo) regulates the proliferation and differentiation of erythroid precursors. (drugbank.com)
  • In contrast, mice with chronic elevated circulating erythropoietin had more Pax-7(+) satellite cells and myoblasts with increased proliferation and survival in culture, decreased muscle injury, and accelerated recovery of maximum load tolerated by isolated muscle. (uzh.ch)
  • Erythropoietin promoted proliferation, survival, and wound recovery in myoblasts via the phosphoinositide 3-kinase/AKT pathway. (uzh.ch)
  • Therefore, endogenous and exogenous erythropoietin contribute to increasing satellite cell number following muscle injury, improve myoblast proliferation and survival, and promote repair and regeneration in this mouse induced muscle injury model independent of its effect on erythrocyte production. (uzh.ch)
  • Pillai, A & Mahadik, SP 2006, ' Differential effects of haloperidol and olanzapine on the expression of erythropoietin and its receptor in rat hippocampus and striatum ', Journal of Neurochemistry , vol. 98, no. 5, pp. 1411-1422. (elsevierpure.com)
  • Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
  • To understand the effect of these compounds in the initiation and progression of leukemia we did a series of analysis, which include hematological and biochemical parameters, histopathological evaluations of the liver and the spleen and expression analysis of selected genes such as Bcl-2, p53, p45 NFE2 , Raf-1, Erk-1, IFNgamma receptor and erythropoietin in spleen. (oldcitypublishing.com)
  • Effects of aliskiren-loaded nanoparticles on (pro-)renin and renin receptor gene expression in the heart and kidney of spontaneously hypertensive rats. (sav.sk)
  • Most strikingly, the gene expression of multiple C-type lectin receptors, which have previously been reported to orchestrate host defense against fungi and select bacteria, were markedly dysregulated. (bvsalud.org)
  • EPO activates the neuronal EPO receptor and, subsequently, JAK-2 and thereby PI3K. (jneurosci.org)
  • In this context, we have characterized the orphan cytokine receptor CRLF3, which is expressed in various tissues throughout eumetazoan species, as an ancient receptor that is sensitive to erythropoietin-like ligands. (uni-goettingen.de)
  • [ 10 ] Whereas hypoxia in an individual with normally functioning kidneys leads to erythropoietin gene transcription, and hence increased RBC production, CKD results in primary deficiency of erythropoietin production by the interstitial fibroblasts, also known as type I interstitial cells. (medscape.com)
  • This is a self-reinforcing process: Cognitive exertion leads to minor hypoxia, which we term 'functional hypoxia', which in turn stimulates the production of Epo and its receptors in the corresponding active nerve cells. (neurosciencenews.com)
  • Secondary erythrocytosis is erythrocytosis that develops secondary to disorders that cause tissue hypoxia, inappropriately increased erythropoietin production, or increased sensitivity to erythropoietin. (msdmanuals.com)
  • Whereas hypoxia in the individual with normal functioning kidneys leads to erythropoietin gene transcription, and hence increased RBC production, in those with anemia of chronic kidney disease, there is primary deficiency of erythropoietin production by the interstitial fibroblasts, also known as type I interstitial cells, thereby leading to anemia. (medscape.com)
  • Erythropoietin (Epo) is a 30-kDa, heavily glycosylated protein produced primarily by the kidney. (rndsystems.com)
  • The biological effects of Epo are mediated by the Erythropoietin receptor (Epo R). At the protein sequence level, the human Epo R is approximately 83% identical to the mouse protein. (rndsystems.com)
  • The comparative identities of the deduced entire amino acid sequence to mammalian EPO receptors were quite low, although functional domains indispensable for erythropoietic activities were found in the molecule. (elsevierpure.com)
  • [ 10 ] Endothelin-1/endothelin receptor signaling plays a role in the calcification and fibrosis of nephrogenic systemic fibrosis. (medscape.com)
  • Orchestration of these actions is usually incompletely comprehended, but structural and functional knowledge of the GH receptor (GHR) is critical for deciphering GH biology (3). (imacst.com)
  • This increases the production of erythropoietin (Epo) and its receptors in the active neurons, stimulating neighboring precursor cells to form new neurons and enhancing connectivity. (neurosciencenews.com)
  • This increases production of Epo and its receptors in the active nerve cells, stimulating neighbouring precursor cells to form new nerve cells and causing the nerve cells to connect to one another more effectively. (neurosciencenews.com)
  • Numerous anthropogenic chemicals and natural plant-derived products can mimic or disrupt the normal function of endogenous sex steroid hormones by direct interaction with their specific nuclear receptors. (uni-goettingen.de)
  • Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway. (uchicago.edu)
  • Are the downstream effects of these receptors also present in tumors? (cancernetwork.com)
  • To compare the quality of therapeutic erythropoietin (EPO) products, including two biosimilars, with respect to content, aggregation, isoform profile and potency. (springer.com)
  • The FDA approved the use of erythropoietin-stimulating agents in cancer patients receiving chemotherapy 15 years ago, but only recently has significant attention forced a re-examination of the controversy over ESA use in these patients. (cancernetwork.com)
  • Study of Single Nucleotide Polymorphisms in Endosomal Toll-Like Receptors-3, 7, and 9 Genes in Patients With Dengue: A Case-Control Study. (cdc.gov)
  • Differential genotypic signatures of Toll-like receptor polymorphisms among dengue-chikungunya mono- and co-infected Eastern Indian patients. (cdc.gov)
  • In general, the defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. (wikipedia.org)
  • Miljus N, Heibeck S, Jarrar M, Micke M, Ostrowski D, Ehrenreich H, Heinrich R (2014) Erythropoietin-mediated protection of insect brain neurons involves JAK and STAT but not PI3K transduction pathways. (atsu.edu)
  • Ostrowski D, Ehrenreich H, Heinrich R (2011) Erythropoietin promotes survival and regeneration of insect neurons in vivo and in vitro. (atsu.edu)
  • In fact, in individuals with advanced stages of chronic kidney disease, the etiology of anemia tends to be multifactorial (eg, decreased RBC production due to lack of erythropoietin, increased RBC destruction due to hemolysis [intravascular or extravascular], as well as increased blood loss due to multiple venipunctures for an array of indications). (medscape.com)
  • Control of hypertension and the use of angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin II receptor blockers especially in those with proteinuria have been shown to protect against chronic kidney disease and delay its progression to kidney failure. (bvsalud.org)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • demonstrate that anti-GHRmAb 18.24 also inhibits rabbit and human GHR signaling and inducible receptor proteolysis. (imacst.com)
  • In an in vitro model of cerebral ischemia (oxygen glucose deprivation, OGD) we investigated whether erythropoietin (EPO) plays a critical role in ischemic preconditioning. (jneurosci.org)
  • This process is both relevant and instructive for understanding receptor activation mechanisms therapeutically. (imacst.com)
  • Ostrowski TD, Ostrowski D, Hasser EM, Kline DD (2014) Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function. (atsu.edu)
  • Toll-like receptors (TLR), in particular TLR4 and TLR7, play a role in the development of nephrogenic systemic fibrosis. (medscape.com)
  • The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
  • Blood pressure control using angiotensin converting enzyme inhibitors and angioten- sin receptor blockers as the first line agents because these drugs have beneficial effects on glomerular haemodynamics and proteinuria in addition to their antihypertensive actions b. (bvsalud.org)
  • The severity of anemia of CKD is directly related to the degree of loss of kidney function, as the kidneys are responsible for approximately 90% of erythropoietin production. (medscape.com)
  • 8] The kidneys are responsible for approximately 90% of erythropoietin production in an individual. (medscape.com)
  • And in experiments with mice, Iacobucci also showed that introducing the mutant receptor in blood cells gave rise to leukemia. (news-medical.net)