Bone marrowCharacterized by ineffective erythropoiesisIncluding erythropoiesis-stimulAnemiaStages of erythropoiesisFetal ErythropoiesisMyelodysplasticSickle cell diRegulationRBCsPrecursorsErythropoietinHematopoietic stemHemoglobinHepcidinBiomarkerMacrophagesGeneFetusAgentsClinicallyDifferentiationErythrocytesDiseasesProcessesStemOccursMolecularPatientsProcessMiceNormalLiverInsightsStressHumanLevelsIronSignificantlyRoleFactorsEffectsFormation
Bone marrow7
- After seven months, erythropoiesis occurs in the bone marrow. (wikipedia.org)
- However, in humans with certain diseases and in some animals, erythropoiesis also occurs outside the bone marrow, within the spleen or liver. (wikipedia.org)
- this mechanism is called erythropoiesis, and it occurs in the bone marrow. (pediaa.com)
- Erythropoiesis is the process by which erythrocytes are formed in the bone marrow. (pediaa.com)
- With the help of AQP0 staining, we could define up to five stages of erythropoiesis in both mouse and human bone marrow using flow cytometry. (biomedcentral.com)
- Erythropoiesis is the process of erythrocyte production in adult bone marrow [ 1 ]. (biomedcentral.com)
- 17 Heme content was measured as described elsewhere.18 Erythropoiesis To obtain burst-forming units-erythroid (BFU-E) and colony-forming units-erythroid (CFU-E) 3 cells Linoleylethanolamide from fetal liver or adult bone marrow were cultured in MethoCult M3334 (Stemcell Technologies Vancouver Canada). (bioerc-iend.org)
Characterized by ineffective erythropoiesis2
- β-Thalassemia (BT) is an inherited genetic disorder that is characterized by ineffective erythropoiesis (IE), leading to anemia and abnormal iron metabolism. (thalassaemia.org.cy)
- Anemia of cancer is characterized by ineffective erythropoiesis, which is due to a number of factors. (medscape.com)
Including erythropoiesis-stimul1
- In this scenario, supportive treatment to raise hemoglobin levels and diminish symptoms from anemia, including erythropoiesis-stimulating agents (ESAs), may become necessary. (springermedizin.at)
Anemia3
- These findings will likely improve understanding of disordered erythropoiesis, including thalassemia, myelodysplastic syndrome, and congenital dyserythropoietic anemia, and guide future studies that focus on CDKIs. (biomedcentral.com)
- T he Haase Lab studies oxygen-regulation of erythropoiesis and iron metabolism with a focus on the mechanisms that lead to the development of anemia associated with chronic kidney disease (CKD), also known as renal anemia. (haaselab.org)
- It is characterized by severe anemia and stress erythropoiesis that is not well characterized. (dim-tg.org)
Stages of erythropoiesis1
- The eight stages of erythropoiesis are described below. (pediaa.com)
Fetal Erythropoiesis1
- Increased fetal erythropoiesis is usually a fetal response to intrauterine stress and fetal hypoxia associated with increased fetal oxygen consumption resulting in fetal hypoxia that could be related to several primary etiologic factors. (medscape.com)
Myelodysplastic2
- Erythropoiesis-stimulating agents (ESAs) reduce red blood cell (RBC) transfusions in approximately 40% of patients with myelodysplastic syndrome (MDS) in clinical trials. (aamds.org)
- Guillermo Garcia-Manero, MD, from MD Anderson Cancer Center, explores imetelstat trial results of patients with transfusion-dependent lower-risk myelodysplastic syndromes who experience failure to or are ineligible for treatment with erythropoiesis-stimulating agents. (theoncologynurse.com)
Sickle cell di1
- Our project aims to investigate and better characterize (normal and pathological) erythropoiesis and to determine the effect of therapeutic approaches, primarily gene therapy of sickle cell disease, on erythropoiesis and circulating red blood cell properties. (dim-tg.org)
Regulation9
- Gene expression - Other factors such as transcription factors , miRNA , post-translational modification of histones, cytokines , and cofactors are also involved in the regulation of erythropoiesis through the regulation of gene expression. (pediaa.com)
- Some other factors are also involved in the regulation of gene expression to regulate erythropoiesis. (pediaa.com)
- From Stem Cell to Red Cell: Regulation of Erythropoiesis at Multiple Levels by Multiple Proteins, RNAs, and Chromatin Modifications. (pediaa.com)
- As reported in our article recently published in Blood entitled "Unexpected roles for p19 INK4d in posttranscriptional regulation of GATA1 and modulation of human terminal erythropoiesis" [ 3 ], we demonstrated what roles p19 INK4d plays in human terminal erythropoiesis. (biomedcentral.com)
- Unexpected role for p19ink4d in post-transcriptional regulation of gata1 and modulation of human terminal erythropoiesis. (biomedcentral.com)
- The in vivo regulation of erythropoiesis involves the integration of a range of intrinsic and cell extrinsic cues. (edu.au)
- Over the last decade the Haase group has focused on investigating the role of HIF in the regulation of erythropoiesis and iron metabolism. (haaselab.org)
- More recently, the Haase lab investigated the role of HIF in the regulation of hepcidin and was able to show that the hypoxic suppression of hepcidin occurs indirectly through HIF-2-mediated stimulation of erythropoiesis. (haaselab.org)
- Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis. (ox.ac.uk)
RBCs1
- Current methods to induce erythropoiesis from PSC suffer from low yields of RBCs, most of which are immature and contain embryonic and fetal rather than adult hemoglobins. (ca.gov)
Precursors3
- This hormone stimulates proliferation and differentiation of red cell precursors, which activates increased erythropoiesis in the hemopoietic tissues, ultimately producing red blood cells (erythrocytes). (wikipedia.org)
- After cell sorting, the gene expressions of membrane proteins in early and late erythropoiesis precursors and in nonerythroid cells were characterized using microarray analysis. (biomedcentral.com)
- Among characterized gene candidates, aquaporin 0 (AQP0) expressed as a surface protein in early- and late-stage erythropoiesis precursors and was not expressed on nonerythroid cells. (biomedcentral.com)
Erythropoietin3
- Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. (ca.gov)
- A feedback loop involving erythropoietin helps regulate the process of erythropoiesis so that, in non-disease states, the production of red blood cells is equal to the destruction of red blood cells and the red blood cell number is sufficient to sustain adequate tissue oxygen levels but not so high as to cause sludging, thrombosis, or stroke. (wikidoc.org)
- Erythropoietin - The major factor that governs erythropoiesis is a hormone called erythropoietin. (pediaa.com)
Hematopoietic stem1
- During erythropoiesis, mature red blood cells are formed from hematopoietic stem cells. (pediaa.com)
Hemoglobin2
- During erythropoiesis, the cells start to produce hemoglobin, lose nuclei and organelles, and induce plasma membrane remodeling. (elifesciences.org)
- In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level of greater than 11 g/dL [see WARNINGS AND PRECAUTIONS ]. (rxlist.com)
Hepcidin2
- Does hepcidin affect erythropoiesis in hemodialysis patients? (uth.gr)
- Inflammatory cytokines suppress erythropoiesis in the BM and stimulate hepcidin production in the liver, which impacts iron absorption and mobilization negatively. (haaselab.org)
Biomarker1
- In addition, because patients with dyserythropoiesis generally exhibited a reduced population of APQ0 high cells relative to healthy participants, the analysis results also suggested that the levels of APQ0 high cells in early erythropoiesis serve as a novel biomarker that distinguishes normal from dysregulated erythropoiesis. (biomedcentral.com)
Macrophages2
- There is also 'functional failure' due to retention of iron in macrophages and decreased iron availability for erythropoiesis despite adequate iron stores in the reticuloendothelial system. (medscape.com)
- This study aimed to examine the tissue-specific contributions of macrophages and extracellular ATP, as a signal of disturbed tissue homeostasis, to erythropoiesis under conditions of repeated psychological stress. (ac.rs)
Gene1
- dblp: EpoDB: An Erythropoiesis Gene Expression Database/Knowledge Base. (dagstuhl.de)
Fetus3
- In the early fetus, erythropoiesis takes place in the mesodermal cells of the yolk sac. (wikipedia.org)
- The site of erythropoiesis varies according to the age of the fetus. (wikidoc.org)
- Shown below is an image depicting erythropoiesis in the fetus and adults. (wikidoc.org)
Agents2
- In this work, we assessed the potential of oxidative stress parameters to predict the response to erythropoiesis-stimulating agents (ESAs) in lower-risk MDS patients. (uc.pt)
- Evans M, Carrero JJ, Bellocco R, Barany P, Qureshi AR, Seeberger A, Jacobson SH, Hylander-Rössner B, Rotnitzky A, Sjölander A. Initiation of erythropoiesis-stimulating agents and outcomes: a nationwide observational cohort study in anaemic chronic kidney disease patients. (janusinfo.se)
Clinically1
- Lack of either causes maturation failure in the process of erythropoiesis, which manifests clinically as reticulocytopenia, an abnormally low amount of reticulocytes. (wikipedia.org)
Differentiation2
- Cul4a targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis. (biomedcentral.com)
- Mice carrying a allele deleted in the third exon common to both and isoform display normal erythropoiesis.9 Together these findings suggest that is required for the differentiation of fetal erythroid progenitors. (bioerc-iend.org)
Erythrocytes4
- Erythropoiesis (from Greek 'erythro' meaning "red" and 'poiesis' "to make") is the process which produces red blood cells (erythrocytes), which is the development from erythropoietic stem cell to mature red blood cell. (wikipedia.org)
- Erythropoiesis refers to the formation of erythrocytes. (medicinehack.com)
- Erythropoiesis is the process by which red blood cells (erythrocytes) are produced. (wikidoc.org)
- Erythropoiesis is the mechanism of formation of erythrocytes during the replenishing of new erythrocytes. (pediaa.com)
Diseases3
- Psychological stress is a significant contributor to various chronic diseases and affects multiple physiological processes including erythropoiesis. (ac.rs)
- TY - JOUR AU - Momčilović, Sanja AU - Bogdanović, Andrija AU - Milošević, Maja AU - Mojsilović, Slavko AU - Marković, Dragana C. AU - Kočović, Dušica M. AU - Vignjević Petrinović, Sanja PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1329 AB - Psychological stress is a significant contributor to various chronic diseases and affects multiple physiological processes including erythropoiesis. (ac.rs)
- article{ author = "Momčilović, Sanja and Bogdanović, Andrija and Milošević, Maja and Mojsilović, Slavko and Marković, Dragana C. and Kočović, Dušica M. and Vignjević Petrinović, Sanja", year = "2023", abstract = "Psychological stress is a significant contributor to various chronic diseases and affects multiple physiological processes including erythropoiesis. (ac.rs)
Processes1
- The findings are of interest in understanding molecular processes involved in regulating erythropoiesis, as well as the potential to develop host-directed therapies for malarial parasites that target human reticulocytes. (elifesciences.org)
Stem2
- The goal of the present study was to investigate the potential of ic-MPL dimerization to induce erythropoiesis from human embryonic stem cells (hESC) and to identify the signaling pathways activated by this strategy. (ca.gov)
- Erythropoiesis is a complex process that results in the production of red blood cells from stem cells. (dim-tg.org)
Occurs1
- In the third trimester in the fetal development, erythropoiesis occurs in the liver. (pediaa.com)
Molecular11
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Patients5
- The expression levels of AQP0 are downregulated in patients with dyserythropoiesis, indicating a critical role of AQP0 in erythropoiesis. (biomedcentral.com)
- These functionally high prohepcidin levels may be associated with the factors that inhibit erythropoiesis in HD patients. (uth.gr)
- Changes in Metabolomic Profiles Induced by Switching from an Erythropoiesis-Stimulating Agent to a Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor in Hemodialysis Patients: A Pilot Study. (bvsalud.org)
- In this prospective, single-center study, we comprehensively investigated changes in plasma metabolomic profiles following the switch from an erythropoiesis -stimulating agent (ESA) to an HIF-PHI, daprodustat, in 10 maintenance hemodialysis patients . (bvsalud.org)
- Le diagnostic de thalassémie a été posé chez six patients (19,4 %) et celui de déficit en glucose-6-phosphate déshydrogénase chez sept patients (22,6 %), parmi lesquels six patients étaient atteints d'une forme modérée et un patient d'une forme sévère. (who.int)
Process1
- Based on the differential expression levels of cell-surface molecules during erythropoiesis, flow cytometry analysis is a useful tool for analyzing the erythropoiesis process [ 8 ]. (biomedcentral.com)
Mice2
- Mechanistically, we identified dysregulated erythropoiesis with reduced numbers of reticulocytes, the preferred host cells of P. yoelii , in Ac-deficient mice. (elifesciences.org)
- Furthermore, we demonstrate that administration of the Ac inhibitor carmofur to wildtype mice has similar effects on P. yoelii infection and erythropoiesis. (elifesciences.org)
Normal1
- This study provides evidence that murine acid ceramidase (Ac) is required for normal erythropoiesis and the development of rodent malaria. (elifesciences.org)
Liver1
- By the third or fourth month, erythropoiesis moves to the liver. (wikipedia.org)
Insights1
- To get insights into the specific functions of and in erythropoiesis we used animal and cultured cell models that differentially express the two isoforms. (bioerc-iend.org)
Stress1
- Key Points Canonical Notch signaling is dispensable for steady-state and posttransplantation myelopoiesis, as well as stress erythropoiesis. (ox.ac.uk)
Human2
- We have previously shown that homo-dimerization of the intracellular component of MPL (ic-MPL) induces erythropoiesis from human cord blood progenitors. (ca.gov)
- Here, by determining the absolute abundances of 103 TFs and co-factors during the course of human erythropoiesis, we provide a dynamic and quantitative scale for TFs in the nucleus. (ox.ac.uk)
Levels1
- Increased levels of physical activity can cause an increase in erythropoiesis. (wikipedia.org)
Iron1
- Specifically, we have identified HIF-2 as the key regulator of renal EPO synthesis and have established that HIF coordinates erythropoiesis with iron metabolism by directly regulating iron uptake and release. (haaselab.org)
Significantly1
- ic-MPL dimerization is significantly more potent than EPO in inducing erythropoiesis and its effect is additive to EPO. (ca.gov)
Role1
- 10 Nevertheless the specific role of isoforms in erythropoiesis is still debated. (bioerc-iend.org)
Factors1
- Erythropoiesis is regulated by many factors. (pediaa.com)
Effects1
- Effects of various modes of androgen substitution therapy on erythropoiesis. (bvsalud.org)
Formation1
- Après des études de médecine à l'Université de Genève et une formation clinique en pathologie, médecine interne et maladies infectieuses à Genève et au Massachusetts General Hospital de Boston, Didier Trono s'engage dans une carrière scientifique au Whitehead Institute du MIT. (epfl.ch)