• In one large cohort from Canada, older adults taking an implicated statin alongside erythromycin or clarithromycin were significantly more likely to be admitted to hospital with rhabdomyolysis or acute kidney injury, and significantly more likely to die within 30 days than similar adults taking azithromycin instead. (thefreedictionary.com)
  • Erythromycin belongs to a group of drugs known as macrolides . (newworldencyclopedia.org)
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  • Erythromycin is an inhibitor of the cytochrome P450 system, which means it can have a rapid effect on levels of other drugs metabolised by this system, e.g., warfarin. (wikipedia.org)
  • The activity of the CYP3A enzymes can be induced or inhibited by certain drugs (e.g. dexamethasone) which can cause it to affect the metabolism of many different drugs, e.g. erythromycin. (wikipedia.org)
  • If other CYP3A substrates - drugs that are broken down by CYP3A - such as simvastatin (Zocor), lovastatin (Mevacor), or atorvastatin (Lipitor)-are taken concomitantly with erythromycin, levels of the substrates increase, often causing adverse effects. (wikipedia.org)
  • However, elderly patients are more likely to have erythromycin-induced hearing loss, heart rhythm problems, and bleeding problems, and age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving erythromycin injection. (mayoclinic.org)
  • To investigate whether erythromycin therapy lowers the frequency of the common cold and subsequent exacerbation in patients with COPD. (nih.gov)
  • Patients were randomly assigned to erythromycin therapy or to no active treatment in September 1997. (nih.gov)
  • Fifty-five patients received erythromycin at study entry (erythromycin group). (nih.gov)
  • Forty-one patients (76%) in the control group experienced common colds more than once, compared to 7 patients (13%) in the erythromycin group. (nih.gov)
  • Thirty patients (56%) in the control group and 6 patients (11%) in the erythromycin group had one or more exacerbations. (nih.gov)
  • Significantly more patients were hospitalized due to exacerbations in the control group than in the erythromycin group (p = 0.0007). (nih.gov)
  • Erythromycin therapy has beneficial effects on the prevention of exacerbations in COPD patients. (nih.gov)
  • Erythromycin acts by inhibition of protein synthesis in susceptible organisms by reversibly binding to 50S ribosomal subunits, thereby inhibiting translocation of aminoacyl transfer-RNA and inhibiting polypeptide synthesis. (nih.gov)
  • If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting erythromycin. (medhelp.org)
  • Therefore, before using erythromycin, report all medications you are currently using to your doctor or pharmacist. (medhelp.org)
  • Eli Lilly's research team, led by J. M. McGuire, managed to isolate Erythromycin from the metabolic products of a strain of Streptomyces erythreus (designation changed to " Saccharopolyspora erythraea ") found in the samples. (princeton.edu)
  • Erythromycin may also be prescribed to prevent this infection in people who haven't been vaccinated against whooping cough and who are in close contact with someone who has it. (netdoctor.co.uk)
  • Erythromycin may also used to prevent bacterial infection following surgery, burns or trauma. (netdoctor.co.uk)
  • The dose of erythromycin prescribed, how often to take it and how long for, depends on the type of infection you have, your age and your kidney function. (netdoctor.co.uk)
  • Erythromycin is usually taken twice a day (every 12 hours) or four times a day (every six hours), depending on the type of infection being treated. (netdoctor.co.uk)
  • Unless your doctor tells you otherwise, it is important that you finish the prescribed course of erythromycin, even if you feel better or it seems the infection has cleared up. (netdoctor.co.uk)
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  • Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of erythromycin injection in children. (mayoclinic.org)
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  • Studies have shown evidence both for and against the association of pyloric stenosis and exposure to erythromycin prenatally and postnatally. (wikipedia.org)