Erythroid promoter nf e2 transcription factor. Medical search. Frequent questions

The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. (nih.gov)
However, the link between Nrf2 promoter polymorphisms and susceptibility to oxidative stress-related diseases such as vitiligo is unknown. (nih.gov)
These findings indicate that the C allele of rs35652124 located in the promoter region of Nrf2 gene is associated with protective effect on vitiligo in a Han Chinese population. (nih.gov)
Nuclear factor erythroid-2-related factor 2 (Nrf2) is a transcription factor that is upregulated in times of oxidative stress. (hindawi.com)
Nrf2 activates transcription of antioxidant enzymes by binding to the antioxidant response element (ARE) in the promoter regions of its target genes [ 23 , 24 ]. (hindawi.com)
Upon exposure to ROS, Keap1 undergoes a conformational change that allows Nrf2 to translocate to the nucleus, bind to the ARE region, and initiate transcription of target genes [ 24 ]. (hindawi.com)
Oxidized Keap1 dissociates from Nrf2, allowing Nrf2 to translocate to the nucleus, bind to the ARE region, and initiate transcription of target genes. (hindawi.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
Our cancer research investigates the dichotomous role of the Nrf2 transcription factor in cancer, with special interest in lung cancer research. (uef.fi)
The key mediator of cellular protection against ROS and RNS is transcription factor Nrf2, which regulates the expression of numerous protective genes. (uef.fi)

In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
A recent study showed that mitochondria clustering around the perinuclear region can act as signaling for increased oxidative stress affecting hypoxia inducible promoters [ 12 ]. (hindawi.com)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)

ATAC-seq evaluation showed decreased chromatin accessibility, and additional research pointed these sites correlate with gain access to of transcription elements to enhancers linked to acinar identification genes [94]. (morainetownshipdems.org)
It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. (nih.gov)

Mechanistically, knockdown resulted in decreased activation from the JAK2/STAT3 pathway, inhibition of STAT3 phosphorylation and decreased transcription of STAT3 focus on genes [85]. (morainetownshipdems.org)
Candidate genes showing distinctive expression patterns in response to ethanol were clustered by pattern and further analyzed for related function, pathway membership and common transcription factor binding within and across clusters. (biomedcentral.com)

It shows a stack of six IkappaBalpha ankyrin repeats facing the C-terminal domains of the NF-kappaB Rel homology regions. (embl.de)

Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)

In addition, the subcellular distribution of mitochondria can affect the cellular transcriptome and transcription rates. (hindawi.com)

Risk factors for depression initiate an infection-like inflammation in the brain that involves activation microglial Toll-like receptors and glycogen synthase kinase-3β (GSK3β). (mdpi.com)

As part of civil aviation safety research into aeromedical factors impacting flight safety, we have undertaken a time course study on the effects of acute ethanol exposure to the legal intoxication level of blood alcohol concentration (BAC), 0.08 g/dL (0.08% wt/vol), on human gene expression in non-chronic users. (biomedcentral.com)

Activation of NF-κB and IRF3/7 signaling mediated by MyD88 and TRIF initiates the production of pro-inflammatory cytokines, such as tumor necrosis factor (TNF), interleukin (IL)-6, IL-1β and type I/III IFNs. (molcells.org)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)

NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
NF-κB pathways can be mainly activated by two pathways. (springer.com)
ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
Analysis showed function-based networks, shared transcription factor binding sites and signaling pathways for members of the clusters. (biomedcentral.com)

tightly you dissipate your download, contribute the nursing of it, and bind in with your triphosphatase endocytosis promoter and bilayer pore( the activation Early occurs to the endocytic 4 products of your source phosphorylation). (evakoch.com)

Both CarD and RbpA bind near the upstream edge of the −10 element where they likely facilitate DNA bending and impede transcription bubble collapse. (regenerativemedicine.net)

Structure of an IkappaBalpha/NF-kappaB complex. (embl.de)
We determined a 2.76 -resolution crystal structure of a mycobacterial transcription initiation complex (TIC) with RbpA as well as a CarD/RbpA/TIC model. (regenerativemedicine.net)

In vivo studies demonstrate the essential role of RbpA, show the effects of RbpA truncations on transcription and cell physiology, and indicate additional functions for RbpA not evident in vitro. (regenerativemedicine.net)

The structure of the IkappaBalpha ankyrin repeat domain, bound to a partially truncated NF-kappaB heterodimer (p50/ p65), has been determined by X-ray crystallography at 2.7 A resolution. (embl.de)

These studies provide detailed evidence for the more general hypothesis that commitment and differentiation are primarily driven by the sequential appearance of key transcriptional factors, which bind chromatin at specific, high-affinity sites. (ox.ac.uk)
1. A novel erythroid differentiation related gene EDRF1 upregulating globin gene expression in HEL cells. (nih.gov)
5. Nitric oxide-releasing agents and cGMP analogues inhibit murine erythroleukemia cell differentiation and suppress erythroid-specific gene expression: correlation with decreased DNA binding of NF-E2 and altered c-myb mRNA expression. (nih.gov)
7. Dependence for the proliferative response to erythropoietin on an established erythroid differentiation program in a human hematopoietic cell line, UT-7. (nih.gov)
18. Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation. (nih.gov)
20. Transcriptional and posttranscriptional regulation of erythroid gene expression in anthracycline-induced differentiation of human erythroleukemic cells. (nih.gov)
Dysfunction and abnormal differentiation of immune cells and hematopoietic precursors are well described in patients with cancer, although the role of transcription factors in these defects is not well established. (scientificarchives.com)
Thus, it is conceivable to speculate that an abnormal expression of proto-oncogenes in lymphoid cells and myeloid cells may be due to a general imbalance of transcription factors responsible for the lineage-specific differentiation. (scientificarchives.com)
Among transcription factors C/EBPα/β, BACH1/2 and ETS play pivotal roles in myeloid and lymphoid cell differentiation. (scientificarchives.com)

Both GATA-1 and GATA-2 nucleate the binding of various protein complexes including SCL/LMO2/E2A/Ldb-1 and NF-E2. (ox.ac.uk)
flanking) region of human GCL is regulated by activator protein-1 (AP-1) and antioxidant response element (ARE), and are modulated by oxidants, phenolic antioxidants, growth factors, inflammatory and anti-inflammatory agents in various cells. (nih.gov)
13. Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. (nih.gov)
These are (i) a polyadenylation site for late mRNAs, which is fairly close to the 5 end of the LCR, (ii) E2 protein binding sites, which vary in relative position and in number from 4 in genital HPVs to 10 in BPV-1, (iii) one E1 protein binding site, and (iv) the TATA box of the E6 gene promoter. (nih.gov)
Therefore, the E2 enzymes are critical for protein ubiquitination and stability. (biomedcentral.com)
C/EBPΑ (CCAAT/enhancer binding protein (C/EBP) alpha), a protein encoded by the C/EBPΑ gene in humans, was originally identified 30 years ago as a transcription factor that binds both promoter and enhancer regions. (scientificarchives.com)
It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN. (nih.gov)
HN - 2017 MH - ADAM12 Protein UI - D000072199 MN - D8.811.277.656.675.374.102.125 MN - D9.400.430.500.125 MN - D12.776.395.33.125 MS - A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS. (nih.gov)
HN - 2017 (1997) MH - ADAM17 Protein UI - D000072198 MN - D8.811.277.656.675.374.102.375 MN - D9.400.430.500.375 MN - D12.776.395.33.375 MN - D23.50.301.264.35.57 MN - D23.101.100.110.57 MS - A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. (nih.gov)

10. Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells. (nih.gov)
On the other hand, a reduced set of genes, called transcription factors (TFs), has the role of regulating the transcriptional program of the cells. (hindawi.com)
These results open a new opportunity to test whether altered transcriptional regulation of mature immune cells in cancer may be intrinsically related to abnormal functioning of transcription factors in early hematopoiesis or occurs independently via direct effects of tumor-derived factors on circulating immune cells. (scientificarchives.com)

Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357). (nih.gov)
ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
however, there is an unusually large E2 called E2-230K or UBE2O that can ubiquitinate proteins in an E3-independent manner [ 1 ]. (biomedcentral.com)

LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). (nih.gov)

In committed erythroid progenitors, GATA-2 is replaced by GATA-1 and binding is extended to additional sites including the alpha-globin promoters. (ox.ac.uk)

Muscle wasting in these conditions is mainly caused by increased proteolysis, at least in part regulated by nuclear factor-kappaB. (researchgate.net)
Studies suggest that inhibition of nuclear factor-kappaB is one of the mechanisms by which curcumin exerts its ant-inflammatory effects. (researchgate.net)

Because of the easy accessibility of purified, highly specialized, mature erythroid cells from peripheral blood, the hemoglobinopathies were among the first tractable human molecular diseases. (nih.gov)
Analysis of expression of transcription factors in CD34+CD45dim hematopoietic precursors showed that in contrast to the downregulation of transcription factor in mature peripheral blood immune cells, expression of these regulators in stem/precursor cells was significantly increased in patients with lung cancer, especially in patients with detectable metastases. (scientificarchives.com)

3. Differential expression and functional role of GATA-2, NF-E2, and GATA-1 in normal adult hematopoiesis. (nih.gov)

Expression of Pu.1, C/Ebpa and Bach1 Transcription Factors in Immune Cells in Patients with Cancer. (scientificarchives.com)
Here, we evaluated expression of C/EBPa, PU.1 and BACH1 transcription factors in lymphoid and myeloid cells, including NK cells, T cells, neutrophils and monocytes, isolated from healthy donors and cancer patients. (scientificarchives.com)

16. Targeted remodeling of human beta-globin promoter chromatin structure produces increased expression and decreased silencing. (nih.gov)

The recruitment of polymerase II, which ultimately leads to a rapid increase in alpha-globin transcription, occurs late in maturation. (ox.ac.uk)

11. Function of GATA transcription factors in hydroxyurea-induced HEL cells. (nih.gov)
12. [Analysis of the binding of GATA factors to the regulatory elements of human beta-globin gene in hydroxyurea-induced and uninduced HEL cells]. (nih.gov)
15. Reduction of DNA binding activity of the GATA-1 transcription factor in the apoptotic process induced by overexpression of PU.1 in murine erythroleukemia cells. (nih.gov)
17. Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells. (nih.gov)
We believe that an approach, such as the one shown here, could help to understand the one regulation of transcription in eukaryotic cells. (hindawi.com)
CBP HAT promoter has no event with the respiratory cells but some causative Pi within skeletal enzyme( Liu et al. (evakoch.com)
The results revealed a significant suppression of transcription factors participating in the development of immune cells in patients with cancer. (scientificarchives.com)
Immune abnormalities in cancer may be due to the effect of tumor/stroma-derived factors on mature circulating immune cells or on their precursors in the bone marrow. (scientificarchives.com)
Transcription factors are key regulators of these cells acting through their capacity to bind DNA and control gene transcription, which thus regulates the development of specific hematopoietic lineages from stem cells. (scientificarchives.com)

2000 . Functional significance of Sp1, Sp2, and Sp3 transcription factors in regulation of the murine CTP:phosphocholine cytidylyltransferase α promoter. (nih.gov)
The lack of experimental information regarding the regulation of the whole set of transcription factors and their targets in different cell types is one of the main reasons to this incompleteness. (hindawi.com)
The said phenomena are indicative of a sophisticated machinery involved in the regulation of gene transcription: highly connected TFs are also regulated by others, which may (or may not) be highly connected. (hindawi.com)

This is particularly relevant for skin, the largest body organ that serves as biological barrier for physical and chemical environmental factors. (encyclopedia.pub)

14. In vivo erythroid recovery following paclitaxel injury: correlation between GATA-1, c-MYB, NF-E2, Epo receptor expressions, and apoptosis. (nih.gov)
There are digital pathways in which release of HAT or HDAC times interact their dolichol receptor and transcription degradation, which in Co-precipitation, trim the broader domains of these iNOS( Shahbazian & Grunstein 2007). (evakoch.com)

9. Induction of erythroid gene expression by microcell fusion. (nih.gov)
We present the topological parameters which define the network as well as some global structural features and introduce a relative inuence parameter to quantify the relevance of a transcription factor in the context of induction of a phenotype. (hindawi.com)

It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. (nih.gov)

Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. (nih.gov)
This family is comprised of seven members of which c-Maf, MafA, and MafB belong to the large Maf subfamily because these transcription factors contain the complete structure and functional domains including the DNA-binding domain and the transcription activation domain [ 8 ]. (biomedcentral.com)
Activation of the autocrine/paracrine cyclooxygenase 2 (Cox2)/prostaglandin E2 (PGE2) pathway associates with podocyte damage in this setting. (mdpi.com)

These factors may act as oxidants or mediators in the process of generation of ROS and RNS, and together with endogenously formed reactive species make the skin a major target for oxidative stress contributing to the onset and development of various skin pathologies. (encyclopedia.pub)

Four E2 binding sites serve as landmarks, and two of them divide the LCR into functionally distinct segments, which we have called the 5 , the central, and the 3 segment. (nih.gov)
This segment contains transcription ter- mination and polyadenylation sites for late transcripts as well as a negative regulatory element acting at the level of late mRNA stability [36,48]. (nih.gov)

Although the detailed mechanisms are not fully understood, the Maf family transcription factors raise high attention [ 8 ]. (biomedcentral.com)

Prostate-specific antitumor activity by probasin promoter-directed p202 expression. (jefferson.edu)

LAMA 84 is actually a human leucocytic cell line with basophilic characteristic and K562 is a erythroblastic cell line with granulocytic and erythroid characteristics, aside from staying extremely a lot more differentiated than LAMA 84. (mirnadatabase.com)

This segment has a size of about 300 bp and is bracketed by the termination codon of L1 and an E2 binding site (marked #1 in fig. 1). (nih.gov)

UBE2O was found to interact with c-Maf, a critical transcription factor in MM, by the affinity purification/tandem mass spectrometry assay and co-immunoprecipitation assays. (biomedcentral.com)

the E-value for the ANK domain shown below is 4.18e2. (embl.de)

2011 . Coffee, broccoli and spices are strong inducers of electrophile response element-dependent transcription in vitro and in vivo-studies in electrophile response element transgenic mice. (nih.gov)

Anatomy23

Organisms8

Diseases1

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes79

Disciplines and Occupations1

Information Science3

Nrf213

Oxidative5

NFE2L21

Enhancers2

Genes2

Regions1

Activates1

Cellular1

Initiate1

Gene1

Tumor2

Pathways4

Activation1

Bind1

Complex2

Role1

Structure1

Differentiation9

Protein9

Transcriptional3

Proteins3

Enhancer1

Progenitors1

Nuclear factor2

Peripheral blood2

Hematopoiesis1

Bach12

Chromatin1

Alpha-globin1

Cells9

Regulation3

Biological1

Receptor2

Induction2

Interaction1

Activation3

Oxidative stress1

Sites2

Mechanisms1

Expression1

Cell1

Binding site1

Critical1

Shown1

Response element1