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  • RBCs
  • Circulating RBCs retain a low number of the receptor copies that is higher in young cells compared with mature and senescent RBC populations. (uzh.ch)
  • Modulation of the NMDAR activity in RBCs by agonists or antagonists is associated with the alterations in whole cell ion currents. (uzh.ch)
  • Thus functional NMDARs are present in erythroid precursor cells and in circulating RBCs. (uzh.ch)
  • accumulation
  • Activation of the receptor results in the transient Ca(2+) accumulation, cell shrinkage, and alteration in the intracellular pH, which is associated with the change in hemoglobin oxygen affinity. (uzh.ch)
  • Along with the changes in cell volume and cation content, accumulation of Ca 2+ was shown to facilitate intercellular adhesion ( 60 ). (physiology.org)
  • In addition, PM-MTH were able to upregulate preferentially γ-globin messenger ribonucleic acid production and to increase fetal hemoglobin (HbF) accumulation, the percentage of HbF-containing cells, and their HbF content without stimulating α-globin gene expression, which is responsible for the clinical symptoms of ß-thalassemia. (dovepress.com)
  • tissue
  • Taken together, these data show that zebrafish tfr1a and tfr1b share biochemical function but have restricted domains of tissue expression, and establish a genetic model to study the specific function of Tfr1 in erythroid cells. (biologists.org)
  • 2. The method of claim 1 , wherein the cell is a diseased or abnormal cell from a tissue or a cell line that exhibits a disease or abnormal condition selected from the group consisting of cancer, infection, immune disorder, cardiovascular disease, and inflammatory disorder. (google.es)
  • cellular
  • Taken together, these findings suggest that the VP1u binds to a yet-unknown erythroid-specific cellular receptor and thus restricts the virus entry to permissive cells. (mdpi.com)
  • Both innate and adaptive cellular immune responses are required for an effective host defense against M.tb and individuals with defective cell-mediated immunity (CMI) have a predisposition towards developing TB, or towards more severe disease [ 10 ]. (hindawi.com)
  • protein
  • In certain embodiments, the invention relates to inhibitors of β-TrCP1, β-TrCP2 (F-box protein members) RSK1, or RSK2 (p90 rsk /MAPKAP kinase-1 or 2) that sensitize tumor cells to chemotherapy-induced cell death or apoptosis. (google.es)
  • tumor cells
  • Combining interleukin-2 with interleukin-12 may kill more tumor cells. (bioportfolio.com)
  • RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. (bioportfolio.com)
  • Interleukin-12 may kill tumor cells by stopping blood flow to the tumor. (bioportfolio.com)
  • In certain embodiments, the invention relates to inhibitors of at least one of β-TrCP1/2 or RSK1/2 proteins that sensitize tumor cells to chemotherapy-induced death or apoptosis. (google.es)
  • receptor
  • The receptor tetramers in erythroid precursor cells are composed of the NR1, NR2A, 2C, 2D, NR3A, and 3B subunits of which the glycine-binding NR3A and 3B and glutamate-binding NR2C and 2D subunits prevailed. (uzh.ch)
  • CFU-GEMM express also CD38 but do not express the α subunit of the interleukin-3 (IL-3) receptor, which is acquired during the transition of these cells to BFU-E, CFU-GM, and CD45RA [ 7 , 8 ], which is specifically expressed by BFU-E [ 5 , 6 ]. (hindawi.com)
  • cord blood
  • In cord blood, only CD56 + NK cells expressed granulysin and perforin constitutively. (hindawi.com)
  • Constitutive expression of perforin and granulysin by cord blood NK-cells likely provides innate immunity, while BCG vaccination-induced expression of these cytolytic mediators may contribute towards protection of the neonate against tuberculosis. (hindawi.com)
  • results
  • These results suggest that in chicken embryo erythroid cells newly synthesized vimentin is rapidly assembled into filaments from a soluble precursor. (caltech.edu)
  • The results showed that the MS2-VP1u bioconjugate mimicked the specific internalization of the native B19V into erythroid precursor cells, which further coincides with the restricted infection profile. (mdpi.com)
  • Based on a single cell approach we could qualitatively confirm these results (Figure 1A , 2 leftmost columns), although the extend of the Ca 2+ increase was smaller compared to the cited investigations, which is presumably caused by differences in the methodology. (frontiersin.org)
  • Expression
  • Following BCG vaccination of neonates, both BCG and PPD induced increased expression of granulysin and perforin by CD4 + and CD8 + T cells. (hindawi.com)
  • Although it is conceivable that CD36 is expressed by erythroid cells of all types, how its expression is modulated during the transition from CFU-GEMM to CFU-E is not known. (hindawi.com)
  • tissues
  • tfr1b morphants exhibited growth retardation and brain necrosis, similar to the central nervous system defects observed in the Tfr1 null mouse, indicating that tfr1b is probably used by non-erythroid tissues for iron acquisition. (biologists.org)
  • specific
  • It has been suggested that the strain of BCG and the route of administration may affect the efficacy of the vaccine [ 5 - 8 ] as well as determine the nature of the antigen-specific T-cell responses [ 9 ]. (hindawi.com)
  • role
  • To further investigate the role of the RBD in connection with a B19V-unrelated capsid, we chemically coupled the VP1u of B19V to the bacteriophage MS2 capsid and tested the internalization capacity of the bioconjugate on permissive cells. (mdpi.com)