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  • tissues
  • These results are discussed with relation to the coordinate regulation of alpha- and beta-globin synthesis in erythroid tissues. (ox.ac.uk)
  • expression
  • High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes. (ox.ac.uk)
  • dysplasia
  • Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes. (sigmaaldrich.com)
  • We established a novel single-cell assay to quantify disrupted F-actin filament network in erythroblasts and demonstrate that reduced expression of DOCK4 leads to disruption of the actin filaments, resulting in erythroid dysplasia that phenocopies the red blood cell (RBC) defects seen in samples from MDS patients. (sigmaaldrich.com)
  • chromatin
  • We found that common genetic variation at BCL11A associated with fetal hemoglobin (HbF) level lies in noncoding sequences decorated by an erythroid enhancer chromatin signature. (nih.gov)
  • colonies
  • This correlates with the low overall Hb levels seen in MDS patients compared with healthy individuals and is consistent with the positive impact of TCF4 on erythroid development while not having impact on white colonies. (eur.nl)
  • human
  • To address this question we have established a human inducible erythroid cell system, which recapitulate DICE-dependent translational regulation in vitro and in vivo. (uni-wuerzburg.de)
  • fetal
  • An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. (nih.gov)
  • myelodysplastic
  • Because TCF4 affects erythroid/MK development and these lineages are affected in myelodysplastic syndrome (MDS), we studied the impact of TCF4 expression in this disease. (eur.nl)
  • characteristic
  • The preferential utilization of the upstream polyadenylation signal may be an erythroid-specific characteristic of ferrochelatase gene expression. (biochemj.org)
  • Disorders
  • Our study supports ATP2B4 as a potential target for modulating rbc hydration in erythroid disorders and malaria infection. (jci.org)
  • significantly
  • The reduction of erythroid growth did not differ significantly between exposure to intact and lysed IE and the mean growth relative to unexposed controls was 59.4 ± 5.2 for lysed IE and 57 ± 8.5% for intact IE. (springermedizin.de)