GlobulinThrombocytopeniaIntravenousAntigensBone marrowInnate immuneHemolysisHumoralSedimentationIVIGSYSTEMInflammatoryThrombocytopenicDestruction of erythrocytesVitroHemolytic anemiaProteinInfectionTransfusionRBCsAntigenHypersensitivityViralSystemicAdaptiveAnaphylacticResponseMutationMethotrexateFunctionalHemeImmunizationOrgansBlood cellsContributesReactionsTargetsFunctionMembraneClinicalCirculationHumanCellSurface
Globulin9
- The incidence of fetuses at risk for anemia due to maternal alloimmunization to red cell antigens has decreased dramatically since the institution of routine anti-D immune globulin (RhoGAM) prophylaxis for Rh-negative women in the 1960s. (medscape.com)
- In 1960, the administration of Rh D IgG, also known as anti-D immune globulin, or RhoGAM, was demonstrated to prevent Rh D alloimmunization, leading to the licensing of anti-D IgG in 1968 for use in North America. (medscape.com)
- In a woman whose blood is Rh incompatible with her infant, this test helps find out how much Rh immune globulin (RhoGAM) she must receive to prevent her body from producing abnormal proteins that attack the unborn baby in future pregnancies. (mountsinai.org)
- The standard dose of Rh immune globulin is enough in this case. (mountsinai.org)
- The more of the baby's cells there are, the more Rh immune globulin the mother must receive. (mountsinai.org)
- Guidelines on the use of intravenous immune globulin for hematologic conditions. (medscape.com)
- 10,000/ µ L) persisted despite a collaboration among multiple agencies was required to identify platelet transfusion and administration of intravenous immune the extent of mercury contamination, evaluate and treat the globulin (IVIG). (cdc.gov)
- rabies immune globulin, human (RIG) decreases effects of BCG vaccine live by Other (see comment). (medscape.com)
- efgartigimod alfa will decrease the level or effect of rabies immune globulin, human (RIG) by receptor binding competition. (medscape.com)
Thrombocytopenia7
- Primary immune thrombocytopenia (ITP) is characterized by isolated low platelet count and it is a diagnosis of exclusion, contrasting to secondary ITP. (spandidos-publications.com)
- Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated destruction and impaired production of platelets, with isolated thrombocytopenia. (spandidos-publications.com)
- Some of the many underlying disorders that are associated with immune thrombocytopenia are also lymphoproliferative disorders. (spandidos-publications.com)
- Which medications in the drug class Thrombopoietic Agents are used in the treatment of Immune Thrombocytopenia (ITP)? (medscape.com)
- It is indicated for thrombocytopenia in adults with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. (medscape.com)
- Indicated for chronic immune thrombocytopenia (ITP) in adults who are newly diagnosed or those who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. (medscape.com)
- American Society of Hematology 2019 guidelines for immune thrombocytopenia. (medscape.com)
Intravenous1
- Abdominal ultrasound treated with platelet transfusions, intravenous immune globu- findings demonstrated splenomegaly. (cdc.gov)
Antigens5
- Maternal alloimmunization, also known as isoimmunization, occurs when a woman's immune system is sensitized to foreign erythrocyte surface antigens, stimulating the production of immunoglobulin G (IgG) antibodies. (medscape.com)
- [ 2 , 3 ] These antibodies can cross the placenta during pregnancies in alloimmunized women and, if the fetus is positive for these specific erythrocyte surface antigens, result in hemolysis of fetal erythrocytes and anemia. (medscape.com)
- This article reviews the pathophysiology, diagnosis, and management of erythrocyte Rh D alloimmunization and includes a discussion of rarer erythrocyte antigens. (medscape.com)
- Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and. (edu.au)
- Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and function to evade naturally acquired immunity. (edu.au)
Bone marrow4
- The cells of the immune system originate in the bone marrow. (pearson.com)
- However, the erythroid response in the bone marrow may be blunted by the immune process or the underlying disease, thereby leading to non-regenerative anemias. (vin.com)
- Jubelirer SJ, Harpold R. The role of the bone marrow examination in the diagnosis of immune thrombocytopenic purpura: case series and literature review. (medscape.com)
- Blood cells, such as erythrocytes or immune cells, are continuously replaced by new ones supplied by hematopoietic stem cells located in a specialized niche of the bone marrow. (disabled-world.com)
Innate immune1
- The complement system is part of the innate immune system. (medscape.com)
Hemolysis1
Humoral4
- Functional interaction between the immune and neuroendocrine systems is mediated by humoral mediators, neurotransmitters, and cytokines, including TRH and PRL. (bris.ac.uk)
- Humoral immune function as assessed by antibody- farm ing cell response and serum IgM titre to sheep erythrocytes, and cell-mediated immune function evaluated utilizing natural killer cell activity and the mixed lymphocyte reaction were not altered. (cdc.gov)
- Oral exposure to patulin for 28 days did not alter the ability of female B6C3F(1) mice to mount either a cell-mediated or humoral immune response. (cdc.gov)
- These findings demonstrate that expression of a proexendin-4 transgene may be associated with activation of humoral and cellular immune responses in mice. (diabetesjournals.org)
Sedimentation2
- What is an Erythrocyte Sedimentation Rate (ESR)? (medlineplus.gov)
- An erythrocyte sedimentation rate (ESR) is a blood test that that can show if you have inflammation in your body. (medlineplus.gov)
IVIG1
- lin (IVIG) for possible immune thrombocytopenic purpura, The patient's signs and symptoms, the abnormal laboratory and antibiotics for possible infectious causes. (cdc.gov)
SYSTEM19
- All donor blood samples must be tested pre‐transfusion to determine the blood type of donor erythrocytes, based on the ABO typing system. (cardiff.ac.uk)
- The Rh system was discovered in 1940 when Landsteiner and Weiner performed their landmark experiments wherein rhesus monkey erythrocytes were injected into rabbits and guinea pigs. (medscape.com)
- Lymphocytes are the cornerstone of the adaptive immune system. (wikipedia.org)
- In the therapeutic effect of UVBI, a certain place belongs to the restructuring of the body's immune system. (kalinka-store.com)
- Inflammation is your immune system's response to injury, infection, and many types of conditions, including immune system disorders , certain cancers , and blood disorders . (medlineplus.gov)
- In the same way, the immune system tissues are strategically distributed throughout the body, particularly at those points where pathogens can most easily gain entry to the body such as the respiratory and digestive tract mucosae. (pearson.com)
- In this topic, we will review the cells, tissues, and organs that make up the immune system. (pearson.com)
- Your goals for learning are: To list the cells of the immune system and describe their major functions. (pearson.com)
- The immune system has two major anatomical parts: The first consists of specialized immune cells, many of which are leukocytes, also known as white blood cells or their close relatives. (pearson.com)
- Let's examine the cells of the immune system more closely. (pearson.com)
- This chapter evaluates the effects of fluoride on the gastrointestinal system (GI), the kidney, the liver, and the immune system, focusing primarily on new data that have been generated since the earlier NRC (1993) review. (nationalacademies.org)
- The possibility that a small percentage of the population reacts systemically to fluoride, perhaps through changes in the immune system, cannot be ruled out (see section on the immune system later in this chapter). (nationalacademies.org)
- 3. Hematology: The Erythrocytes, White Blood Cells, and Immune System. (vin.com)
- Allergy is an overactive immune (hypersensitivity) reaction to a harmless entity sensed as dangerous by the immune system. (bdbiosciences.com)
- Many dogs with IMHA have severe leukocytosis (with or without left shift) and also considerable serum liver enzyme elevations (prior to prednisolone) suggestive of serious inflammatory processes, which may enhance the immune destruction by activating the macrophage system and the thrombotic tendency. (vin.com)
- As a result, an overall breakdown of the immune system takes place, in short what develops is AIDS in a new packaging. (twoday.net)
- Previous literature reports have suggested that patulin is toxic to the immune system. (cdc.gov)
- The studies presented were conducted to provide a comprehensive assessment of the effects of patulin on the immune system. (cdc.gov)
- In addition to playing an important role in host defense against infection, the complement system is a mediator in both the pathogenesis and prevention of immune complex diseases, such as systemic lupus erythematosus (SLE). (medscape.com)
Inflammatory2
- These studies demonstrate, for the first time, that the T cell-dependent immune response is critically dependent on the early activation of TRH and PRL and that the neuroendocrine changes occurring during it are profoundly different from those occurring during the T cell-independent and inflammatory responses (LPS model). (bris.ac.uk)
- It promotes the inflammatory response, eliminates pathogens, and enhances the immune response. (medscape.com)
Thrombocytopenic5
- Intracranial hemorrhage in immune thrombocytopenic purpura: a retrospective analysis. (medscape.com)
- The epidemiology of immune thrombocytopenic purpura. (medscape.com)
- Immune thrombocytopenic purpura - current management practices. (medscape.com)
- Tarantino MD, Buchanan GR. The pros and cons of drug therapy for immune thrombocytopenic purpura in children. (medscape.com)
- Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone. (medscape.com)
Destruction of erythrocytes2
- Although premature, accelerated destruction of erythrocytes is a clinical manifestation of many diseases. (innvista.com)
- A diagnosis of IMHA must demonstrate accelerated immune destruction of erythrocytes. (vin.com)
Vitro2
- The present study investigates the effect of curcumin on PMRS activity of erythrocytes isolated from Wistar rats in vitro and in vivo and validated through an in silico docking simulation study using Molegro Virtual Docker (MVD). (hindawi.com)
- The present study was conducted to investigate the in vitro dose-dependent effect of curcumin on PMRS activity of erythrocytes and validated through in vivo studies on Wistar rats. (hindawi.com)
Hemolytic anemia2
- Immune-mediated hemolytic anemia (IMHA) is a common hematological disorder in dogs, may be primary (idiopathic, autoimmune) or occur secondarily to underlying diseases and is often associated with life-threatening complications. (vin.com)
- Immune-mediated hemolytic anemia (IMHA) arises when an immune response targets directly or indirectly erythrocytes and hemolytic anemia ensues. (vin.com)
Protein3
- GSH is a hydrophilic antioxidant with nucleophilic thiol group and has been reported to participate in regulation of gene expression, protein synthesis, cell proliferation, signal transduction, cytokine production, apoptosis, immune response, and protein glutathionylation [ 11 ]. (hindawi.com)
- Melinda also has a particular interest in innate immune protein and pattern recognition molecule mannose binding lectin. (edu.au)
- Understanding the role of platelet protein HMGB1 in transfusion-related immune modulation. (edu.au)
Infection4
- This report demonstrated that an opportunistic invasive fungal infection may indicate an underlying cellular immune impairment of the host. (biomedcentral.com)
- Acquired forms are generally caused by such extrinsic (extracellular) defects as infection, systemic disease, drugs or toxins, liver or kidney disease, or abnormal immune responses. (innvista.com)
- Characterisation of transfusion-induced immune modulation with underlying viral infection. (edu.au)
- Photomicrographs of blood samples from swine evaluated for evidence of Mycoplasma suis infection via scanning electron microscopy (A and B) and compound microscopy (C and D). In panel A, an M suis (arrow) organism is attached to the surface of an erythrocyte in a blood sample from an infected pig. (avma.org)
Transfusion3
- The most common routes of maternal sensitization are via blood transfusion or fetomaternal hemorrhage (ie, transplacental passage of fetal erythrocytes) associated with delivery, trauma, spontaneous or induced abortion, ectopic pregnancy, or invasive obstetric procedures. (medscape.com)
- Melinda is a biomedical scientist with expertise in the fields of innate immunology, inflammation, blood transfusion and erythrocyte structure and function. (edu.au)
- Investigating the relationship between pre-existing inflammation, blood component transfusion and immune paralysis. (edu.au)
RBCs1
- The image revealed a number of malformed erythrocytes, or red blood cells (RBCs), also referred to as microcytes. (cdc.gov)
Antigen1
- Different populations of immune cells are engaged in an allergic reaction, including antigen presenting cells (e.g., dendritic cells), mast cells and Ig-E producing B cells and T cells. (bdbiosciences.com)
Hypersensitivity1
- Type III hypersensitivity reaction is also known as immune-complex reaction. (bdbiosciences.com)
Viral1
- In response, we examined the viral distribution and mRNA expression profiles of immune-related genes in chickens infected with both viruses. (frontiersin.org)
Systemic1
- Severe cutaneous and systemic immune mediated reactions: Monitor patients for the development of systemic immune mediated reactions involving skin and other organs. (nih.gov)
Adaptive1
- New studies point to the complex interplay between the complement cascade and adaptive immune response, and complement is also being studied in association with ischemic injury as a target of therapy. (medscape.com)
Anaphylactic2
Response4
- Since in classic chemotherapies it is observed a decrease in immune response, methotrexate (MTX) was used only to compare the PnV effects on innate immune cells with a highly immunosuppressive antineoplastic drug. (nature.com)
- The venom was effective at impairing tumor development in murine xenogeneic model, activating the innate immune response and increasing tumor infiltrating macrophages. (nature.com)
- We examined the role of neuroendocrine changes, particularly TRH and PRL, during the T cell-dependent immune response. (bris.ac.uk)
- However, the pathogenicity, transmissibility, and host immune-related response of chickens infected by those wild bird-origin H5N6 AIVs remain unknown. (frontiersin.org)
Mutation1
- Under its impact, erythrocytes in human blood undergo mutation. (twoday.net)
Methotrexate2
- RePub, Erasmus University Repository: Using fluorescence polarization immunoassay for determination of erythrocyte methotrexate polyglutamates, a quick and easy test? (eur.nl)
- Using fluorescence polarization immunoassay for determination of erythrocyte methotrexate polyglutamates, a quick and easy test? (eur.nl)
Functional2
- Erythrocytes are functional and are released into the blood. (wikipedia.org)
- stimulation of regeneration, improvement of the functional properties of erythrocytes. (kalinka-store.com)
Heme3
- Erythrocytes consist mainly of hemoglobin , a complex molecule containing heme groups whose iron atoms temporarily link to oxygen molecules in the lungs or gills and release them throughout the body. (wikidoc.org)
- The color of erythrocytes is due to the heme group of hemoglobin. (wikidoc.org)
- A typical erythrocyte contains about 270 million hemoglobin molecules, with each carrying four heme groups. (wikidoc.org)
Immunization1
- In 1953, Chown verified that the passage of fetal Rh D-positive erythrocytes into the maternal circulation caused Rh immunization. (medscape.com)
Organs1
- With the wide application of immune checkpoint inhibitors (ICIs) in cancer treatment, immune-related adverse events occur frequently, involving almost all organs and systems. (wjgnet.com)
Blood cells3
- Red blood cells, also called erythrocytes, are the oxygen-carrying cells. (wikipedia.org)
- The fetal-maternal erythrocyte distribution test is used to measure the number of the unborn baby's red blood cells in a pregnant woman's blood. (mountsinai.org)
- Erythrocytes are red blood cells. (medlineplus.gov)
Contributes2
- 1. Enhances intracellular and intercellular metabolism, restores cell parameters, thanks to which it contributes to the restoration of protective (immune) properties and impaired functions of the body. (kalinka-store.com)
- Our findings provide important new evidence that variation in the expression and function of the EBAs plays an important role in evasion of acquired Abs and that a substantial amount of phenotypic diversity results from variation in expression of different EBAs that contributes to immune evasion by P. falciparum. (edu.au)
Reactions1
- Cell mediated immune reactions. (crl.edu)
Targets1
- In this study, we used novel approaches to determine the importance of P. falciparum erythrocyte-binding Ags (EBAs), which are important invasion ligands, as targets of human invasion-inhibitory Abs and define their role in contributing to immune evasion through variation in function. (edu.au)
Function2
- However, Ags involved in mediating immune evasion have not been defined, and studies of the function of human Abs are limited. (edu.au)
- Upon interaction with SIRPα, controls innate immune effector function, such as host cell phagocytosis. (biolegend.com)
Membrane2
- Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes. (rcsb.org)
- Under the influence of quantum energy, new surfactants are formed on the surface of erythrocytes, which change the electric charge on the membrane, which reduces the viscosity of the blood and increases its oxygen capacity. (kalinka-store.com)
Clinical1
- What is the Clinical Evidence for Erythrocyte Immune Destruction? (vin.com)
Circulation1
- The spleen enlarges as it removes more and more dead or defective erythrocytes from the circulation. (innvista.com)
Human2
- The diameter of a typical human erythrocyte disk is 6-8 µm, much smaller than most other human cells . (wikidoc.org)
- Abs that inhibit Plasmodium falciparum invasion of erythrocytes form an important component of human immunity against malaria, but key target Ags are largely unknown. (edu.au)
Cell2
- Erythrocytes in mammals are anucleate when mature, meaning that they lack a cell nucleus and as a result, have no DNA . (wikidoc.org)
- By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking. (biolegend.com)
Surface1
- In panel C, several M suis organisms (arrows) are evident on the surface of erythrocytes in a blood film from an infected pig. (avma.org)