The CD59 is an 18- to 25-kD glycoprotein expressed on all human peripheral blood leukocytes , erythrocytes. (lu.se)
Antibody6
A mechanistic study of the dissociation of individual antibody-antigen pairs by atomic force microscopy. (degruyter.com)
It simply does not require specific antigen-antibody interactions for initiation. (medscape.com)
Analysis of an in-house oblique enzyme-linked immunosorbent assay of feline panleukopenia VP2 subunit antigen compared to hemagglutination inhibition assay to watch tiger antibody ranges by Bayesian strategy Background: Feline panleukopenia virus (FPV) is an etiologic pathogen of feline panleukopenia that infects all members of Felidae together with tigers (Panthera tigris). (elisareagents.com)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
Antibodies3
Impairment of genomic DNA binding to a putative dysfunctional receptor on erythrocytes independent of complement and antibodies in systemic lupus erythematosus. (degruyter.com)
This type of reaction occurs when a patient without certain red cell antigens is exposed to these antigens through blood transfusion, resulting in the development of new antibodies and haemolysis after 3-14 days. (passmed.uk)
c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
Genes2
Antigens encoded by both Ly6 and CD59 genes are important to T-cell and NK-cell function. (lu.se)
The combination of a specific environmental precipitant represented by the hepatitis C virus infection, an altered metabolic detoxification pathway due to treatment with pegylated interferon alpha 2a and a facilitating genetic background such as polymorphism in metabolic detoxification pathways and specific human leukocyte antigen genes possibly conspired synergistically in the development of aplastic anemia in this patient. (biomedcentral.com)
Complement regulatory1
The glycosylation of the complement regulatory protein, human erythrocyte CD59. (ox.ac.uk)
Inheritance1
This is thought to be due to the association that both AS and uveitis have with the inheritance of the HLA-B27 antigen. (findzebra.com)
There are ~225,000 molecules of GPC and GPD per erythrocyte. (wikidoc.org)
Autoantibodies can bind to basic structural molecules and interfere with the synthesis of structural elements and facilitate the uptake of antigen. (hindawi.com)
After processing, antigen is presented on MHC molecules. (hindawi.com)
EPCR protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. [3] It belongs to the MHC class I / CD1 family of proteins, that is characterized by having a deep groove, that in other proteins in the family (but not in EPCR) is usually used for antigen binding. (wikidoc.org)
Human2
The Lan blood group system (short for Langereis) is a human blood group defined by the presence or absence of the Lan antigen on a person's red blood cells. (wikipedia.org)
More than 85% of those affected in the UK have a specific human leukocyte antigen known as the HLA-B27 antigen. (findzebra.com)
Molecular1
Serologic reagents and molecular assays for Lan antigen typing were not commercially available as of 2013. (wikipedia.org)
Receptor1
The C3b/C4b receptor (CR1, CD35) on erythrocytes: methods for study of the polymorphisms. (degruyter.com)
Specific1
Right panel: antigen binds to the BCR of antigen-specific B cells and is internalized. (hindawi.com)
Liver2
Two isoforms are known and the gene is expressed in a wide variety of tissues including kidney , thymus , stomach , breast , adult liver and erythrocyte. (wikidoc.org)
Anemia occurs as a result of autoantibody-mediated CP activation on the surface of the erythrocyte, leading to the deposition of complement opsonins that drive extravascular hemolysis in the liver. (ashpublications.org)
Function1
Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
Range1
Medical management of this patient will involve screening for a wider range of possible antigens and access to a blood bank with a sufficient number of available units for a clean transfusion. (passmed.uk)
Blood group4
The antigen was first described in 1961, and Lan was officially designated a blood group in 2012. (wikipedia.org)
It is thought that other porphyrin transporters, such as ABCG2 (which carries the Junior blood group antigen), may compensate. (wikipedia.org)
In 1972 a numerical system for the antigens in this blood group was introduced. (wikidoc.org)
We also evaluated bone marrow specimens, which generally are considered less suitable than blood owing to variable expression of glycosyl phosphatidylinositol (GPI)-linked antigens during hematopoietic cell differentiation. (elsevierpure.com)
In the non erythroid cell lines, expression is lower than in the erythrocyte and the protein is differentially glycosylated . (wikidoc.org)
Both secreted autoantibodies and BCR on B cells can modulate the processing and presentation of antigen and thereby affect the nature of presented T-cell determinants. (hindawi.com)
BCR-mediated antigen uptake can influence antigen processing and the nature of MHC-displayed T-cell determinants. (hindawi.com)
Lower1
PNH-deficient monocytes expressed only marginally lower CD59, making it a less robust marker for highlighting PNH+ monocytes compared with CD14 or CD55. (elsevierpure.com)
Important1
PAS-2 ' ) plays a functionally important role in maintaining erythrocyte shape and regulating membrane material properties, possibly through its interaction with protein 4.1. (wikidoc.org)
Expression1
Normal monocytes exhibited significantly dimmer CD59 expression than normal granulocytes. (elsevierpure.com)
Cells2
220 The Lan antigen is more strongly expressed on cord blood cells than on adult red blood cells. (wikipedia.org)
B cells are highly efficient APCs in situations of low antigen concentrations. (hindawi.com)
Development1
The gene is expressed early in the development of the erythrocyte, specifically in the erythroid burst-forming unit and erythroid colony-forming unit . (wikidoc.org)
Study1
Artificially induced unusual shape of erythrocytes: an atomic force microscopy study. (degruyter.com)
Patients1
The antigen is named after one of the patients - a Mrs Gerbich. (wikidoc.org)