• Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a family of proteins present on the membrane surface of red blood cells (RBCs or erythrocytes) that are infected by the malarial parasite Plasmodium falciparum. (wikipedia.org)
  • It was discovered in 1984 when it was reported that infected RBCs had unusually large-sized cell membrane proteins, and these proteins had antibody-binding (antigenic) properties. (wikipedia.org)
  • Curcumin modulates cellular activity through interacting with membrane-bound proteins and modulating signaling cascade activity by altering the fluidity of the membrane bilayer [ 17 ]. (hindawi.com)
  • We investigated the erythrocytes membrane proteins in groups of patients with insulin resistance, prediabetes, and T2DM. (4science.ge)
  • The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30 kD, the so-called Rh30 polypeptides. (novusbio.com)
  • Heterogeneously glycosylated membrane proteins of 50 and 45 kD, the Rh50 glycoproteins, are coprecipitated with the Rh30 polypeptides on immunoprecipitation with anti-Rh-specific mono- and polyclonal antibodies. (novusbio.com)
  • Ankyrins link integral membrane proteins to the spectrin-based membrane skeleton. (dana-farber.org)
  • Hereditary defects in membrane skeleton proteins. (dana-farber.org)
  • This indicates that AE1 and probably other integral membrane proteins have a 'lipid-anchoring' function. (dana-farber.org)
  • 1992). These oxygen free radicals can modify DNA, proteins and membrane lipids, leading to cellular degeneration (Olanow, 1992). (scialert.net)
  • 1978. Altered erythrocyte membrane proteins in sickle cell patients associated with the severity of the disease. (mote.org)
  • This report describes Ca2+-dependent binding of 125I-labeled calmodulin (125I-CaM) to erythrocyte membranes and identification of two new CaM-binding proteins. (jhu.edu)
  • Cyclic adenosine 3',5'-monophosphate-dependent protein kinase of human erythrocyte membranes. (elsevierpure.com)
  • Band 3 protein (B3p) content in isolated erythrocyte membranes was determined with the analytical electrophoresis method. (4science.ge)
  • Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1. (ox.ac.uk)
  • The best characterized and most likely target is the erythrocyte surface-expressed variant protein family Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). (ox.ac.uk)
  • The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. (cancerindex.org)
  • Together with data obtained after treatment with various agents known to affect membrane organization in vitro , our findings suggest that a phosphorylation-controlled interaction between the cytoskeleton and the integral membrane protein band 3 is part of the membrane-centered mechanism that plays a role in deformability as well as aggregation. (frontiersin.org)
  • Studies of inborn errors of metabolism and membrane protein composition, in combination with the structural and functional changes that occur during RBC aging, have led to a membrane-centered molecular understanding of red blood cell function and survival, and of the role of membrane molecules in cell morphology and membrane organization. (frontiersin.org)
  • Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
  • Clinical manifestations of erythrocyte membrane protein coding gene mutations in hereditary spherocytosis]. (cdc.gov)
  • Hereditary disorders may cause hemolysis as a result of erythrocyte membrane abnormalities, enzymatic defects, and hemoglobin abnormalities. (medscape.com)
  • Erythrocyte membrane abnormalities in neuroacanthocytosis: Evidence for a neuron-erythrocyte axis? (medscape.com)
  • De Franceschi L, Corrocher R. Erythrocyte membrane anion exchange abnormalities in chorea-acanthocytosis: The band 3 network. (medscape.com)
  • Plasma membrane redox system (PMRS) is an electron transport chain system ubiquitously present in all cell types that transfers electrons from intracellular substrates to extracellular acceptors maintaining redox homeostasis for a successful cell physiology [ 1 ]. (hindawi.com)
  • Many if not all of these processes depend on the organization of the RBC membrane that enables the complex, dynamic interactions between the cell membrane and various intracellular and extracellular molecules. (frontiersin.org)
  • Expression of the VAR2CSA variant of PfEMP1 leads to pregnancy-associated malaria, which occurs when infected erythrocytes massively sequester in the placenta by binding to low-sulfated Chondroitin Sulfate A (CSA) present in the intervillous spaces. (rcsb.org)
  • Using flow cytometry, the correlation in individual responses to each domain with responses to intact A4-infected erythrocytes expressing A4 PfEMP1 on their surface as well as responses to two alternative parasite clones and one clinical isolate was assessed. (ox.ac.uk)
  • An immobilization protocol was established where RBCs are coupled via molecular bonds of the membrane glycoproteins to wheat germ agglutinin (WGA), which is covalently and flexibly tethered to the support. (degruyter.com)
  • The present study was aimed to evaluate the oxidants, enzymatic and nonenzymatic antioxidants, glycoproteins and membrane adenosine triphosphatases (ATPases). (scialert.net)
  • The increased levels of oxidants and decreased levels of enzymatic, nonenzymatic antioxidants, glycoproteins and ATPases were observed in erythrocytes of aged rats. (scialert.net)
  • Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)
  • Therefore, it seems that in the process of modification of erythrocyte membranes of patients with disorders of carbohydrate metabolism participate both, hyperglycemia and oxidative stress conditions associated with diabetes. (4science.ge)
  • Influence of heavy metal mixtures on erythrocyte metabolism. (cdc.gov)
  • Plasma membrane redox system (PMRS) is an electron transport chain system ubiquitously present throughout all cell types. (hindawi.com)
  • During the past decade our laboratory and others have shown that hereditary spherocytosis is caused by defects in the connections that attach the membrane skeleton to the overlying lipid bilayer. (dana-farber.org)
  • Hereditary hemolytic anemias are a group of disorders with a variety of causes, including red cell membrane defects, red blood cell enzyme disorders, congenital dyserythropoietic anemias, thalassemia syndromes and hemoglobinopathies. (haematologica.org)
  • Curcumin, isolated from Curcuma longa, has modulatory effects on cellular physiology due to its membrane interaction ability and antioxidant potential. (hindawi.com)
  • These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats. (scialert.net)
  • The results suggest that oxidative damage of erythrocyte caused by phenyl hydrazine could be prevented by calcium channel antagonist, diltiazem, which may act as antioxidant also. (scirp.org)
  • Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte band 3. (4science.ge)
  • The molecular organization of the membrane of the red blood cell controls cell morphology and function and is thereby a main determinant of red blood cell homeostasis in the circulation. (frontiersin.org)
  • There is increasing evidence from our laboratory and others that some organelles (e.g., lysosomes, Golgi) also have membrane skeletons. (dana-farber.org)
  • Hierarchical nanostructured erythrocyte -like hollow carbon ( EHC ) with a hollow hemispherical macroporous core of ca. 230 nm in diameter and 30-40 nm thick mesoporous shell was synthesized and explored as a cathode catalyst support in a proton exchange membrane fuel cell ( PEMFC ). (rsc.org)
  • A hybrid cell membrane-coated biomimetic nanosystem (PM/RM@PLGA@P/R) was constructed in this paper to fulfil the targeted delivery of ginsenoside (Rg1) and perfluorohexane (PFH). (physiciansweekly.com)
  • Using tapping-mode AFM, which is known as gentle imaging mode and therefore most appropriate for soft biological samples like erythrocytes, it was possible to resolve membrane skeleton structures without major distortions or deformations of the cell surface. (degruyter.com)
  • The role of membrane organization is prominently reflected in red blood cell deformation and aggregation. (frontiersin.org)
  • The structure of a cell enables it to change its shape while moving along the narrow capillaries, which are narrower than the diameter of an erythrocyte. (pravda.ru)
  • Sterols are essential components of cell membranes, and both animals and plants produce them. (drugs.com)
  • 2002). However, during aging an oxidant challenge exceeds the capacity of the cell s defense system, membrane damage may occur. (scialert.net)
  • The membrane potential of the red blood cells was determined before and after cell shrinkage as the external potassium concentration at which there was no change in diSC35 fluorescence. (cdc.gov)
  • Our laboratory focuses on the organization and functions of the spectrin-based membrane skeleton. (dana-farber.org)
  • Sterols play a unique role for the structural and dynamical organization of membranes. (mdpi.com)
  • In particular, the impact of α-spinasterol on the structure and organization of lipid membranes was investigated and compared with those of cholesterol. (mdpi.com)
  • Also, we found that most of these correlations were absent in misshapen red blood cells that have an inborn defect in the interaction between the membrane and the cytoskeleton. (frontiersin.org)
  • Supplementation with the omega-3 fatty acid mix increased EPA and DHA concentrations in erythrocyte membranes and improved working memory function, but had no effect on other cognitive measures and parent- and teacher-rated behavior in the study population. (nih.gov)
  • 2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
  • Lepke S, Passow H. Effects of fluoride on potassium and sodium permeability of the erythrocyte membrane. (cdc.gov)
  • PurposeThe aim of this study was to assess the relationship between specific erythrocyte fatty acids levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).MethodsWe analysed baseline pretreatment data in a subset of 23 patients with T1D from a previously publis. (swan.ac.uk)
  • PurposeThe aim of this study was to assess the relationship between specific erythrocyte fatty acids levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).MethodsWe analysed baseline pretreatment data in a subset of 23 patients with T1D from a previously published randomised controlled trial consisting of comprehensive erythrocyte-derived fatty acid profiles and a panel of inflammation-associated endothelial markers. (swan.ac.uk)
  • The composition of fatty acids in lipid membranes seems to be influenced by diet. (sharkyear.com)
  • Hemolysis is the premature destruction of erythrocytes. (medscape.com)
  • The clinical severity of the anemia depends on whether the onset of hemolysis is gradual or abrupt as well as the extent of erythrocyte destruction. (medscape.com)
  • However, patients with mild hemolysis may develop marked anemia if their bone marrow erythrocyte production is transiently shut off by viral (parvovirus B19) or other infections. (medscape.com)
  • A hemolytic anemia will develop if bone marrow activity cannot compensate for the erythrocyte loss. (medscape.com)
  • This complex plays a critical role in erythrocyte shape and deformability. (cancerindex.org)
  • The observations suggest that deformability and aggregation share at least one common, membrane-related molecular mechanism. (frontiersin.org)
  • The hemorheological parameters, erythrocyte aggregation and deformability are determined in jaundice patients and are compared with that of healthy subjects. (iospress.com)
  • The erythrocyte deformability is determined by measurement of passage time (reciprocal of deformability) of erythrocyte suspension in phosphate buffered saline at hematocrit 6% through cellulose … membranes. (iospress.com)
  • Normal erythrocyte membrane Gs alpha bioactivity in two unrelated patients with acrodysostosis. (bmj.com)
  • For a subgroup of 81 participants, erythrocyte membrane fatty acid composition was analyzed before and after the intervention. (nih.gov)
  • We analyzed the impact of short-term SLO supplementation on certain biochemical parameters and erythrocyte FA composition in a group of young healthy women. (sharkyear.com)
  • In conclusion, our results show that even short-term SLO supplementation can improve human erythrocyte fatty acid composition and other parameters that may have health-promoting consequences. (sharkyear.com)
  • The present study investigates the effect of curcumin on PMRS activity of erythrocytes isolated from Wistar rats in vitro and in vivo and validated through an in silico docking simulation study using Molegro Virtual Docker (MVD). (hindawi.com)
  • The present study was conducted to investigate the in vitro dose-dependent effect of curcumin on PMRS activity of erythrocytes and validated through in vivo studies on Wistar rats. (hindawi.com)
  • A mature erythrocyte has no nucleus. (pravda.ru)
  • Sodium flux through the membrane occurred in exchange for protons and was inhibited by amiloride. (cdc.gov)
  • Impairment of genomic DNA binding to a putative dysfunctional receptor on erythrocytes independent of complement and antibodies in systemic lupus erythematosus. (degruyter.com)
  • Babesia species and organisms of the closely related genus Theileria parasitize the erythrocytes of wild and domestic animals.These parasites are members of the order Piroplasmida, named for the pear-shaped forms found within infected red blood cells (RBCs). (medscape.com)
  • Forty male rats were equally divided into 4 groups namely A, B, C and D. The erythrocytes membrane properties were tested through measurements of osmofragility and solubility with non-ionic detergent in addition to blood films for all animal groups. (rjb.ro)
  • The current study reports data on the membrane properties of the phytosterol (3β,5α,22 E )-stigmasta-7,22-dien-3-β-ol (α-spinasterol), which represents an important component of argan oil and have not been investigated so far in molecular detail. (mdpi.com)
  • Thanks to the camouflage of erythrocyte membrane (RM) and platelet membrane (PM), the nanosystem in question possesses remarkable features including immune escape and self-targeting. (physiciansweekly.com)
  • Although much experimental evidence indicates that AE1 is required for membrane skeleton assembly, AE1-/- red blood cells have a normal membrane skeleton. (dana-farber.org)
  • Capillaries were called in Greek - erythrocytes - i.e. red blood cells. (pravda.ru)
  • Studies show that red and white blood cells (along with other components of the blood) carry a negative electrical charge on the outer side of their membranes. (pravda.ru)
  • Therefore, a compact nano-core with PLGA@P/R was formed, with a hybrid membrane covering the surface of the core, forming a "core-shell" structure. (physiciansweekly.com)
  • The PCA-derived vascular biomarker cluster was positively associated with linoleic acid, n-6PUFA:n-3PUFA ratio and inversely associated with EPA.ConclusionSpecific erythrocyte membrane fatty acid compositions are associated with impaired vascular health and IR in adults with T1D. (swan.ac.uk)
  • Erythrocytes are the most numerous cells in blood by volume ratio. (pravda.ru)