Soluble transferrin receptorTransferrin saturationHepcidinHemoglobinConcentrationConcentrationsAnemiaAlbuminAnaemiaProtoporphyrinSpecificityZincProteinLevelsMeasurementTIBCCorrelationsPeripheralInflammatoryBoneInflammation0.05DiagnosticLevelValuesAnalysisStoresStatusHighResultsBlood cellsChildrenStudyMethodCOUNTS
Soluble transferrin receptor2
- Assessment of iron status is challenging, and indices such as serum ferritin, soluble transferrin receptor, and zinc protoporphyrin have specific weaknesses. (ox.ac.uk)
- Esmaeili R, Zhang M, Sternberg MR, Mapango C, Pfeiffer CM . A new multiplex immunoassay for serum ferritin, soluble transferrin receptor, C-reactive protein, α-1-glycoprotein, and retinol-binding protein showed variable comparability with traditional reference assays external icon . (cdc.gov)
Transferrin saturation4
- 3. Serum transferrin receptor concentration, Transferrin saturation, free erythrocyte protoporphyrin, Red blood cells indices, and Serum iron to detect Iron supply. (biocoreopen.org)
- We measured the serum concentrations of hepcidin, interleukin- 6 (IL-6) and selenium, red blood cell count, hemoglobin concentration, hematocrit, erythrocyte indices and biochemical markers of iron metabolism (serum iron, total iron-binding capacity, transferrin saturation and serum ferritin). (umbalk.org)
- Values consistent with iron deficiency include a low serum iron level, low transferrin saturation, and a high total iron-binding capacity. (aafp.org)
- When screening for hereditary hemochromatosis, serum iron, iron-binding capacity, and transferrin saturation may be helpful. (medscape.com)
Hepcidin7
- The study demonstrated statistically significant differences in the serum concentrations of hepcidin, IL-6 and selenium between IDA children and healthy controls, a statistically significant higher proportion of children having below-threshold serum selenium concentrations in the study group compared to controls, statistically significant correlations between hepcidin and selenium serum concentrations, hematological indicators and biochemical markers of iron metabolism in the IDA children. (umbalk.org)
- In the absence of hepcidin, plasma iron and ferritin levels increase resulting in iron accumulation in the organs. (baskent.edu.tr)
- Hepcidin increases in response to increase in plasma iron, ferritin and in response to inflammation, whereas decreases in hypoxia and increased erythropoesis in healthy people. (baskent.edu.tr)
- We investigated here the effect of adenine-induced CKD in rats on erythrocyte count (EC), hematocrit (PCV) and hemoglobin (Hb) concentration, as well as on the activity of L-γ-glutamyl transferase (GGT) and the concentrations of iron (Fe), transferrin (Tf), ferritin (F), total iron binding capacity (TIBC) / unsaturated iron binding capacity (UIBC) and hepcidin (Hp) in serum and erythropoietin (Epo) in renal tissue. (uaeu.ac.ae)
- Mice bearing LC-06-JCK were administered rat anti-mouse IL-6 receptor antibody MR16-1 and their serum hepcidin levels and hematological parameters were determined. (biomedcentral.com)
- Serum hepcidin and ferritin levels were statistically elevated in mice bearing LC-06-JCK. (biomedcentral.com)
- Administration of MR16-1 to mice bearing LC-06-JCK significantly suppressed levels of both serum hepcidin and ferritin, with increased values of MCV and MCH. (biomedcentral.com)
Hemoglobin3
- Nakil öncesi düşük olan serum prohepsidin düzeyinin, hemoglobin, hematokrit ve eritrosit sayıları ile birlikte nakil sonrası anlamlı şekilde yükseldiği, nakil öncesi normalin üst sınırında olan serum demiri ve normalden yüksek olan retikülosit, ferritin ve eritropoetin düzeylerinin, nakil sonrası izlemde anlamlı şekilde düştüğü gözlendi. (baskent.edu.tr)
- LC-06-JCK-bearing mice showed lower values of MCV, mean corpuscular hemoglobin (MCH), and serum iron as compared to NTB mice. (biomedcentral.com)
- These laboratory values or calculations include hemoglobin , hematocrit , the number of RBCs, indices of RBC size and color, and other factors depending on the type of anemia (see Table 26-1 ). (ashp.org)
Concentration2
- This testing may be appropriate in practices where women consistently visit their physician throughout pregnancy, but it is less feasible when analysis of serum ferritin concentration is unavailable or when prenatal care visits are sporadic. (cdc.gov)
- The serum ferritin concentration decreases. (medscape.com)
Concentrations4
- Renal damage was assessed histopathologically, and also by measuring the serum concentrations of the uremic toxin indoxyl sulfate (IS), creatinine, and urea, and by creatinine clearance. (uaeu.ac.ae)
- The serum transferrin receptor and erythrocyte zinc protoporphyrin concentrations are increased. (medscape.com)
- Mineva EM, Schleicher RL, Chaudhary-Webb, M, May KL, Botelho JC, Vesper HW, Pfeiffer CM. A candidate reference measurement procedure for quantifying serum concentrations of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 using isotope-dilution liquid chromatography-tandem mass spectrometry external icon . (cdc.gov)
- When compared with ADV-negative and influenza-positive patients, those with ADV infections showed significantly elevated serum CRP concentrations and left-shifted leukocyte counts. (webmedcentral.com)
Anemia6
- A general improvement in the renal status of rats with CKD after GA is shown due to its antiinflammatory and anti-oxidant actions, and reduction of the uremic toxin IS, which is known to suppress Epo production, and this may be a reason for its ameliorative actions on the indices of anemia studied. (uaeu.ac.ae)
- Measurement of the serum ferritin level is the most accurate test to diagnose iron deficiency anemia. (aafp.org)
- Although iron deficiency is the most common cause of microcytic anemia, up to 40 percent of patients with iron deficiency anemia will have normocytic erythrocytes. (aafp.org)
- 2 , 6 - 11 A serum ferritin level should be obtained in patients with anemia and a mean corpuscular volume less than 95 μm 3 . (aafp.org)
- Ferritin reflects iron stores and is the most accurate test to diagnose iron deficiency anemia. (aafp.org)
- In patients with chronic inflammation, iron deficiency anemia is likely when the ferritin level is less than 50 ng per mL (112.35 pmol per L). 7 Ferritin values greater than or equal to 100 ng per mL (224.70 pmol per L) generally exclude iron deficiency anemia. (aafp.org)
Albumin1
- LC-06-JCK-bearing mice showed decreased body weight and serum albumin with increased serum amyloid A. MR16-1 treatment showed significant inhibition of decreased body weight and serum albumin levels, and suppressed serum amyloid A level. (biomedcentral.com)
Anaemia6
- ABSTRACT Erythrocyte indices used to differentiate between iron deficiency anaemia (IDA) and thalassaemias have been studied mainly in countries with a high prevalence of IDA or beta-thalassaemias. (who.int)
- We studied the predictive value and Youden index of several indices in 85 children aged 6 months to 12 years with microcytosis and/or hypochromia, with or without anaemia (determined by serum measurement of iron or therapeutic iron trial). (who.int)
- Haemoglobin and serum ferritin are the most common ways to detect anaemia. (biocoreopen.org)
- There are difficulties in determining children with iron deficiency anaemia in developing countries due to cost of serum ferritin estimation. (bvsalud.org)
- Weak significant positive correlations were seen between serum ferritin and MCV, and MCH irrespective of the anaemic status of study subjects anaemia status (p = 0.020, and 0.040 respectively). (bvsalud.org)
- Following stratification according to presence or absence of anaemia, a significant positive correlation was seen between serum ferritin and MCV among subjects with anaemia. (bvsalud.org)
Protoporphyrin2
- Erythropoietic protoporphyria (EPP) is an inherited disorder of the haem metabolic pathway characterised by accumulation of protoporphyrin in blood, erythrocytes and tissues, and cutaneous manifestations of photosensitivity. (biomedcentral.com)
- In EPP, the enzyme deficiency causes accumulation of protoporphyrin in various tissues (skin, liver) and blood (erythrocytes and plasma). (biomedcentral.com)
Specificity2
- Also validity testing of red cell indices as screening tools was performed using the sensitivity, specificity, and predictive values. (bvsalud.org)
- TfR-F index incorporated the high sensitivity of sTfR, a proxy for cellular iron need, and the high specificity of ferritin, a proxy for iron stores. (bmj.com)
Zinc3
- Clinical symptoms (cough, wheezing, dyspnoea), spirometry indices and serum zinc and IgE levels were recorded before and after the intervention. (europa.eu)
- A 5 mL sample of blood was taken from all patients for serum zinc analysis. (europa.eu)
- The mean serum zinc level was 61.8 (SD 7.3) μg/dL and 60.9 (SD 4.3) μg/dL in the case and control groups, respectively, before treatment. (europa.eu)
Protein4
- ay sonrasındaki son izlemlerinde (ortanca 27 ay) serum prohepsidin düzeyleri, tam kan sayımı, demir değişkenleri, eritropoetin, C-reaktif protein ve karaciğer fonksiyonları ile kontrollerin serum prohepsidinleri çalışıldı. (baskent.edu.tr)
- Nakil öncesi serum prohepsidin düzeyinin karaciğer demir yoğunluğu, karaciğer demir ve fibrozis derecesi, nakil öncesi tam kan sayımı ve demir değişkenleri ile ilişkisi saptanmazken, C-reaktif protein, alanin aminotransferaz, aspartat aminotransferaz, total ve direk bilirubin ve alkalen fosfataz ile pozitif, karaciğer inflamatuvar aktivite derecesiyle negatif ilişkisi saptandı. (baskent.edu.tr)
- Als Basisblutentnahme sollen Hämoglobin, Hämatokrit, MCV (mittleres zelluläres Volumen), MCH (mittleres zelluläres Hämoglobin), C-reaktives Protein und Ferritin bestimmt werden. (sems-journal.ch)
- Chaudhary-Webb M, Schleicher RL, Erhardt JG, Pendergrast EC, Pfeiffer CM. An HPLC ultraviolet method using low sample volume and protein precipitation for the measurement of retinol in human serum suitable for laboratories in low- and middle-income countries external icon . (cdc.gov)
Levels8
- BACKGROUND: Elevated levels of triglycerdes in the serum are associated with patologicals conditions that they accelerate to aterosclerose, beyond they evidences will exist of that to hypertrigliceridemia is an independent factor of risk for illnesses coronarias therefore I contributed for the cardiopatias by an effect aterogênico straight of the lipoproteínas rich in triglicerídeos. (scielo.br)
- None of the red cell indices were found to reach significant correlation levels with the red cell indices in non-anaemic study subjects. (bvsalud.org)
- This study investigates the possible correlation between iron deficiency and ADHD in children and adolescents attending a South African child and adolescent psychiatry outpatient service.Method: In this retrospective study, we gathered data from 245 outpatient children and adolescents who had their serum ferritin and/or iron levels tested between February 2011 and January 2016. (bvsalud.org)
- Parenteral injection of iron dextran may result in high serum iron levels (eg, 500-1000 µg/dL) for several weeks. (medscape.com)
- As a baseline set of blood tests, haemoglobin, haematocrit, mean cellular volume (MCV), mean cellular haemoglobin (MCH) and serum ferritin levels are the important parameters to monitor iron deficiency. (sems-journal.ch)
- This in turn causes depletion of macrophage iron, relatively low levels of serum ferritin, and preferential portal and hepatocyte iron loading [ 13 , 23 ]. (hindawi.com)
- Red Blood Cell (RBC) indices and HbF levels were assessed. (mdpi.com)
- In select cases radiographs of the lung, throat swabs (for group A streptococci), blood cultures and serum leukotriene levels (IL-6, IL-10, and LBP) were obtained. (webmedcentral.com)
Measurement2
- Chen H, McCoy LF, Schleicher RL, Pfeiffer CM. Measurement of 25-hydroxyvitamin D3 (25OHD3) and 25-hydroxyvitamin D2 (25OHD2) in human serum using liquid chromatography-tandem mass spectrometry and its comparison to a radioimmunoassay method external icon . (cdc.gov)
- Fazili Z, Pfeiffer CM. Measurement of folates in serum and conventionally prepared whole blood lysates: application of an automated 96-well plate isotope-dilution tandem MS method external icon . (cdc.gov)
TIBC1
Correlations1
- Serum ferritin was measured by ELIZA while red cell indices were determined by auto-analysis.Correlations analysis was performed to test the relationship between serum ferritin and the red cell indices. (bvsalud.org)
Peripheral1
- Unlikle-most viral illnesses, however, infection with adenovirus (ADV) is often characterized by high fever of long duration, leukocytosis with neutrophilia and elevated peripheral blood inflammatory indices. (webmedcentral.com)
Inflammatory1
Bone1
- 2. Bone marrow Iron and Serum ferritin to evaluate iron status and Iron stores. (biocoreopen.org)
Inflammation1
- 8 , 12 Ferritin is also an acute phase reactant and can be elevated in patients with chronic inflammation or infection. (aafp.org)
0.051
- Alpha value was placed at 0.05 There was a decline in ferritin and packed cell volume from pre-to post-donation. (bvsalud.org)
Diagnostic1
- In order to improve the diagnostic accuracy of ferritin or sTfR as a stand-alone marker, the normal cut-off value needed to be increased by 810% and 83% respectively. (bmj.com)
Level2
- Complete blood count, eosinophil count and serum total IgE level was performed. (europa.eu)
- The amount of circulating iron bound to transferrin is reflected by the serum iron level. (medscape.com)
Values2
- Athletes with repeatedly low ferritin values benefit from an intermittent oral substitution. (sems-journal.ch)
- A long-term daily oral iron intake or iv-supplementation in the presence of normal or even high ferritin values does not make sense and may be harmful. (sems-journal.ch)
Analysis1
Stores1
- Iron in excess of these requirements is deposited in body stores as ferritin or hemosiderin. (medscape.com)
Status1
High2
- Fazili Z, Whitehead RD Jr, Paladugula N,Pfeiffer CM. A high-throughput LC-MS/MS method suitable for population biomonitoring measures five serum folate vitamers and one oxidation product external icon . (cdc.gov)
- Pawlosky RJ, Flanagan VP, Pfeiffer CM. Determination of 5-methyltetrahydrofolic acid in human serum by stable-isotope dilution high-performance liquid chromatography-mass spectrometry external icon . (cdc.gov)
Results1
- Fazili Z, Pfeiffer CM, Zhang M, Jain R. Erythrocyte folate extraction and quantitative determination by liquid chromatography-tandem mass spectrometry: comparison of results with microbiologic assay external icon . (cdc.gov)
Blood cells2
- An erythrocyte has a lifespan of 120 days so that 0.8% of red blood cells are destroyed and replaced each day. (medscape.com)
- Red blood cells (RBCs), or erythrocytes, circulate through the blood and function to carry oxygen to tissues. (ashp.org)
Children1
- We sought to determine the relationship between red cell indices and serum ferritin among pre-school children. (bvsalud.org)
Study1
- This study evaluated the pre-and post-donation ferritin and packed cell volume (PCV) of donors attending University of Calabar Teaching Hospital.Method: The study adopted descriptive longitudinal approach. (bvsalud.org)
Method1
- The serum ferritin was analyzed using ELISA method while the PCV was analyzed using the microhematocrit method. (bvsalud.org)
COUNTS1
- Serum CRP, WBC counts (Gpt/L), neutrophil counts (Gpt/L) and percentage of neutrophils were determined upon hospital admission. (webmedcentral.com)