• Thus for meaningful "apples-to-apples" comparisons involving cell deformability, it is important to utilize the same qualitative approach. (wikipedia.org)
  • Deformability is an intrinsic cellular property of erythrocytes determined by geometric and material properties of the cell membrane, although as with many measurable properties the ambient conditions may also be relevant factors in any given measurement. (wikipedia.org)
  • 3) Visco-elastic properties of erythrocyte membrane, mainly determined by the special membrane skeletal network of erythrocytes. (wikipedia.org)
  • Stored packed red blood cells (sometimes denoted "pRBC" or "StRBC") also experience changes in membrane properties like deformability during storage and related processing, as part of a broader phenomenon known as "storage lesion. (wikipedia.org)
  • 2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
  • Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)
  • Defects in such disparate systems (ie, basal ganglia and erythrocytes) have led to the suggestion that a common neurohematological membrane defect is involved. (medscape.com)
  • In vitro exposure of erythrocytes to oxygen radical generating systems (such as H 2 O 2 , ascorbate/Fe 3+ , cumene hydroperoxide, tert-butyl hydroperoxide, etc.) was shown to induce lipid peroxidation, protein degradation, loss of deformability, an increase in osmotic fragility, membrane lipid bilayer perturbation, inhibition of enzymes and hemolysis [5-12]. (scirp.org)
  • Membrane lipids of RBCs are believed to be the foundation of these cells' exquisite stability and deformability [ 21 ]. (biomedcentral.com)
  • Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin. (medscape.com)
  • Nakashima K, Beutler E. Erythrocyte cellular and membrane deformability in hereditary spherocytosis. (medscape.com)
  • cAMP-signalling regulates gametocyte-infected erythrocyte deformability required for malaria parasite transmission , PLOS Pathogens , May 7, 2015. (pasteur.fr)
  • Splenic sequestration of these abnormal RBCs is the dominant cause of decreased erythrocyte survival in hereditary elliptocytosis. (medscape.com)
  • We tested the deformability of RBCs using a high-throughput microfluidic device which mimics blood flow through microcapillaries. (cfidsresearch.com)
  • Red blood cells (RBCs) deformability can be defined as the ability of the cells to deform when subjected to certain flow conditions. (webmedcentral.com)
  • Hence, the main objective of the present paper is to measure RBCs deformability index (DI) in a hyperbolic microchannel and examine the effect of both diamide and glutaraldehyde on the cell deformation of human and ovine RBC. (webmedcentral.com)
  • Erythrocytes are susceptible to oxidative damage as a result of the high polyunsaturated fatty acid content of their membranes and the high cellular concentrations of oxygen and haemoglobin [1]. (scirp.org)
  • These properties such as cellular deformability, biconcave shape, and proper hemoglobin function are compromised in a range of diseases known as anemic disorders. (mit.edu)
  • For example, perfusion is more sensitive to relatively small changes in deformability (compared to filterability), thus making it preferable for assessing RBC deformability in contexts where microcirculatory implications are of particular interest. (wikipedia.org)
  • CONCLUSION: In this preliminary clinical study, 3 months of oral administration of Egb 761 significantly reduced MDA levels of erythrocytes membranes, decreased fibrinogen levels, promoted erythrocytes deformability, and improved blood viscosity and viscoelasticity, which may facilitate blood perfusion. (tmu.edu.tw)
  • The other flavonoids (chrysin, 2-carboxy ethyl dihydroxy flavone, apigenin, cirsimaritin, α-naphto flavone and flavanone) failed to protect erythrocytes against the observed oxidative damages. (scirp.org)
  • In healthy erythrocytes, significant oxidative damage is prevented by a very efficient antioxidant system, consisting of a number of antioxidant compounds and enzymes [2]. (scirp.org)
  • However, when free radicals overwhelm the capacity of antioxidant system in the erythrocyte, oxidative damages may occur endangering the integrity of the erythrocytes [3,4]. (scirp.org)
  • Erythrocytes are potent scavengers of oxidative stress, and their shape changes appreciably in response to oxidative stress and certain inflammatory conditions including obesity and diabetes. (cfidsresearch.com)
  • The ultimate hematocrit from the erythrocyte suspension system was modified to 3.0? (healthandwellnesssource.org)
  • The erythrocyte deformability is determined by measurement of passage time (reciprocal of deformability) of erythrocyte suspension in phosphate buffered saline at hematocrit 6% through cellulose … membranes. (iospress.com)
  • The shape of erythrocytes change from biconcave discoid to an ellipsoid due shear flow in microcapillaries that provides a larger specific surface area-to-volume ratio for optimal microvascular perfusion and tissue oxygenation establishing the importance not only of total hematocrit but also of the capacity for large deformations in physiology. (cfidsresearch.com)
  • The effects of eleven flavonoids on lipid peroxidation, protein degradation, deformability and osmotic fragility of human erythrocytes exposed in vitro to 10 mM H 2 O 2 for 60 min at 37˚C have been studied. (scirp.org)
  • Quercetin and 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside significantly protected erythrocytes against loss of deformability and increased osmotic fragility, indicating that the loss of erythrocyte deformability and the increase in osmotic fragility of erythrocytes exposed to H 2 O 2 are related to protein degradation rather than to lipid peroxidation. (scirp.org)
  • Normal erythrocyte osmotic fragility in hereditary spherocytosis. (medscape.com)
  • Deformability represents intrinsic property of erythrocytes to undergo deformation that is crucial for their passage through the narrow capillaries. (acva.sk)
  • It also affects the microcirculatory blood flow significantly, where erythrocytes are forced to pass through blood vessels with diameters smaller than their size. (wikipedia.org)
  • Introduction Hypertension is connected with microcirculatory disruption, and erythrocyte deformability is a significant determinant from the microcirculation. (healthandwellnesssource.org)
  • Shape change of erythrocytes under applied forces (i.e., shear forces in blood flow) is reversible and the biconcave-discoid shape, which is normal for most mammals, is maintained after the removal of the deforming forces. (wikipedia.org)
  • We also observed reduced erythrocyte deformability at high shear rates. (annaly-nevrologii.com)
  • But circulating erythrocytes - whether they are gametocyte-infected or not - are deformable, thus preventing their clearance via the spleen, which constantly filters the blood and only retains stiff, old or abnormal erythrocytes. (pasteur.fr)
  • Her research is focused on understanding how host factors from the human erythrocyte influence the biology and pathogenesis of the malaria parasite Plasmodium falciparum. (stanford.edu)
  • Here the lipid profiles of red blood cells infected with the five different sexual stages of Plasmodium falciparum were analysed by mass spectrometry and compared to those from uninfected and asexual trophozoite infected erythrocytes. (biomedcentral.com)
  • Hereditary elliptocytosis and its related disorders are caused by mutations that disrupt the RBC cytoskeleton, a multiprotein complex responsible for the elasticity and durability of the circulating erythrocytes. (medscape.com)
  • The circulation rate from the erythrocyte suspension system as a share of this of HBS at 100 mmH2O was utilized as an index of erythrocyte deformability. (healthandwellnesssource.org)
  • By increasing the stiffness of erythrocytes infected by the causal agent of malaria, Viagra favors their elimination from the blood circulation and may therefore reduce transmission of the parasite from humans to mosquitoes. (pasteur.fr)
  • However, gametocyte-infected erythrocytes can easily pass through the spleen and persist for several days in the blood circulation. (pasteur.fr)
  • Erythrocytes, better known as red blood cells, among various functions, are mainly tasked with the oxygen transport in vertebrates through blood circulation. (mit.edu)
  • The lipid profiles of infected erythrocytes are characteristic for the particular parasite life cycle and maturity stages of gametocytes. (biomedcentral.com)
  • These parameters included lipid peroxidation stress of erythrocytes, erythrocyte deformability, plasma and blood viscosity, blood viscoelasticity, and retinal capillary blood flow velocity. (tmu.edu.tw)
  • Hereditary elliptocytosis and hereditary pyropoikilocytosis are congenital hemolytic disorders in which erythrocytes either are elongated into an oval form or are irregularly shaped (see images below). (medscape.com)
  • Cigar-shaped erythrocytes seen in hereditary elliptocytosis. (medscape.com)
  • In hereditary elliptocytosis, circulating erythrocytes undergo a progressive transformation from a normal discocyte to an elliptocyte. (medscape.com)
  • Erythrocytes in hereditary elliptocytosis lack elasticity and remain elliptical. (medscape.com)
  • Agre P, Asimos A, Casella JF, McMillan C. Inheritance pattern and clinical response to splenectomy as a reflection of erythrocyte spectrin deficiency in hereditary spherocytosis. (medscape.com)
  • citation needed] Erythrocyte deformability is altered under various pathophysiological conditions. (wikipedia.org)
  • Using an in vitro model reproducing filtration by the spleen, the scientists were able to identify several pharmacological agents that inhibit phosophodiesterases and can therefore increase the stiffness of infected erythrocytes. (pasteur.fr)
  • Sickle-cell disease is characterized by extensive impairment in erythrocyte deformability, being dependent on the oxygen partial pressure. (wikipedia.org)
  • We measure hundreds of cells from each patient, so, because of this, even though the number of patients is low, we get a very statistically significant distinction between patient and healthy cells' deformability. (cfidsresearch.com)
  • Therefore, the pathological changes in elastic properties of the erythrocyte membranes in stroke are not corrected by ongoing standard therapy. (annaly-nevrologii.com)
  • Erythrocyte deformability refers to the ability of erythrocytes (red blood cells, RBC) to change shape under a given level of applied stress, without hemolysing (rupturing). (wikipedia.org)
  • Population genetic studies dating back to the mid-20th century first proposed that erythrocytes (red blood cells), the host cell for P. falciparum, have been under natural selection due to malaria. (stanford.edu)
  • Notably, it has been recently shown that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is underlined by changes in the mechanical properties of blood cells, including decreased erythrocyte deformability and decreased lymphocyte and neutrophil stiffness as compared to blood cells from SARS-CoV-2-naïve individuals 6 . (jove.com)
  • Rodrigues RO, Faustino V, Pinto E, Pinho D, Lima R. Red Blood Cells deformability index assessment in a hyperbolic microchannel: the diamide and glutaraldehyde effect. (webmedcentral.com)
  • The authors showed that this agent, used at a standard dose, had the potential to increase the stiffness of sexual forms of the parasite and thus favor the elimination of infected erythrocytes by the spleen. (pasteur.fr)
  • quercetin, 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside and 3-hydroxy flavone significantly protected erythrocytes against protein degradation. (scirp.org)
  • This is an important property because erythrocytes must change their shape extensively under the influence of mechanical forces in fluid flow or while passing through microcirculation. (wikipedia.org)
  • Perfusion (or perfusability) is a deformability-based metric that may offer a particularly physiologically-relevant representation of storage-induced deterioration of RBC occurring in blood banks, and the associated impacts of storage conditions/systems. (wikipedia.org)
  • In other words, erythrocytes behave like elastic bodies, while they also resist to shape change under deforming forces. (wikipedia.org)
  • The extent and geometry of this shape change can be affected by the mechanical properties of the erythrocytes, the magnitude of the applied forces, and the orientation of erythrocytes with the applied forces. (wikipedia.org)
  • Illustration: Left: an infected erythrocyte changes its shape to pass through the spleen filter. (pasteur.fr)
  • Normal erythrocytes, however, regain their discoid shape. (medscape.com)
  • This complex plays a critical role in erythrocyte shape and deformability. (cancerindex.org)
  • Although the notion that malaria has helped shape the human genome is well- accepted, the lack of a nucleus in human erythrocytes has hindered our ability to study genetic interactions between these unusual host cells and P. falciparum parasites. (stanford.edu)
  • Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature. (nih.gov)
  • Erythocyte deformability is a measurable property, and various means for its measurement have been explored - with each having results and significance being highly particularized to the given approach employed. (wikipedia.org)
  • These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats. (scialert.net)
  • While the clinical implications are still being explored, deformability can be indicative of quality or preservation thereof for stored RBC product available for blood transfusion. (wikipedia.org)
  • They showed that the deformability of gametocyte-infected erythrocytes is regulated by a signaling pathway that involves cAMP. (pasteur.fr)
  • Hemolysis and Decreased Deformability of Erythrocytes Exposed to Butoxyacetic Acid, a Metabolite of 2-Butoxyethanol: II. (europa.eu)
  • Some deformability tests may be more physiologically-relevant than others for given applications. (wikipedia.org)
  • The sexual forms of the parasite develop in human erythrocytes sequestered in the bone marrow before they are released into the blood. (pasteur.fr)
  • With immediate effect, and kidney problems or failure, and damage to the reproductive system interestingly, erythrocyte deformability was. (afip.org)
  • Erythrocyte deformability has also been demonstrated to be impaired in diabetes, peripheral vascular diseases, sepsis and a variety of other diseases. (wikipedia.org)
  • During a new study, the scientists thus sought to stiffen the infected erythrocytes. (pasteur.fr)
  • A study of erythrocyte deformability in sickle cell disease. (ajol.info)
  • citation needed] Erythrocyte deformability is an important determinant of blood viscosity, hence blood flow resistance in the vascular system. (wikipedia.org)