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  • gene
  • Hermans et al (3) have suggested and have provided some evidence that tumors in which the TMPRSS2:ERG fusion gene is not expressed are able to overexpress instead another transcription factor of the erythroblast transformation-specific family. (thefreedictionary.com)
  • Correction of severe anaemia using immuno-regulated gene therapy is achieved by restoring the early erythroblast compartment. (ox.ac.uk)
  • differentiation
  • Our study reveals novel cross-talk between HSCs and erythroblasts, and sheds a new light on the regulatory mechanisms regulating the balance between HSC self-renewal and differentiation. (epfl.ch)
  • Conclusions -De-differentiation of fibroblasts to intermediate CD34 + progenitors gives rise to endothelial cells and erythroblasts in a SOX17-dependent manner. (ahajournals.org)
  • Expression of signal transduction proteins during the differentiation of primary human erythroblasts. (unich.it)
  • cells
  • Erythroblast cells as a target for Bartonella quintana in homeless people. (thefreedictionary.com)
  • Culture conditions capable of generating ex vivo human erythroblasts (EBs) in numbers sufficient for transfusion have been established by several investigators (reviewed in [ 1 ]) increasing the likelihood that these cells could serve as alternative transfusion products [ 2 ]. (hindawi.com)
  • Sorted CD34 + cells were transdifferentiated into induced endothelial cells (iECs) and induced erythroblasts (iErythroblasts) using lineage specific growth factors. (ahajournals.org)
  • This study reports on a population of tumor-inducible, erythroblast-like cells (Ter-cells) in the spleen of hepatocellular carcinoma (HCC) bearing mice, which facilitates tumor progression by secreting neurotrophic factor artemin into the blood. (ilca-online.org)
  • targets
  • Overall, we define an unexpected EPO action mode via an EPOR-Spi2A serpin-cathepsin axis in maturing erythroblasts, with lysosomal cathepsins as novel therapeutic targets. (rupress.org)
  • novel
  • In this study, we report on a novel EPO/EPOR-serpin-lysosomal cathepsin axis that can sharply modulate the survival of maturing erythroblasts as an unexpected target for cytoprotection. (rupress.org)