• This was followed by ergotamine, ergonovine (=ergometrine) and other alkaloids. (erowid.org)
  • The results suggest that ergotamine and ergosine are very stable ergot alkaloids, and neither their concentrations, nor their respective R/S ratios, are significantly influenced by heating, protic solvents or UV light. (lns.lu)
  • A series of experiments were conducted to evaluate the effects of ergot alkaloids (dihydroergotamine, ergonovine, and ergotamine) on E. coli O157:H7 and Salmonella in both pure and mixed ruminal fluid culture. (usda.gov)
  • Among the many biologically active constituents of ergot, ergotamine and ergonovine are the most important. (britannica.com)
  • Ergotamine is in a class of medications called ergot alkaloids. (nih.gov)
  • The term ergot alkaloid refers to a diverse group of about forty different toxins which are formed by Claviceps spp. (thebeefsite.com)
  • An example of a biologically active, non-ergot, agent produced by Claviceps purpurea. (pharmacology2000.com)
  • Produced by fungi in the Claviceps genera, particularly C. purpurea , ergot is a term that describes the sclerotia (also known as ergot bodies). (allabouttoxins.com)
  • Derived from the fungus Claviceps purpurea, ergot alkaloids have been utilized for centuries in various therapeutic applications. (pharmaoffer.com)
  • Ergot: the genus Claviceps. (wikipedia.org)
  • Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. (wikipedia.org)
  • Ergot alkaloids are mycotoxins produced by fungi of the genus Claviceps, which infect cereal crops and grasses. (uantwerpen.be)
  • Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). (bvsalud.org)
  • This fungus produces the ergot responsible for the ergot alkaloid group of mycotoxins and parasitizes the seed heads of plants at the time of flowering. (thebeefsite.com)
  • These selected substances bind ergot alkaloids in the gastrointestinal tract, reduce their bioavailability and increase their excretion as an adsorbent-toxin complex, thus helping control the negative impacts of these mycotoxins. (thebeefsite.com)
  • Selected mycotoxins : ochratoxins, trichothecenes, ergot / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization. (who.int)
  • Additionally, in the same report, the absence of sclerotia did not exclude the presence of ergot alkaloids in the grain. (allabouttoxins.com)
  • For food safety assessment, analytical techniques are currently used to determine the presence of ergot alkaloids in food and feed samples. (uantwerpen.be)
  • Endophytic toxins in grasses include ergot alkaloids in tall fescue and tremorgens (e.g., lolitrem B) in perennial ryegrass. (thebeefsite.com)
  • Detection of ergopeptine alkaloids in endophyte-infected, toxic Ky-31 tall fescue by mass spectrometry/mass spectrometry" (PDF). (wikipedia.org)
  • Other factors such as different ergot alkaloids (i.e., ergovaline), exposure to a combination of alkaloids, characteristics of the grazed forage, or management strategies may influence fecal shedding of Escherichia coli O157:H7 or Salmonella in cattle grazing endophyte-infected tall fescue. (usda.gov)
  • The common nucleus of these alkaloids named lysergic acid was subsequently synthesizedand shown to have 4 stereoisomers, d- and 1-lysergic acid and d- and 1-isolysergic acid. (erowid.org)
  • Erowid.org: Erowid Reference 1486 : Influence of ergot alkaloids and lysergic acid derivatives on an inherited behavior anomaly in mice. (erowid.org)
  • Analytical Studies Of Ergot Alkaloids And Their Derivatives. (erowid.org)
  • Effect of Lisuride and Other Ergot Derivatives on Monoaminergic Neurot. (erowid.org)
  • Differences in the Dopaminergic Effects of the Ergot Derivatives Bromo. (erowid.org)
  • was the purification and characterization of 4dimethylallyl- L-tryptophan synthetase (DMATS) that catalyzes the first committed step in ergot alkaloid biosynthesis: C-prenylation of L-tryptophan 11 with dimethylallylpyrophosphate in the indole C4 position to form 4-dimethylallyl-L-tryptophan 55 (Fig. 19, also see Fig. 4D).176 Recently, several laboratories have focused on characterizing prenyltransferases, of which DMATS may be the original member of a new superfamily of prenyltransferase enzymes. (atminhibitor.com)
  • Cloning and analysis of a plant-induced non-ribosomal peptide synthetase (NRPS) gene from Neotyphodium lolii and analysis of the E. festucae E2368 genome sequence revealed a complex gene cluster for ergot alkaloid biosynthesis. (massey.ac.nz)
  • The effects of ergot toxicity vary among different livestock species. (allabouttoxins.com)
  • These factors include twinning, hormonal deficiencies, congenital anomalies, ergot alkaloid toxicity or ingestion of tent caterpillar setae. (ontario.ca)
  • Roduct belonging to a class of diverse molecules broadly known as ergot alkaloids. (atminhibitor.com)
  • Information on the chemical and toxicological properties of individual ergot alkaloids is too limited at the present time for their selection as individual marker toxins when it comes to monitoring the extent of contamination. (thebeefsite.com)
  • This work provides a genetic foundation for elucidating biochemical steps in the ergovaline pathway, the ecological role of individual ergot alkaloid compounds, and the regulation of their synthesis in planta. (massey.ac.nz)
  • Perennial ryegrass endophyte (Neotyphodium lolii) alkaloids are frequently present in pastures containing the neurotoxin lolitrem B, together with the vaso-constrictor ergovaline, at levels associated with ryegrass staggers, heat stress, ill-thrift and lowered milk production. (thebeefsite.com)
  • Some strains produce the ergot alkaloid ergovaline, which is implicated in livestock toxicoses caused by ingestion of endophyteinfected grasses. (massey.ac.nz)
  • Erowid.org: Erowid Reference 3230 : Historical View On Ergot Alkaloids. (erowid.org)
  • May be effective in reversing severe vasoconstriction associated with ergot overdosage. (pharmacology2000.com)
  • With a structure similar to noradrenaline, serotonin, and dopamine, ergot alkaloids stimulate vasoconstriction in the body. (allabouttoxins.com)
  • Despite their advantageous properties, ergot alkaloids require careful administration due to their potential side effects, including peripheral vasoconstriction and central nervous system disturbances. (pharmaoffer.com)
  • Ergot occurrence is most prevalent in places with high soil surface moisture in spring and early summer or with wet weather prevailing during the flowering stage of cereal crops. (allabouttoxins.com)
  • Ergot alkaloids are produced by a parasitic fungus that grows on cereal crops. (britannica.com)
  • In order to compensate for the lack of rapid tests for the detection of ergot alkaloids, the aim of this study was to develop a specific recognition element for ergot alkaloids, which could be further applied to produce a colorimetric reaction in the presence of these toxins. (uantwerpen.be)
  • In contrast, for ergocristine, ergokryptine, ergocornine and ergometrine, heating can decrease the concentrations of these alkaloids and heat, protic solvents and UV light influence the R/S ratio towards the S-form, though the respective influence on the epimerization of these compounds is variable. (lns.lu)
  • Ergot has been known for centuries and numerous outbreaks of ergotism occurred in the Middle Ages accounting for thousands of deaths. (erowid.org)
  • Chronic intake of cereals contaminated with ergot alkaloids can cause ergotism and result in the loss of toes and fingers or even death. (lns.lu)
  • Coadministration of letermovir and ergot alkaloids is contraindicated due to risk of ergotism. (medscape.com)
  • Southern analysis showed the cluster was linked with previously identified ergot alkaloid biosynthetic genes, dmaW and lpsA, at a subtelomeric location. (massey.ac.nz)
  • Non-ergot alkaloid with beta-blocking properties that may be effective for migraine prophylaxis. (pharmacology2000.com)
  • Non-ergot alkloid, classified as a first-generation antidepressant, that may be effective for migraine prophylaxis. (pharmacology2000.com)
  • The primary medicinal use of ergot alkaloids lies in their efficacy in migraine management. (pharmaoffer.com)
  • In summary, ergot alkaloids represent a significant pharmaceutical API category with diverse applications in migraine management and obstetrics. (pharmaoffer.com)
  • Interestingly, the ergot body size is not directly correlated to the concentration of ergot alkaloids. (allabouttoxins.com)
  • In addition, the total concentration of all ergot alkaloids is reduced through heating. (lns.lu)
  • 0.10) by ergot alkaloid concentration or type. (usda.gov)
  • A concentration-response relationship was hypothesized between ergot in feed and reductions in plasma prolactin, sperm motility, sperm function, and increase in sperm abnormalities. (bvsalud.org)
  • Poultry appears to be able to handle higher dietary alkaloid concentrations than ruminants or swine . (allabouttoxins.com)
  • Table 1: Ergot concentrations allowed in grain feed (Scott, 2009). (allabouttoxins.com)
  • 0.10) were found in growth rates in pure culture for either strain of E. coli O157:H7 when comparing increasing concentrations of the same ergot alkaloid or when comparing different ergot alkaloids. (usda.gov)
  • This means that neither the total alkaloid content, nor a single alkaloid can be recommended as reliable indicators of the potential adverse effects to livestock associated with the ingestion of ergot contaminated feeds. (thebeefsite.com)
  • Thorough characterization of a homologous enzyme in an Aspergillus fumigatus ergot gene cluster, FgaMT, supported this hypothesis.186 Conversion of 56 into the cyclized chanoclavine-I 57 is facilitated by the FAD-linked oxidoreductase EasE and EasC, which was initially annotated as a catalase. (atminhibitor.com)
  • In 1906 ergotoxine was the first ergot alkaloid discovered. (erowid.org)
  • Ergot alkaloids (also named ergolines) exert toxic effects in all animal species, and the most prominent toxic signs can be attributed to the interaction of ergot alkaloids with adrenergic, serotinergic and dopaminergic receptors. (thebeefsite.com)
  • Comparative analysis of the EAS gene cluster in four different epichloë strains showed marked differences in gene expression and ergot alkaloid synthesis. (massey.ac.nz)
  • 3) The Ergot alkaloids revealed species differences in the structure-activity relationships for inhibition of Pgp. (nih.gov)
  • SOLVED) Best indication of a therapeutic response to ergot alkaloids for a client with uterine bleeding? (collegeeducationtutors.com)
  • Consequently, for a client with uterine bleeding, a decrease in bleeding would be the most pertinent sign of a therapeutic response to ergot alkaloids. (collegeeducationtutors.com)
  • The best indicator of a therapeutic response to ergot alkaloids would be. (collegeeducationtutors.com)
  • The Interaction of Lisuride, an Ergot Derivative, with Serotonergic an. (erowid.org)
  • Each alkaloid coexists under two forms (R and S), though only the R-form presents toxic effects. (lns.lu)
  • In all species, the reduction in feed intake is linked to the aromatic properties of ergot alkaloids. (allabouttoxins.com)
  • The incidence of ergot infection of grains and its severity varies annually. (allabouttoxins.com)
  • An example of this is the occurrence of pyrrolizidine or tropane alkaloids in (herbal) teas or spices. (bund.de)
  • The uptake of ergot alkaloid contaminated cereal products can be lethal to humans and animals. (uantwerpen.be)
  • Ergot alkaloids are a prominent category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that possess diverse medicinal properties. (pharmaoffer.com)
  • However, all these effects are not strong enough to change the composition of ergot alkaloids in feed substantially and to transform toxic feed into non-toxic feed. (lns.lu)
  • Ergot alkaloids may reverse the pressor effects of epinephrine. (nih.gov)
  • However, the European Food Safety Authority has reported a strong correlation between the content of sclerotia and the levels of ergot alkaloids. (allabouttoxins.com)