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Neuregulin-1NeuregulinsReceptor, erbB-3Receptor, erbB-2Receptor, Epidermal Growth FactorGenes, erbBProto-OncogenesEpidermal Growth FactorProto-Oncogene ProteinsOncogene Proteins v-erbBProtein-Tyrosine KinasesOncogenesMolecular Sequence DataSignal TransductionBase SequenceRNA, MessengerGenes, erbB-2Proto-Oncogene Proteins c-mycGenes, mycCell Transformation, NeoplasticTumor Cells, CulturedProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-mybCell LineGenes, rasBreast NeoplasmsPhosphorylationPiebaldismGene Expression RegulationTranscription, GeneticCell DivisionProto-Oncogene Proteins c-retTransfectionGenes, junProto-Oncogene Proteins p21(ras)Gene ExpressionGene AmplificationProto-Oncogene Proteins c-cblGenes, fosReceptor Protein-Tyrosine KinasesGene Expression Regulation, NeoplasticCell Line, TumorAmino Acid SequenceDNARNA, NeoplasmProto-Oncogene Proteins c-metNucleic Acid HybridizationBlotting, NorthernProto-Oncogene Proteins c-mosProto-Oncogene Proteins c-junQuinazolinesMutationDNA-Binding ProteinsDNA, NeoplasmCells, Cultured3T3 CellsProto-Oncogene Proteins c-kitTranscription FactorsGenes, mosProto-Oncogene Proteins c-vavMice, TransgenicNervous System NeoplasmsTyrosineMucin-4Carcinoma, MedullaryEnzyme ActivationPolymerase Chain ReactionGrowth SubstancesCell DifferentiationPhosphotyrosineProto-Oncogene Proteins pp60(c-src)Oncogene Protein v-cblProtein BindingRecombinant Fusion ProteinsBlotting, WesternUbiquitin-Protein LigasesAntibodies, MonoclonalOligonucleotides, AntisenseGenes, fmsRecombinant ProteinsProto-Oncogene Proteins c-fesCloning, MolecularBlotting, SouthernDNA PrimersImmunohistochemistryDown-RegulationApoptosisPromoter Regions, GeneticProto-Oncogene Proteins c-aktBinding SitesLeukemia, Erythroblastic, AcuteHepatocyte Growth FactorProto-Oncogene Proteins c-pim-1Receptor, trkADimerizationLigandsMice, NudeNerve Growth FactorsMastocytosisPhosphatidylinositol 3-Kinases
Epidermal growth fEGFRErbB2ErbB4NeuregulinTumorTransmembraneCytoplasmic domainHER2AffinityKinase domainGlioblastomaLigandsSchwannPathwayDifferentiationOncogeneTranscriptionalLigandSubfamilyConsistsGeneDefectiveMetastasisTyrosine kinase inhApoptosisPromotesCatalytic subunitHepatocyteCellSevereMembersHuman
Epidermal growth f13
  • ErbB3, also called Her3 (human epidermal growth factor receptor 3), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. (rndsystems.com)
  • MA5-14485 targets Epidermal Growth Factor Receptor in IHC (P) applications and shows reactivity with Human samples. (thermofisher.com)
  • EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. (thermofisher.com)
  • This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
  • It is also frequently called HER2 (from human epidermal growth factor receptor 2 ) or HER2/neu . (iiab.me)
  • HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. (iiab.me)
  • HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. (iiab.me)
  • Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. (aacrjournals.org)
  • Activation of MAPK is initiated by one of the four ErbB receptors (ErbB1/epidermal growth factor receptor (EgfR), ErbB2-4), which leads to signaling through Raf (RAF proto-oncogene serine/threonine-protein kinase), Mek (mitogen-activated protein kinase kinase 1/2) and Erk. (biomedcentral.com)
  • Several members of the Epidermal Growth Factor Receptor (EGFR) family, have been identified in the nucleus and nucleolus of many cancer cells, but their function in these compartments remains unexplored. (biomedcentral.com)
  • This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. (nih.gov)
  • Epidermal growth factor receptor, a well-known biomarker for targeted therapy at present, was first brought up with potential clinical responsiveness to tyrosine kinase inhibitor gefitinib in 2004[ 6 ]. (biomedcentral.com)
  • Herein, we summarized the novel agents in tyrosine kinase inhibitors especially for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) inhibitors, checkpoint inhibitors, and other potential immunotherapy aiming to provide a landscape of emerging agents for NSCLC as well as insights and perspectives for the future in anticancer treatment. (biomedcentral.com)
EGFR8
  • EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. (thermofisher.com)
  • EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. (thermofisher.com)
  • Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. (thermofisher.com)
  • Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. (thermofisher.com)
  • ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. (iiab.me)
  • Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR -activating mutations by restoring the phosphatidylinositol 3-kinase/Akt signaling pathway via phosphorylation of MET, but not EGFR or ErbB3. (aacrjournals.org)
  • We focused our research on the nucleolar function that a specific member of EGFR family, the ErbB3 receptor, plays in glioblastoma, a tumor without effective therapies. (biomedcentral.com)
  • Since the EGFR signalling promotes proliferation in tumor the EGFR receptors often represent a marker of resistance with poor prognosis. (biomedcentral.com)
ErbB210
  • Heregulins bind directly to ErbB3 and ErbB4 receptors, leading to multiple dimerization possibilities including heterodimerization with the ErbB2 receptor. (nih.gov)
  • We have generated ErbB3-, ErbB2- and heregulin-deficient mice to assess their roles in development and differentiation. (nih.gov)
  • ErbB3 heterodimerizes with ErbB2 to form a high affinity receptor complex. (rndsystems.com)
  • Because ErbB3 contains a defective kinase domain, the kinase domain of ErbB2 is responsible for initiating the tyrosine phosphorylation signal through the heterodimeric receptor. (rndsystems.com)
  • It has been found that a discrete three amino acid signal in the ErbB3 cytoplasmic domain is critical for transactivation of ErbB2. (rndsystems.com)
  • Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
  • ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. (bio-techne.com)
  • ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. (bio-techne.com)
  • ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system. (bio-techne.com)
  • Typically, heterodimerization with ErbB2 forms the high affinity receptor complex. (bio-techne.com)
ErbB43
  • In contrast, ErbB3 homodimerization or heterodimerization with ErbB4 forms a low affinity heregulin-binding complex. (rndsystems.com)
  • However, ErbB4 has also been shown to heterodimerize with both ErbB1 and ErbB3. (bio-techne.com)
  • Her studies in Neuregulin 1 integrate themes in fields like Myelin, ERBB4 and ErbB Receptors. (research.com)
Neuregulin4
  • Here, Neuregulin 1 mediated proliferative stimuli, promotes ErbB3 relocalization from the nucleolus to the cytoplasm and increases pre-rRNA synthesis. (biomedcentral.com)
  • Generally, these receptors explain their function on the cell membrane where, after the binding with growth factors or neuregulin undergo to homo or hetero oligomerization with the activation of the intrinsic tyrosine kinase activity and the subsequent recruitment of proteins involved in the cytoplasmic signalling pathways. (biomedcentral.com)
  • Carmen Birchmeier spends much of her time researching Cell biology, Hepatocyte growth factor, Neuregulin, Receptor tyrosine kinase and Neuregulin 1. (research.com)
  • Her Neuregulin research integrates issues from Schwann cell, Neural crest, ERBB3, Neuregulin 1 and ErbB Receptors. (research.com)
Tumor1
  • The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
Transmembrane1
  • Human ErbB3 consists of 1342 amino acids (aa) with a 19 aa signal sequence, a 624 aa extracellular domain, a 21 aa transmembrane region, and a 678 aa cytoplasmic domain. (rndsystems.com)
Cytoplasmic domain2
  • The cytoplasmic domain of ErbB3 also contains six consensus binding motifs for the SH2 domain of the regulatory p85 subunit of phosphoinositide 3-kinase (PI 3-kinase, PI3K) as well as one proline-rich consensus binding motif for the SH3 domain of p85. (rndsystems.com)
  • Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (iiab.me)
HER22
  • Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. (iiab.me)
  • [10] [11] HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. (iiab.me)
Affinity1
  • Monomeric ErbB3 serves as a low affinity receptor for the heregulins (HRG). (rndsystems.com)
Kinase domain2
  • Among ErbB family members, ErbB3 is unique in that it contains a defective kinase domain. (rndsystems.com)
  • lacks kinase domain), and erbB-4. (iiab.me)
Glioblastoma2
  • These data point to the existence of an ErbB3-mediated non canonical pathway that glioblastoma cells use to control ribosomes synthesis and cell proliferation. (biomedcentral.com)
  • These results highlight the potential role for the nucleolar ErbB3 receptor, as a new target in glioblastoma. (biomedcentral.com)
Ligands1
  • The ERBB family of type 1 receptor tyrosine kinases and their ligands have crucial functions during mammopoiesis, but the signaling networks that ultimately regulate ERBB activity in the breast have remained elusive. (silverchair.com)
Schwann1
Pathway2
  • The mitogen-activated protein kinase (MAPK)/Erk pathway plays a central role in cell communication: it orchestrates signaling from external receptors to internal transcriptional machinery, which leads to changes in phenotype [ 6 , 7 ]. (biomedcentral.com)
  • In addition, the ErbB receptors integrate a diverse array of signals, both at the cell surface level and through cross-talk with other pathways, such as the phosphoinositide 3-kinase (Pi3k) pathway [ 11 ]. (biomedcentral.com)
Differentiation3
  • In ErbB3(-/-) embryos, the midbrain/hindbrain region was strikingly affected, with little differentiation of the cerebellar plate. (nih.gov)
  • Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
  • In her work, Cellular differentiation is strongly intertwined with Molecular biology, which is a subfield of Receptor tyrosine kinase. (research.com)
Oncogene3
Transcriptional1
  • Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
Ligand1
  • Furthermore, diverse structural alterations have been identified that cause ligand-independent firing of this receptor, doing so in the absence of receptor over-expression. (iiab.me)
Subfamily1
  • The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
Consists1
  • The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. (iiab.me)
Gene1
  • The prostaglandin-endoperoxide synthase 2 gene (PTGS2), which encodes cyclooxygenase-2, was found to upregulate the expression of TGF-β2 ( 14 ). (spandidos-publications.com)
Defective1
  • ErbB3(-/-) embryos survived until E13.5 exhibiting cardiac cushion abnormalities leading to blood reflux through defective valves. (nih.gov)
Metastasis1
  • In 2005, the first-ever trial combining small molecular targeted agent known as bevacizumab, an anti-vascular endothelial growth factor (VEGF) monoclonal antibody, with doublet chemotherapy, had shown superiority of overall survival with this treatment modality in advanced non-squamous non-small cell lung cancer patients without brain metastasis [ 2 ]. (biomedcentral.com)
Tyrosine kinase inh1
  • Herein, we summarize emerging agents including tyrosine kinase inhibitors, checkpoint inhibitors, and other potential immunotherapy such as chimeric antigen receptor T cell for non-small cell lung cancer attempting to provide insights and perspectives of the future in anticancer treatment. (biomedcentral.com)
Apoptosis1
  • In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. (iiab.me)
Promotes1
Catalytic subunit1
Hepatocyte1
Cell2
Severe1
  • Cranial ganglia defects, while present in all three nulls, were less severe in ErbB3(-/-) embryos. (nih.gov)
Members2
  • ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. (rndsystems.com)
  • However, it does form heterodimers with other EGF receptor family members which do have kinase activity. (nih.gov)
Human1