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  • Downregulation
  • The activities of the new antibodies were also compared to those of the therapeutic antibodies trastuzumab and pertuzumab, which are already in clinical use, and the new antibodies appear to be more effective at inducing downregulation of ErbB2. (uio.no)
  • Genes
  • In 2002 and 2004, Stratton's team discovered mutations in the BRAF and ERBB2 genes in approximately 60 per cent of malignant melanomas and 4 per cent of non-small-cell lung cancers respectively. (wikipedia.org)
  • antibodies
  • In the present study, two new therapeutic antibodies against ErbB2 are investigated. (uio.no)
  • Investigations into which endocytic pathway the cells use to internalize ErbB2 upon treatment with these antibodies reveal that the main pathway(s) used is/are most likely dynamin-dependent. (uio.no)
  • human
  • Anti-human ErbB2 mAb, is derived from mice immunized with the recombinant human ErbB2 (43.4 kDa, 397 a.a. and one extra N-terminal Methionin) purified from E. coli. (prospecbio.com)
  • However
  • ErbB2, however, is special in that it is resistant to internalization and inhibits internalization of other ErbBs upon heterodimerization. (uio.no)