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  • ERBB2
  • We investigated the therapeutic activity of an agonist mAb to mouse tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 (DR5) against ErbB2-driven breast cancer. (pnas.org)
  • We thus demonstrated that the combination of anti-DR5 and anti-ErbB2 mAbs might be an effective form of treatment for ErbB-2-overexpressing breast cancer. (pnas.org)
  • Therefore, in a technical sense, ErbB2 remains an orphan receptor. (apexbt.com)
  • Postoperative ischemia could affect the evaluation of breast cancer tissue for steroid hormone receptors and c-erbB2 levels until fixation using formalin. (turkjsurg.com)
  • The misevaluation of steroid hormone receptors and c-erbB2 levels, which are important prognostic factors in the treatment of breast cancer, could change treatment options. (turkjsurg.com)
  • The aim of this study was to investigate the effects of postoperative ischemia on a breast cancer tissue sample, particularly on steroid hormone receptors and c-erbB2 expression level. (turkjsurg.com)
  • Steroid hormone receptors, estrogen receptors, progesterone receptors, and c-erbB2 expression of breast cancer tissue samples were evaluated using both techniques. (turkjsurg.com)
  • Two groups were created based on the results of steroid hormone receptors and c-erbB2 expression levels using the two histopathological techniques. (turkjsurg.com)
  • A mastectomy specimen should be examined at once to ensure accurate detection of steroid hormone receptors and c-erbB2 levels for the proper treatment of breast cancer patients. (turkjsurg.com)
  • The presence of estrogen receptors (ERs), progesterone receptors (PRs), and c-erbB2 oncogene are accepted as the most important prognostic factors ( 2 - 4 ). (turkjsurg.com)
  • Eventually, all processes may lead to the misevaluation of steroid hormone receptors and c-erbB2 levels, which have high prognostic value for the treatment of breast cancer, and thus, misevaluation may cause alteration in treatment options. (turkjsurg.com)
  • Two groups were created based on steroid hormone receptors and c-erbB2 results: the first group for results of the frozen technique (n=20) and the second group for results of the regular follow-up technique (n=20). (turkjsurg.com)
  • tumor
  • The high levels of the erbB-2 product associated with malignant transformation of NIH/3T3 cells were observed in human mammary tumor cells that overexpressed this gene 3 . (apexbt.com)
  • human
  • From a human genomic library, we obtained six v-erbB-related DNA clones. (semanticscholar.org)
  • Altered ErbB-2 signalling is associated with an unfavourable prognosis in about 30% of human breast malignancies. (biomedcentral.com)
  • This is a critical aspect in the long-term goal of expanding human β-cells for the prevention and/or cure of type 1 and type 2 diabetes. (diabetesjournals.org)
  • Induction of proliferation in human β-cells is a major goal of current research in both types 1 and 2 diabetes. (diabetesjournals.org)
  • vivo
  • Our findings provide in vivo evidence that h tid is a tissue independent and evolutionarily conserved suppressor of ErbB-2. (biomedcentral.com)
  • patients
  • Patients receive nivolumab intravenously (IV) over 30 minutes every 2 weeks (Q2W) and ipilimumab IV over 90 minutes every 6 weeks (Q6W) in the absence of disease progression or unacceptable toxicity. (bioportfolio.com)
  • After completion of study treatment, patients are followed up every 4 weeks for 12 weeks, and then every 3 months for up to 2 years. (bioportfolio.com)
  • mechanisms
  • development of hematopoietic stem cells and T-cells activity during aging as well as understanding antigen recognition mechanisms by their receptors and its coupling to cellular response in mast cells as a model. (weizmann.ac.il)
  • response
  • Remarkably, treatment with a combination of anti-DR5 and anti-ErbB-2 mAbs induced complete response in a majority of mice. (pnas.org)