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  • protein
  • Of the 30 circadian-regulated proteins, the majority peaked between 1400 hours and 2100 hours, and these 30 proteins were associated with basic pathways involved in extracellular matrix organization, tyrosine kinase signaling, and signaling by receptor tyrosine-protein kinase erbB-2. (pnas.org)
  • Previously, Her-2/neu has been shown to signal via a phosphatidylinositol 3 (PI3)-kinase to Akt/protein kinase B (PKB) pathway. (nih.gov)
  • Background: F-box and leucine-rich repeat protein 10 (FBXL10), also known as lysine-specific demethylase 2B (KDM2B) and JmjC domain-containing histone demethylation protein 1B (JHDM1B), is a lysine-specific histone demethylase protein that demethylates Lys4 and Lys36 of histone H3 (1,2). (cellsignal.com)
  • The gene expression signature revealed various genes previously described to be associated with breast cancer, such as the activator protein-1 complex member Fos-like antigen 2 ( Fosl2 ), early growth response 1 ( Egr1 ), gelsolin ( Gsn ), and tumor protein translationally controlled 1 ( Tpt1 ), among others. (aacrjournals.org)
  • Anne Goriely ( anne.goriely@imm.ox.ac.uk) suggested adding the MRAS (RRAS3) -SHOC2.PPP1CA pathways that activate RAF kinase and ERF, an ETS-family protein that inhibits ERK1 (aka MAPK3) and 2 (MAPK1). (cancer.gov)
  • dimerization
  • Unlike other members of the ErbB family, HER-2/neu does not have a known high affinity ligand but is the preferred dimerization partner for the ErbB receptor family. (openthesis.org)
  • Pertuzumab (Omnitarg) is a humanized monoclonal antibody against the HER-2/neu dimerization region that inhibits HER-2/neu mediated signaling. (openthesis.org)
  • The recent crystal structure of HER- 2/neu in complex with pertuzumab shows that the dimerization region encompasses residues 266-333. (openthesis.org)
  • Based on the 3-D structure of the complex of pertuzumab with HER-2/neu, we have designed a conformational peptide construct to mimic the dimerization loop of the HER-2/neu receptor. (openthesis.org)
  • Monoclonal
  • Therefore, relatively few patients with lung cancer are likely to benefit from treatment with trastuzumab, the humanized monoclonal antibody that is effective in the 20% of patients with breast cancer and HER-2 gene amplification and/or 3+ staining by immunohistochemistry. (aacrjournals.org)
  • This observation prompted the development of a humanized monoclonal antibody directed against the extracellular domain of the HER-2 receptor, trastuzumab ( 10 ). (aacrjournals.org)
  • functional
  • Gross G, Waks T, Eshhar Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibodytype specificity. (springer.com)
  • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. (nih.gov)
  • Methods Herein, we describe a multi-platform approach for the production of recombinant Single chain Fragments of antibody variable regions (ScFvs) to ErbB-2 that involves their functional expression in (a) bacteria, (b) transient as well as stable transgenic tobacco plants, and (c) a newly developed cell-free transcription-translation system. (youscribe.com)
  • Results An ScFv (ScFv800E6) was selected by cloning immunoglobulin sequences from murine hybridomas, and was expressed and fully functional in all the expression platforms, thereby representing the first ScFv to ErbB-2 produced in hosts other than bacteria and yeast. (youscribe.com)
  • induces
  • [2] GnRH, in turn, induces the secretion of the gonadotropins , follicle-stimulating hormone (FSH) and luteinizing hormone (LH), from the pituitary gland . (wikipedia.org)
  • These studies indicate that Herceptin applied to cells expressing only c-erbB-YFP induces receptor internalisation into a compartment apparently just under the surface of the plasma cell membrane, supporting the observations of Austin and colleagues [ 2 ] who explored this by electron microscopy. (biomedcentral.com)
  • activate
  • Since this signaling pathway was recently shown to activate NF-kappaB, here we have tested the hypothesis that Her-2/neu can activate NF-kappaB in breast cancer. (nih.gov)
  • Neratinib
  • Figure 2: Combination of neratinib and trastuzumab has an additive effect and prevents re-activation of pHER3 and pAkt. (amazonaws.com)
  • therapeutic
  • In particular, autocrine regulation through ERBB-2 and IGF-1R receptors and the Akt signalling pathway have emerged as novel components of pro-survival signalling in Dupuytren's fibroblasts and thus might provide a basis for a new therapeutic strategy in Dupuytren's disease. (uzh.ch)
  • Human breast cancer therapeutic and preventive agents are primarily grouped based on their mechanism of action about the estrogen receptor-α status of the tumor. (aacrjournals.org)
  • estrogen receptor
  • Although IGF-1 is responsible for most of the role of GH in mediating breast development, GH itself has been found to play a direct, augmenting role as well, as it increases estrogen receptor (ER) expression in breast stromal (connective) tissue , while IGF-1, in contrast, has been found to not do this. (wikipedia.org)
  • biological
  • Consequently, a significant question has been how diverse biological responses are specified by these hormones and receptors. (nih.gov)