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  • activates
  • These results indicate that Her-2/neu activates NF-kappaB via a PI3- to Akt kinase signaling pathway that can be inhibited via the tumor suppressor PTEN, and is mediated by calpain rather than the IkappaB kinase complex. (nih.gov)
  • apoptosis
  • T-cell receptor stimulation without costimulation can result in T-cell anergy or apoptosis. (aacrjournals.org)
  • Here, we investigated the underlying mechanisms and found that overexpression of p185ErbB2 inhibits Taxol-induced apoptosis. (nih.gov)
  • Overexpression of p185ErbB2 in MDA-MB-435 cells by transfection transcriptionally upregulates p21Cip1, which associates with p34Cdc2, inhibits Taxol-mediated p34Cdc2 activation, delays cell entrance to G2/M phase, and thereby inhibits Taxol-induced apoptosis. (nih.gov)
  • correlates
  • Furthermore, each is overexpressed in a minority (15-20%) of the gastrinomas, and the overexpression correlates with aggressive growth and lower curability. (aacrjournals.org)
  • Gabl Coupling to the HGF/Met Receptor Multifunctional Docking Site Requires Binding of Grb2 and Correlates with the Transforming Potential" Oncogene 15:3103-3111 (1997). (patentgenius.com)
  • induces
  • Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibit. (nih.gov)
  • Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN. (nih.gov)
  • breast
  • There is considerable preclinical evidence to indicate that COX-2 has an important role in many cancers including breast. (aacrjournals.org)
  • Hormone therapy has also been used against hormone receptor-positive breast cancer. (hindawi.com)
  • Since this signaling pathway was recently shown to activate NF-kappaB, here we have tested the hypothesis that Her-2/neu can activate NF-kappaB in breast cancer. (nih.gov)
  • cell
  • Seventy patients had squamous cell carcinoma, and nine of these patients (13%) had HER-2 overexpression (3+). (diva-portal.org)
  • In squamous cell carcinoma patients, HER-2 overexpression (3+) correlated with poorer survival (P = 0.035), whereas in adenocarcinoma patients, HER-2 status (3+) did not. (diva-portal.org)
  • In conclusion, HER-2 overexpression (3+) seems to be associated with poorer survival in esophageal carcinomas, especially in patients with squamous cell esophageal carcinoma. (diva-portal.org)
  • The first signal is antigen-specific and is generated by interaction of the T-cell receptor with peptide-bearing MHC molecules. (aacrjournals.org)
  • None of 16 ductal carcinomas in situ of small-cell, papillary, or cribriform growth type had neu overexpression. (nih.gov)
  • Btk plays an important role in B cell development (1,2). (cellsignal.com)
  • The PKC inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal Btk activity (8). (cellsignal.com)
  • Immunohistochemistry
  • The present study retrospectively investigates survival in 97 patients with esophageal carcinoma in regard to their HER-2 status as examined by immunohistochemistry (IHC) and chromogen in situ hybridization (CISH). (diva-portal.org)
  • Humans
  • In this issue, Reinert and colleagues have used a murine model for genital HSV-2 infection to demonstrate that defects in TLR3 or the type I IFN system render mice - like humans - susceptible to HSV infection in the CNS but not in the periphery. (jci.org)