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CarcinomaCarcinoma, Squamous CellGenes, erbBCarcinoma, HepatocellularCarcinoma in SituCarcinoma, PapillaryReceptor, erbB-3Receptor, erbB-2Liver NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Basal CellNeuregulin-1ImmunohistochemistryBreast NeoplasmsCell Line, TumorCarcinoma, Transitional CellReceptor, Epidermal Growth FactorCarcinoma, Intraductal, NoninfiltratingCarcinoma, BronchogenicTumor Markers, BiologicalAdenocarcinomaCarcinoma, Adenoid CysticGene Expression Regulation, NeoplasticCarcinoma, Small CellCarcinoma, MedullaryNeoplasm InvasivenessCarcinoma, LobularTumor Cells, CulturedPrognosisCarcinoma, NeuroendocrineNasopharyngeal NeoplasmsOncogene Proteins v-erbBThyroid NeoplasmsNeoplasm StagingLung NeoplasmsCarcinoma, MucoepidermoidCarcinoma, AdenosquamousHead and Neck NeoplasmsCarcinoma, EndometrioidEsophageal NeoplasmsCarcinoma, DuctalMouth NeoplasmsCarcinoma, EmbryonalOvarian NeoplasmsCarcinoma, Merkel CellAntineoplastic AgentsColonic NeoplasmsLymphatic MetastasisNeoplasm MetastasisSignal TransductionMice, NudeAdrenocortical CarcinomaNeoplasm ProteinsCarcinoma, VerrucousGenes, erbB-2Urinary Bladder NeoplasmsStomach NeoplasmsCarcinoma, Signet Ring CellSkin NeoplasmsRNA, MessengerNeoplasm Recurrence, LocalCell ProliferationCarcinoma, Large CellDNA, NeoplasmImmunoenzyme TechniquesReverse Transcriptase Polymerase Chain ReactionNeoplasm TransplantationRetrospective StudiesLaryngeal NeoplasmsUterine Cervical NeoplasmsSurvival RateApoptosisNeoplasms, Multiple PrimarySurvival AnalysisAntigens, NeoplasmAdenocarcinoma, FollicularCell DivisionTreatment OutcomeCell Transformation, NeoplasticAdenocarcinoma, MucinousMammary Neoplasms, ExperimentalDisease ProgressionPrecancerous ConditionsEmbryonal Carcinoma Stem CellsTumor Suppressor Protein p53Gallbladder NeoplasmsCarcinoma, Non-Small-Cell LungAntibodies, MonoclonalCarcinoma, Papillary, FollicularMutationColorectal NeoplasmsBlotting, WesternPancreatic NeoplasmsEndometrial NeoplasmsAdenocarcinoma, Clear CellTissue Array Analysisalpha-FetoproteinsTongue NeoplasmsProto-Oncogene ProteinsTime Factors
OverexpressionOncogeneSquamousDuctal carcMammaryEpidermalPapillarySerous carcinomaProteinReceptorsRenalTyrosine kinaseMalignantDysplasiaHER2GeneEGFRAmplificationExpressionImmunohistochemistryPrognosisAbstractInvasive carcinomaKinaseAntibodiesClinicopathological featuresCorrelationRecurrentSpecimensGastricPatientsIntraepithelialTumoursOvarianProgressionEstrogen receptorAdenomasMucinousEndometrioidTumor typesHumanTissue
Overexpression13
  • Amplification of the human epidermal growth factor receptor 2 ( HER2 ) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. (wjgnet.com)
  • The degree of HER2 overexpression and amplification varies with the location of the carcinoma, with higher expression in the gastroesophageal and proximal parts compared to the distal parts of the stomach. (wjgnet.com)
  • Amplification of the HER-2 gene with overexpression of the protein occurs in 20-30% of breast cancers, and tumor progression in mammary cancer is associated with elevated levels of tyrosine-phosphorylated neu and erbB-3. (ihcworld.com)
  • Although, ErbB-2 does not have any known high-affinity ligands, its kinase activity can be activated without ligand by either overexpression or heteroassociation with other members of the ErbB family. (activemotif.com)
  • Amplification of the ErbB-2 gene and overexpression of its product has been detected in almost 40% of primary human breast tumors, which correlates with poor prognosis in node positive breast cancer. (activemotif.com)
  • ErbB-2 overexpression is also observed in ovarian, gastric, salivary and non-small cell lung carcinomas. (activemotif.com)
  • 32 % of patients exhibited overexpression of HER-2/neu. (thieme-connect.de)
  • Prospective studies correlating HER-2/neu overexpression with prognosis might provide additional data. (thieme-connect.de)
  • c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes. (thieme-connect.de)
  • Paraffin wax sections of 70 surgically resected colorectal adenocarcinomas were examined for the overexpression of HER2/c-erbB-2 oncoprotein using three different specific antibodies and the avidin-biotin immunoperoxidase technique. (ox.ac.uk)
  • It is suggested that the overexpression of c-erbB-2 gene product is unlikely to be as common and as pronounced in colorectal adenocarcinoma as it is in ductal carcinoma of the breast. (ox.ac.uk)
  • erbB-2 overexpression in human mammary epithelial cells confers growth factor independence. (musc.edu)
  • The epidermal growth factor receptor (ERBB1) and related family member HER-2/ neu (ERBB2) are often overexpressed in aggressive breast cancers and their overexpression is correlated with poor prognosis. (aacrjournals.org)
Oncogene3
  • Over-expression of the c-erbB-2 oncogene occurs in a proportion of human adenocarcinomas and in breast carcinoma is associated with poorer prognosis. (nih.gov)
  • The ErbB-2 proto-oncogene, also called Neu, EGFR-2 or HER-2, is a member of the transmembrane receptor tyrosine kinase family, which also includes EGF receptor and EGFR-3 (HER-3 or ErbB-3). (activemotif.com)
  • Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3. (musc.edu)
Squamous8
  • Oral squamous-cell carcinoma is a common cancer in humans and difficult to treat. (wikipedia.org)
  • Squamous cell carcinoma of the ovary is rare and usually arise from preexisting cystic teratomas, endometriosis or Brenner tumors which undergo carcinomatous degeneration in their epithelial elements. (koreamed.org)
  • Regulation of cyclooxygenase-2 by interferon γ and transforming growth factor α in normal human epidermal keratinocytes and squamous carcinoma cells. (houstonmethodist.org)
  • More than 90% of oral cancers are oral squamous cell carcinoma (OSCC) and the standard method for detection is through a comprehensive clinical examination by oral healthcare professionals. (springeropen.com)
  • More than 90% of the oral cancers are squamous cell carcinomas (OSCC), which arise from the epithelial lining of the oral cavity. (springeropen.com)
  • risk of esophageal squamous cell carcinoma. (who.int)
  • PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)
  • Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)
Ductal carc3
  • The histological type of breast cancer comprised 137 infiltrating ductal carcinoma (not otherwise specified), 4 invasive lobular carcinoma, 3 papillary, 2 mucinous, one each of medullary, tubular and inflammatory carcinoma, 27 ductal carcinoma in situ and 1 Non Hodgkin lymphoma. (ispub.com)
  • Activation of HER-2 is frequent in ductal carcinoma in situ suggesting that HER-2 signaling plays a critical role in the early stages of breast tumorigenesis. (ihcworld.com)
  • Precursors and preinvasive lesions of the breast include atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and lobular neoplasia (LN). There is a significant debate regarding the classification, diagnosis, prognosis and management of these lesions. (biomedcentral.com)
Mammary8
  • Insulin-like growth factor and epidermal growth factor independence in human mammary carcinoma cells with c-erbB-2 gene amplification and progressively elevated levels of tyrosine-phosphorylated p185erbB-2. (wikidata.org)
  • Sections of formalin-fixed, paraffin-embedded tumour tissue from 22 patients with mammary and extramammary Paget's disease have been stained immunohistochemically using a monoclonal antibody (NCL-CB11) raised against a synthetic peptide from the C-terminal end of the predicted sequence of the c-erbB-2 protein product. (nih.gov)
  • All 12 cases of mammary Paget's disease showed membrane staining of intra-epidermal cells, indicating c-erbB-2 over-expression. (nih.gov)
  • 14 King C R, Kraus M H, Aaronson S A. Amplification of a novel v-erbB-related gene in a human mammary carcinoma. (thieme-connect.de)
  • c-Src potentiates proliferation, survival, and invasiveness in response to epidermal growth factor (EGF) in human mammary carcinoma cells. (aspetjournals.org)
  • The role of Ha-ras oncogenes in growth factor independence in rat mammary carcinoma cells. (musc.edu)
  • Cooperative interactions of HER-2 and HPV-16 oncoproteins in the malignant transformation of human mammary epithelial cells. (musc.edu)
  • Transgenic mice overexpressing active Notch1, Notch3, or Notch4 homologs all developed mammary carcinoma [9,10]. (scienceexhibitions.org)
Epidermal9
Papillary3
Serous carcinoma6
  • Purpose Uterine serous carcinoma is a rare, aggressive variant of endometrial cancer. (nih.gov)
  • This multicenter, randomized phase II trial compared carboplatin-paclitaxel with and without trastuzumab in patients with advanced or recurrent uterine serous carcinoma who overexpress HER2/neu. (nih.gov)
  • These encouraging results deserve further investigation to determine their impact on overall survival in patients with advanced or recurrent uterine serous carcinoma who overexpress HER2/neu. (nih.gov)
  • The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. (hindawi.com)
  • Type II tumors include high-grade serous carcinoma, malignant mixed mesodermal tumors, and undifferentiated carcinomas. (hindawi.com)
  • p53 positivity is a parameter in the identification of tubal intraepithelial carcinoma associated with pelvic serous carcinoma. (nordiqc.org)
Protein6
  • The total-ErbB-2 antibody supplied in the FACE ErbB-2 Kits recognizes ErbB-2 protein regardless of its phosphorylation site. (activemotif.com)
  • The TP53 gene is located on the short arm of chromosome 17 (17p13.1) that encodes the nuclear protein p53, whereas the mdm 2 gene maps to the long arm of chromosome 12(12q13-14) and encodes mdm2 protein (1) . (aacrjournals.org)
  • This creates a feedback loop that regulates both the activity of p53 protein and the expression of the mdm2 gene (2, 3) . (aacrjournals.org)
  • The ErbB inhibitor PD158780 and the mitogen-activated protein kinase kinase inhibitor U0126 also markedly inhibited NHK proliferation, migration, and amphiregulin production. (aspetjournals.org)
  • The final cleavage is performed by -secretase, whose substrates include all four Notch receptors and their ligands as well as -amyloid precursor protein, E-cadherin, CD44, ErbB-4, and ephrin-B1 [2-8]. (scienceexhibitions.org)
  • The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases. (nature.com)
Receptors1
  • As ErbB-family ligands and receptors are highly expressed within the stem-cell niche 7 , we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. (nature.com)
Renal4
  • Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
  • Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
  • The present study was designed to analyze the expression of p53 and mdm2 in clear cell renal cell carcinoma with special emphasis on their association with tumor grade and clinical outcome. (aacrjournals.org)
  • A cohort of 97 clear cell renal cell carcinomas was analyzed. (aacrjournals.org)
Tyrosine kinase2
  • Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. (rupress.org)
  • Binding of Sema4D to plexin-B1 stimulates the intrinsic tyrosine kinase activity of ErbB-2, resulting in the phosphorylation of both plexin-B1 and ErbB-2. (rupress.org)
Malignant6
  • [ 2 ] In most instances the luminal epithelial cells undergo malignant change, though a combination of epithelial and myoepithelial malignancy or purely myoepithelial carcinoma may also occur. (medscape.com)
  • Carcinoma ex pleomorphic adenoma represents the most common malignant change to occur in pleomorphic adenomas. (medscape.com)
  • Carcinoma ex pleomorphic adenoma is not a specific diagnosis, as it only indicates a malignant carcinoma arising from an antecedent pleomorphic adenoma. (medscape.com)
  • This has implications for our understanding of ErbB signalling in tissue development and maintenance and the progression of malignant disease. (nature.com)
  • These results indicate that ERBB inhibition should be considered for blocking other tumor cell malignant properties besides growth. (aacrjournals.org)
  • Often p53 positivity is correlated with high grade lesions (e.g., carcinoma of breast, prostate and bladder, malignant lymphoma) and poor prognosis. (nordiqc.org)
Dysplasia2
  • The cancer itself develops tumors in a predictable way starting with hyperkeratosis, then hyperplasia, then dysplasia, then carcinoma. (wikipedia.org)
  • So far, it is well recognized that a multistep process is involved in the progression from normal gastric mucosa to intestinal-type GC, including chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and invasive carcinoma, which was originally proposed by Correa [ 2 , 3 ]. (oncotarget.com)
HER25
  • Omdat bij 70% van de alvleesklierkankerpatiënten de HER2-Neu expressie oververtegenwoordigd is en juist Herceptin bij borstkankerpatiënten met deze receptor uitstekende resultaten laat zien zijn deze trials opgezet. (kanker-actueel.nl)
  • Scholars@Duke publication: Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody. (duke.edu)
  • HER2 (c-erbB-2) oncoprotein expression in colorectal adenocarcinoma: an immunohistological study using three different antibodies. (ox.ac.uk)
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using HER2/ErbB2 (29D8) Rabbit mAb. (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma using HER2/ErbB2 (29D8) RmAb in the presence of control peptide (left) or HER2/ErbB2 Blocking Peptide #1059 (right). (cellsignal.com)
Gene4
  • These are for the most part low-grade tumors that are characterized by a high frequency of mutations of KRAS , BRAF, ERBB2, CTNNB1 (the gene encoding beta catenin), and PIK3CA , low proliferation, and a 5-year survival of approximately 55% [ 2 ]. (hindawi.com)
  • ERBB2 gene amplification detected by fluorescent differential polymerase chain reaction in paraffin-embedded breast carcinoma tissues. (thieme-connect.de)
  • 5 Beckmann M W, Niederacher D, Schnurch H G, Bender H G. The erbB gene family: significance for tumor development, prognosis and new therapeutic modalities. (thieme-connect.de)
  • Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification. (musc.edu)
EGFR1
  • EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. (thermofisher.com)
Amplification1
Expression12
  • Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • The expression of MUC1, MUC2, MUC3, MUC5AC, and MUC6 was investigated immunohistochemically in gastric carcinoma (n = 46) in relation to patient clinicopathological features. (bmj.com)
  • Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
  • This finding could indicate that HER-2/neu expression is a new independent prognostic factor. (thieme-connect.de)
  • 2 Barnes D M, Lammie G A, Millis R R, Gullick W L, Allen D S, Altman D G. An immunohistochemical evaluation of c-erbB-2 expression in human breast carcinoma. (thieme-connect.de)
  • We analyzed the EP3 expression of 140 endometrial carcinoma patients by immunohistochemistry. (oncotarget.com)
  • RL95-2 endometrial cancer cell line was chosen from four endometrial cancer cell lines (RL95-2, Ishikawa, HEC-1-A, and HEC-1-B) according to EP3 expression level. (oncotarget.com)
  • erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line. (musc.edu)
  • In dysplastic lesions, e.g., in Barrett's esophagus, p53 expression increases the risk of carcinoma. (nordiqc.org)
  • In addition, it has to be emphasized, that stromal cells, lymphocytes and endothelial cells in the clinical samples are essential as internal positive tissue controls especially for carcinomas with TP53 mutations causing absence and loss of p53 expression in the tumour cells. (nordiqc.org)
Immunohistochemistry1
Prognosis1
Abstract1
  • Duitse onderzoekers publiceren in oktober a.s. het abstract van een aantal laboratoriumstudies en dierstudies die ze gedaan hebben met Herceptin als basis aangevuld met gemcitabine en/of docetaxel bij inoperabele en gevorderde alvleesklierkanker . (kanker-actueel.nl)
Invasive carcinoma1
  • Malignancy may be not be apparent on gross examination, especially in cases of noninvasive or minimally invasive carcinoma. (medscape.com)
Kinase1
  • Although several lines of evidence also suggest important interactions of ErbB and Src family kinase signaling in normal epithelial cells, little is known about the mechanism of this interaction. (aspetjournals.org)
Antibodies2
  • Each FACE ErbB-2 Kit provides 96 rxns each of 2 antibodies that enable you to monitor and compare the levels of both phosphorylated and total ErbB-2. (activemotif.com)
  • Sensitivity of HER-2/neu antibodies in archival tissue samples of invasive breast carcinomas. (thieme-connect.de)
Clinicopathological features2
  • We also sought to determine the correlation, if any, between clinicopathological features of infiltrating ductal carcinoma and axillary lymph node metastases. (ispub.com)
  • Cases of invasive breast carcinoma with the phosphorylated receptor have displayed aggressive clinicopathological features and adverse prognoses. (ihcworld.com)
Correlation2
  • Correlation of clinicopathological characteristics were analysed in surgically resected specimens of infiltrating ductal carcinomas. (ispub.com)
  • The correlation of the inflammatory profile with the severity of the disease in neoplastic patients with SARS-CoV-2 infection was addressed. (cdc.gov)
Recurrent1
  • Carcinoma ex pleomorphic adenoma is defined as an epithelial and/or myoepithelial malignancy arising from a primary or recurrent pleomorphic adenoma . (medscape.com)
Specimens3
  • When considering only patients who had mastectomy or lumpectomy, the racial breakdown was 65 Chinese (60.7%), 30 Malay (28.0%) and 12 Indian (11.2%) The mean tumour size of infiltrating ductal carcinoma as measured in mastectomy and lumpectomy specimens (n = 107) was 3.75 cm (range 0.6 cm to 9.8 cm). (ispub.com)
  • The finding of occult invasive and intraepithelial fallopian tube carcinomas in prophylactically removed specimens from asymptomatic high-risk BRCA 1/2-mutation carriers supports the notion of an origin for OSC in the fallopian tube. (hindawi.com)
  • Eight tubular adenomas found in the colectomy specimens in association with some carcinomas were also examined. (ox.ac.uk)
Gastric4
  • Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
  • Gastric intestinal metaplasia (GIM) is a precancerous gastric carcinoma (GC) lesion with pivotal roles in carcinogenesis. (oncotarget.com)
  • However, the relationships of AQP3 with GIM classification and with other proteins, and their roles in the transition from GIM to gastric carcinoma (GC) remain unknown. (oncotarget.com)
  • Gastric carcinoma (GC) remains one of the most common malignances and the third leading cause of cancer-related mortality worldwide [ 1 ]. (oncotarget.com)
Patients4
  • [ 9 ] Not surprisingly, carcinoma ex pleomorphic adenoma is rarely encountered in children or in patients younger than 30 years. (medscape.com)
  • Patients with carcinoma ex pleomorphic adenoma classically present with recent and rapid enlargement of a previously longstanding and slow-growing mass. (medscape.com)
  • about half of patients are aware of a swelling for about 2-3 years. (medscape.com)
  • All patients were female except for one male who had invasive ductal carcinoma. (ispub.com)
Intraepithelial2
  • The intraepithelial carcinomas have been referred to as serous intraepithelial carcinomas (STICs) but our own findings (unpublished data) and recent reports have drawn attention to a spectrum of changes that fall short of STICs that we have designated serous tubal intraepithelial lesions (STILs). (hindawi.com)
  • Tbe presence of certain HPV types in the female genital tract was associated with a number of diseases, including condyloma, cervical, vaginal and vulvar intraepithelial neoplasia and carcinoma. (koreamed.org)
Tumours2
  • all nine tumours were c-erbB-2 positive and in eight the in situ component was of comedo or solid type. (nih.gov)
  • The size of infiltrating ductal carcinoma (IDC) tumours at presentation is tabulated in table 1 and the histological grade of IDC, in table 2. (ispub.com)
Ovarian2
  • Accumulating evidence suggests that there are two general pathways in the molecular pathogenesis of what is known as ovarian cancer [ 2 , 3 ]. (hindawi.com)
  • It is estimated that 60% of sporadic ovarian carcinomas and the majority of those diagnosed in BRCA1 mutation carriers are of the high-grade serous type [ 4 , 5 ]. (hindawi.com)
Progression1
  • A stepwise model of progression from cystadenomas to low-grade carcinomas has been proposed for these neoplasms. (hindawi.com)
Estrogen receptor3
  • Nodal positivity correlated with histological grade and tumour size, but not with estrogen receptor or c-erbB-2 status. (ispub.com)
  • Chi square was used to test the association between ethnic group, tumour size (categorized as ≤2 cm, >2 cm and ≤5 cm, and >5 cm), histological grade, estrogen receptor (ER) status, c-erbB-2 status and lymph node metastases. (ispub.com)
  • Treatment with EP3 antagonists induced upregulation of estrogen receptor β and decreased activity of Ras and led to attenuated proliferation and migration of RL95-2 cells. (oncotarget.com)
Adenomas1
  • No positive membrane staining was seen in any of the 70 carcinomas, four adenomas, two hyperplastic polyps, nor in the adjacent normal or transitional mucosa. (ox.ac.uk)
Mucinous1
  • The first (Type I) pathway leads to borderline tumors, which can develop into low-grade serous, mucinous, endometrioid, and clear cell carcinomas. (hindawi.com)
Endometrioid1
  • EP3 staining differed significantly according to WHO tumor grading in both whole cohort (p = 0.01) and the subgroup of endometrioid carcinoma (p = 0.01). (oncotarget.com)
Tumor types1
  • High-grade adenocarcinoma (not otherwise specified), myoepithelial carcinoma, and epithelial-myoepithelial carcinomas are other common tumor types arising in this setting. (medscape.com)
Human3
  • Syrian hamsters are a model for researching Non-small-cell lung carcinoma, which is one of the types of human lung cancer. (wikipedia.org)
  • The FACE ErbB-2 (Y877) Kit contains a phospho-ErbB-2 antibody that was raised in rabbit against a synthetic phospho-peptide corresponding to residues surrounding phosphorylated Tyr877 of human ErbB-2 and recognizes ErbB-2 only when phosphorylated at Tyr877. (activemotif.com)
  • p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells acts as an EGF-independent survival signal. (musc.edu)
Tissue1
  • The histological type of cancer and histological grade of invasive ductal carcinoma (using modified Bloom and Richardson histological grade) were determined in samples that had enough tissue for its assessment. (ispub.com)