Epstein barr virus dna. Medical search. Frequent questions

EBV Plasma Epstein-Barr Virus (EBV) DNA as a Biomarker for Diagnosis of EBV-positive Hodgkin Lymphoma in Syria. (jidc.org)

The DNA is surrounded by a protein nucleocapsid, which is surrounded by a tegument made of protein, which in turn is surrounded by an envelope containing both lipids and surface projections of glycoproteins, which are essential to infection of the host cell. (wikipedia.org)
Epstein-Barr virus infection of B lymphocytes results in a humoral and cellular response to the virus. (medscape.com)
14.9% (95% CI: 12.4-17.4%) for human herpes virus 8 infection. (nature.com)
While it is widely believed that NPC is caused by the interaction of several factors, Epstein-Barr virus (EBV) infection is undoubtedly the most studied aetiological factor for NPC. (hkmj.org)
EBV's primary infection is considered to be caused by viruses through the oropharyngeal epithelium. (selfgrowth.com)
Chronic active Epstein-Barr virus (CAEBV) disease is a rare disorder in which persons are unable to control infection with the virus. (frontiersin.org)
Both the innate immune response (especially NK cells) and the acquired immune response (virus-specific CD4 and CD8 cells) have a critical role in clearing the infection ( 2 ). (frontiersin.org)
Initial control of EBV in healthy persons involves NK cells that can kill virus-infected cells ( 3 , 4 ) and secrete IFN-γ, which inhibits B cell proliferation, and monocytes, which release chemokines in response to virus infection ( 5 ). (frontiersin.org)
Epstein-Barr virus (EBV) infection, malaria, immunodeficiency and spontaneous, somatic mutation can all contribute to the origin and maintenance of this cancer and their mechanisms are the subject of this review. (bmj.com)
The results confirmed the diagnosis of hemophagocytic syndrome related to EB (Epstein-Barr) virus infection. (scirp.org)
To investigate the involvement of stem cells in Epstein-Barr virus infection-related nasopharyngeal carcinoma (NPC), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (CD44v6, CD24, and ALDH1A1) in NPC tissues and NPC cell lines. (hindawi.com)
Since Epstein-Barr virus (EBV) infection is common and NPC is rare, it is a complex disease caused by the interaction of chronic EBV infection, environmental factors, and genetic and epigenetic changes, in a multistep process of carcinogenesis [ 7 , 10 - 13 ]. (hindawi.com)
Cells infected with Epstein-Barr, a common herpes virus that can cause mononucleosis and establishes a latent, lifelong infection of the host. (healthcare-in-europe.com)
Multiple sclerosis, a progressive disease that affects 2.8 million people worldwide and for which there is no definitive cure, is likely caused by infection with the Epstein-Barr virus, according to a study led by Harvard T.H. Chan School of Public Health researchers. (healthcare-in-europe.com)
Its cause is not known, yet one of the top suspects is EBV, a herpes virus that can cause infectious mononucleosis and establishes a latent, lifelong infection of the host. (healthcare-in-europe.com)
Establishing a causal relationship between the virus and the disease has been difficult because EBV infects approximately 95 percent of adults, MS is a relatively rare disease, and the onset of MS symptoms begins about 10 years after EBV infection. (healthcare-in-europe.com)
In this cohort, the risk of MS increased 32-fold after infection with EBV but was unchanged after infection with other viruses. (healthcare-in-europe.com)
The findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS. Ascherio says that the delay between EBV infection and the onset of MS may be partially due to the disease's symptoms being undetected during the earliest stages and partially due to the evolving relationship between EBV and the host's immune system, which is repeatedly stimulated whenever latent virus reactivates. (healthcare-in-europe.com)
Currently there is no way to effectively prevent or treat EBV infection, but an EBV vaccine or targeting the virus with EBV-specific antiviral drugs could ultimately prevent or cure MS," said Ascherio. (healthcare-in-europe.com)
Chronic active Epstein-Barr virus (EBV) infection is a severe systemic disease associated with high rates of mortality and morbidity. (researchgate.net)
Infectious mononucleosis owing to primary Epstein-Barr virus (EBV) infection sometimes causes hepatitis, which is usually self-limiting with mildly elevated transaminases, but can rarely develop into severe hepatitis with jaundice. (researchgate.net)
Cytomegalovirus (CMV) infection is a disease caused by a type of herpes virus. (medlineplus.gov)
All herpes viruses remain in your body for the rest of your life after infection. (medlineplus.gov)
Cutaneous manifestations of human immunodeficiency virus (HIV) disease may result from HIV infection itself or from opportunistic disorders secondary to the decline in immunocompetence from the disease. (medscape.com)
In a new study, researchers from the International Agency for Research on Cancer (IARC) and partner institutions investigating drivers of Burkitt lymphoma have identified a molecular signature that is common to both Epstein-Barr virus infection and exposure to aflatoxin B1, two known etiological factors for this cancer type. (who.int)
The researchers explored genome-wide DNA methylation profiles in samples of endemic Burkitt lymphoma tissue and identified a molecular signature shared by both Epstein-Barr virus infection and aflatoxin B1 exposure that affects the expression of a putative tumour suppressor, TGFBI. (who.int)
Countries used existing surveillance systems for severe acute respiratory infection and influenza-like illness, respiratory virus laboratory resources, pandemic influenza preparedness plans, and ongoing population-based influenza studies to track, study, and respond to SARS-CoV-2 infections. (cdc.gov)
In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)
6 Feature /rnalink: 5 Feature /name: unknown Symptoms An unremitting one-month infectious mononucleosis by Symptoms Epstein-Barr virus (EBV) infection. (lu.se)

Chronic active Epstein-Barr virus disease is usually defined as a chronic illness lasting at least 6 months, an increased EBV level in either the tissue or the blood, and lack of evidence of a known underlying immunodeficiency ( 15 ). (frontiersin.org)

Currently, no consensus has been reached on the optimal blood compartment to be used for surveillance of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNAemia. (unimib.it)
In the later stages of HIV disease, chronic herpes simplex virus (HSV), molluscum contagiosum (MC), and cytomegalovirus (CMV) infections appear. (medscape.com)
Recommendations are given for preventing cytomegalovirus disease with prophylactic or preemptive gancyclovir, herpes simplex virus disease with prophylactic acyclovir, candidiasis with fluconazole, and Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole. (cdc.gov)

METHODS The authors tested their hypothesis using biomarker screening samples from the Hong Kong NPC Study Group 0502 trial, which was a prospective, multicenter clinical trial that used post-RT plasma Epstein-Bar virus (EBV) DNA (pEBV) levels to screen patients with high-risk NPC for adjuvant chemotherapy. (edu.hk)
More specifically, the close relationship between Epstein-Barr virus and nasopharyngeal cancer opens up the possibility of using Epstein-Barr virus DNA as a biomarker for early detection and monitoring of the disease. (hkmj.org)
Moreover, 8-nitroguanine is a potentially mutagenic DNA lesion and has been reported to play a significant role in and to be a biomarker for inflammation-related carcinogenesis [ 5 ]. (hindawi.com)

DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
Progression to malignancy is associated with the expression of viral proteins whose primary function is to drive virus replication by regulating cell proliferation, apoptosis and the recognition of infected cells by the immune system. (ki.se)
Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints. (ki.se)
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins. (bvsalud.org)

Burkitt lymphoma (BL) can be classified into three forms which differ in geographic distribution and Epstein-Barr virus (EBV) association: endemic (eBL), sporadic (sBL) and HIV-associated BL ( table 1 ). (bmj.com)

Scientists from Australia and the USA have developed a lymph node-targeted multi-epitope subunit vaccine that induces strong humoral and cellular immune responses against Epstein-Barr virus (EBV) in mice. (news-medical.net)

Epidemiological studies suggest that the disease is infectious, mainly associated with human herpes virus type 8 (HHV-8). (bvsalud.org)

These observations provide a mechanistic molecular link between M81 virus replication-a central viral function and a cancer risk factor-and the production of a chemokine involved in inflammation and carcinogenesis. (nature.com)
Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas. (nature.com)
Understanding factors required for DNA replication will enrich our knowledge of this important process and potentially identify vulnerabilities that can be exploited in cancer therapy. (aacrjournals.org)
We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)
Defects in the control of cell proliferation are a hallmark of cancer, and DNA replication is a key process for cell proliferation. (aacrjournals.org)
Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. (ki.se)
They also further defined subtype 1 as representing cell proliferation-related processes (cell cycle and DNA replication RNA processing, translation, and protein degradation). (genomeweb.com)

Results Twenty-one cerebrospinal fluid samples, in which a known pathogen had been positively identified by available clinical techniques, were subjected to metagenomic DNA sequencing using massive parallel sequencing. (biorxiv.org)
Diagnosis requires neuroimaging and sometimes cerebrospinal fluid analysis (including Epstein-Barr titers) or brain biopsy. (msdmanuals.com)

Epstein-Barr virus (EBV) is known to be a causative agent of hemophagocytic lymphohistiocytosis (HLH). (researchgate.net)

Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial. (researchmap.jp)

The Epstein-Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. (nature.com)
Epstein-Barr Virus (Strain: B95-8) is a human herpes virus (HHV-4) and has a diameter of approximately 120 to 180 nm. (zeptometrix.com)

Insect cells infected with the recombinant virus produced a protein of 110 kDa, recognized by anti-BALF5 protein-specific polyclonal antibody. (neb.com)
The purified protein exhibited both DNA polymerase and 3'-to-5' exonuclease activities, which were neutralized by the anti-BALF5 protein-specific antibody. (neb.com)
These observations strongly suggest that the presence of EBV DNA polymerase accessory protein, BMRF1 gene product, does influence the enzymatic properties of EBV DNA polymerase catalytic subunit. (neb.com)
4F10 was against the Epstein-Barr virus (EBV) Zta protein and 311 H specifically recognized EBV DNase enzyme. (karger.com)
Lerner, M. R., Andrews, N. C., Miller, G. & Steitz, J. A. Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. (nature.com)

Unlike previous studies, this study used a single automated molecular method that was CE-marked and Food and Drug Administration-approved for use in quantifying CMV and EBV DNA in both plasma and WB. (unimib.it)
The GP42 in the complex is combined with the HLA II molecular molecules, and caused the virus cell fusion under the participation of GP85/GP25 and GP110 glycoprotein. (selfgrowth.com)
Results from the second WHO external quality assessment for the molecular detection of respiratory syncytial virus, 2019-2020. (cdc.gov)
BACKGROUND: External quality assessments (EQAs) for the molecular detection of human respiratory syncytial virus (RSV) are necessary to ensure the standardisation of reliable results. (cdc.gov)
Updating the composition of RSV molecular EQAs with contemporary strains to ensure representation of circulating strains, and ensuring primer matching with EQA panel viruses, is advantageous in assessing diagnostic competencies of laboratories. (cdc.gov)

Epstein-Barr virus promotes genomic instability in Burkitt's lymphoma. (ki.se)

Epstein-Barr virus (EBV) is usually maintained in an asymptomatic and latent form by the host immune system, and primarily by EBV-specific cytotoxic T cells (CTLs). (researchgate.net)
Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. (medscape.com)

Plasma cell-free DNA (cfDNA) methylation has shown promising results in the early detection of multiple cancers recently. (biomedcentral.com)
Highly sensitive stool DNA testing of Fusobacterium nucleatum as a marker for detection of colorectal tumours in a Japanese population. (researchmap.jp)
Long-fragment DNA as a potential marker for stool-based detection of colorectal cancer. (researchmap.jp)
The detection of high-oncogenic HPV genotypes in patients with breast cancer supports the hypothesis of an etiologic role for the virus in breast cancer development. (who.int)

Epstein-Barr virus (EBV), also known as human herpes virus 4, is a widely disseminated double stranded DNA herpesvirus. (medscape.com)
We conducted a meta-analysis among PLWHA in China to describe the prevalence of major cancer risk factors including tobacco smoking, alcohol consumption, overweight and obesity, and cancer-related viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV), human papillomavirus (HPV), Epstein-Barr virus (EBV) and human herpes virus 8 (HHV8). (nature.com)
Epstein-Barr virus (EBV) is a kind of γ-herpes virus that is infected with human beings. (selfgrowth.com)
Viral inactivation of EBV Lysate was validated by the absence of viral growth for other Human Herpes Virus lysates tested in tissue culture-based infectivity assays. (zeptometrix.com)
Our main virus model is EBV, a lymphotropic herpes virus that is associated with lymphoid and epithelial cell malignancies including Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC), immunoblastic lymphoma (IL) and Hodgkin's disease (HD). (ki.se)
Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1. (ki.se)
CMV is a type of herpes virus. (medlineplus.gov)

The Epstein-Barr virus (EBV), formally called Human gammaherpesvirus 4, is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. (wikipedia.org)
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, infecting approximately 95% of the global population. (news-medical.net)

Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: A preliminary study. (medscape.com)

EBV is a double-stranded DNA virus. (wikipedia.org)
It is an enveloped icosahedral virus that contains a nucleocapsid and double-stranded linear DNA. (zeptometrix.com)

We investigated the clinical significance of plasma concentrations of Epstein-Barr virus (EBV) DNA in patients with advanced nasopharyngeal carcinoma. (nih.gov)
Plasma EBV DNA was detectable before treatment in 94 of the 99 patients, but not in 40 healthy controls or 20 cured patients. (nih.gov)
Unlike the rebound of plasma EBV DNA concentrations in the patients who had a relapse, the plasma EBV DNA concentration was persistently low or undetectable in patients with a complete clinical remission. (nih.gov)
0.001) and relapse-free survival (P=0.02) were significantly lower among patients with pretreatment plasma EBV DNA concentrations of at least 1500 copies per milliliter than among those with concentrations of less than 1500 copies per milliliter. (nih.gov)
0.001) than patients with undetectable EBV DNA one week after the completion of radiotherapy. (nih.gov)
Quantification of plasma EBV DNA is useful for monitoring patients with nasopharyngeal carcinoma and predicting the outcome of treatment. (nih.gov)
Furthermore, in patients who received preemptive therapy, CMV DNA showed a delayed decrease in plasma compared with WB. (unimib.it)
Epstein-Barr Virus DNA viral loads: Is there a correlation between paired whole blood and plasma collected from a cohort of pediatric renal transplant patients? (ucd.ie)
A previous paper revealed that the platelet number of patients with influenza virus-associated encephalopathy (IE) was correlated with the o. (researchgate.net)
In immunocompromised patients, Epstein-Barr virus DNA may be detected in CSF. (msdmanuals.com)

A recombinant baculovirus containing the complete sequence for the Epstein-Barr virus (EBV) DNA polymerase catalytic subunit, BALF5 gene product, under the control of the baculovirus polyhedrin promoter was constructed. (neb.com)

Reference: Functional expression and characterization of the Epstein-Barr virus DNA polymerase catalytic subunit. (neb.com)
Decitabine inhibits tumor cell proliferation and up-regulates e-cadherin expression in Epstein-Barr virus-associated gastric cancer. (researchmap.jp)

Thus, M81 induced chronic inflammation in its target cells and this resulted in increased virus production. (nature.com)

Papilloma viruses (HPV), hepatitis B- (HBV) and C-viruses (HCV), Epstein-Barr virus (EBV), Kaposi sarcoma virus (KSHV), human T-cell-leukemia virus (HTLV) may contribute to the pathogenesis of as much as 15-20% of all human cancers. (ki.se)

Viruses can't replicate themselves and most fizzle out almost immediately when not contained within a more complex organism. (thesmartset.com)
Viruses are obligate intracellular parasites - they can only reproduce within the cell of a host organism. (thesmartset.com)

Staal SP, Ambinder R, Beschorner WE, Hayward GS, Mann R. A survey of Epstein-Barr virus DNA in lymphoid tissue. (medscape.com)

Clinical Importance of Epstein⁻Barr Virus-Associated Gastric Cancer. (researchmap.jp)
The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer. (researchmap.jp)
Epstein-barr virus in gastric carcinoma. (researchmap.jp)

Dive into machine learning algorithms for influenza virus host prediction with hemagglutinin sequences. (cdc.gov)
The incorporation of COVID-19 surveillance into existing influenza sentinel surveillance systems can support continued global surveillance for respiratory viruses with pandemic potential. (cdc.gov)

DNA mutations that occur after birth may be related to this cancer. (epnet.com)

A common feature of these oncogenic viruses is their capacity to establish persistent infections that are either asymptomatic or are accompanied by benign cell proliferations. (ki.se)

A real-time polymerase chain reaction assay for quantitation of Epstein-Barr virus (EBV) DNA in serum was developed. (manchester.ac.uk)
Special lab tests such as a CMV DNA serum PCR test may be done to check for presence of substances in your blood produced by CMV. (medlineplus.gov)

Epstein-Barr virus (EBV) is associated with Hodgkin lymphoma (HL) and can be detected by in situ hybridization (ISH) of viral nucleic acid (EBER) in tumor cells. (wustl.edu)

Specimens from the Cancer Cooperative Intergroup Trial E2496 were used to compare pretreatment plasma EBV-DNA quantification with EBV tumor status by EBER-ISH. (wustl.edu)

The disease is progressive with markedly elevated levels of EBV DNA in the blood and infiltration of organs by EBV-positive lymphocytes. (frontiersin.org)
In vitro studies show that the virus can infect various cell types such as endothelial cells and B-lymphocytes 15 . (bvsalud.org)

We found that the M81 non-coding Epstein-Barr-encoded RNA EBER2, which carries polymorphisms that are mainly restricted to viruses found in endemic nasopharyngeal carcinomas, markedly stimulated this process. (nature.com)

and conditions associated with human immunodeficiency virus such as hairy leukoplakia and central nervous system lymphomas. (wikipedia.org)

The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress. (ki.se)

The testing of lymph node accumulation of vaccine immunogens revealed that the Amphiphile-modified CpG DNA adjuvant is highly capable of increasing lymph node drainage and retention of immunogens, in addition to persistently inducing an acute inflammatory response in local and distal lymph nodes. (news-medical.net)

The DNA polymerase and the exonuclease activities of the EBV DNA polymerase catalytic subunit were sensitive to ammonium sulfate in contrast to those of the polymerase complex purified from EBV-producing lymphoblastoid cells, which were stimulated by salt. (neb.com)

The virus is also associated with the childhood disorders of Alice in Wonderland syndrome and acute cerebellar ataxia and, by some evidence, higher risks of developing certain autoimmune diseases, especially dermatomyositis, systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome. (wikipedia.org)

The virus is about 122-180 nm in diameter and is composed of a double helix of deoxyribonucleic acid (DNA) which contains about 172,000 base pairs encoding 85 genes. (wikipedia.org)

Herpes simplex virus encephalitis (HSVE) is associated with significant morbidity and mortality, even with appropriate antiviral therapy. (researchgate.net)

Various complications related toEpstein-Barr virus (EBV), either directly or secondary to unregulated immune response, are described in the literature. (medscape.com)
To further increase vaccine-induced immune response, an Amphiphile-modified CpG DNA adjuvant was incorporated into the vaccine. (news-medical.net)
If your immune system becomes weakened in the future, this virus may have the chance to reactivate, causing symptoms. (medlineplus.gov)

The virus infects resting B cells in the oropharynx and induces transcriptional programming of these cells to establish life-long viral latency. (news-medical.net)

By acting as a Trojan horse for cell invasion, viruses have taught us many of the basic principles that regulate cell proliferation, differentiation and death. (ki.se)

Anatomy9

Organisms57

Diseases15

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes29

Information Science4

Plasma Epstein-Barr1

Infection29

Active Epstein-Barr1

Cytomegalovirus3

Biomarker3

Proteins4

Burkitt1

Humoral and cellular1

Infectious1

Replication9

Cerebrospinal Fluid2

Hemophagocytic1

Hepatocellular carcinoma1

Strain2

Protein5

Molecular5

Genomic1

Latent2

Detection4

Herpes virus7

Herpesvirus2

Squamous Cell Carc1

Double-stranded2

Patients10

Gene1

Expression2

Chronic1

Kaposi1

Organism2

Lymphoid1

Gastric3

Influenza2

Mutations1

Infections1

Serum2

Situ Hybridization1

Pretreatment plasma1

Lymphocytes2

Carcinomas1

Human immun1

Nuclear1

Inflammatory1

Subunit1

Systemic1

Genes1

Morbidity1

Immune3

Oropharynx1

Cell proliferation1