• This technique can be used to map both linear and conformational epitopes, but is labor-intensive and slow, typically limiting analysis to a small number of amino acid residues. (wikipedia.org)
  • The analysis suggests that linear epitopes are relatively short, confined to five to seven residues, resulting in apparent off-target binding to peptides corresponding to a large number of unrelated human proteins. (mcponline.org)
  • Using peptide coated indirect ELISA, we localized the neutralizing determinants of the strongly inhibitory mAbs to a sequence-unique epitope on the later-ridge of domain III of the DV1 E protein, centered near residues T346 and D360 ( Our results showed two selected mAbs DV1-E1 and DV1-E2 can specifically target and significantly neutralize DV1. (sigmaaldrich.com)
  • The identification of DV1 mAbs epitope with key residues can also provide vital information for vaccine design. (sigmaaldrich.com)
  • Even for a ligand like the biantennary decasaccharide with micromolar binding affinity, the binding epitopes could easily be mapped to the terminal beta-D-Gal-(1-4)-beta-D-GlcNAc (beta-D-GlcNAc = N-acetyl-D-glucosamine) residues located at the nonreducing end of the two carbohydrate chains. (nih.gov)
  • Epitope mapping is also crucial to developing vaccines against prevalent viral diseases such as Dengue virus. (wikipedia.org)
  • Epitope mapping using randomly generated peptide libraries. (nih.gov)
  • PepSets peptide libraries make it possible to rapidly identify the epitopes of T-Cells, T-Cell clones, T-Helper Cell Clones, T-cell lines, and unpurified T-cells, such as lymph node cells and peripheral blood mononuclear cells (PBMC). (mimotopes.com)
  • A protocol based on saturation transfer difference (STD) NMR spectra was developed to characterize the binding interactions at an atom level, termed group epitope mapping (GEM). (nih.gov)
  • This new NMR technique can identify the binding epitope of even complex ligands very quickly, which is a great improvement over time-consuming chemical modifications. (nih.gov)
  • In addition to the previously characterized IR6 region in the variable domain, specific sequences in the N- and C-terminal invariable domains of VlsE were found to be major B cell epitopes in affected patients. (prohealth.com)
  • Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor. (nih.gov)
  • If one laboratory determines HLA presenting molecules at the serotype level (example: A2) and another at the genotype level (example: A*0201) both will be included in the map. (lanl.gov)
  • Genetics and the download epitope mapping of Species. (warren-nh.com)
  • other species from the download epitope mapping of the summer of the unique number to the purifying mutations and bills of second probability, Advanced Calculus lectures an national light for procedures in global publication and German grandson at the mutation and documentation funds. (warren-nh.com)
  • We will use our excellent technology to provide Peptide Array-Based Epitope Mapping services to our global customers. (creative-peptides.com)